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Meeting Report

Antibody engineering & therapeutics, the annual meeting of the antibody society December 7–10, 2015, San Diego, CA, USA

, , , , , , , , & show all
Pages 617-652 | Received 05 Feb 2016, Accepted 08 Feb 2016, Published online: 24 Feb 2016

References

  • Yamada DH, Elsaesser H, Lux A, Timmerman JM, Morrison SL, de la Torre JC, Nimmerjahn F, Brooks DG. Suppression of Fcgamma-receptor-mediated antibody effector function during persistent viral infection. Immunity 2015; 42:379-90; PMID:25680277; http://dx.doi.org/10.1016/j.immuni.2015.01.005
  • Diebolder CA, Beurskens FJ, de Jong RN, Koning RI, Strumane K, Lindorfer MA, Voorhorst M, Ugurlar D, Rosati S, Heck AJ, et al. Complement is activated by IgG hexamers assembled at the cell surface. Science 2014; 343:1260-3; PMID:24626930; http://dx.doi.org/10.1126/science.1248943
  • de Jong RN, Beurskens FJ, Verploegen S, Strumane K, van Kampen MD, Voorhorst M, Horstman W, Engelberts PJ, Oostindie SC, Wang G, et al. A novel platform for the potentiation of therapeutic antibodies based on antigen-dependent formation of IgG hexamers at the cell surface. PLoS Biol 2016; 14:e1002344; PMID:26736041; http://dx.doi.org/10.1371/journal.pbio.1002344
  • Melis JP, Strumane K, Ruuls SR, Beurskens FJ, Schuurman J, Parren PW. Complement in therapy and disease: regulating the complement system with antibody-based therapeutics. Mol Immunol 2015; 67:117-30; PMID:25697848; http://dx.doi.org/10.1016/j.molimm.2015.01.028
  • Baker MP, Reynolds HM, Lumicisi B, Bryson CJ. Immunogenicity of protein therapeutics: the key causes, consequences and challenges. Self Nonself 2010; 1:314-22; PMID:21487506; http://dx.doi.org/10.4161/self.1.4.13904
  • Begley CG, Ellis LM. Drug development: raise standards for preclinical cancer research. Nature 2012; 483:531-3; PMID:22460880; http://dx.doi.org/10.1038/483531a
  • Bradbury A, Pluckthun A. Reproducibility: standardize antibodies used in research. Nature 2015; 518:27-9; PMID:25652980; http://dx.doi.org/10.1038/518027a
  • Bradbury AR, Pluckthun A. Getting to reproducible antibodies: the rationale for sequenced recombinant characterized reagents. Protein Eng Des Sel 2015; 28:303-5; PMID:26446960; http://dx.doi.org/10.1093/protein/gzv051
  • Berglund L, Bjorling E, Oksvold P, Fagerberg L, Asplund A, Szigyarto CA, Persson A, Ottosson J, Wernerus H, Nilsson P, et al. A genecentric Human Protein Atlas for expression profiles based on antibodies. Mol Cell Proteomics 2008; 7:2019-27; PMID:18669619; http://dx.doi.org/10.1074/mcp.R800013-MCP200
  • Bordeaux J, Welsh A, Agarwal S, Killiam E, Baquero M, Hanna J, Anagnostou V, Rimm D. Antibody validation. Biotechniques 2010; 48:197-209; PMID:20359301; http://dx.doi.org/10.2144/000113382
  • Elliott S, Busse L, Bass MB, Lu H, Sarosi I, Sinclair AM, Spahr C, Um M, Van G, Begley CG. Anti-Epo receptor antibodies do not predict Epo receptor expression. Blood 2006; 107:1892-5; PMID:16249375; http://dx.doi.org/10.1182/blood-2005-10-4066
  • Freedman LP, Cockburn IM, Simcoe TS. The economics of reproducibility in preclinical research. PLoS Biol 2015; 13:e1002165; PMID:26057340; http://dx.doi.org/10.1371/journal.pbio.1002165
  • Kontermann RE, Brinkmann U. Bispecific antibodies. Drug Discov Today 2015; 20:838-47; PMID:25728220; http://dx.doi.org/10.1016/j.drudis.2015.02.008
  • Metz S, Panke C, Haas AK, Schanzer J, Lau W, Croasdale R, Hoffmann E, Schneider B, Auer J, Gassner C, et al. Bispecific antibody derivatives with restricted binding functionalities that are activated by proteolytic processing. Protein Eng Des Sel 2012; 25:571-80; PMID:22976197; http://dx.doi.org/10.1093/protein/gzs064
  • Desnoyers LR, Vasiljeva O, Richardson JH, Yang A, Menendez EE, Liang TW, Wong C, Bessette PH, Kamath K, Moore SJ, et al. Tumor-specific activation of an EGFR-targeting probody enhances therapeutic index. Sci Transl Med 2013; 5:207ra144; PMID:24132639; http://dx.doi.org/10.1126/scitranslmed.3006682
  • Wong KR, Menendez E, Craik CS, Kavanaugh WM, Vasiljeva O. In vivo imaging of protease activity by Probody therapeutic activation. Biochimie. 2016 Mar;122:62-7; http://dx.doi.org/10.1016/j.biochi.2015.11.003.
