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Review Article

The limited knowledge of placental damage due to neglected infections: ongoing problems in Latin America

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Pages 151-169 | Received 03 Nov 2019, Accepted 08 Mar 2020, Published online: 02 Jun 2020

References

  • Aagaard KM, Lahon A, Suter MA, Arya RP, Seferovic MD, Vogt MB, Hu M, Stossi F, Mancini MA, Harris RA, et al. eng. 2017. Primary human placental trophoblasts are permissive for Zika Virus (ZIKV) replication. Sci Rep. 7:41389. doi:10.1038/srep41389.
  • Adibi JJ, Zhao Y, Cartus AR, Gupta P, Davidson LA. 2016. Placental mechanics in the Zika-microcephaly relationship. Cell Host Microbe. 20(1):9–11. eng. doi:10.1016/j.chom.2016.06.013
  • Agrawal V, Hirsch E. 2012. Intrauterine infection and preterm labor. Semin Fetal Neonatal Med. 17(1):12–19. eng. doi:10.1016/j.siny.2011.09.001
  • Agudelo OM, Aristizabal BH, Yanow SK, Arango E, Carmona-Fonseca J, Maestre A. 2014. Submicroscopic infection of placenta by plasmodium produces Th1/Th2 cytokine imbalance, inflammation and hypoxia in women from north-west Colombia. Malar J. 13:122. eng. doi:10.1186/1475-2875-13-122.
  • Aisemberg J, Vercelli C, Billi S, Ribeiro ML, Ogando D, Meiss R, McCann SM, Rettori V, Franchi AM. 2007. Nitric oxide mediates prostaglandins’ deleterious effect on lipopolysaccharide-triggered murine fetal resorption. Proc Natl Acad Sci U S A. 104(18):7534–7539. eng. doi:10.1073/pnas.0702279104
  • Aldo P, You Y, Szigeti K, Horvath TL, Lindenbach B, Mor G. 2016. HSV-2 enhances ZIKV infection of the placenta and induces apoptosis in first-trimester trophoblast cells. Am J Reprod Immunol. 76(5):348–357. eng. doi:10.1111/aji.12578
  • Alimi TO, Fuller DO, Quinones ML, Xue RD, Herrera SV, Arevalo-Herrera M, Ulrich JN, Qualls WA, Beier JC. 2015. Prospects and recommendations for risk mapping to improve strategies for effective malaria vector control interventions in Latin America. Malar J. 14:519. eng. doi:10.1186/s12936-015-1052-1.
  • Aliota MT, Caine EA, Walker EC, Larkin KE, Camacho E, Osorio JE. 2016. Characterization of lethal Zika virus infection in AG129 mice. PLoS Negl Trop Dis. 10(4):e0004682. eng. doi:10.1371/journal.pntd.0004682
  • Arango EM, Samuel R, Agudelo OM, Carmona-Fonseca J, Maestre A, Yanow SK. 2013. Molecular detection of malaria at delivery reveals a high frequency of submicroscopic infections and associated placental damage in pregnant women from northwest Colombia. Am J Trop Med Hyg. 89(1):178–183. eng. doi:10.4269/ajtmh.12-0669
  • Arumugasaamy N, Ettehadieh LE, Kuo CY, Paquin-Proulx D, Kitchen SM, Santoro M, Placone JK, Silveira PP, Aguiar RS, Nixon DF, et al. 2018. Biomimetic placenta-fetus model demonstrating maternal-fetal transmission and fetal neural toxicity of Zika virus. Ann Biomed Eng. 46(12):1963–1974. eng. doi:10.1007/s10439-018-2090-y.
  • Avila-Garcia M, Mancilla-Ramirez J, Segura-Cervantes E, Farfan-Labonne B, Ramirez-Ramirez A, Galindo-Sevilla N. 2013. Transplacental transmission of cutaneous Leishmania mexicana strain in BALB/c mice. Am J Trop Med Hyg. 89(2):354–358. eng. doi:10.4269/ajtmh.12-0716
  • Baergen RN. 2011. Manual of pathology of the human placenta. Boston, MA: Springer. doi:10.1007/978-1-4419-7494-5
  • Bailey MS, Lockwood DN. 2007. Cutaneous leishmaniasis. Clin Dermatol. 25(2):203–211. eng. doi:10.1016/j.clindermatol.2006.05.008
  • Bardina SV, Bunduc P, Tripathi S, Duehr J, Frere JJ, Brown JA, Nachbagauer R, Foster GA, Krysztof D, Tortorella D, et al. 2017. Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity. Science. 356(6334):175–180. eng. doi:10.1126/science.aal4365.
  • Bastos MM, Boechat N, Gomes ATPC, Neves MGPMS, Cavaleiro JAS. 2012. O uso de porfirinas em terapia fotodinâmica no tratamento da leishmaniose cutânea. Rev Virtual Quim. 4(3):257–267.
  • Basurko C, Carles G, Youssef M, Guindi WE. 2009. Maternal and fetal consequences of dengue fever during pregnancy. Eur J Obstet Gynecol Reprod Biol. 147(1):29–32. eng. doi:10.1016/j.ejogrb.2009.06.028
  • Baud D, Greub G. 2011. Intracellular bacteria and adverse pregnancy outcomes. Clin Microbiol infect. 17(9):1312–1322, eng.
  • Baud D, Gubler DJ, Schaub B, Lanteri MC, Musso D. 2017. An update on Zika virus infection. Lancet. 390(10107):2099–2109. eng. doi:10.1016/S0140-6736(17)31450-2
  • Bayer A, Lennemann NJ, Ouyang Y, Bramley JC, Morosky S, Marques ET Jr., Cherry S, Sadovsky Y, Coyne CB. 2016. Type III interferons produced by human placental trophoblasts confer protection against Zika virus infection. Cell Host Microbe. 19(5):705–712. eng. doi:10.1016/j.chom.2016.03.008
  • Ben Slimane T, Chouihi E, Ben Hadj Ahmed S, Chelbi I, Barhoumi W, Cherni S, Zoghlami Z, Gharbi M, Zhioua E. 2014. An investigation on vertical transmission of Leishmania infantum in experimentally infected dogs and assessment of offspring’s infectiousness potential by xenodiagnosis. Vet Parasitol. 206(3–4):282–286. eng. doi:10.1016/j.vetpar.2014.10.020
  • Berger BA, Bartlett AH, Saravia NG, Galindo Sevilla N. 2017. Pathophysiology of leishmania infection during pregnancy. Trends Parasitol. 33(12):935–946. eng. doi:10.1016/j.pt.2017.08.012
  • Bhatnagar J, Rabeneck DB, Martines RB, Reagan-Steiner S, Ermias Y, Estetter LB, Suzuki T, Ritter J, Keating MK, Hale G, et al. 2017. Zika virus RNA replication and persistence in brain and placental tissue. Emerg Infect Dis. 23(3):405–414. eng. doi:10.3201/eid2303.161499.
