Oral Complications From the Treatment of Oral Cavity and Oropharyngeal Cancers

REFERENCES

• The American Cancer Society. Key Statistics for Oral Cavity and Oropharyngeal Cancers, 2020. www.cancer.org/cancer/oral-cavity-and-oropharyngeal-cancer/about/key-statistics.html.
   Google Scholar
• Senkomago V, Henley SJ, Thomas CC, et al. Human Papillomavirus-Attributable Cancers — United States, 2012–2016. MMWR Morb Mortal Wkly Rep 2019;68(33):724–28.
   PubMed Web of Science ®Google Scholar
• Ellington TD, Henley SJ, Senkomago V, et al. Trends in incidence of cancers of the oral cavity and pharynx — United States 2007–2016. MMWR Morb Mortal Wkly Rep 2020;69(15):433–38.
   PubMed Web of Science ®Google Scholar
• Montero PH, Patel SG. Cancer of the oral cavity. Surg Oncol Clin N Am 2015 Jul;24(3):491–508. doi: 10.1016/j.soc.2015.03.006. Epub 2015 Apr 15.
   PubMed Web of Science ®Google Scholar
• Chera BS, Amdur RJ, Green R, et al. Phase II trial of de-intensified chemoradiotherapy for human papillomavirus-associated oropharyngeal squamous cell carcinoma. J Clin Oncol 2019 Oct 10;37(29):2661–2669. doi: 10.1200/JCO.19.01007. Epub 2019 Aug 14.
   PubMed Web of Science ®Google Scholar
• Hargreaves S, Beasley M, Hurt C, Jones TM, Evans M. Deintensification of adjuvant treatment after transoral surgery in patients with human papillomavirus-positive oropharyngeal cancer: The conception of the PATHOS study and its development. Front Oncol 2019 Oct 1;9:936. doi: 10.3389/fonc.2019.00936. eCollection 2019.
   Web of Science ®Google Scholar
• National Comprehensive Cancer Network. NCCN Practice Guidelines in Oncology: Head and Neck Cancers version 2.2013. jnccn.org/view/journals/jnccn/11/8/article-p917.xml.
   Google Scholar
• Burtness B, Harrington KJ, Greil R, et al. Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): A randomised, open-label, phase 3 study. Lancet 2019 Nov 23;394(10212):1915–1928. doi: 10.1016/S0140-6736(19)32591-7. Epub 2019 Nov 1.
   PubMed Web of Science ®Google Scholar
• Mendenhall WM, Dagan R, Bryant CM, Fernandes RP. Radiation oncology for head and neck cancer: Current standards and future changes. Oral Maxillofac Surg Clin North Am 2019 Feb;31(1):31–38. doi: 10.1016/j.coms.2018.08.003. Epub 2018 Oct 25.
   Web of Science ®Google Scholar
• Yeh S-A. Radiotherapy for head and neck cancer. Semin Plast Surg 2010 May;24(2):127–36. doi: 10.1055/s-0030-1255330.
   PubMedGoogle Scholar
• Shazib MA, Woo S-B, Sroussi H, et al. Oral immune-related adverse events associated with PD-1 inhibitor therapy: A case series. Oral Dis 2020 Mar;26(2):325–333. doi: 10.1111/odi.13218. Epub 2020 Jan 9.
   PubMed Web of Science ®Google Scholar
• Sibaud V, Meyer N, Lamant L, et al. Dermatologic complications of anti-PD-1/PD-L1 immune checkpoint antibodies. Curr Opin Oncol 2016 Jul;28(4):254–63. doi: 10.1097/CCO.0000000000000290.
   PubMed Web of Science ®Google Scholar
• Vera-Llonch M, Oster G, Hagiwara M, Sonis S. Oral mucositis in patients undergoing radiation treatment for head and neck carcinoma. Cancer 2006 Jan 15;106(2):329–36. doi: 10.1002/cncr.21622.
   PubMed Web of Science ®Google Scholar
• Moslemi D, Nokhandani AM, Otaghsaraei MT, et al. Management of chemo/radiation-induced oral mucositis in patients with head and neck cancer: A review of the current literature. Radiother Oncol 2016 Jul;120(1):13–20. doi: 10.1016/j.radonc.2016.04.001. Epub 2016 Apr 21.
   PubMed Web of Science ®Google Scholar
• Elad S, Zadik Y. Chronic oral mucositis after radiotherapy to the head and neck: A new insight. Support Care Cancer 2016 Nov;24(11):4825–30. doi: 10.1007/s00520-016-3337-5. Epub 2016 Jul 30.
