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Review Article

Oral Cavity is the Gateway to the Body: Role of Oral Health Professionals: A Narrative Review

, DDS
Article: 2193372 | Received 09 Oct 2022, Accepted 16 Mar 2023, Published online: 30 Mar 2023

References

  • Peng X, Cheng L, You Y, et al. Oral microbiota in human systematic diseases. Int J Oral Sci. 2022;14(1):14. doi:10.1038/s41368-022-00163-7.
  • Deo PN, Deshmukh R. Oral microbiome: unveiling the fundamentals. J Oral Maxillofac Pathol. 2019;23(1):122–11. doi:10.4103/jomfp.JOMFP_304_18.
  • Kilian M, Chapple IL, Hannig M, et al. The oral microbiome - an update for oral healthcare professionals. Br Dent J. 2016;221(10):657–666. doi:10.1038/sj.bdj.2016.865.
  • Lee YH, Chung SW, Auh QS, et al. Progress in oral microbiome related to oral and systemic diseases: an update. Diagn (Basel). 2021;11(7):1283. doi:10.3390/diagnostics11071283.
  • Edlund A, Santiago-Rodriguez TM, Boehm TK, Pride DT. Bacteriophage and their potential roles in the human oral cavity. J Oral Microbiol. 2015;7(1):27423. doi:10.3402/jom.v7.27423.
  • Pride DT, Salzman J, Haynes M, et al. Evidence of a robust resident bacteriophage population revealed through analysis of the human salivary virome. ISME J. 2012;6(5):915–926. doi:10.1038/ismej.2011.169.
  • Parras-Moltó M, López-Bueno A. Methods for enrichment and sequencing of oral viral assemblages: saliva, oral mucosa, and dental plaque viromes. Methods Mol Biol. 2018;1838:143–161. doi:10.1007/978-1-4939-8682-8_11.
  • Berg G, Rybakova D, Fischer D, et al. Microbiome definition re-visited: old concepts and new challenges. Microbiome. 2020;8(1):103. doi:10.1186/s40168-020-00875-0.
  • Tutuncu EE, Ozgur D, Karamese M. Saliva samples for detection of SARS-CoV-2 in mildly symptomatic and asymptomatic patients. J Med Virol. 2021;93(5):2932–2937. doi:10.1002/jmv.26821.
  • Dubé CD, Guiot SR. Direct interspecies electron transfer in anaerobic digestion: a review. Adv Biochem Eng Biotechnol. 2015;151:101–115. doi:10.1007/978-3-319-21993-6_4.
  • Amerongen AV, Veerman EC. Saliva–the defender of the oral cavity. Oral Dis. 2002;8(1):12–22. doi:10.1034/j.1601-0825.2002.1o816.x.
  • Fábián TK, Hermann P, Beck A, Fejérdy P, Fábián G. Salivary defense proteins: their network and role in innate and acquired oral immunity. Int J Mol Sci. 2012;13(4):4295–4320. doi:10.3390/ijms13044295.
  • Li X, Kolltveit KM, Tronstad L, Olsen I. Systemic diseases caused by oral infection. Clin Microbiol Rev. 2000;13(4):547–558. doi:10.1128/CMR.13.4.547.
  • Abdelbary MMH, Hatting M, Bott A, et al. The oral-gut axis: salivary and fecal microbiome dysbiosis in patients with inflammatory bowel disease. Front Cell Infect Microbiol. 2022;12:1010853. doi:10.3389/fcimb.2022.1010853.
  • Kitamoto S, Nagao-Kitamoto H, Hein R, Schmidt TM, Kamada N. The bacterial connection between the oral cavity and the gut diseases. J Dent Res. 2020;99(9):1021–1029. doi:10.1177/0022034520924633.
  • Atarashi K, Suda W, Luo C, et al. Ectopic colonization of oral bacteria in the intestine drives TH cell induction and inflammation. Science. 2017;358(6361):359–365. doi:10.1126/science.aan4526.