  • Boeuf P, Tan A, Romagosa C, Radford J, Mwapasa V, Molyneux ME, Meshnick SR, Hunt NH, Rogerson SJ. 2008. Placental hypoxia during placental malaria. J Infect Dis. 197(5):757–765. eng. doi:10.1086/526521
  • Boehme CC, Novosel A, Eichenlaub S, Fleischmann E, Loscher T. 2006. Congenital visceral Leishmaniasis. Emerg Infect Dis. 12(2):359–360. doi:10.3201/eid1202.050449d.
  • Brabin BJ. 1983. An analysis of malaria in pregnancy in Africa. Bull World Health Organ. 61(6):1005–1016.
  • Brasil P, Pereira JP Jr., Moreira ME, Ribeiro Nogueira RM, Damasceno L, Wakimoto M, Rabello RS, Valderramos SG, Halai UA, Salles TS, et al. 2016. Zika virus infection in pregnant women in Rio de Janeiro. N Engl J Med. 375(24):2321–2334. eng. doi:10.1056/NEJMoa1602412.
  • Brown JA, Singh G, Acklin JA, Lee S, Duehr JE, Chokola AN, Frere JJ, Hoffman KW, Foster GA, Krysztof D, et al. 2019. Dengue virus immunity increases Zika virus-induced damage during pregnancy. Immunity. 50(3):751–762e755. eng. doi:10.1016/j.immuni.2019.01.005.
  • Bruel A, Kavanagh D, Noris M, Delmas Y, Wong EKS, Bresin E, Provot F, Brocklebank V, Mele C, Remuzzi G, et al. 2017. Hemolytic uremic syndrome in pregnancy and postpartum. Clinical Journal of the American Society of Nephrology: CJASN. 12(8):1237–1247. eng. doi:10.2215/CJN.00280117.
  • Burdet J, Sacerdoti F, Cella M, Franchi AM, Ibarra C. 2013. Role of TNF-alpha in the mechanisms responsible for preterm delivery induced by Stx2 in rats. Br J Pharmacol. 168(4):946–953. eng. doi:10.1111/j.1476-5381.2012.02239.x
  • Burdet J, Zotta E, Cella M, Franchi AM, Ibarra C. 2010. Role of nitric oxide in shiga toxin-2-induced premature delivery of dead fetuses in rats. PLoS One. 5(12):e15127. eng. doi:10.1371/journal.pone.0015127
  • Burton GJ, Fowden AL, Thornburg KL. 2016. Placental origins of chronic disease. Physiol Rev. 96(4):1509–1565. eng. doi:10.1152/physrev.00029.2015
  • Caldas AJ, Costa JM, Gama ME, Ramos EA, Barral A. 2003. Visceral leishmaniasis in pregnancy: a case report. Acta Trop. 88(1):39–43. eng. doi:10.1016/S0001-706X(03)00160-8
  • Calvet G, Aguiar RS, Melo ASO, Sampaio SA, de Filippis I, Fabri A, Araujo ESM, de Sequeira PC, de Mendonca MCL, de Oliveira L, et al. 2016. Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis. 16(6):653–660. eng. doi:10.1016/S1473-3099(16)00095-5.
  • Cao B, Parnell LA, Diamond MS, Mysorekar IU. 2017. Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice. J Exp Med. 214(8):2303–2313. eng. doi:10.1084/jem.20170957
  • Carmona-Fonseca J, Arango E, Maestre A. 2013. Placental malaria in Colombia: histopathologic findings in Plasmodium vivax and P. falciparum infections. Am J Trop Med Hyg. 88(6):1093–1101. eng. doi:10.4269/ajtmh.12-0363
  • Carvalho BO, Lopes SC, Nogueira PA, Orlandi PP, Bargieri DY, Blanco YC, Mamoni R, Leite JA, Rodrigues MM, Soares IS, et al. 2010. On the cytoadhesion of plasmodium vivax-infected erythrocytes. J Infect Dis. 202(4):638–647. eng. doi:10.1086/654815.
  • Carvalho FR, Medeiros T, Vianna RAO, Douglass-Jaimes G, Nunes PCG, Quintans MDS, Souza CF, Cavalcanti SMB, Dos Santos FB, Oliveira SA, et al. eng. 2019. Simultaneous circulation of arboviruses and other congenital infections in pregnant women in Rio de Janeiro, Brazil. Acta Trop. 192:49–54. doi:10.1016/j.actatropica.2019.01.020.
  • Charlier C, Beaudoin MC, Couderc T, Lortholary O, Lecuit M. 2017. Arboviruses and pregnancy: maternal, fetal, and neonatal effects. Lancet Child Adolesc Health. 1(2):134–146. eng. doi:10.1016/S2352-4642(17)30021-4
  • Chart H, Perry NT, Cheasty T, Wright PA. 2002. The kinetics of antibody production to antigens of Escherichia coli O157 in a pregnant woman with haemolytic uraemic syndrome. J Med Microbiol. 51(6):522–525. eng. doi:10.1099/0022-1317-51-6-522
  • Chen J, Liang Y, Yi P, Xu L, Hawkins HK, Rossi SL, Soong L, Cai J, Menon R, Sun J. 2017. Outcomes of Congenital Zika disease depend on timing of infection and maternal-fetal interferon action. Cell Rep. 21(6):1588–1599. eng. doi:10.1016/j.celrep.2017.10.059
  • Conroy A, Serghides L, Finney C, Owino SO, Kumar S, Gowda DC, Liles WC, Moore JM, Kain KC. 2009. C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria. PLoS One. 4(3):e4953. eng. doi:10.1371/journal.pone.0004953
  • Conroy AL, McDonald CR, Silver KL, Liles WC, Kain KC. 2011. Complement activation: a critical mediator of adverse fetal outcomes in placental malaria? Trends Parasitol. 27(7):294–299. eng. doi:10.1016/j.pt.2011.02.005
  • Conroy AL, Silver KL, Zhong K, Rennie M, Ward P, Sarma JV, Molyneux ME, Sled J, Fletcher JF, Rogerson S, et al. 2013. Complement activation and the resulting placental vascular insufficiency drives fetal growth restriction associated with placental malaria. Cell Host Microbe. 13(2):215–226. eng. doi:10.1016/j.chom.2013.01.010.