   PubMed Web of Science ®Google Scholar
• Lalla RV, Treister N, Sollecito T, et al. Oral complications at six months after radiation therapy for head and neck cancer. Oral Dis 2017 Nov;23(8):1134–1143. doi: 10.1111/odi.12710. Epub 2017 Aug 3.
   Web of Science ®Google Scholar
• Rosenthal DI, Trotti A. Strategies for managing radiation-induced mucositis in head and neck cancer. Semin Radiat Oncol 2009 Jan;19(1):29–34. doi: 10.1016/j.semradonc.2008.09.006.
   Web of Science ®Google Scholar
• Sonis ST. The pathobiology of mucositis. Nat Rev Cancer 2004 Apr;4(4):277–84. doi: 10.1038/nrc1318.
   PubMed Web of Science ®Google Scholar
• Sroussi HY, Epstein JB, Bensadoun R-J, et al. Common oral complications of head and neck cancer radiation therapy: Mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease and osteoradionecrosis. Cancer Med 2017 Dec;6(12):2918–2931. doi: 10.1002/cam4.1221. Epub 2017 Oct 25.
   PubMed Web of Science ®Google Scholar
• Elting LS, Chang YC. Costs of oral complications of cancer therapies: Estimates and a blueprint for future study. J Natl Cancer Inst Monogr 2019 Aug 1;2019(53):lgz010. doi: 10.1093/jncimonographs/lgz010.
   Google Scholar
• Bensinger W, Schubert M, Ang KK, et al. NCCN Task Force report. Prevention and management of mucositis in cancer care. J Natl Compr Canc Netw 2008;6 Suppl 1:S1–21; quiz S22-4.
   Google Scholar
• Sonis S. Pathobiology of oral mucositis: Novel insights and opportunities. J Support Oncol 2007 Oct;5(9 Suppl 4):3–11.
   PubMedGoogle Scholar
• Zhu X-X, Yang X-J, Chao Y-L, et al. The potential effect of oral microbiota in the prediction of mucositis during radiotherapy for nasopharyngeal carcinoma. EBioMedicine 2017 Apr;18:23–31. doi: 10.1016/j.ebiom.2017.02.002. Epub 2017 Feb 7.
   PubMed Web of Science ®Google Scholar
• Spielberger R, Stiff P, Bensinger W, et al. Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med 2004 Dec 16;351(25):2590–8. doi: 10.1056/NEJMoa040125.
   PubMed Web of Science ®Google Scholar
• Anderson CM, Lee CM, Saunders DP, et al. Phase IIb, randomized, double-blind trial of gc4419 versus placebo to reduce severe oral mucositis due to concurrent radiotherapy and cisplatin for head and neck cancer. J Clin Oncol 2019 Dec;37(34):3256–65. doi: 10.1200/JCO.19.01507.
   PubMed Web of Science ®Google Scholar
• Chao KSC, Majhail N, Huang CJ, et al. Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: A comparison with conventional techniques. Radiother Oncol 2001 Dec;61(3):275–80. doi: 10.1016/s0167-8140(01)00449-2.
   Web of Science ®Google Scholar
• Panarese V, Majid Moshirfar. Pilocarpine. Treasure Island, FL: StatPearls Publishing; 2020.
   Google Scholar
• Brizel DM, Wasserman TH, Henke M, et al. Phase III randomized trial of amifostine as a radioprotector in head and neck cancer. J Clin Oncol 2000 Oct 1;18(19):3339–45. doi: 10.1200/JCO.2000.18.19.3339.
   PubMed Web of Science ®Google Scholar
• Jellema AP, Slotman BJ, Muller MJ, et al. Radiotherapy alone, versus radiotherapy with amifostine 3 times weekly, versus radiotherapy with amifostine five times weekly. Cancer 2006 Aug 1;107(3):544–53. doi: 10.1002/cncr.22020.
   PubMed Web of Science ®Google Scholar
• Ranganathan K, Simon E, Lynn J, et al. Novel formulation strategy to improve the feasibility of amifostine administration. Pharm Res 2018 Mar 19;35(5):99. doi: 10.1007/s11095-018-2386-5.
   Web of Science ®Google Scholar
• Fischer DJ, Epstein JB. Management of patients who have undergone head and neck cancer therapy. Dent Clin North Am 2008 Jan;52(1):39–60, viii. doi: 10.1016/j.cden.2007.09.004.
   PubMedGoogle Scholar
• Gupta N, Pal M, Rawat S, et al. Radiation-induced dental caries, prevention and treatment — a systematic review. Natl J Maxillofac Surg Jul–Dec 2015;6(2):160–6. doi: 10.4103/0975-5950.183870.