  • Qi Y, Wu HM, Yang Z, et al. New insights into the role of oral microbiota dysbiosis in the pathogenesis of inflammatory bowel disease. Dig Dis Sci. 2022;67(1):42–55. doi:10.1007/s10620-021-06837-2.
  • Zhao H, Zhang W, Cheng D, You L, Huang Y, Lu Y. Investigating dysbiosis and microbial treatment strategies in inflammatory bowel disease based on two modified Koch’s postulates. Front Med (Lausanne). 2022;9:1023896. doi:10.3389/fmed.2022.1023896.
  • Kuraji R, Sekino S, Kapila Y, Numabe Y. Periodontal disease-related nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: an emerging concept of oral-liver axis. Periodontol 2000. 2021;87(1):204–240. doi:10.1111/prd.12387.
  • Yoneda M, Naka S, Nakano K, et al. Involvement of a periodontal pathogen, porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease. BMC Gastroenterol. 2012;12(1):16. doi:10.1186/1471-230X-12-16.
  • Abe K, Fujita M, Hayashi M, Okai K, Takahashi A, Ohira H. Gut and oral microbiota in autoimmune liver disease. Fukushima J Med Sci. 2020;65(3):71–75. doi:10.5387/fms.2019-21.
  • Rao B, Lou J, Lu H, et al. Oral microbiome characteristics in patients with autoimmune hepatitis. Front Cell Infect Microbiol. 2021;11:656674. doi:10.3389/fcimb.2021.656674.
  • Bajaj JS, Matin P, White MB, et al. Periodontal therapy favorably modulates the oral-gut-hepatic axis in cirrhosis. Am J Physiol Gastrointestinal Liver Physiol. 2018;315(5):G824–837. doi:10.1152/ajpgi.00230.2018.
  • Xiao E, Mattos M, Vieira GHA, et al. Diabetes enhances IL-17 expression and alters the oral microbiome to increase its pathogenicity. Cell Host & Microbe. 2017;22(1):120–128.e4. doi:10.1016/j.chom.2017.06.014.
  • Matsha TE, Prince Y, Davids S, et al. Oral microbiome signatures in diabetes mellitus and periodontal disease. J Dent Res. 2020;99(6):658–665. doi:10.1177/0022034520913818.
  • Negrini TC, Carlos IZ, Duque C, Caiaffa KS, Arthur RA. Interplay among the oral microbiome, oral cavity conditions, the host immune response, diabetes mellitus, and its associated-risk factors-an overview. Frontiers in Oral Health. 2021;2:697428. doi:10.3389/froh.2021.697428.
  • Isola G, Polizzi A, Santonocito S, Alibrandi A, Williams RC. Periodontitis activates the NLRP3 inflammasome in serum and saliva. J Periodontol. 2022;93(1):135–145. doi:10.1002/JPER.21-0049.
  • Coker MO, Lebeaux RM, Hoen AG, et al. Metagenomic analysis reveals associations between salivary microbiota and body composition in early childhood. Sci Rep. 2022;12(1):13075. doi:10.1038/s41598-022-14668-y.
  • Keller A, Rohde JF, Raymond K, Heitmann BL. Association between periodontal disease and overweight and obesity: a systematic review. J Periodontol. 2015;86(6):766–776. doi:10.1902/jop.2015.140589.
  • Li N, Li Y, Qian C, et al. Dysbiosis of the saliva microbiome in patients with polycystic ovary syndrome. Front Cell Infect Microbiol. 2021;10:624504. doi:10.3389/fcimb.2020.624504.
  • Yang Y, Cai Q, Zheng W, et al. Oral microbiome and obesity in a large study of low-income and African-American populations. J Oral Microbiol. 2019;11(1):1650597. doi:10.1080/20002297.2019.1650597.
  • Giordano-Kelhoffer B, Lorca C, March Llanes J, et al. Oral microbiota, its equilibrium, and implications in the pathophysiology of human diseases: a systematic review. Biomedicines. 2022;10(8):1803. doi:10.3390/biomedicines10081803.