  • Contopoulos-Ioannidis D, Newman-Lindsay S, Chow C, LaBeaud AD. 2018. Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis. PLoS Negl Trop Dis. 12(6):e0006510. eng. doi:10.1371/journal.pntd.0006510
  • Cordovez A, Prado V, Maggi L, Cordero J, Martinez J, Misraji A, Rios R, Soza G, Ojeda A, Levine MM. 1992. Enterohemorrhagic Escherichia coli associated with hemolytic-uremic syndrome in Chilean children. J Clin Microbiol. 30(8):2153–2157. eng. doi:10.1128/JCM.30.8.2153-2157.1992
  • Corry J, Arora N, Good CA, Sadovsky Y, Coyne CB. 2017. Organotypic models of type III interferon-mediated protection from Zika virus infections at the maternal-fetal interface. Proc Natl Acad Sci U S A. 114(35):9433–9438. eng. doi:10.1073/pnas.1707513114
  • Costa AA, Saldanha AC, Leite BM, Ramos B, Junior IA, Noronha AL, Bafica A, Barral A, Corbett CE, Costa JM. 2005. Imaging exams of bone lesions in patients with diffuse cutaneous leishmaniasis (DCL). Acta Trop. 96(1):9–15. eng. doi:10.1016/j.actatropica.2005.06.016
  • Costa MA. 2016. The endocrine function of human placenta: an overview. Reprod Biomed Online. 32(1):14–43. eng. doi:10.1016/j.rbmo.2015.10.005
  • Costa-da-Silva AL, Ioshino RS, Petersen V, Lima AF, Cunha MDP, Wiley MR, Ladner JT, Prieto K, Palacios G, Costa DD, et al. 2017. First report of naturally infected Aedes aegypti with chikungunya virus genotype ECSA in the Americas. PLoS Negl Trop Dis. 11(6):e0005630. eng. doi:10.1371/journal.pntd.0005630.
  • Couderc T, Chretien F, Schilte C, Disson O, Brigitte M, Guivel-Benhassine F, Touret Y, Barau G, Cayet N, Schuffenecker I, et al. 2008. A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease. PLoS Pathog. 4(2):e29. eng. doi:10.1371/journal.ppat.0040029.
  • D’Oliveira A Jr., Machado P, Bacellar O, Cheng LH, Almeida RP, Carvalho EM. 2002. Evaluation of IFN-gamma and TNF-alpha as immunological markers of clinical outcome in cutaneous leishmaniasis. Rev Soc Bras Med Trop. 35(1):7–10. eng. doi:10.1590/S0037-86822002000100002
  • de Araújo TVB, Ximenes RAA, Miranda-Filho DB, Souza WV, Montarroyos UR, de Melo APL, Valongueiro S, de Albuquerque MFPM, Braga C, Filho SPB, 2018. Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study. Lancet Infect Dis. 18(3):328–336. eng. doi:10.1016/S1473-3099(17)30727-2.
  • de Noronha L, Zanluca C, Burger M, Suzukawa AA, Azevedo M, Rebutini PZ, Novadzki IM, Tanabe LS, Presibella MM, CN DDS. 2018. Zika Virus Infection at different pregnancy stages: anatomopathological findings, target cells and viral persistence in placental tissues. Front Microbiol. 9:2266. eng. doi:10.3389/fmicb.2018.02266.
  • Desjeux P. 1996. Leishmaniasis. Public Health Aspects and Control Clin Dermatol. 14(5):417–423, eng.
  • Dotters-Katz SK, Grace MR, Strauss RA, Chescheir N, Kuller JA. 2015. Chikungunya fever: obstetric considerations on an emerging virus. Obstet Gynecol Surv. 70(7):453–457. eng. doi:10.1097/OGX.0000000000000184
  • Driggers RW, Ho CY, Korhonen EM, Kuivanen S, Jaaskelainen AJ, Smura T, Rosenberg A, Hill DA, DeBiasi RL, Vezina G, et al. 2016. Zika Virus infection with prolonged maternal viremia and fetal brain abnormalities. N Engl J Med. 374(22):2142–2151. eng. doi:10.1056/NEJMoa1601824.
  • Duaso J, Rojo G, Jana F, Galanti N, Cabrera G, Bosco C, Lopez-Munoz R, Maya JD, Ferreira J, Kemmerling U. 2011. Trypanosoma cruzi induces apoptosis in ex vivo infected human chorionic villi. Placenta. 32(5):356–361. eng. doi:10.1016/j.placenta.2011.02.005
  • Economopoulou A, Dominguez M, Helynck B, Sissoko D, Wichmann O, Quenel P, Germonneau P, Quatresous I. 2009. Atypical Chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005-2006 outbreak on Reunion. Epidemiol Infect. 137(4):534–541. eng. doi:10.1017/S0950268808001167
  • Eltoum IA, Zijlstra EE, Ali MS, Ghalib HW, Satti MM, Eltoum B, AM E-H. 1992. Congenital kala-azar and leishmaniasis in the placenta. Am J Trop Med Hyg. 46(1):57–62. eng. doi:10.4269/ajtmh.1992.46.57
  • Escobar M, Nieto AJ, Loaiza-Osorio S, Barona JS, Rosso F. 2017. Pregnant women hospitalized with chikungunya virus infection, Colombia, 2015. Emerg Infect Dis. 2311: eng. DOI:10.3201/eid2311.170480.
  • Fernandez E, Dejnirattisai W, Cao B, Scheaffer SM, Supasa P, Wongwiwat W, Esakky P, Drury A, Mongkolsapaya J, Moley KH, et al. 2017. Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection. Nat Immunol. 18(11):1261–1269. eng. doi:10.1038/ni.3849.
  • Franca GV, Schuler-Faccini L, Oliveira WK, Henriques CM, Carmo EH, Pedi VD, Nunes ML, Castro MC, Serruya S, Silveira MF, et al. 2016. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet. 388(10047):891–897. eng. doi:10.1016/S0140-6736(16)30902-3.
  • Frank C, Werber D, Cramer JP, Askar M, Faber M, An der Heiden M, Bernard H, Fruth A, Prager R, Spode A, et al. 2011. Epidemic profile of Shiga-toxin-producing Escherichia coli O104: h4outbreak in Germany. N Engl J Med. 365(19):1771–1780. eng. doi:10.1056/NEJMoa1106483.
  • Fried M, Domingo GJ, Gowda CD, Mutabingwa TK, Duffy PE. 2006. Plasmodium falciparum: chondroitin sulfate A is the major receptor for adhesion of parasitized erythrocytes in the placenta. Exp Parasitol. 113(1):36–42. eng. doi:10.1016/j.exppara.2005.12.003
  • Fried M, Duffy PE. 1996. Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta. Science. 272(5267):1502–1504. eng. doi:10.1126/science.272.5267.1502
  • Fried M, Muga RO, Misore AO, Duffy PE. 1998. Malaria elicits type 1 cytokines in the human placenta: IFN-gamma and TNF-alpha associated with pregnancy outcomes. J Immunol. 160(5):2523–2530, eng.
  • Fritel X, Rollot O, Gerardin P, Gauzere BA, Bideault J, Lagarde L, Dhuime B, Orvain E, Cuillier F, Ramful D, et al. 2010. Chikungunya virus infection during pregnancy, Reunion, France, 2006. Emerg Infect Dis. 16(3):418–425. eng. doi:10.3201/eid1604.091403.
  • Gerardin P, Samperiz S, Ramful D, Boumahni B, Bintner M, Alessandri JL, Carbonnier M, Tiran-Rajaoefera I, Beullier G, Boya I, et al. 2014. Neurocognitive outcome of children exposed to perinatal mother-to-child Chikungunya virus infection: the CHIMERE cohort study on Reunion Island. PLoS Negl Trop Dis. 8(7):e2996. eng. doi:10.1371/journal.pntd.0002996.
  • GBD 2015 Mortality and Causes of Death Collaborators. 2016.
  • Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 388(10053):1459–1544. eng. doi:10.1016/S0140-6736(16)31012-1
  • Gubler DJ. 2002. Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol. 10(2):100–103. eng. doi:10.1016/S0966-842X(01)02288-0
  • Gurung P, Kanneganti TD. 2015. Innate immunity against Leishmania infections. Cell Microbiol. 17(9):1286–1294. eng. doi:10.1111/cmi.12484
  • Hermanns K, Gohner C, Kopp A, Schmidt A, Merz WM, Markert UR, Junglen S, Drosten C. 2018. Zika virus infection in human placental tissue explants is enhanced in the presence of dengue virus antibodies in-vitro. Emerg Microbes Infect. 7(1):198. eng. doi:10.1038/s41426-018-0199-6
  • Hussein HS. 2007. Prevalence and pathogenicity of Shiga toxin-producing Escherichia coli in beef cattle and their products. J Anim Sci. 85(13 Suppl):E63–72. eng. doi:10.2527/jas.2006-421
  • Ibarra C, Amaral MM, Palermo MS. 2013. Advances in pathogenesis and therapy of hemolytic uremic syndrome caused by Shiga toxin-2. IUBMB Life. 65(10):827–835. eng. doi:10.1002/iub.1206
  • Ismail MR, Ordi J, Menendez C, Ventura PJ, Aponte JJ, Kahigwa E, Hirt R, Cardesa A, Alonso PL. 2000. Placental pathology in malaria: a histological, immunohistochemical, and quantitative study. Hum Pathol. 31(1):85–93. eng. doi:10.1016/S0046-8177(00)80203-8
  • Jurado KA, Simoni MK, Tang Z, Uraki R, Hwang J, Householder S, Wu M, Lindenbach BD, Abrahams VM, Guller S, et al. 2016. Zika virus productively infects primary human placenta-specific macrophages. JCI Insight. 1(13). eng. doi:10.1172/jci.insight.88461
  • Kallur SD, Surapaneni T, Boorugu HK, Aziz N, Gala AR, Donnuri S. 2019. Need for guidelines for the combined management of pregnancy and dengue: a retrospective study from an Indian tertiary care maternity hospital. Trop Doct. 49(1):7–9. eng. doi:10.1177/0049475518800638
  • Kam YW, Lee CY, Teo TH, Howland SW, Amrun SN, Lum FM, See P, Kng NQ, Huber RG, Xu MH, et al. 2017. Cross-reactive dengue human monoclonal antibody prevents severe pathologies and death from Zika virus infections. JCI Insight. 2(8). eng. doi:10.1172/jci.insight.92428
  • Karmali MA, Petric M, Lim C, Fleming PC, Steele BT. 1983. Escherichia coli cytotoxin, haemolytic-uraemic syndrome, and haemorrhagic colitis. Lancet. 322(8362):1299–1300. eng. doi:10.1016/S0140-6736(83)91167-4
  • Kemp MW. 2014. Preterm birth, intrauterine infection, and fetal inflammation. Front Immunol. 5:574. eng. doi:10.3389/fimmu.2014.00574.
  • Krishnan L, Guilbert LJ, Russell AS, Wegmann TG, Mosmann TR, Belosevic M. 1996. Pregnancy impairs resistance of C57BL/6 mice to Leishmania major infection and causes decreased antigen-specific IFN-gamma response and increased production of T helper 2 cytokines. J Immunol. 156(2):644–652, eng.
  • Laoprasopwattana K, Suntharasaj T, Petmanee P, Suddeaugrai O, Geater A. 2016. Chikungunya and dengue virus infections during pregnancy: seroprevalence, seroincidence and maternal-fetal transmission, southern Thailand, 2009-2010. Epidemiol Infect. 144(2):381–388. eng. doi:10.1017/S0950268815001065
  • Lenglet Y, Barau G, Robillard PY, Randrianaivo H, Michault A, Bouveret A, Gerardin P, Boumahni B, Touret Y, Kauffmann E, et al. 2006. [Chikungunya infection in pregnancy: evidence for intrauterine infection in pregnant women and vertical transmission in the parturient. Survey of the Reunion Island outbreak]. J Gynecol Obstet Biol Reprod (Paris). 35(6):578–583. fre. doi:10.1016/S0368-2315(06)76447-X.
  • Leparc-Goffart I, Nougairede A, Cassadou S, Prat C, de Lamballerie X. 2014. Chikungunya in the Americas. Lancet. 383(9916):514. eng. doi:10.1016/S0140-6736(14)60185-9
  • Liang G, Gao X, Gould EA. 2015. Factors responsible for the emergence of arboviruses; strategies, challenges and limitations for their control. Emerg Microbes Infect. 4(1):e18. eng. doi:10.1038/emi.2015.18
  • Lopez-Perez M, Pacheco MA, Buritica L, Escalante AA, Herrera S, Arevalo-Herrera M. 2016. Malaria in pregnancy: a passive surveillance study of pregnant women in low transmission areas of Colombia, Latin America. Malar J. 15:66. eng. doi:10.1186/s12936-016-1125-9.
  • Low GC, Cooke WE. 1926. A congenital case of Kala-Azar. The Lancet. 208(5389):1209–1211. doi:10.1016/S0140-6736(01)05214-X.
  • Luo H, Winkelmann ER, Fernandez-Salas I, Li L, Mayer SV, Danis-Lozano R, Sanchez-Casas RM, Vasilakis N, Tesh R, Barrett AD, et al. eng. 2018. Zika, dengue and yellow fever viruses induce differential anti-viral immune responses in human monocytic and first trimester trophoblast cells. Antiviral Res. 151:55–62. doi:10.1016/j.antiviral.2018.01.003.
  • Ma J, Ketkar H, Geng T, Lo E, Wang L, Xi J, Sun Q, Zhu Z, Cui Y, Yang L, et al. eng. 2018. Zika virus non-structural protein 4A blocks the RLR-MAVS signaling. Front Microbiol. 9:1350. doi:10.3389/fmicb.2018.01350.
  • Machado Filho AC, da Costa EP, Reis IS, Fernandes EA, Paim BV, Martinez-Espinosa FE. 2014. Effects of vivax malaria acquired before 20 weeks of pregnancy on subsequent changes in fetal growth. Am J Trop Med Hyg. 90(2):371–376. eng. doi:10.4269/ajtmh.13-0285
  • Malária. 2019. The Global Found; [accessed 2019 Jul 24th]. https://www.theglobalfund.org/en/malaria/.
  • Maspi N, Abdoli A, Ghaffarifar F. 2016. Pro- and anti-inflammatory cytokines in cutaneous leishmaniasis: a review. Pathog Glob Health. 110(6):247–260. eng. doi:10.1080/20477724.2016.1232042
  • McDonald CR, Tran V, Kain KC. 2015. Complement activation in placental malaria. Front Microbiol. 6:1460. eng. doi:10.3389/fmicb.2015.01460.
  • Medawar P. 1952. Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Symp Soc Exp Biol. 7:320–338.
