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Multi-Site N-glycan mapping study 1: Capillary electrophoresis – laser induced fluorescence

Ákos SzekrényesHorváth Laboratory of Bioseparation Sciences; University of Debrecen; Debrecen, H-4032, Hungary
,
SungAe Suhr ParkDrug Product Development; P&PD; Amgen; Inc.; Thousand Oaks, CA91320, USA
,
Marcia SantosSCIEX; Brea, CA92821, USA
,
Clarence LewSCIEX; Brea, CA92821, USA
,
Aled JonesProZyme; Inc.; Hayward, CA94545, USA
,
Ted HaxoProZyme; Inc.; Hayward, CA94545, USA
,
Michael KimzeyProZyme; Inc.; Hayward, CA94545, USA
,
Shiva PourkavehProZyme; Inc.; Hayward, CA94545, USA
,
Zoltán SzabóProZyme; Inc.; Hayward, CA94545, USA
,
Zoran SosicAnalytical Development; Biogen; Cambridge, MA02142, USA
,
Peng FengAnalytical Development; Biogen; Cambridge, MA02142, USA
,
Csaba VáradiHorváth Laboratory of Bioseparation Sciences; University of Debrecen; Debrecen, H-4032, Hungary
,
François de l'EscailleAnalis s.a. R&D Diag.; Suarlée (Namur), Belgium
,
Jean-Bernard FalmagneAnalis s.a. R&D Diag.; Suarlée (Namur), Belgium
,
Preeti SejwalBioanalytical and Discovery Analytical Sciences; Bristol-Myers Squibb; Lawrenceville, NJ08648, USA;Current affiliation: Process Analytical, AbbVie, North Chicago, IL60064, USA.
,
Thomas NiedringhausProtein Analytical Chemistry Department; Genentech; Inc.; South San Francisco, CA94080, USA
,
David MichelsProtein Analytical Chemistry Department; Genentech; Inc.; South San Francisco, CA94080, USA
,
Gordon FreckletonBioanalytical Sciences; Eli Lilly and Company (previously ImClone); Branchburg, NJ08876, USA
,
Melissa HammVaccine Bioprocess Research and Development; Merck Research Laboratories; West Point, PA19486, USA
,
Anastasiya ManuilovAnalytical Research and Development; Pfizer; Inc.; Andover, MA01810, USA
,
Melissa SchwartzAnalytical Science; Boehringer Ingelheim; Inc.; Fremont, CA94555, USA
,
Jiann-Kae LuoRegeneron Pharmaceuticals; Inc.; Tarrytown, NY10591, USA
,
Jonathan van DyckAnalytical Sciences; Seattle Genetics; Inc.; Bothell, WA98021, USA
,
Pui-King LeungImmunoGen; Inc.; Waltham, MA02451, USA
,
Marcell OlajosAnalytical Research and Development; Gedeon Richter; Plc.; Budapest, H-1475, Hungary
,
Yingmei GuEli Lilly and Company; Indianapolis; IN46285, USA
,
Kai GaoDivision of Monoclonal Antibody; National Institutes for Food and Drug Control; Beijing, PR China
,
Wenbo WangDivision of Monoclonal Antibody; National Institutes for Food and Drug Control; Beijing, PR China
,
Jo WegsteinProZyme; Inc.; Hayward, CA94545, USA
,
Samnang TepProZyme; Inc.; Hayward, CA94545, USA
&
András GuttmanHorváth Laboratory of Bioseparation Sciences; University of Debrecen; Debrecen, H-4032, Hungary;MTA-PE Translational Glycomics Group; MUKKI; University of Pannonia; Veszprém, HungaryCorrespondence[email protected]
 show all
Pages 56-64 | Received 24 Jun 2015, Accepted 09 Oct 2015, Published online: 09 Dec 2015

References

  • Fournier J. A Review of Glycan Analysis Requirements. Bio Pharm International 2015; 28:32-37
  • Mittermayr S, Bones J, Doherty M, Guttman A, Rudd PM. Multiplexed analytical glycomics: rapid and confident IgG N-glycan structural elucidation. J Proteome Res 2011; 10:3820-9; PMID:21699237; http://dx.doi.org/10.1021/pr200371s
  • Salas-Solano O, Kennel B, Park SS, Roby K, Sosic Z, Boumajny B, Free S, Reed-Bogan A, Michels D, McElroy W, et al. Robustness of iCIEF methodology for the analysis of monoclonal antibodies: an interlaboratory study. J Sep Sci 2012; 35:3124-9; PMID:23065998; http://dx.doi.org/10.1002/jssc.201200633
  • Salas-Solano O, Babu K, Park SS, Zhang X, Zhang L, Sosic Z, Boumajny B, Zeng M, Cheng K-C, Reed-Bogan A, et al. Intercompany Study to Evaluate the Robustness of Capillary Isoelectric Focusing Technology for the Analysis of Monoclonal Antibodies. Chromatographia 2011; 73:1137-44; http://dx.doi.org/10.1007/s10337-011-2017-3
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  • Szekrenyes A, Partyka J, Varadi C, Krenkova J, Foret F, Guttman A. Sample preparation for N-glycosylation analysis of therapeutic monoclonal antibodies by electrophoresis. Methods Mol Biol 2015; 1274:183-95; PMID:25673493; http://dx.doi.org/10.1007/978-1-4939-2353-3_16
  • ISO 5725-2: 1994. Accuracy (Trueness and Precision) of Measurements. ICS: 03.120.30; 17.020; TC/SC: ISO/TC 69/SC 6; Stage: 90.92 (2015-07-09)
  • http://glycobase.nibrt.ie/glycobase/show_nibrt.action.
  • Harvey DJ, Merry AH, Royle L, Campbell MP, Dwek RA, Rudd PM. Proposal for a standard system for drawing structural diagrams of N- and O-linked carbohydrates and related compounds. Proteomics 2009; 9:3796-801; PMID:19670245; http://dx.doi.org/10.1002/pmic.200900096

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