  • Stefan N, Zimmermann M, Simon M, Zangemeister-Wittke U, Pluckthun A. Novel prodrug-like fusion toxin with protease-sensitive bioorthogonal PEGylation for tumor targeting. Bioconjug Chem 2014; 25:2144-56; PMID:25350699; http://dx.doi.org/10.1021/bc500468s
  • Verdurmen WP, Luginbuhl M, Honegger A, Pluckthun A. Efficient cell-specific uptake of binding proteins into the cytoplasm through engineered modular transport systems. J Control Release 2015; 200:13-22; PMID:25526701; http://dx.doi.org/10.1016/j.jconrel.2014.12.019
  • de Goeij BE, Satijn D, Freitag CM, Wubbolts R, Bleeker WK, Khasanov A, Zhu T, Chen G, Miao D, van Berkel PH, et al. High turnover of tissue factor enables efficient intracellular delivery of antibody-drug conjugates. Mol Cancer Ther 2015; 14:1130-40; PMID:25724665; http://dx.doi.org/10.1158/1535-7163.MCT-14-0798
  • Breij EC, de Goeij BE, Verploegen S, Schuurhuis DH, Amirkhosravi A, Francis J, Miller VB, Houtkamp M, Bleeker WK, Satijn D, et al. An antibody-drug conjugate that targets tissue factor exhibits potent therapeutic activity against a broad range of solid tumors. Cancer Res 2014; 74:1214-26; PMID:24371232; http://dx.doi.org/10.1158/0008-5472.CAN-13-2440
  • Tzeng A, Kwan BH, Opel CF, Navaratna T, Wittrup KD. Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution. Proc Natl Acad Sci U S A 2015; 112:3320-5; PMID:25733854; http://dx.doi.org/10.1073/pnas.1416159112
  • Zhu EF, Gai SA, Opel CF, Kwan BH, Surana R, Mihm MC, Kauke MJ, Moynihan KD, Angelini A, Williams RT, et al. Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2. Cancer Cell 2015; 27:489-501; PMID:25873172; http://dx.doi.org/10.1016/j.ccell.2015.03.004
  • Liu X, Pu Y, Cron K, Deng L, Kline J, Frazier WA, Xu H, Peng H, Fu YX, Xu MM. CD47 blockade triggers T cell-mediated destruction of immunogenic tumors. Nat Med 2015; 21:1209-15; PMID:26322579; http://dx.doi.org/10.1038/nm.3931
  • Bronte V. Tumors STING adaptive antitumor immunity. Immunity 2014; 41:679-81; PMID:25517609; http://dx.doi.org/10.1016/j.immuni.2014.11.004
  • Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, Li XD, Mauceri H, Beckett M, Darga T, et al. STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity 2014; 41:843-52; PMID:25517616; http://dx.doi.org/10.1016/j.immuni.2014.10.019
  • Fan Z, Yu P, Wang Y, Fu ML, Liu W, Sun Y, Fu YX. NK-cell activation by LIGHT triggers tumor-specific CD8+ T-cell immunity to reject established tumors. Blood 2006; 107:1342-51; PMID:16223768; http://dx.doi.org/10.1182/blood-2005-08-3485
  • Ferris RL. Immunology and immunotherapy of head and neck cancer. J Clin Oncol 2015; 33:3293-304; PMID:26351330; http://dx.doi.org/10.1200/JCO.2015.61.1509
  • Carmi Y, Spitzer MH, Linde IL, Burt BM, Prestwood TR, Perlman N, Davidson MG, Kenkel JA, Segal E, Pusapati GV, et al. Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity. Nature 2015; 521:99-104; PMID:25924063; http://dx.doi.org/10.1038/nature14424