   Google Scholar
• Dong Y, Ridge JA, Li T, et al. Long-term toxicities in 10-year survivors of radiation treatment for head and neck cancer. Oral Oncol Aug;71:122–128. doi: 10.1016/j.oraloncology.2017.05.009. Epub 2017 Jun 23.
   Google Scholar
• Moon DH, Moon SH, Wang K, et al. Incidence of, and risk factors for, mandibular osteoradionecrosis in patients with oral cavity and oropharynx cancers. Oral Oncol 2017 Sep;72:98–103. doi: 10.1016/j.oraloncology.2017.07.014. Epub 2017 Jul 16.
   PubMed Web of Science ®Google Scholar
• Rivero JA, Shamji O, Kolokythas A. Osteoradionecrosis: A review of pathophysiology, prevention and pharmacologic management using pentoxifylline, a-tocopherol and clodronate. Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Nov;124(5):464–471. doi: 10.1016/j.oooo.2017.08.004. Epub 2017 Aug 23.
   Web of Science ®Google Scholar
• Ceponis P, Keilman C, Guerry C, Freiberger J. Hyperbaric oxygen therapy and osteonecrosis. Oral Dis 2017 Mar;23(2):141–151. doi: 10.1111/odi.12489. Epub 2016 May 27.
   Web of Science ®Google Scholar
• Sultan A, Hanna GJ, Margalit DN, et al. The use of hyperbaric oxygen for the prevention and management of osteoradionecrosis of the jaw: A Dana-Farber/Brigham and Women’s Cancer Center multidisciplinary guideline. Oncologist 2017 Mar;22(3):343–350. doi: 10.1634/theoncologist.2016-0298. Epub 2017 Feb 16.
   Web of Science ®Google Scholar
• Gawdi R, Cooper JS. Hyperbaric Contraindications. Treasure Island, Fla.:StatPearls Publishing; 2020. www.ncbi.nlm.nih.gov/books/NBK557661.
   Google Scholar
• Feldmeier J, Carl U, Hartmann K, Sminia P. Hyperbaric oxygen: Does it promote growth or recurrence of malignancy? Undersea Hyperb Med Spring 2003;30(1):1–18.
   Google Scholar
• Dissard A, Dang NP, Barthelemy I, et al. Efficacy of pentoxifylline-tocopherol-clodronate in mandibular osteoradionecrosis. Laryngoscope 2020 Nov;130(11):E559–E566. doi: 10.1002/lary.28399. Epub 2019 Nov 20.
   Web of Science ®Google Scholar
• Breik O, Tocaciu S, Briggs K, Tasfia Saief S, Richardson S. Is there a role for pentoxifylline and tocopherol in the management of advanced osteoradionecrosis of the jaws with pathological fractures? Case reports and review of the literature. Int J Oral Maxillofac Surg 2019 Aug;48(8):1022–1027. doi: 10.1016/j.ijom.2019.03.894. Epub 2019 Apr 10.
   Web of Science ®Google Scholar
• Louise Kent M, Brennan MT, Noll JL, et al. Radiation-induced trismus in head and neck cancer patients. Support Care Cancer 2008 Mar;16(3):305–9. doi: 10.1007/s00520-007-0345-5. Epub 2007 Oct 27.
   Web of Science ®Google Scholar
• Teguh DN, Levendag PC, Voet P, et al. Trismus in patients with oropharyngeal cancer: Relationship with dose in structures of mastication apparatus. Head Neck 2008 May;30(5):622–30. doi: 10.1002/hed.20760.
   Web of Science ®Google Scholar
• Bensadoun RJ, Riesenbeck D, Lockhart PB, et al. A systematic review of trismus induced by cancer therapies in head and neck cancer patients. Support Care Cancer 2010 Aug;18(8):1033–8. doi: 10.1007/s00520-010-0847-4. Epub 2010 Mar 6.
   Web of Science ®Google Scholar
• Dijkstra PU, Kalk WWI, Roodenburg JLN. Trismus in head and neck oncology: A systematic review. Oral Oncol 2004 Oct;40(9):879–89. doi: 10.1016/j.oraloncology.2004.04.003.
   PubMed Web of Science ®Google Scholar
• Kim H-S, Yun P-Y, Kim Y-K. A clinical evaluation of botulinum toxin-A injections in the temporomandibular disorder treatment. Maxillofac Plast Reconstr Surg 2016 Jan 28;38(1):5. doi: 10.1186/s40902-016-0051-7. eCollection 2016 Dec.
   PubMedGoogle Scholar
• Gil-Martínez A, Paris-Alemany A, López-de-Uralde-Villanueva I, La Touche R. Management of pain in patients with temporomandibular disorder (TMD): Challenges and solutions. J Pain Res 2018 Mar 16;11:571–587. doi: 10.2147/JPR.S127950. eCollection 2018.
