mAbs, Volume 9, Issue 7 (2017)

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mAbs, Volume 9, Issue 7 (2017)

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Brief Report

Article
Nonspecificity in a nonimmune human scFv repertoire
Ryan L. Kelly, Jessie Zhao, Doris Le & K. Dane Wittrup
Pages: 1029-1035
Published online: 18 Sep 2017
AbstractforNonspecificity in a nonimmune human scFv repertoire | Full Text | References | PDF (1.1 MB) | Supplemental
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Short Communication

Rapid Communication
Chaperone proteins as single component reagents to assess antibody nonspecificity
Ryan L. Kelly, James C. Geoghegan, Jared Feldman, Tushar Jain, Monique Kauke, Doris Le, Jessie Zhao & K. Dane Wittrup
Pages: 1036-1040
Published online: 18 Sep 2017
AbstractforChaperone proteins as single component reagents to assess antibody nonspecificity | Full Text | References | PDF (656 KB) | Supplemental
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Report

Report
Evolving patterns in a collaboration network of global R&D on monoclonal antibodies
Xiangjun Kong, Jian-bo Wan, Hao Hu, Shibing Su & Yuanjia Hu
Pages: 1041-1051
Published online: 18 Aug 2017
AbstractforEvolving patterns in a collaboration network of global R&D on monoclonal antibodies | Full Text | References | PDF (1.3 MB) | Supplemental
  • 1566 Views
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Report
Mammalian cell surface display for monoclonal antibody-based FACS selection of viral envelope proteins
Tim-Henrik Bruun, Veronika Grassmann, Benjamin Zimmer, Benedikt Asbach, David Peterhoff, Alexander Kliche & Ralf Wagner
Pages: 1052-1064
Published online: 08 Sep 2017
AbstractforMammalian cell surface display for monoclonal antibody-based FACS selection of viral envelope proteins | Full Text | References | PDF (1.3 MB) | Supplemental
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Report
ELISA reagent coverage evaluation by affinity purification tandem mass spectrometry
Scott M. Henry, Elissa Sutlief, Oscar Salas-Solano & John Valliere-Douglass
Pages: 1065-1075
Published online: 03 Aug 2017
AbstractforELISA reagent coverage evaluation by affinity purification tandem mass spectrometry | Full Text | References | PDF (996.1 KB)
  • 2894 Views
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Report
GingisKHAN™ protease cleavage allows a high-throughput antibody to Fab conversion enabling direct functional assessment during lead identification of human monoclonal and bispecific IgG1 antibodies
Jörg Moelleken, Manuel Endesfelder, Christian Gassner, Sabine Lingke, Simone Tomaschek, Oksana Tyshchuk, Stefan Lorenz, Ulrike Reiff & Michael Mølhøj
Pages: 1076-1087
Published online: 06 Sep 2017
AbstractforGingisKHAN™ protease cleavage allows a high-throughput antibody to Fab conversion enabling direct functional assessment during lead identification of human monoclonal and bispecific IgG1 antibodies | Full Text | References | PDF (1.3 MB) | Supplemental
  • 3018 Views
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Report
Two-faced Fcab prevents polymerization with VEGF and reveals thermodynamics and the 2.15 Å crystal structure of the complex
Elisabeth Lobner, Anne-Sophie Humm, Georg Mlynek, Konstantin Kubinger, Michael Kitzmüller, Michael W. Traxlmayr, Kristina Djinović-Carugo & Christian Obinger
Pages: 1088-1104
Published online: 05 Sep 2017
AbstractforTwo-faced Fcab prevents polymerization with VEGF and reveals thermodynamics and the 2.15 Å crystal structure of the complex | Full Text | References | PDF (2.2 MB)
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Report
Maximizing in vivo target clearance by design of pH-dependent target binding antibodies with altered affinity to FcRn
Danlin Yang, Craig Giragossian, Steven Castellano, Marcio Lasaro, Haiguang Xiao, Himanshu Saraf, Cynthia Hess Kenny, Irina Rybina, Zhong-Fu Huang, Jennifer Ahlberg, Tammy Bigwarfe, Maria Myzithras, Erica Waltz, Simon Roberts, Rachel Kroe-Barrett & Sanjaya Singh
Pages: 1105-1117
Published online: 18 Sep 2017
AbstractforMaximizing in vivo target clearance by design of pH-dependent target binding antibodies with altered affinity to FcRn | Full Text | References | PDF (1.6 MB) | Supplemental