  • Reichert JM. Antibodies to watch in 2016. MAbs 2016, Feb-Mar;8(2):197-204; PMID: 26651519; http://dx.doi.org/10.1080/19420862.2015.1125583
  • Moasser MM, Krop IE. The evolving landscape of HER2 targeting in breast cancer. JAMA Oncol 2015; 1:1154-61; PMID:26204261; http://dx.doi.org/10.1001/jamaoncol.2015.2286
  • McCormack PL. Pertuzumab: a review of its use for first-line combination treatment of HER2-positive metastatic breast cancer. Drugs 2013; 73:1491-502; PMID:23982598; http://dx.doi.org/10.1007/s40265-013-0109-0
  • Baron JM, Boster BL, Barnett CM. Ado-trastuzumab emtansine (T-DM1): a novel antibody-drug conjugate for the treatment of HER2-positive metastatic breast cancer. J Oncol Pharm Pract 2015; 21:132-42; PMID:24682654; http://dx.doi.org/10.1177/1078155214527144
  • Feldmann M, Maini RN. Lasker clinical medical research award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat Med 2003; 9:1245-50; PMID:14520364; http://dx.doi.org/10.1038/nm939
  • Goodall LJ, Ovecka M, Rycroft D, Friel SL, Sanderson A, Mistry P, Davies ML, Stoop AA. Pharmacokinetic and pharmacodynamic characterisation of an anti-mouse TNF receptor 1 domain antibody formatted for in vivo half-life extension. PLoS One 2015; 10:e0137065; PMID:26352810; http://dx.doi.org/10.1371/journal.pone.0137065
  • McCann FE, Perocheau DP, Ruspi G, Blazek K, Davies ML, Feldmann M, Dean JL, Stoop AA, Williams RO. Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis. Arthritis Rheumatol 2014; 66:2728-38; PMID:24965881; http://dx.doi.org/10.1002/art.38755
  • Eggermont AM, Spatz A, Robert C. Cutaneous melanoma. Lancet 2014; 383:816-27; PMID:24054424; http://dx.doi.org/10.1016/S0140-6736(13)60802-8
  • Topalian SL, Drake CG, Pardoll DM. Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell 2015; 27:450-61; PMID:25858804; http://dx.doi.org/10.1016/j.ccell.2015.03.001
  • Raedler LA. Opdivo (Nivolumab): second PD-1 inhibitor receives FDA approval for unresectable or metastatic melanoma. Am Health Drug Benefits 2015; 8:180-3; PMID:26629287
  • Philips GK, Atkins M. Therapeutic uses of anti-PD-1 and anti-PD-L1 antibodies. Int Immunol 2015; 27:39-46; PMID:25323844; http://dx.doi.org/10.1093/intimm/dxu095
  • Rizvi NA, Mazieres J, Planchard D, Stinchcombe TE, Dy GK, Antonia SJ, Horn L, Lena H, Minenza E, Mennecier B, et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial. Lancet Oncol 2015; 16:257-65; PMID:25704439; http://dx.doi.org/10.1016/S1470-2045(15)70054-9
  • Pluckthun A. Designed ankyrin repeat proteins (DARPins): binding proteins for research, diagnostics, and therapy. Annu Rev Pharmacol Toxicol 2015; 55:489-511; PMID:25562645; http://dx.doi.org/10.1146/annurev-pharmtox-010611-134654
  • Wurch T, Pierre A, Depil S. Novel protein scaffolds as emerging therapeutic proteins: from discovery to clinical proof-of-concept. Trends Biotechnol 2012; 30:575-82; PMID:22944617; http://dx.doi.org/10.1016/j.tibtech.2012.07.006