  • Bartova J, Sommerova P, Lyuya-Mi Y, et al. Periodontitis as a risk factor of atherosclerosis. J Immunol Res. 2014;2014:636893. doi:10.1155/2014/636893.
  • Zhang J, Xie M, Huang X, et al. The effects of porphyromonas gingivalis on atherosclerosis-related cells. Front Immunol. 2021;12:766560. doi:10.3389/fimmu.2021.766560.
  • Blekkenhorst LC, Bondonno NP, Liu AH, et al. Nitrate, the oral microbiome, and cardiovascular health: a systematic literature review of human and animal studies. Am J Clin Nutr. 2018;107(4):504–522. doi:10.1093/ajcn/nqx046.
  • Koch CD, Gladwin MT, Freeman BA, Lundberg JO, Weitzberg E, Morris A. Enterosalivary nitrate metabolism and the microbiome: intersection of microbial metabolism, nitric oxide, and diet in cardiac and pulmonary vascular health. Free Radical Biology & Medicine. 2017;105:48–67. doi:10.1016/j.freeradbiomed.2016.12.015.
  • Hezel MP, Weitzberg E. The oral microbiome and nitric oxide homoeostasis. Oral Dis. 2015;21(1):7–16. doi:10.1111/odi.12157.
  • Kapil V, Haydar SM, Pearl V, Lundberg JO, Weitzberg E, Ahluwalia A. Physiological role for nitrate-reducing oral bacteria in blood pressure control. Free Radical Biology & Medicine. 2013;55:93–100. doi:10.1016/j.freeradbiomed.2012.11.013.
  • Pussinen PJ, Kopra E, Pietiäinen M, et al. Periodontitis and cardiometabolic disorders: the role of lipopolysaccharide and endotoxemia. Periodontol 2000. 2022;89(1):19–40. doi:10.1111/prd.12433.
  • Kleinstein SE, Nelson KE, Freire M. Inflammatory networks linking oral microbiome with systemic health and disease. J Dent Res. 2020;99(10):1131–1139. doi:10.1177/0022034520926126.
  • Kumar PS, Matthews CR, Joshi V, de Jager M, Aspiras M. Tobacco smoking affects bacterial acquisition and colonization in oral biofilms. Infect Immun. 2011;79(11):4730–4738. doi:10.1128/IAI.05371-11.
  • Mammen MJ, Scannapieco FA, Sethi S. Oral‐lung microbiome interactions in lung diseases. Periodontol 2000. 2020;83(1):234–241. doi:10.1111/prd.12301.
  • Pathak JL, Yan Y, Zhang Q, Wang L, Ge L. The role of oral microbiome in respiratory health and diseases. Respir Med. 2021;185:106475. doi:10.1016/j.rmed.2021.106475.
  • Bassis CM, Erb-Downward JR, Dickson RP, et al. Analysis of the upper respiratory tract microbiotas as the source of the lung and gastric microbiotas in healthy individuals. MBio. 2015;6(2):e00037. doi:10.1128/mBio.00037-15.
  • Didilescu AC, Skaug N, Marica C, Didilescu C. Respiratory pathogens in dental plaque of hospitalized patients with chronic lung diseases. Clin Oral Investig. 2005;9(3):141–147. doi:10.1007/s00784-005-0315-6.
  • Mammen MJ, Sethi S. COPD and the microbiome. Respirology. 2016;21(4):590–599. doi:10.1111/resp.12732.
  • Willis JR, Saus E, Iraola-Guzmán S, et al. Citizen-science based study of the oral microbiome in cystic fibrosis and matched controls reveals major differences in diversity and abundance of bacterial and fungal species. J Oral Microbiol. 2021;13(1):1897328. doi:10.1080/20002297.2021.1897328.
  • Fleury V, Zekeridou A, Lazarevic V, et al. Oral dysbiosis and inflammation in parkinson’s disease. J Parkinson’s Dis. 2021;11(2):619–631. doi:10.3233/JPD-202459.