  • Meinecke CK, Schottelius J, Oskam L, Fleischer B. 1999. Congenital transmission of visceral leishmaniasis (Kala Azar) from an asymptomatic mother to her child. Pediatrics. 104(5):e65. eng. doi:10.1542/peds.104.5.e65
  • Mescouto-Borges MR, Maues E, Costa DL, Pranchevicius MC, Romero GA. 2013. Congenitally transmitted visceral leishmaniasis: report of two Brazilian human cases. The Brazilian Journal of Infectious Diseases: An Official Publication of the Brazilian Society of Infectious Diseases. 17(2):263–266. eng. doi:10.1016/j.bjid.2012.10.017
  • Messina JP, Brady OJ, Pigott DM, Golding N, Kraemer MU, Scott TW, Wint GR, Smith DL, Hay SI. 2015. The many projected futures of dengue. Nat Rev Microbiol. 13(4):230–239. eng. doi:10.1038/nrmicro3430
  • Miner JJ, Cao B, Govero J, Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK, et al. 2016. Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise. Cell. 165(5):1081–1091. eng. doi:10.1016/j.cell.2016.05.008.
  • Mitropoulos P, Konidas P, Durkin-Konidas M. 2010. New World cutaneous leishmaniasis: updated review of current and future diagnosis and treatment. J Am Acad Dermatol. 63(2):309–322. eng. doi:10.1016/j.jaad.2009.06.088
  • Mlakar J, Korva M, Tul N, Popovic M, Poljsak-Prijatelj M, Mraz J, Kolenc M, Resman Rus K, Vesnaver Vipotnik T, Fabjan Vodusek V, et al. 2016. Zika virus associated with microcephaly. N Engl J Med. 374(10):951–958. eng. doi:10.1056/NEJMoa1600651.
  • Morgan DJ, Guimaraes LH, Machado PR, D’Oliveira A Jr., Almeida RP, Lago EL, Faria DR, Tafuri WL, Dutra WO, Carvalho EM. 2007. Cutaneous leishmaniasis during pregnancy: exuberant lesions and potential fetal complications. Clin Infect Dis. 45(4):478–482. eng. doi:10.1086/520017
  • Muehlenbachs A, Fried M, McGready R, Harrington WE, Mutabingwa TK, Nosten F, Duffy PE. 2010. A novel histological grading scheme for placental malaria applied in areas of high and low malaria transmission. J Infect Dis. 202(10):1608–1616. eng. doi:10.1086/656723
  • Nataro JP, Kaper JB. 1998. Diarrheagenic Escherichia coli. Clin Microbiol Rev. 11(1):142–201, eng.
  • Nations WHOFaAOotU. 2018. Shiga toxin-producing Escherichia coli (‎STEC)‎ and food: attribution, characterization, and monitoring: report.
  • Naucke TJ, Lorentz S. 2012. First report of venereal and vertical transmission of canine leishmaniosis from naturally infected dogs in Germany. Parasit Vectors. 5:67. eng. doi:10.1186/1756-3305-5-67.
  • Neu N, Duchon J, Zachariah P. 2015. TORCH infections. Clin Perinatol. 42(1):77–103. viii. eng. doi:10.1016/j.clp.2014.11.001
  • Noronha L, Zanluca C, Azevedo ML, Luz KG, Santos CN. 2016. Zika virus damages the human placental barrier and presents marked fetal neurotropism. Mem Inst Oswaldo Cruz. 111(5):287–293. eng. doi:10.1590/0074-02760160085
  • Nosten F, Ter Kuile F, Maelankirri L, Decludt B, White NJ. 1991. Malaria during pregnancy in an area of unstable endemicity. Trans R Soc Trop Med Hyg. 85(4):424–429. eng. doi:10.1016/0035-9203(91)90205-D
  • Nunes P, Nogueira R, Coelho J, Rodrigues F, Salomao N, Jose C, de Carvalho J, Rabelo K. 2019. A stillborn multiple organs’ investigation from a maternal DENV-4 Infection: histopathological and inflammatory mediators characterization. Viruses. 11. 4.
  • Nunes PC, Paes MV, de Oliveira CA, Soares AC, de Filippis AM, Lima Mda R, de Barcelos Alves AM, da Silva JF, de Oliveira Coelho JM, de Carvalho Rodrigues F, et al. 2016. Detection of dengue NS1 and NS3 proteins in placenta and umbilical cord in fetal and maternal death. J Med Virol. 88(8):1448–1452. eng. doi:10.1002/jmv.24479.
  • Nuwayri-Salti NFKH. 1985. Direct non-insect-vector transmission of Leishmania parasites in mice. Int J Parasitol. 15(2):497–500. doi:10.1016/0020-7519(85)90043-8.
  • Nyakundi PM, Muigai R, Were JB, Oster CN, Gachihi GS, Kirigi G. 1988. Congenital visceral leishmaniasis: case report. Trans R Soc Trop Med Hyg. 82(4):564. eng. doi:10.1016/0035-9203(88)90508-1
  • Ogando DG, Paz D, Cella M, Franchi AM. 2003. The fundamental role of increased production of nitric oxide in lipopolysaccharide-induced embryonic resorption in mice. Reproduction. 125(1):95–110. eng. doi:10.1530/rep.0.1250095
  • Ojha CR, Rodriguez M, Lapierre J, Muthu Karuppan MK, Branscome H, Kashanchi F, El-Hage N. 2018. Complementary mechanisms potentially involved in the pathology of Zika virus. Front Immunol. 92340: eng. DOI:10.3389/fimmu.2018.02340.
  • Paes M, de Noronha L, Zanluca C, Burger M, Suzukawa AA, Azevedo M, Rebutini PZ, Novadzki IM, Tanabe LS, Presibella MM, et al. 2018. Zika virus infection at different pregnancy stages: anatomopathological findings, target cells and viral persistence in placental tissues. Viruses. 9:2266. eng.
  • Pagliano P, Ascione T, Di Flumeri G, Boccia G, De Caro F. 2016. Visceral leishmaniasis in immunocompromised: diagnostic and therapeutic approach and evaluation of the recently released IDSA guidelines. Infez Med. 24(4):265–271, eng.
  • Pagliano P, Carannante N, Rossi M, Gramiccia M, Gradoni L, Faella FS, Gaeta GB. 2005. Visceral leishmaniasis in pregnancy: a case series and a systematic review of the literature. J Antimicrob Chemother. 55(2):229–233. eng. doi:10.1093/jac/dkh538
  • PAHO. 2019. Epidemiological Report of the Americas. World Health Organization; [accessed 2019 May 22]. http://iris.paho.org/xmlui/bitstream/handle/123456789/50505/Leishreport2019_eng.pdf?sequence=9&isAllowed=y.
  • Paixao E, Teixeira M, Costa M, Barreto M, Rodrigues L. 2018a. Symptomatic Dengue during Pregnancy and Congenital Neurologic Malformations. Emerg Infect Dis. 24:1748–1750. doi:10.3201/eid2409.170361.