  • 6383 Views
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Report
Fabs-in-tandem immunoglobulin is a novel and versatile bispecific design for engaging multiple therapeutic targets
Shiyong Gong, Fang Ren, Danqing Wu, Xuan Wu & Chengbin Wu
Pages: 1118-1128
Published online: 31 Jul 2017
AbstractforFabs-in-tandem immunoglobulin is a novel and versatile bispecific design for engaging multiple therapeutic targets | Full Text | References | PDF (1.1 MB) | Supplemental
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Report
Functional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization
Di Zhang, Anthony A. Armstrong, Susan H. Tam, Stephen G. McCarthy, Jinquan Luo, Gary L. Gilliland & Mark L. Chiu
Pages: 1129-1142
Published online: 24 Aug 2017
AbstractforFunctional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization | Full Text | References | PDF (1.3 MB) | Supplemental
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Report
Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies
Rajkumar Ganesan, Ernest L. Raymond, Detlev Mennerich, Joseph R. Woska Jr., Gary Caviness, Christine Grimaldi, Jennifer Ahlberg, Rocio Perez, Simon Roberts, Danlin Yang, Kavita Jerath, Kristopher Truncali, Lee Frego, Eliud Sepulveda, Priyanka Gupta, Su-Ellen Brown, Michael D. Howell, Keith A. Canada, Rachel Kroe-Barrett, Jay S. Fine, Sanjaya Singh & M. Lamine Mbow
Pages: 1143-1154
Published online: 28 Aug 2017
AbstractforGeneration and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies | Full Text | References | PDF (1.3 MB) | Supplemental
  • 5064 Views
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Report
Preferential interactions of trehalose, L-arginine.HCl and sodium chloride with therapeutically relevant IgG1 monoclonal antibodies
Chaitanya Sudrik, Theresa Cloutier, Phuong Pham, Hardeep S. Samra & Bernhardt L. Trout
Pages: 1155-1168
Published online: 05 Sep 2017
AbstractforPreferential interactions of trehalose, L-arginine.HCl and sodium chloride with therapeutically relevant IgG1 monoclonal antibodies | Full Text | References | PDF (999.7 KB) | Supplemental
  • 4190 Views
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Report
Characterization of highly concentrated antibody solution - A toolbox for the description of protein long-term solution stability
Marie-Therese Schermeyer, Anna K. Wöll, Bas Kokke, Michel Eppink & Jürgen Hubbuch
Pages: 1169-1185
Published online: 19 Jul 2017
AbstractforCharacterization of highly concentrated antibody solution - A toolbox for the description of protein long-term solution stability | Full Text | References | PDF (1.1 MB) | Supplemental
  • 6381 Views
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Report
A Quadrupole Dalton-based multi-attribute method for product characterization, process development, and quality control of therapeutic proteins
Weichen Xu, Rod Brian Jimenez, Rachel Mowery, Haibin Luo, Mingyan Cao, Nitin Agarwal, Irina Ramos, Xiangyang Wang & Jihong Wang
Pages: 1186-1196
Published online: 11 Sep 2017
AbstractforA Quadrupole Dalton-based multi-attribute method for product characterization, process development, and quality control of therapeutic proteins | Full Text | References | PDF (1.4 MB)
  • 6917 Views
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Report
Biosimilarity under stress: A forced degradation study of Remicade® and Remsima™
Karthik Pisupati, Alexander Benet, Yuwei Tian, Solomon Okbazghi, Jukyung Kang, Michael Ford, Sergei Saveliev, K. Ilker Sen, Eric Carlson, Thomas J. Tolbert, Brandon T. Ruotolo, Steven P. Schwendeman & Anna Schwendeman
Pages: 1197-1209
Published online: 17 Aug 2017
AbstractforBiosimilarity under stress: A forced degradation study of Remicade® and Remsima™ | Full Text | References | PDF (1.2 MB) | Supplemental
  • 5462 Views
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Report
Pharmacokinetics of an intracerebroventricularly administered antibody in rats
Yuki Noguchi, Motohiro Kato, Kazuhisa Ozeki & Masaki Ishigai
Pages: 1210-1215
Published online: 27 Jul 2017
AbstractforPharmacokinetics of an intracerebroventricularly administered antibody in rats | Full Text | References | PDF (586 KB)
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