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Mammalian cell surface display for monoclonal antibody-based FACS selection of viral envelope proteins

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Pages 1052-1064 | Received 22 May 2017, Accepted 03 Aug 2017, Published online: 08 Sep 2017

References

  • UNAIDS. UNAIDS Fact Sheet November 2016 [accessed 2017 Jan 08]. http://www.unaids.org/en/resources/fact-sheet.
  • Karlsson Hedestam GB, Fouchier RA, Phogat S, Burton DR, Sodroski J, Wyatt RT. The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus. Nat Rev Microbiol. 2008;6(2):143-55. doi:10.1038/nrmicro1819. PMID:18197170
  • Ward AB, Wilson IA. Insights into the trimeric HIV-1 envelope glycoprotein structure. Trends Biochem Sci. 2015;40(2):101-7. doi:10.1016/j.tibs.2014.12.006. PMID:25600289
  • Hraber P, Seaman MS, Bailer RT, Mascola JR, Montefiori DC, Korber BT. Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection. AIDS. 2014;28(2):163-9. doi:10.1097/QAD.0000000000000106. PMID:24361678
  • Moore PL, Williamson C, Morris L. Virological features associated with the development of broadly neutralizing antibodies to HIV-1. Trends Microbiol. 2015;23(4):204-11. doi:10.1016/j.tim.2014.12.007. PMID:25572881
  • Wibmer CK, Moore PL, Morris L. HIV broadly neutralizing antibody targets. Curr Opin HIV AIDS. 2015;10(3):135-43. doi:10.1097/COH.0000000000000153. PMID:25760932
  • Burton DR, Mascola JR. Antibody responses to envelope glycoproteins in HIV-1 infection. Nat Immunol. 2015;16(6):571-6. doi:10.1038/ni.3158. PMID:25988889
  • Parren PW, Marx PA, Hessell AJ, Luckay A, Harouse J, Cheng-Mayer C, Moore JP, Burton DR. Antibody Protects Macaques against Vaginal Challenge with a Pathogenic R5 Simian/Human Immunodeficiency Virus at Serum Levels Giving Complete Neutralization In Vitro. J Virol. 2001;75(17):8340-7. doi:10.1128/JVI.75.17.8340-8347.2001. PMID:11483779
  • Hessell AJ, Rakasz EG, Poignard P, Hangartner L, Landucci G, Forthal DN, Koff WC, Watkins DI, Burton DR. Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers. PLoS Pathog. 2009;5(5):e1000433. doi:10.1371/journal.ppat.1000433. PMID:19436712
  • Baba TW, Liska V, Hofmann-Lehmann R, Vlasak J, Xu W, Ayehunie S, Cavacini LA, Posner MR, Katinger H, Stiegler G, et al. Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection. Nat Med. 2000;6(2):200-6. doi:10.1038/72309. PMID:10655110
  • Sagar M, Wu X, Lee S, Overbaugh J. Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivity. J Virol. 2006;80(19):9586-98. doi:10.1128/JVI.00141-06. PMID:16973562
  • Wei X, Decker JM, Wang S, Hui H, Kappes JC, Wu X, Salazar-Gonzalez JF, Salazar MG, Kilby JM, Saag MS, et al. Antibody neutralization and escape by HIV-1. Nature. 2003;422(6929):307-12. doi:10.1038/nature01470. PMID:12646921
  • Kwong PD, Doyle ML, Casper DJ, Cicala C, Leavitt SA, Majeed S, Steenbeke TD, Venturi M, Chaiken I, Fung M, et al. HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites. Nature. 2002;420(6916):678-82. doi:10.1038/nature01188. PMID:12478295
  • Lewis G, Finzi A, DeVico A, Pazgier M. Conformational Masking and Receptor-Dependent Unmasking of Highly Conserved Env Epitopes Recognized by Non-Neutralizing Antibodies That Mediate Potent ADCC against HIV-1. Viruses. 2015;7(9):5115-32. doi:10.3390/v7092856. PMID:26393642
  • Sather DN, Carbonetti S, Malherbe DC, Pissani F, Stuart AB, Hessell AJ, Gray MD, Mikell I, Kalams SA, Haigwood NL, et al. Emergence of Broadly Neutralizing Antibodies and Viral Coevolution in Two Subjects during the Early Stages of Infection with Human Immunodeficiency Virus Type 1. J Virol. 2014;88(22):12968-81. doi:10.1128/JVI.01816-14. PMID:25122781
  • Du SX, Xu L, Zhang W, Tang S, Boenig RI, Chen H, Mariano EB, Zwick MB, Parren PW, Burton DR, et al. A directed molecular evolution approach to improved immunogenicity of the HIV-1 envelope glycoprotein. PLoS One. 2011;6(6):e20927. doi:10.1371/journal.pone.0020927. PMID:21738594
  • Ching L, Stamatatos L. Alterations in the immunogenic properties of soluble trimeric human immunodeficiency virus type 1 envelope proteins induced by deletion or heterologous substitutions of the V1 loop. J Virol. 2010;84(19):9932-46. doi:10.1128/JVI.00868-10. PMID:20660181