  • Paixao ES, Harron K, Campbell O, Teixeira MG, Costa M, Barreto ML, Rodrigues LC. 2018. Dengue in pregnancy and maternal mortality: a cohort analysis using routine data. Sci Rep. 8(1):9938. eng. doi:10.1038/s41598-018-28387-w
  • Palermo MS, Exeni RA, Fernandez GC. 2009. Hemolytic uremic syndrome: pathogenesis and update of interventions. Expert Rev Anti Infect Ther. 7(6):697–707. eng. doi:10.1586/eri.09.49
  • Pangrazio KK, Costa EA, Amarilla SP, Cino AG, Silva TM, Paixao TA, Costa LF, Dengues EG, Diaz AA, Santos RL. 2009. Tissue distribution of Leishmania chagasi and lesions in transplacentally infected fetuses from symptomatic and asymptomatic naturally infected bitches. Vet Parasitol. 165(3–4):327–331. eng. doi:10.1016/j.vetpar.2009.07.013
  • Park AY, Hondowicz B, Kopf M, Scott P. 2002. The role of IL-12 in maintaining resistance to Leishmania major. J Immunol. 168(11):5771–5777. eng. doi:10.4049/jimmunol.168.11.5771
  • Petitt M, Tabata T, Puerta-Guardo H, Harris E, Pereira L. 2017. Zika virus infection of first-trimester human placentas: utility of an explant model of replication to evaluate correlates of immune protection ex vivo. Curr Opin Virol. 27:48–56. eng. doi:10.1016/j.coviro.2017.11.008.
  • Platt DJ, Smith AM, Arora N, Diamond MS, Coyne CB, Miner JJ. 2018. Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice. Sci Transl Med. 10(426): eng. DOI:10.1126/scitranslmed.aao7090.
  • Priyamvada L, Quicke KM, Hudson WH, Onlamoon N, Sewatanon J, Edupuganti S, Pattanapanyasat K, Chokephaibulkit K, Mulligan MJ, Wilson PC, et al. 2016. Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus. Proc Natl Acad Sci U S A. 113(28):7852–7857. eng. doi:10.1073/pnas.1607931113.
  • Quicke KM, Bowen JR, Johnson EL, McDonald CE, Ma H, O’Neal JT, Rajakumar A, Wrammert J, Rimawi BH, Pulendran B, et al. 2016. Zika Virus Infects Human Placental Macrophages. Cell Host Microbe. 20(1):83–90. eng. doi:10.1016/j.chom.2016.05.015.
  • Raa H, Grimmer S, Schwudke D, Bergan J, Walchli S, Skotland T, Shevchenko A, Sandvig K. 2009. Glycosphingolipid requirements for endosome-to-Golgi transport of Shiga toxin. Traffic. 10(7):868–882. eng. doi:10.1111/j.1600-0854.2009.00919.x
  • Ramful D, Carbonnier M, Pasquet M, Bouhmani B, Ghazouani J, Noormahomed T, Beullier G, Attali T, Samperiz S, Fourmaintraux A, et al. 2007. Mother-to-child transmission of Chikungunya virus infection. Pediatr Infect Dis J. 26(9):811–815. eng. doi:10.1097/INF.0b013e3180616d4f.
  • Ramos R, Viana R, Brainer-Lima A, FloreAncio T, Carvalho MD, van der Linden V, Amorim A, Rocha MA, Medeiros F. 2018. Perinatal Chikungunya Virus-associated Encephalitis Leading to Postnatal-Onset Microcephaly and Optic Atrophy. Pediatr Infect Dis J. 37(1):94–95. eng. doi:10.1097/INF.0000000000001690
  • Regla-Nava JA, Elong Ngono A, Viramontes KM, Huynh AT, Wang YT, Nguyen AT, Salgado R, Mamidi A, Kim K, Diamond MS, et al. 2018. Cross-reactive Dengue virus-specific CD8(+) T cells protect against Zika virus during pregnancy. Nat Commun. 9(1):3042. eng. doi:10.1038/s41467-018-05458-0.
  • Reithinger R, Dujardin JC. 2007. Molecular diagnosis of leishmaniasis: current status and future applications. J Clin Microbiol. 45(1):21–25. eng. doi:10.1128/JCM.02029-06
  • Repetto HA. 1997. Epidemic hemolytic-uremic syndrome in children. Kidney Int. 52(6):1708–1719. eng. doi:10.1038/ki.1997.508
  • Repetto HA. 2005. Long-term course and mechanisms of progression of renal disease in hemolytic uremic syndrome. Kidney Int Suppl. 68(97):S102–106. eng. doi:10.1111/j.1523-1755.2005.09717.x
  • Ribeiro CF, Lopes VG, Brasil P, Coelho J, Muniz AG, Nogueira RM. 2013. Perinatal transmission of dengue: a report of 7 cases. J Pediatr. 163(5):1514–1516. eng. doi:10.1016/j.jpeds.2013.06.040
  • Ribeiro CF, Lopes VGS, Brasil P, Pires ARC, Rohloff R, Nogueira RMR. 2017. Dengue infection in pregnancy and its impact on the placenta. Int J Infect Dis. 55:109–112. eng. doi:10.1016/j.ijid.2017.01.002.
  • Riera C, Valladares JE. 1996. Viable Leishmania infantum in urine and semen in experimentally infected dogs. Parasitol Today. 12(10):412. eng. doi:10.1016/0169-4758(96)90062-9
  • Rivas M, Chinen I, Miliwebsky E, Masana M. 2014. Risk Factors for Shiga Toxin-Producing Escherichia coli-Associated Human Diseases. Microbiol Spectr. 25: eng. DOI:10.1128/microbiolspec.EHEC-0002-2013.
  • Robbins JR, Bakardjiev AI. 2012. Pathogens and the placental fortress. Curr Opin Microbiol. 15(1):36–43. eng. doi:10.1016/j.mib.2011.11.006
  • Robbins JR, Skrzypczynska KM, Zeldovich VB, Kapidzic M, Bakardjiev AI. 2010. Placental syncytiotrophoblast constitutes a major barrier to vertical transmission of Listeria monocytogenes. PLoS Pathog. 6(1):e1000732, eng.
  • Robbins JR, Zeldovich VB, Poukchanski A, Boothroyd JC, Bakardjiev AI. 2012. Tissue barriers of the human placenta to infection with Toxoplasma gondii. Infect Immun. 80(1):418–428. eng. doi:10.1128/IAI.05899-11
  • Robinson MC. 1955. An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. I. Clinical features. Trans R Soc Trop Med Hyg. 49(1):28–32. eng. doi:10.1016/0035-9203(55)90080-8
  • Rodriguez-Morales AJ, Cardona-Ospina JA, Ramirez-Jaramillo V, Gaviria JA, Gonzalez-Moreno GM, Castrillon-Spitia JD, Lopez-Villegas A, Morales-Jimenez E, Ramirez-Zapata V, Rueda-Merchan GE, et al. 2018. Diagnosis and outcomes of pregnant women with Zika virus infection in two municipalities of Risaralda, Colombia: second report of the ZIKERNCOL study. Travel Med Infect Dis. 25:20–25. eng.
