mAbs, Volume 7, Issue 5 (2015)

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mAbs, Volume 7, Issue 5 (2015)

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Short Communication

Rapid Communication
Consistency of quality attributes for the glycosylated monoclonal antibody Humira® (adalimumab)
Paul W Tebbey, Amy Varga, Michael Naill, Jerry Clewell & Jaap Venema
Pages: 805-811
Published online: 26 Aug 2015
AbstractforConsistency of quality attributes for the glycosylated monoclonal antibody Humira® (adalimumab) | Full Text | References | PDF (463.9 KB) | Supplemental
  • 11140 Views
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Rapid Communication
Functionalized micro-capillary film for the rapid at-line analysis of IgG aggregates in a cell culture bioreactor
Matthew J Townsend, David E Gruber, Marcel Kuiper, Radu A Lazar, Ray P Field, Richard E Turner & Nigel KH Slater
Pages: 812-819
Published online: 26 Aug 2015
AbstractforFunctionalized micro-capillary film for the rapid at-line analysis of IgG aggregates in a cell culture bioreactor | Full Text | References | PDF (394 KB)
  • 1248 Views
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Brief Report

Article
Increasing the potency of neutralizing single-domain antibodies by functionalization with a CD11b/CD18 binding domain
Martin A Rossotti, Andrés González-Techera, Julio Guarnaschelli, Lucia Yim, Ximena Camacho, Marcelo Fernández, Pablo Cabral, Carmen Leizagoyen, José A Chabalgoity & Gualberto González-Sapienza
Pages: 820-828
Published online: 26 Aug 2015
AbstractforIncreasing the potency of neutralizing single-domain antibodies by functionalization with a CD11b/CD18 binding domain | Full Text | References | PDF (490.1 KB) | Supplemental
  • 1613 Views
  • 14 CrossRef citations
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Free Access
Article
Integrated pharmacokinetic, pharmacodynamic and immunogenicity profiling of an anti-CCL21 monoclonal antibody in cynomolgus monkeys
S Dudal, K Subramanian, T Flandre, WS Law, PJ Lowe, A Skerjanec, J-C Genin, M Duval, A Piequet, A Cordier, G Jarai, G Van Heeke, S Taplin, C Krantz, S Jones, AP Warren, FR Brennan, J Sims & P Lloyd
Pages: 829-837
Published online: 26 Aug 2015
AbstractforIntegrated pharmacokinetic, pharmacodynamic and immunogenicity profiling of an anti-CCL21 monoclonal antibody in cynomolgus monkeys | Full Text | References | PDF (838.4 KB) | Supplemental
  • 1835 Views
  • 12 CrossRef citations
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Report