  • Fan Z, Li Z, Zhao S, et al. Salivary Aβ1–42 may be a quick-tested biomarker for clinical use in Alzheimer’s disease: a meta-analysis. J Neurol. 2022. doi:10.1007/s00415-022-11509-w.
  • Liu S, Dashper SG, Zhao R. Association between oral bacteria and alzheimer’s disease: a systematic review and meta-analysis. J Alzheimer Dis. 2022; Advance online publication. doi:10.3233/JAD-220627.
  • Li C, Chen Y, Wen Y, et al. A genetic association study reveals the relationship between the oral microbiome and anxiety and depression symptoms. Front Psychiatry. 2022;13:960756. doi:10.3389/fpsyt.2022.960756.
  • Simpson CA, Adler C, du Plessis MR, et al. Oral microbiome composition, but not diversity, is associated with adolescent anxiety and depression symptoms. Physiol Behav. 2020;226:113126. doi:10.1016/j.physbeh.2020.113126.
  • Wingfield B, Lapsley C, McDowell A, et al. Variations in the oral microbiome are associated with depression in young adults. Sci Rep. 2021;11(1):15009. doi:10.1038/s41598-021-94498-6.
  • Ahrens AP, Sanchez-Padilla DE, Drew JC, Oli MW, Roesch L, Triplett EW. Saliva microbiome, dietary, and genetic markers are associated with suicidal ideation in university students. Sci Rep. 2022;12(1):14306. doi:10.1038/s41598-022-18020-2.
  • Yuan S, Fang C, Leng WD, et al. Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers. Mil Med Res. 2021;8(1):54. doi:10.1186/s40779-021-00344-1.
  • Fang C, Wu L, Zhu C, Xie WZ, Hu H, Zeng XT. A potential therapeutic strategy for prostatic disease by targeting the oral microbiome. Med Res Rev. 2021;41(3):1812–1834. doi:10.1002/med.21778.
  • Alwithanani N, Bissada NF, Joshi N, et al. Periodontal treatment improves prostate symptoms and lowers serum PSA in men with high PSA and chronic periodontitis. Dentistry. 2015;5(3):1. doi:10.4172/2161-1122.1000284.
  • Lee J, Roberts JS, Atanasova KR, Chowdhury N, Yilmaz Ö. A novel kinase function of a nucleoside‐diphosphate‐kinase homologue in porphyromonas gingivalis is critical in subversion of host cell apoptosis by targeting heat‐shock protein 27. Cell Microbiol. 2018;20(5):e12825. doi:10.1111/cmi.12825.
  • Meurman JH, Uittamo J. Oral micro-organisms in the etiology of cancer. Acta Odontol Scand. 2008;66(6):321–326. doi:10.1080/00016350802446527.
  • Nauclér CS, Geisler J, Vetvik K. The emerging role of human cytomegalovirus infection in human carcinogenesis: a review of current evidence and potential therapeutic implications. Oncotarget. 2019;10(42):4333–4347. doi:10.18632/oncotarget.27016.
  • Peters BA, Wu J, Pei Z, et al. Oral microbiome composition reflects prospective risk for esophageal cancers. Cancer Res. 2017;77(23):6777–6787. doi:10.1158/0008-5472.CAN-17-1296.
  • Castellarin M, Warren RL, Freeman JD, et al. Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res. 2012;22(2):299–306. doi:10.1101/gr.126516.111.
  • Gaba FI, González RC, Martïnez RG. The role of oral Fusobacterium nucleatum in female breast cancer: a systematic review and meta-analysis. Int J Dent. 2022;2022:1876275. doi:10.1155/2022/1876275.
  • Cobb CM, Kelly PJ, Williams KB, Babbar S, Angolkar M, Derman RJ. The oral microbiome and adverse pregnancy outcomes. Int J Women Health. 2017;9:551–559. doi:10.2147/IJWH.S142730.
  • Balan P, Chong YS, Umashankar S, et al. Keystone species in pregnancy gingivitis: a snapshot of oral microbiome during pregnancy and postpartum period. Front Microbiol. 2018;9:2360. doi:10.3389/fmicb.2018.02360.