  • Cooke RM, Brown AJ, Marshall FH, Mason JS. Structures of G protein-coupled receptors reveal new opportunities for drug discovery. Drug Discov Today 2015; 20:1355-64; PMID:26303408; http://dx.doi.org/10.1016/j.drudis.2015.08.003
  • Errey JC, Dore AS, Zhukov A, Marshall FH, Cooke RM. Purification of stabilized GPCRs for structural and biophysical analyses. Methods Mol Biol 2015; 1335:1-15; PMID:26260590; http://dx.doi.org/10.1007/978-1-4939-2914-6_1
  • Hutchings CJ, Cseke G, Osborne G, Woolard J, Zhukov A, Koglin M, Jazayeri A, Pandya-Pathak J, Langmead CJ, Hill SJ, et al. Monoclonal anti-beta1-adrenergic receptor antibodies activate G protein signaling in the absence of beta-arrestin recruitment. MAbs 2014; 6:246-61; PMID:24253107; http://dx.doi.org/10.4161/mabs.27226
  • Bankert KC, Oxley KL, Smith SM, Graham JP, de Boer M, Thewissen M, Simons PJ, Bishop GA. Induction of an altered CD40 signaling complex by an antagonistic human monoclonal antibody to CD40. J Immunol 2015; 194:4319-27; PMID:25795759; http://dx.doi.org/10.4049/jimmunol.1402903
  • de Vos AF, Melief MJ, van Riel D, Boon L, van Eijk M, de Boer M, Laman JD. Antagonist anti-human CD40 antibody inhibits germinal center formation in cynomolgus monkeys. Eur J Immunol 2004; 34:3446-55; PMID:15517614; http://dx.doi.org/10.1002/eji.200424973
  • Alabraba EB, Lai V, Boon L, Wigmore SJ, Adams DH, Afford SC. Coculture of human liver macrophages and cholangiocytes leads to CD40-dependent apoptosis and cytokine secretion. Hepatology 2008; 47:552-62; PMID:17999420; http://dx.doi.org/10.1002/hep.22011
  • Jones TD, Carter PJ, Pluckthun A, Vasquez M, Holgate RG, Hotzel I, Popplewell AG, Parren PW, Enzelberger M, Rademaker HJ, et al. The INNs and outs of antibody nonproprietary names. MAbs 2016; 8:1-9; PMID:26716992; http://dx.doi.org/10.1080/19420862.2015.1114320
  • Wang Y, Zhu M, Yu P, Fu YX. Promoting immune responses by LIGHT in the face of abundant regulatory T cell inhibition. J Immunol 2010; 184:1589-95; PMID:20042587; http://dx.doi.org/10.4049/jimmunol.0901582
  • WHO-INN. International nonproprietary names (INN) for biological and biotechnological substances 2014 (http://www.who.int/medicines/services/inn/BioRev2014.pdf).
  • WHO-INN. International Nonproprietary Names (http://www.who.int/medicines/services/inn/en/).
  • AMA. Application Forms [Internet]. Chicago (IL). [cited 2016 Feb 5]. Available from http://www.ama-assn.org/ama/pub/physician-resources/medical-science/united-states-adopted-names-council/application-forms.page?
  • AMA. Application Forms [Internet]. Chicago (IL). [cited 2016 Feb 5]. Available from http://www.ama-assn.org/ama/pub/physician-resources/medical-science/united-states-adopted-names-council.page?
  • Scheepers C, Shrestha RK, Lambson BE, Jackson KJ, Wright IA, Naicker D, Goosen M, Berrie L, Ismail A, Garrett N, et al. Ability to develop broadly neutralizing HIV-1 antibodies is not restricted by the germline Ig gene repertoire. J Immunol 2015; 194:4371-8; PMID:25825450; http://dx.doi.org/10.4049/jimmunol.1500118