  • Rogerson SJ. 2017. Management of malaria in pregnancy. Indian J Med Res. 146(3):328–333. eng. doi:10.4103/ijmr.IJMR_1304_17
  • Rogerson SJ, Pollina E, Getachew A, Tadesse E, Lema VM, Molyneux ME. 2003. Placental monocyte infiltrates in response to Plasmodium falciparum malaria infection and their association with adverse pregnancy outcomes. Am J Trop Med Hyg. 68(1):115–119. eng. doi:10.4269/ajtmh.2003.68.1.0680115
  • Romero I, Tellez J, Suarez Y, Cardona M, Figueroa R, Zelazny A, Gore Saravia N. 2010. Viability and burden of Leishmania in extralesional sites during human dermal leishmaniasis. PLoS Negl Trop Dis. 49: eng. DOI:10.1371/journal.pntd.0000819.
  • Romero RCT. 2002. Preterm labor, intrauterine infection, and the fetal inflammatory response syndrome. NeoReviews. 3:5. doi:10.1542/neo.3-5-e73.
  • Rosenberg AZ, Yu W, Hill DA, Reyes CA, Schwartz DA. 2017. Placental Pathology of Zika Virus: viral Infection of the Placenta Induces Villous Stromal Macrophage (Hofbauer Cell) Proliferation and Hyperplasia. Arch Pathol Lab Med. 141(1):43–48. eng. doi:10.5858/arpa.2016-0401-OA
  • Rosypal AC, Troy GC, Zajac AM, Frank G, Lindsay DS. 2005. Transplacental transmission of a North American isolate of Leishmania infantum in an experimentally infected beagle. J Parasitol. 91(4):970–972. eng. doi:10.1645/GE-483R.1
  • Sacerdoti F, Amaral MM, Aisemberg J, Cymeryng CB, Franchi AM, Ibarra C. 2015. Involvement of hypoxia and inflammation in early pregnancy loss mediated by Shiga toxin type 2. Placenta. 36(6):674–680. eng. doi:10.1016/j.placenta.2015.03.005
  • Sacerdoti F, Amaral MM, Zotta E, Franchi AM, Ibarra C. 2014. Effects of Shiga toxin type 2 on maternal and fetal status in rats in the early stage of pregnancy. Biomed Res Int. 2014:384645. eng. doi:10.1155/2014/384645.
  • Sacerdoti F, Scalise ML, Burdet J, Amaral MM, Franchi AM, Ibarra C. 2018. Shiga Toxin-Producing Escherichia coli Infections during Pregnancy. Microorganisms. 64: eng. DOI:10.3390/microorganisms6040111.
  • Sacks D, Noben-Trauth N. 2002. The immunology of susceptibility and resistance to Leishmania major in mice. Nat Rev Immunol. 2(11):845–858. eng. doi:10.1038/nri933
  • Salles TS, da Encarnacao Sa-guimaraes T, ESL DA, Guimaraes-Ribeiro V, MDF DM, de Castro-salles PF, Dos Santos CR, Do Amaral Melo AC, Soares MR, Ferreira DF, et al. 2018. History, epidemiology and diagnostics of dengue in the American and Brazilian contexts: a review. Parasit Vectors. 11(1):264. eng. doi:10.1186/s13071-018-2830-8.
  • Scalise ML, Amaral MM, Reppetti J, Damiano AE, Ibarra C, Sacerdoti F. 2019. Cytotoxic effects of Shiga toxin-2 on human extravillous trophoblast cell lines. Reproduction. 157(3):297–304. eng. doi:10.1530/REP-18-0581
  • Schneider H, Miller RK. 2010. Receptor-mediated uptake and transport of macromolecules in the human placenta. Int J Dev Biol. 54(2–3):367–375. eng. doi:10.1387/ijdb.082773hs
  • Schwartz DA. 2017. Viral infection, proliferation, and hyperplasia of Hofbauer cells and absence of inflammation characterize the placental pathology of fetuses with congenital Zika virus infection. Arch Gynecol Obstet. 295(6):1361–1368. eng. doi:10.1007/s00404-017-4361-5
  • Scott P, Novais FO. 2016. Cutaneous leishmaniasis: immune responses in protection and pathogenesis. Nat Rev Immunol. 16(9):581–592. eng. doi:10.1038/nri.2016.72
  • Senanayake MP, Senanayake SM, Vidanage KK, Gunasena S, Lamabadusuriya SP. 2009. Vertical transmission in chikungunya infection. Ceylon Med J. 18(3):47–50. eng. doi:10.4038/cmj.v54i2.865
  • Sharma JB, Gulati N. 1992. Potential relationship between dengue fever and neural tube defects in a northern district of India. Int J Gynaecol Obstet. 39(4):291–295. eng. doi:10.1016/0020-7292(92)90260-P
  • Sheridan MA, Balaraman V, Schust DJ, Ezashi T, Roberts RM, Franz AWE. 2018. African and Asian strains of Zika virus differ in their ability to infect and lyse primitive human placental trophoblast. PLoS One. 13(7):e0200086. eng. doi:10.1371/journal.pone.0200086
  • Sheridan MA, Yunusov D, Balaraman V, Alexenko AP, Yabe S, Verjovski-Almeida S, Schust DJ, Franz AW, Sadovsky Y, Ezashi T, et al. 2017. Vulnerability of primitive human placental trophoblast to Zika virus. Proc Natl Acad Sci U S A. 114(9):E1587–E1596. eng. doi:10.1073/pnas.1616097114.
  • Silva FL, Oliveira RG, Silva TM, Xavier MN, Nascimento EF, Santos RL. 2009. Venereal transmission of canine visceral leishmaniasis. Vet Parasitol. 160(1–2):55–59. eng. doi:10.1016/j.vetpar.2008.10.079
  • Souza RM, Ataide R, Dombrowski JG, Ippolito V, Aitken EH, Valle SN, Alvarez JM, Epiphanio S, Marinho CR. 2013. Placental histopathological changes associated with Plasmodium vivax infection during pregnancy. PLoS Negl Trop Dis. 7(2):e2071. eng. doi:10.1371/journal.pntd.0002071
  • Steele BT, Goldie J, Alexopoulou I, Shimizu A. 1984. Post-partum haemolytic-uremic syndrome and verotoxin-producing Escherichia coli. Lancet. 323(8375):511. eng. doi:10.1016/S0140-6736(84)92877-0
  • Stritt A, Tschumi S, Kottanattu L, Bucher BS, Steinmann M, von Steiger N, Stephan R, Hachler H, Simonetti GD. 2013. Neonatal hemolytic uremic syndrome after mother-to-child transmission of a low-pathogenic stx2b harboring shiga toxin-producing Escherichia coli. Clin Infect Dis. 56(1):114–116. eng. doi:10.1093/cid/cis851
  • Suguitan AL Jr., Leke RG, Fouda G, Zhou A, Thuita L, Metenou S, Fogako J, Megnekou R, Taylor DW. 2003. Changes in the levels of chemokines and cytokines in the placentas of women with Plasmodium falciparum malaria. J Infect Dis. 188(7):1074–1082. eng. doi:10.1086/378500
  • Suwanmanee S, Luplertlop N. 2017. Dengue and Zika viruses: lessons learned from the similarities between these Aedes mosquito-vectored arboviruses. J Microbiol. 55(2):81–89. eng. doi:10.1007/s12275-017-6494-4
  • Symmers WS. 1960. Leishmaniasis acquired by contagion: a case of marital infection in Britain. Lancet. 1(7116):127–132. eng. doi:10.1016/S0140-6736(60)90052-0
  • Tabata T, Petitt M, Puerta-Guardo H, Michlmayr D, Wang C, Fang-Hoover J, Harris E, Pereira L. 2016. Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission. Cell Host Microbe. 20(2):155–166. eng. doi:10.1016/j.chom.2016.07.002
  • Tanaka H, Toyoda N, Adachi E, Takeda T. 2000. Immunologic evaluation of an Escherichia coli O157-infected pregnant woman. A case report. J Reprod Med. 45(5):442–444, eng.