  • Selvarajah S, Puffer BA, Lee FH, Zhu P, Li Y, Wyatt R, Roux KH, Doms RW, Burton DR. Focused dampening of antibody response to the immunodominant variable loops by engineered soluble gp140. AIDS Res Hum Retroviruses. 2008;24(2):301-14. doi:10.1089/aid.2007.0158. PMID:18284327
  • Schiffner T, Kong L, Duncan CJ, Back JW, Benschop JJ, Shen X, Huang PS, Stewart-Jones GB, DeStefano J, Seaman MS, et al. Immune focusing and enhanced neutralization induced by HIV-1 gp140 chemical cross-linking. J Virol. 2013;87(18):10163-72. doi:10.1128/JVI.01161-13. PMID:23843636
  • Sanders RW, Derking R, Cupo A, Julien JP, Yasmeen A, de Val N, Kim HJ, Blattner C, de la Peña AT, Korzun J, et al. A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies. PLoS Pathog. 2013;9(9):e1003618. doi:10.1371/journal.ppat.1003618. PMID:24068931
  • Pugach P, Ozorowski G, Cupo A, Ringe R, Yasmeen A, de Val N, Derking R, Kim HJ, Korzun J, Golabek M, et al. A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene. J Virol. 2015;89(6):3380-95. doi:10.1128/JVI.03473-14. PMID:25589637
  • Sharma SK, deVal N, Bale S, Guenaga J, Tran K, Feng Y, Dubrovskaya V, Ward AB, Wyatt RT. Cleavage-Independent HIV-1 Env Trimers Engineered as Soluble Native Spike Mimetics for Vaccine Design. Cell Rep. 2015;11(4):539-50. doi:10.1016/j.celrep.2015.03.047. PMID:25892233
  • Sanders RW, van Gils MJ, Derking R, Sok D, Ketas TJ, Burger JA, Ozorowski G, Cupo A, Simonich C, Goo L, et al. HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers. Science. 2015;349(6244):aac4223. doi:10.1126/science.aac4223. PMID:26089353
  • Feng Y, Tran K, Bale S, Kumar S, Guenaga J, Wilson R, de Val N, Arendt H, DeStefano J, Ward AB, et al. Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies. PLoS Pathog. 2016;12(8):e1005767. doi:10.1371/journal.ppat.1005767. PMID:27487086
  • Malherbe DC, Doria-Rose NA, Misher L, Beckett T, Puryear W, Schuman JT, Kraft Z, O'Malley J, Mori M, Srivastava I, et al. Sequential immunization with a subtype B HIV-1 envelope quasispecies partially mimics the in vivo development of neutralizing antibodies. J Virol. 2011;85(11):5262-74. doi:10.1128/JVI.02419-10. PMID:21430056
  • Dosenovic P, Von Boehmer L, Escolano A, Jardine J, Freund NT, Gitlin AD, McGuire AT, Kulp DW, Oliveira T, Scharf L, et al. Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice. Cell. 2015;161(7):1505-15. doi:10.1016/j.cell.2015.06.003. PMID:26091035
  • Escolano A, Steichen JM, Dosenovic P, Kulp DW, Golijanin J, Sok D, Freund NT, Gitlin AD, Oliveira T, Araki T, et al. Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice. Cell. 2016;166(6):1445-58. doi:10.1016/j.cell.2016.07.030. PMID:27610569
  • Briney B, Sok D, Jardine JG, Nemazee D, Burton DR, Schief WR, Briney B, Sok D, Jardine JG, Kulp DW, et al. Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies Article Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies. Cell. 2016;166(6):1459-70.e11. doi:10.1016/j.cell.2016.08.005. PMID:27610570
  • Bruun TH, Mühlbauer K, Benen T, Kliche A, Wagner R. A mammalian cell based FACS-panning platform for the selection of HIV-1 envelopes for vaccine development. PLoS One. 2014;9(10):e109196. doi:10.1371/journal.pone.0109196. PMID:25279768
  • Gorny MK, Xu JY, Karwowska S, Buchbinder A, Zolla-Pazner S. Repertoire of neutralizing human monoclonal antibodies specific for the V3 domain of HIV-1 gp120. J Immunol. 1993;150(2):635-43. PMID:7678279
  • Corti D, Langedijk JP, Hinz A, Seaman MS, Vanzetta F, Fernandez-Rodriguez BM, Silacci C, Pinna D, Jarrossay D, Balla-Jhagjhoorsingh S, et al. Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals. PLoS One. 2010;5(1):e8805. doi:10.1371/journal.pone.0008805. PMID:20098712
  • Gardner TJ, Stein KR, Duty JA, Schwarz TM, Noriega VM, Kraus T, Moran TM, Tortorella D. Functional screening for anti-CMV biologics identifies a broadly neutralizing epitope of an essential envelope protein. Nat Commun. 2016;7:13627. doi:10.1038/ncomms13627. PMID:27966523