   PubMed Web of Science ®Google Scholar
• Epstein JB, Hong C, Logan RM, et al. A systematic review of orofacial pain in patients receiving cancer therapy. Support Care Cancer 2010 Aug;18(8):1023–31. doi: 10.1007/s00520-010-0897-7. Epub 2010 Jun 11.
   Web of Science ®Google Scholar
• Grond S, Zech D, Lynch J, et al. Validation of World Health Organization guidelines for pain relief in head and neck cancer. A prospective study. Ann Otol Rhinol Laryngol 1993 May;102(5):342–8. doi: 10.1177/000348949310200504.
   Web of Science ®Google Scholar
• Ritchie A, Kramer JM. Recent advances in the etiology and treatment of burning mouth syndrome. J Dent Res 2018 Oct;97(11):1193–1199. doi: 10.1177/0022034518782462. Epub 2018 Jun 18.
   PubMed Web of Science ®Google Scholar
• Delanian S, Lefaix J-L, Pradat P-F. Radiation-induced neuropathy in cancer survivors. Radiother Oncol 2012 Dec;105(3):273–82. doi: 10.1016/j.radonc.2012.10.012.
   PubMed Web of Science ®Google Scholar
• Jiang J, Li Y, Shen Q, et al. Effect of pregabalin on radiotherapy-related neuropathic pain in patients with head and neck cancer: A randomized controlled trial. J Clin Oncol 2019 Jan 10;37(2):135–143. doi: 10.1200/JCO.18.00896. Epub 2018 Nov 20.
   PubMed Web of Science ®Google Scholar
• Taplitz RA, Kennedy EB, Bow EJ, et al. Antimicrobial prophylaxis for adult patients with cancer-related immunosuppression: ASCO and IDSA clinical practice guideline update. J Clin Oncol 2018;36(30):3043–54.
   PubMed Web of Science ®Google Scholar
• DJ K. General aspects of thrombocytopenia, platelet transfusions and thrombopoietic growth factors. In: Kitchens C, Kessler CMC, Konkle B, eds. Consultative Hemostasis and Thrombosis. Philadelphia: Elsevier; 2013.
   Google Scholar
• Weycker D, Hatfield M, Grossman A, et al. Risk and consequences of chemotherapy-induced thrombocytopenia in U.S. clinical practice. BMC Cancer 2019 Feb 14;19(1):151. doi: 10.1186/s12885-019-5354-5.
   PubMedGoogle Scholar
• Connolly C, Bambhania K, Naidoo J. Immune-related adverse events: A case-based approach. Front Oncol 2019 Jun 20;9:530. doi: 10.3389/fonc.2019.00530. eCollection 2019.
   PubMed Web of Science ®Google Scholar
• Epstein JB, Thariat J, Bensadoun R-J, et al. Oral complications of cancer and cancer therapy. CA Cancer J Clin Nov–Dec 2012;62(6):400–22. doi: 10.3322/caac.21157. Epub 2012 Sep 12.
   Google Scholar
• Elad S, Cheng KKF, Lalla RV, et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 2020 Oct 1;126(19):4423–4431. doi: 10.1002/cncr.33100. Epub 2020 Jul 28.
   PubMed Web of Science ®Google Scholar
• Yarom N, Shapiro CL, Peterson DE, et al. Medication-related osteonecrosis of the jaw: MASCC/ISOO/ASCO clinical practice guideline. J Clin Oncol 2019 Sep 1;37(25):2270–2290. doi: 10.1200/JCO.19.01186. Epub 2019 Jul 22.
   PubMed Web of Science ®Google Scholar
• Koudougou C, Bertin H, Lecaplain B, et al. Postimplantation radiation therapy in head and neck cancer patients: Literature review. Head Neck 2020 Apr;42(4):794–802. doi: 10.1002/hed.26065. Epub 2020 Jan 3.
   PubMed Web of Science ®Google Scholar
• Chambrone L, Mandia J Jr., Shibli JA, Romito GA, Abrahao M. Dental implants installed in irradiated jaws: A systematic review. J Dent Res 2013 Dec;92(12 Suppl):119S–30S. doi: 10.1177/0022034513504947. Epub 2013 Oct 24.
   PubMedGoogle Scholar
• Schmitt CM, Buchbender M, Lutz R, Neukam FW. Oral implant survival in patients with bisphosphonate (BP)/antiresorptive and radiation therapy and their impact on osteonecrosis of the jaws. A systematic review. Eur J Oral Implantol 2018;11 Suppl 1:S93–s111.
   Google Scholar