  • The United Nations Development Program (UNDP). 2019. [accessed 2019 May 15th]. https://www.undp.org/content/undp/en/home/sustainable-development-goals/goal-3-good-health-and-well-being.html.
  • Thomas DE, Elliott EJ. 2013. Interventions for preventing diarrhea-associated hemolytic uremic syndrome: systematic review. BMC Public Health. 13:799. eng. doi:10.1186/1471-2458-13-799.
  • Torres AG, Amaral MM, Bentancor L, Galli L, Goldstein J, Kruger A, Rojas-Lopez M. 2018. Recent Advances in Shiga Toxin-Producing Escherichia coli Research in Latin America. Microorganisms. 6(4):100. eng. doi:10.3390/microorganisms6040100
  • Torres JR, Falleiros-Arlant LH, Duenas L, Pleitez-Navarrete J, Salgado DM, Castillo JB. 2016. Congenital and perinatal complications of chikungunya fever: a Latin American experience. Int J Infect Dis. 51:85–88. eng. doi:10.1016/j.ijid.2016.09.009.
  • Ulinski T, Lervat C, Ranchin B, Gillet Y, Floret D, Cochat P. 2005. Neonatal hemolytic uremic syndrome after mother-to-child transmission of Escherichia coli O157. Pediatr Nephrol. 20(9):1334–1335. eng. doi:10.1007/s00467-005-1871-3
  • Varela G, Chinen I, Gadea P, Miliwebsky E, MI M, Gonzalez S, Gonzalez G, MJ G, CC C, Algorta G, et al. 2008. [Detection and characterization of Shiga toxin-producing Escherichia coli from clinical cases and food in Uruguay]. Rev Argent Microbiol. 40(2):93–100. spa.
  • Villamil-Gomez WE, Guijarro E, Castellanos J, Rodriguez-Morales AJ. 2017. Congenital Zika syndrome with prolonged detection of Zika virus RNA. J Clin Virol. 95:52–54. eng. doi:10.1016/j.jcv.2017.08.010.
  • Von Stebut E, Ehrchen JM, Belkaid Y, Kostka SL, Molle K, Knop J, Sunderkotter C, Udey MC. 2003. Interleukin 1alpha promotes Th1 differentiation and inhibits disease progression in Leishmania major-susceptible BALB/c mice. J Exp Med. 198(2):191–199. eng. doi:10.1084/jem.20030159
  • Wahid B, Ali A, Rafique S, Idrees M. 2017. Global expansion of chikungunya virus: mapping the 64-year history. Int J Infect Dis. 58:69–76. eng. doi:10.1016/j.ijid.2017.03.006.
  • Walker PG, Ter Kuile FO, Garske T, Menendez C, Ghani AC. 2014. Estimated risk of placental infection and low birthweight attributable to Plasmodium falciparum malaria in Africa in 2010: a modelling study. The Lancet Global Health. 2(8):e460–467. eng. doi:10.1016/S2214-109X(14)70256-6
  • Weisblum Y, Oiknine-Djian E, Vorontsov OM, Haimov-Kochman R, Zakay-Rones Z, Meir K, Shveiky D, Elgavish S, Nevo Y, Roseman M, et al. 2017. Zika Virus Infects Early- and Midgestation Human Maternal Decidual Tissues, Inducing Distinct Innate Tissue Responses in the Maternal-Fetal Interface. J Virol. 91(4). eng. doi:10.1128/JVI.01905-16
  • WHO. 2019. Update on the e-2020 initiative of 21 malaria-eliminating countries.  Geneva, Switzerland: World Health Organization. (WHO/CDS/GMP/2018.10).
  • WHO. 2017. Integrating neglected tropical diseases into global health and development: fourth WHO report on neglected tropical diseases. Geneva, Switzerland: World Health Organization. (Licence: CC BY-NC-SA 3.0 IGO.).
  • Wilder-Smith A. 2019. The first licensed dengue vaccine: can it be used in travelers? Curr Opin Infect Dis. 32(5):394–400. eng. doi:10.1097/QCO.0000000000000573
  • Willis E, Hensley SE. 2017. Characterization of Zika virus binding and enhancement potential of a large panel of flavivirus murine monoclonal antibodies. Virology. 508:1–6. eng. doi:10.1016/j.virol.2017.04.031.
  • Xavier-Neto J, Carvalho M, Pascoalino BD, Cardoso AC, Costa AM, Pereira AH, Santos LN, Saito A, Marques RE, Smetana JH, et al. 2017. Hydrocephalus and arthrogryposis in an immunocompetent mouse model of ZIKA teratogeny: A developmental study. PLoS Negl Trop Dis. 11(2):e0005363. eng. doi:10.1371/journal.pntd.0005363.
  • Yoshimura K, Fujii J, Tanimoto A, Yutsudo T, Kashimura M, Yoshida S. 2000. Effects of Shiga toxin 2 on lethality, fetuses, delivery, and puerperal behavior in pregnant mice. Infect Immun. 68(4):2254–2258. eng. doi:10.1128/IAI.68.4.2254-2258.2000
  • Yoshimura K, Tanimoto A, Abe T, Ogawa M, Yutsudo T, Kashimura M, Yoshida S. 2002. Shiga toxin 1 and 2 induce apoptosis in the amniotic cell line WISH. J Soc Gynecol Investig. 9(1):22–26. eng. doi:10.1177/107155760200900105
  • Zeldovich VB, Bakardjiev AI. 2012. Host defense and tolerance: unique challenges in the placenta. PLoS Pathog. 8(8):e1002804. eng. doi:10.1371/journal.ppat.1002804
  • Zinchuk A, Nadraga A. 2010. Congenital visceral leishmaniasis in Ukraine: case report. Ann Trop Paediatr. 30(2):161–164. eng. doi:10.1179/146532810X12703902516400
  • Zulu MZ, Martinez FO, Gordon S, Gray CM. 2019. The Elusive Role of Placental Macrophages: the Hofbauer Cell. J Innate Immun. 11(6):447–456. eng. doi:10.1159/000497416

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