  • Szymczak AL, Workman CJ, Wang Y, Vignali KM, Dilioglou S, Vanin EF, Vignali DA. Correction of multi-gene deficiency in vivo using a single ‘self-cleaving’ 2A peptide-based retroviral vector. Nat Biotechnol. 2004;22(5):589-94. doi:10.1038/nbt957. PMID:15064769
  • Yao F, Svensjö T, Winkler T, Lu M, Eriksson C, Eriksson E. Tetracycline repressor, tetR, rather than the tetR-mammalian cell transcription factor fusion derivatives, regulates inducible gene expression in mammalian cells. Hum Gene Ther. 1998;9(13):1939-50. doi:10.1089/hum.1998.9.13-1939. PMID:9741432
  • Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A. 1992;89(12):5547-51. doi:10.1073/pnas.89.12.5547. PMID:1319065
  • Buchacher A, Predl R, Strutzenberger K, Steinfellner W, Trkola A, Purtscher M, Gruber G, Tauer C, Steindl F, Jungbauer A, et al. Generation of Human Monoclonal Antibodies against HIV-1 Proteins; Electrofusion and Epstein-Barr Virus Transformation for Peripheral Blood Lymphocyte Immortalization. AIDS Res Hum Retroviruses. 1994;10(4):359-69. doi:10.1089/aid.1994.10.359. PMID:7520721
  • Walker LM, Huber M, Doores KJ, Falkowska E, Pejchal R, Julien JP, Wang SK, Ramos A, Chan-Hu PY, Moyle M, et al. Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature. 2011;477(7365):466-70. doi:10.1038/nature10373. PMID:21849977
  • Walker LM, Phogat SK, Chan-Hui PY, Wagner D, Phung P, Goss JL, Wrin T, Simek MD, Fling S, Mitcham JL, et al. Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target. Science. 2009;326(5950):285-9. doi:10.1126/science.1178746. PMID:19729618
  • Heyndrickx L, Heath A, Sheik-Khalil E, Alcami J, Bongertz V, Jansson M, Malnat M, Montefiori D, Moog C, Morris L, et al. International Network for Comparison of HIV Neutralization Assays: The NeutNet Report II. PLoS One. 2012;7(5):e36438. doi:10.1371/journal.pone.0036438. PMID:22590544
  • Moscoso CG, Sun Y, Poon S, Xing L, Kan E, Martin L, Green D, Lin F, Vahlne AG, Barnett S, et al. Quaternary structures of HIV Env immunogen exhibit conformational vicissitudes and interface diminution elicited by ligand binding. Proc Natl Acad Sci U S A. 2011;108(15):6091-6. doi:10.1073/pnas.1016113108. PMID:21444771
  • Li Y, O'Dell S, Walker LM, Wu X, Guenaga J, Feng Y, Schmidt SD, McKee K, Louder MK, Ledgerwood JE, et al. Mechanism of Neutralization by the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01. J Virol. 2011;85(17):8954-67. doi:10.1128/JVI.00754-11. PMID:21715490
  • Blattner C, Lee JH, Sliepen K, Derking R, Falkowska E, de la Peña AT, Cupo A, Julien JP, van Gils M, Lee PS, et al. Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers. Immunity. 2014;40(5):669-80. doi:10.1016/j.immuni.2014.04.008. PMID:24768348
  • McGuire AT, Hoot S, Dreyer AM, Lippy A, Stuart A, Cohen KW, Jardine J, Menis S, Scheid JF, West AP, et al. Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies. J Exp Med. 2013;210(4):655-63. doi:10.1084/jem.20122824. PMID:23530120
  • Hoot S, McGuire AT, Cohen KW, Strong RK, Hangartner L, Klein F, Diskin R, Scheid JF, Sather DN, Burton DR, et al. Recombinant HIV Envelope Proteins Fail to Engage Germline Versions of Anti-CD4bs bNAbs. PLoS Pathog. 2013;9(1):e1003106. doi:10.1371/journal.ppat.1003106. PMID:23300456
  • Szymczak AL, Workman CJ, Wang Y, Vignali KM, Dilioglou S, Vanin EF, Vignali DA. Correction of multi-gene deficiency in vivo using a single ‘self-cleaving’ 2A peptide-based retroviral vector. Nat Biotechnol. 2004;22(5):589-94. doi:10.1038/nbt957. PMID:15064769
  • Bernard P, Gabant P, Bahassi EM, Couturier M. Positive-selection vectors using the F plasmid ccdB killer gene. Gene. 1994;148(1):71-4. doi:10.1016/0378-1119(94)90235-6. PMID:7926841
  • Rodenburg CM, Li Y, Trask SA, Chen Y, Decker J, Robertson DL, Kalish ML, Shaw GM, Allen S, Hahn BH, et al. Near full-length clones and reference sequences for subtype C isolates of HIV type 1 from three different continents. AIDS Res Hum Retroviruses. 2001;17(2):161-8. doi:10.1089/08892220150217247. PMID:11177395
  • Shapiro HM. Practical Flow Cytometry. Hoboken (NJ), Wiley:2005.
  • Khare PD, Rosales AG, Bailey KR, Russell SJ, Federspiel MJ. Epitope selection from an uncensored peptide library displayed on avian leukosis virus. Virology. 2003;315(2):313-21. doi:10.1016/S0042-6822(03)00530-0. PMID:14585334