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A fully human monoclonal antibody with novel binding epitope and excellent neutralizing activity to multiple human IFN-α subtypes: A candidate therapy for systemic lupus erythematosus

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Pages 969-980 | Received 27 Mar 2015, Accepted 21 May 2015, Published online: 26 Aug 2015

References

  • Ronnblom L. Potential role of IFN alpha in adult lupus. Arthritis Res Ther 2010; 12 Suppl 1:S3; PMID:20392290; http://dx.doi.org/10.1186/ar2884
  • Tsokos GC. Systemic lupus erythematosus. N Engl J Med 2008; 358:929-39; PMID:18305268; http://dx.doi.org/10.1056/NEJMra071297
  • Eisenberg R. Why can't we find a new treatment for SLE? J Autoimmun 2009; 32:223-30; PMID:19329279; http://dx.doi.org/10.1016/j.jaut.2009.02.006
  • Xiong W, Lahita RG. Novel treatments for systemic lupus erythematosus. Ther Adv Musculoskelet Dis 2011; 3:255-66; PMID:22870484; http://dx.doi.org/10.1177/1759720X11415456
  • Anolik JH, Aringer M. New treatments for SLE: cell-depleting and anti-cytokine therapies. Best Pract Res Clin Rheumatol 2005; 19:859-78; PMID:16150407; http://dx.doi.org/10.1016/j.berh.2005.05.006
  • Lavoie TB, Kalie E, Crisafulli-Cabatu S, Abramovich R, DiGioia G, Moolchan K, Pestka S, Schreiber G. Binding and activity of all human alpha interferon subtypes. Cytokine 2011; 56:282-9; PMID:21856167; http://dx.doi.org/10.1016/j.cyto.2011.07.019
  • Krause CD, Pestka S. Evolution of the Class 2 cytokines and receptors, and discovery of new friends and relatives. Pharmacol Ther 2005; 106:299-346; PMID:15922016; http://dx.doi.org/10.1016/j.pharmthera.2004.12.002
  • Weissmann C, Weber H. The Interferon Genes. Progress in Nucleic Acid Research and Molecular Biology 1986; 33:251-300; PMID:3025923
  • Banchereau J, Pascual V. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 2006; 25:383-92; PMID:16979570; http://dx.doi.org/10.1016/j.immuni.2006.08.010
  • Bennett L, Palucka AK, Arce E, Cantrell V, Borvak J, Banchereau J, Pascual V. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 2003; 197:711-23; PMID:12642603; http://dx.doi.org/10.1084/jem.20021553
  • Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Ortmann WA, Espe KJ, Shark KB, Grande WJ, Hughes KM, Kapur V, et al. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci 2003; 100:2610-5; PMID:12604793; http://dx.doi.org/10.1073/pnas.0337679100
  • Yao Y, Higgs BW, Morehouse C, de Los Reyes M, Trigona W, Brohawn P, White W, Zhang J, White B, Coyle AJ, et al. Development of potential pharmacodynamic and diagnostic markers for Anti-IFN-alpha monoclonal antibody trials in systemic lupus erythematosus. Hum Genomics Proteomics 2009; 2009; pii: 374312; PMID:20948567
  • Hua J, Kirou K, Lee C, Crow MK. Functional assay of type I interferon in systemic lupus erythematosus plasma and association with anti-RNA binding protein autoantibodies. Arthritis Rheum 2006; 54:1906-16; PMID:16736505; http://dx.doi.org/10.1002/art.21890
  • Agrawal H, Jacob N, Carreras E, Bajana S, Putterman C, Turner S, Neas B, Mathian A, Koss MN, Stohl W, et al. Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease. J Immunol 2009; 183:6021-9; PMID:19812195; http://dx.doi.org/10.4049/jimmunol.0803872
  • Kirou KA, Gkrouzman E. Anti-interferon alpha treatment in SLE. Clin Immunol 2013; 148:303-12; PMID:23566912; http://dx.doi.org/10.1016/j.clim.2013.02.013
  • Kalie E, Jaitin DA, Podoplelova Y, Piehler J, Schreiber G. The stability of the ternary interferon-receptor complex rather than the affinity to the individual subunits dictates differential biological activities. J Biol Chem 2008; 283:32925-36; PMID:18801736; http://dx.doi.org/10.1074/jbc.M806019200
  • Thomas C, Moraga I, Levin D, Krutzik PO, Podoplelova Y, Trejo A, Lee C, Yarden G, Vleck SE, Glenn JS, et al. Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell 2011; 146:621-32; PMID:21854986; http://dx.doi.org/10.1016/j.cell.2011.06.048