Article
MoFvAb: Modeling the Fv region of antibodies
Alexander Bujotzek, Angelika Fuchs, Changtao Qu, Jörg Benz, Stefan Klostermann, Iris Antes & Guy Georges
Pages: 838-852
Published online: 26 Aug 2015
AbstractforMoFvAb: Modeling the Fv region of antibodies | Full Text | References | PDF (1.1 MB) | Supplemental
  • 2169 Views
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Article
Targeting CD64 mediates elimination of M1 but not M2 macrophages in vitro and in cutaneous inflammation in mice and patient biopsies
Dmitrij Hristodorov, Radoslav Mladenov, Verena von Felbert, Michael Huhn, Rainer Fischer, Stefan Barth & Theo Thepen
Pages: 853-862
Published online: 26 Aug 2015
AbstractforTargeting CD64 mediates elimination of M1 but not M2 macrophages in vitro and in cutaneous inflammation in mice and patient biopsies | Full Text | References | PDF (680.8 KB) | Supplemental
  • 3257 Views
  • 46 CrossRef citations
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Article
Processing of complex N-glycans in IgG Fc-region is affected by core fucosylation
Alexandra Castilho, Clemens Gruber, Andreas Thader, Chris Oostenbrink, Maria Pechlaner, Herta Steinkellner & Friedrich Altmann
Pages: 863-870
Published online: 26 Aug 2015
AbstractforProcessing of complex N-glycans in IgG Fc-region is affected by core fucosylation | Full Text | References | PDF (602.2 KB) | Supplemental
  • 2081 Views
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Article
Structure-guided residence time optimization of a dabigatran reversal agent
Felix Schiele, Joanne van Ryn, Tobias Litzenburger, Michael Ritter, Daniel Seeliger & Herbert Nar
Pages: 871-880
Published online: 26 Aug 2015
AbstractforStructure-guided residence time optimization of a dabigatran reversal agent | Full Text | References | PDF (592.1 KB) | Supplemental
  • 1681 Views
  • 9 CrossRef citations
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Article
Development of a quantitative mass spectrometry multi-attribute method for characterization, quality control testing and disposition of biologics
Richard S Rogers, Nancy S Nightlinger, Brittney Livingston, Phil Campbell, Robert Bailey & Alain Balland
Pages: 881-890
Published online: 12 Aug 2015
AbstractforDevelopment of a quantitative mass spectrometry multi-attribute method for characterization, quality control testing and disposition of biologics | Full Text | References | PDF (1.1 MB)
  • 11660 Views
  • 158 CrossRef citations
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Article
Functional assessment of antibody oxidation by native mass spectrometry
Markus Haberger, Anna-Katharina Heidenreich, Tilman Schlothauer, Michaela Hook, Jana Gassner, Katrin Bomans, Michelle Yegres, Adrian Zwick, Boris Zimmermann, Harald Wegele, Lea Bonnington, Dietmar Reusch & Patrick Bulau
Pages: 891-900
Published online: 03 Aug 2015
AbstractforFunctional assessment of antibody oxidation by native mass spectrometry | Full Text | References | PDF (547.4 KB) | Supplemental
  • 3176 Views
  • 27 CrossRef citations
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Open Access
Article
Metal ion interactions with mAbs: Part 1
pH and conformation modulate copper-mediated site-specific fragmentation of the IgG1 hinge region
Zephania Kwong Glover, Louisette Basa, Benjamin Moore, Jennifer S Laurence & Alavattam Sreedhara
Pages: 901-911
Published online: 26 Aug 2015
AbstractforMetal ion interactions with mAbs: Part 1 | Full Text | References | PDF (660.7 KB) | Supplemental
  • 3056 Views
  • 42 CrossRef citations
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Article
A novel in vitro assay to predict neonatal Fc receptor-mediated human IgG half-life
Colby A Souders, Stuart C Nelson, Yang Wang, Andrew R Crowley, Mark S Klempner & William Thomas Jr
Pages: 912-921
Published online: 26 Aug 2015
AbstractforA novel in vitro assay to predict neonatal Fc receptor-mediated human IgG half-life | Full Text | References | PDF (490.7 KB)
  • 4065 Views
  • 36 CrossRef citations
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Article
Engineered antibody domains with significantly increased transcytosis and half-life in macaques mediated by FcRn
Tianlei Ying, Yanping Wang, Yang Feng, Ponraj Prabakaran, Rui Gong, Lili Wang, Karalyne Crowder & Dimiter S Dimitrov
Pages: 922-930
Published online: 26 Aug 2015
AbstractforEngineered antibody domains with significantly increased transcytosis and half-life in macaques mediated by FcRn | Full Text | References | PDF (793.8 KB)
  • 2252 Views
  • 23 CrossRef citations
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Article
A bi-functional antibody-receptor domain fusion protein simultaneously targeting IGF-IR and VEGF for degradation
Yang Shen, Lin Zeng, Ruslan Novosyadlyy, Amelie Forest, Aiping Zhu, Andrew Korytko, Haifan Zhang, Scott W Eastman, Michael Topper, Sagit Hindi, Nicole Covino, Kris Persaud, Yun Kang, Douglas Burtrum, David Surguladze, Marie Prewett, Sudhakar Chintharlapalli, Victor J Wroblewski, Juqun Shen, Paul Balderes, Zhenping Zhu, Marshall Snavely & Dale L Ludwig
Pages: 931-945
Published online: 26 Aug 2015
AbstractforA bi-functional antibody-receptor domain fusion protein simultaneously targeting IGF-IR and VEGF for degradation | Full Text | References | PDF (1.2 MB) | Supplemental
  • 2315 Views
  • 15 CrossRef citations
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Article
A bispecific antibody targeting CD47 and CD20 selectively binds and eliminates dual antigen expressing lymphoma cells
Emily C Piccione, Silvia Juarez, Jie Liu, Serena Tseng, Christine E Ryan, Cyndhavi Narayanan, Lijuan Wang, Kipp Weiskopf & Ravindra Majeti
Pages: 946-956
Published online: 26 Aug 2015
AbstractforA bispecific antibody targeting CD47 and CD20 selectively binds and eliminates dual antigen expressing lymphoma cells | Full Text | References | PDF (1.1 MB) | Supplemental
  • 6574 Views
  • 101 CrossRef citations
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Article
TTAC-0001, a human monoclonal antibody targeting VEGFR-2/KDR, blocks tumor angiogenesis
Weon Sup Lee, Bo-Jeong Pyun, Sung-Woo Kim, Sang Ryeol Shim, Ju Ryoung Nam, Ji Young Yoo, Younggeon Jin, Juyoun Jin, Young-Guen Kwon, Chae-Ok Yun, Do-Hyun Nam, Keunhee Oh, Dong-Sup Lee, Sang Hoon Lee & Jin-San Yoo
Pages: 957-968
Published online: 12 Aug 2015
AbstractforTTAC-0001, a human monoclonal antibody targeting VEGFR-2/KDR, blocks tumor angiogenesis | Full Text | References | PDF (754.9 KB) | Supplemental
  • 1778 Views
  • 16 CrossRef citations
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Article
A fully human monoclonal antibody with novel binding epitope and excellent neutralizing activity to multiple human IFN-α subtypes: A candidate therapy for systemic lupus erythematosus
Peng Du, Lei Xu, Weiyi Qiu, Dadi Zeng, Junjie Yue, Shuang Wang, Peitang Huang & Zhiwei Sun
Pages: 969-980
Published online: 26 Aug 2015
AbstractforA fully human monoclonal antibody with novel binding epitope and excellent neutralizing activity to multiple human IFN-α subtypes: A candidate therapy for systemic lupus erythematosus | Full Text | References | PDF (740.8 KB) | Supplemental
  • 1249 Views
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