  • Ye C, You M, Huang P, et al. Clinical study showing a lower abundance of Neisseria in the oral microbiome aligns with low birth weight pregnancy outcomes. Clin Oral Investig. 2022;26(3):2465–2478. doi:10.1007/s00784-021-04214-x.
  • Wang X, Buhimschi CS, Temoin S, Bhandari V, Han YW, Buhimschi IA. Comparative microbial analysis of paired amniotic fluid and cord blood from pregnancies complicated by preterm birth and early-onset neonatal sepsis. PLoS One. 2013;8(2):e56131. doi:10.1371/journal.pone.0056131.
  • Cheng Z, Do T, Mankia K, et al. Dysbiosis in the oral microbiomes of anti-CCP positive individuals at risk of developing rheumatoid arthritis. Ann Rheum Dis. 2021;80(2):162–168. doi:10.1136/annrheumdis-2020-216972.
  • Corrêa JD, Calderaro DC, Ferreira GA, et al. Subgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal status. Microbiome. 2017;5(1):34. doi:10.1186/s40168-017-0252-z.
  • Hajishengallis G, Chavakis T. Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nat Rev Immunol. 2021;21(7):426–440. doi:10.1038/s41577-020-00488-6.
  • Tseng YC, Yang HY, Lin WT, et al. Salivary dysbiosis in Sjögren’s syndrome and a commensal-mediated immunomodulatory effect of salivary gland epithelial cells. NPJ Biofilms Microbiomes. 2021;7(1):21. doi:10.1038/s41522-021-00192-w.
  • Singh H, Torralba MG, Moncera KJ, et al. Gastro-intestinal and oral microbiome signatures associated with healthy aging. Geroscience. 2019;41(6):907–921. doi:10.1007/s11357-019-00098-8.
  • Lazarevic V, Manzano S, Gaïa N, et al. Effects of amoxicillin treatment on the salivary microbiota in children with acute otitis media. Clin Microbiol Infect. 2013;19(8):E335–342. doi:10.1111/1469-0691.12213.
  • Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol. 1998;25(2):134–144. doi:10.1111/j.1600-051x.1998.tb02419.x.
  • Christina P, Velitchka DP, Vladimir P. Microbiology of periodontal diseases. A Rev, Biotechnol Biotechnol Equip. 2013;27(3):3754–3759. doi:10.5504/BBEQ.2013.0027.
  • Scannapieco FA, Dongari-Bagtzoglou A. Dysbiosis revisited: understanding the role of the oral microbiome in the pathogenesis of gingivitis and periodontitis: a critical assessment. J Periodontol. 2021;92(8):1071–1078. doi:10.1002/JPER.21-0120.
  • Zhu J, Chu W, Luo J, Yang J, He L, Li J. Dental materials for oral microbiota dysbiosis: an update. Front Cell Infect Microbiol. 2022;12:900918. doi:10.3389/fcimb.2022.900918.
  • Struzycka I. The oral microbiome in dental caries. Pol J Microbiol. 2014;63(2):127–135. doi:10.33073/pjm-2014-018.
  • Inchingolo AD, Malcangi G, Semjonova A, et al. Oralbiotica/Oralbiotics: the impact of oral microbiota on dental health and demineralization: a systematic review of the literature. Children (Basel). 2022;9(7):1014. doi:10.3390/children9071014.
  • Kaidonis J, Townsend G. The ‘sialo-microbial-dental complex’ in oral health and disease. Ann Anat. 2016;203:85–89. doi:10.1016/j.aanat.2015.02.002.
  • Bowen WH, Burne RA, Wu H, Koo H. Oral biofilms: pathogens, matrix, and polymicrobial interactions in microenvironments. Trends Microbiol. 2018;26(3):229–242. doi:10.1016/j.tim.2017.09.008.
  • Kaczor-Urbanowicz KE, Martin Carreras-Presas C, Aro K, Tu M, Garcia-Godoy F, Wong DT. Saliva diagnostics - current views and directions. Exp Biol Med (Maywood). 2017;242(5):459–472. doi:10.1177/1535370216681550.