  • Ouyang S, Gong B, Li JZ, Zhao LX, Wu W, Zhang FS, Sun L, Wang SJ, Pan M, Li C, et al. Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus. J Mol Med (Berl) 2012; 90:837-46; PMID:22307521; http://dx.doi.org/10.1007/s00109-012-0866-3
  • Smith K, Crowe SR, Garman L, Guthridge CJ, Muther JJ, McKee E, Zheng NY, Farris AD, Guthridge JM, Wilson PC, et al. Human monoclonal antibodies generated following vaccination with AVA provide neutralization by blocking furin cleavage but not by preventing oligomerization. Vaccine 2012; 30:4276-83; PMID:22425791; http://dx.doi.org/10.1016/j.vaccine.2012.03.002
  • Pascual V, Farkas L, Banchereau J. Systemic lupus erythematosus: all roads lead to type I interferons. Curr Opin Immunol 2006; 18:676-82; PMID:17011763; http://dx.doi.org/10.1016/j.coi.2006.09.014
  • Becker-Merok A, Ostli-Eilersten G, Lester S, Nossent J. Circulating interferon- 2 levels are increased in the majority of patients with systemic lupus erythematosus and are associated with disease activity and multiple cytokine activation. Lupus 2012; 22:155-63; PMID:23213068; http://dx.doi.org/10.1177/0961203312468964
  • Theofilopoulos AN, Baccala R, Beutler B, Kono DH. Type I interferons (alpha/beta) in immunity and autoimmunity. Annu Rev Immunol 2005; 23:307-36; PMID:15771573; http://dx.doi.org/10.1146/annurev.immunol.23.021704.115843
  • Strunk JJ, Gregor I, Becker Y, Li Z, Gavutis M, Jaks E, Lamken P, Walz T, Enderlein J, Piehler J. Ligand binding induces a conformational change in ifnar1 that is propagated to its membrane-proximal domain. J Mol Biol 2008; 377:725-39; PMID:18294654; http://dx.doi.org/10.1016/j.jmb.2008.01.017
  • Lamken P, Gavutis M, Peters I, Van der Heyden J, Uze G, Piehler J. Functional cartography of the ectodomain of the type I interferon receptor subunit ifnar1. J Mol Biol 2005; 350:476-88; PMID:15946680; http://dx.doi.org/10.1016/j.jmb.2005.05.008
  • Kalunian K, Merrill JT, Maciuca R, Ouyang WJ, McBride JM, Townsend MJ, Park E, Li J, Wei X, Morimoto A, et al. Efficacy and Safety of Rontalizumab (Anti-Interferon Alpha) in SLE Subjects with Restricted Immunosuppressant Use: Results of A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study. Arthritis Rheum 2012; 64:S1111-S; http://dx.doi.org/10.1002/art.34669
  • Mathian A, Weinberg A, Gallegos M, Banchereau J, Koutouzov S. IFN-alpha Induces Early Lethal Lupus in Preautoimmune (New Zealand Black x New Zealand White)F1 but Not in BALB/c Mice. J Immunol 2005; 174:2499-506; PMID:15728455; http://dx.doi.org/10.4049/jimmunol.174.5.2499
  • Yu R, Wang S, Yu YZ, Du WS, Yang F, Yu WY, Sun ZW. Neutralizing antibodies of botulinum neurotoxin serotype A screened from a fully synthetic human antibody phage display library. J Biomol Screen 2009; 14:991-8; PMID:19726786; http://dx.doi.org/10.1177/1087057109343206
  • Chen R, Weng Z. Docking unbound proteins using shape complementarity, desolvation, and electrostatics. Proteins 2002; 47:281-94; PMID:11948782; http://dx.doi.org/10.1002/prot.10092
  • Li LCR, Weng ZP. RDOCK: Refinement of rigid-body protein docking predictions. Proteins 2003; 53:693-707; PMID:14579360; http://dx.doi.org/10.1002/prot.10460
  • Schymkowitz J, Borg J, Stricher F, Nys R, Rousseau F, Serrano L. The FoldX web server: an online force field. Nucleic Acids Res 2005; 33:W382-8; PMID:15980494; http://dx.doi.org/10.1093/nar/gki387
  • Nacionales DC, Kelly KM, Lee PY, Zhuang H, Li Y, Weinstein JS, Sobel E, Kuroda Y, Akaogi J, Satoh M, et al. Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane). Am J Pathol 2006; 168:1227-40; PMID:16565497; http://dx.doi.org/10.2353/ajpath.2006.050125
  • Lee PY, Weinstein JS, Nacionales DC, Scumpia PO, Li Y, Butfiloski E, van Rooijen N, Moldawer L, Satoh M, Reeves WH. A Novel Type I IFN-Producing Cell Subset in Murine Lupus. J Immunol 2008; 180:5101-8; PMID:18354236; http://dx.doi.org/10.4049/jimmunol.180.7.5101

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