  • Dawes C, Wong D. Role of saliva and salivary diagnostics in the advancement of oral health. J Dent Res. 2019;98(2):133–141. doi:10.1177/0022034518816961.
  • Landry V, Coburn P, Kost K, Liu X, Li-Jessen N. Diagnostic accuracy of liquid biomarkers in airway diseases: toward point-of-care applications. Front Med (Lausanne). 2022;9:855250. doi:10.3389/fmed.2022.855250.
  • Khurshid Z, Zafar MS, Khan RS, Najeeb S, Slowey PD, Rehman IU. Role of salivary biomarkers in oral cancer detection. Adv Clin Chem. 2018;86:23–70. doi:10.1016/bs.acc.2018.05.002.
  • Setti G, Pezzi ME, Viani MV, et al. Salivary MicroRNA for diagnosis of cancer and systemic diseases: a systematic review. Int J Mol Sci. 2020;21(3):907. doi:10.3390/ijms21030907.
  • Martina E, Campanati A, Diotallevi F, Offidani A. Saliva and oral diseases. J Clin Med. 2020;9(2):466. doi:10.3390/jcm9020466.
  • Jaiswal A, Madaan S, Acharya N, Kumar S, Talwar D, Dewani D. Salivary uric acid: a noninvasive wonder for clinicians? Cureus. 2021;13(11):e19649. doi:10.7759/cureus.19649.
  • Nijakowski K, Surdacka A. Salivary biomarkers for diagnosis of inflammatory bowel diseases: a systematic review. Int J Mol Sci. 2020;21(20):7477. doi:10.3390/ijms21207477.
  • Khan RS, Khurshid Z, Yahya Ibrahim Asiri F. Advancing point-of-care (PoC) testing using human saliva as liquid biopsy. Diagn (Basel). 2017;7(3):39. doi:10.3390/diagnostics7030039.
  • Ladgotra A, Verma P, Raj SS. Estimation of salivary and serum biomarkers in diabetic and non-diabetic patients - a comparative study. J Clin Diagn Res. 2016;10(6):ZC56–61. doi:10.7860/JCDR/2016/19135.7995.
  • Grootveld M, Percival BC, Page G, et al. Updates and original case studies focused on the nmr-linked metabolomics analysis of human oral fluids part II: applications to the diagnosis and prognostic monitoring of oral and systemic cancers. Metabolites. 2022;12(9):778. doi:10.3390/metabo12090778.
  • Assad DX, Mascarenhas ECP, de Lima CL, et al. Salivary metabolites to detect patients with cancer: a systematic review. Int J Clin Oncol. 2020;25(6):1016–1036. doi:10.1007/s10147-020-01660-7.
  • Kapila YL. Oral health’s inextricable connection to systemic health: special populations bring to bear multimodal relationships and factors connecting periodontal disease to systemic diseases and conditions. Periodontol 2000. 2021;87(1):11–16. doi:10.1111/prd.12398.
  • Radaic A, Kapila YL. The oralome and its dysbiosis: new insights into oral microbiome-host interactions. Comput Struct Biotechnol J. 2021;19:1335–1360. doi:10.1016/j.csbj.2021.02.010.
  • Tanner A, Kressirer CA, Rothmiller S, Johansson I, Chalmers NI. The caries microbiome: implications for reversing dysbiosis. Adv Dent Res. 2018;29(1):78–85. doi:10.1177/0022034517736496.
  • Gheisary Z, Mahmood R, Harri Shivanantham A, et al. The clinical, microbiological, and immunological effects of probiotic supplementation on prevention and treatment of periodontal diseases: a systematic review and meta-analysis. Nutrients. 2022;14(5):1036. doi:10.3390/nu14051036.
  • Nath S, Zilm P, Jamieson L, et al. Development and characterization of an oral microbiome transplant among Australians for the treatment of dental caries and periodontal disease: a study protocol. PLoS One. 2021;16(11):e0260433. doi:10.1371/journal.pone.0260433.