1,268
Views
137
CrossRef citations to date
0
Altmetric
Original Articles

Health economic impacts and cost-effectiveness of aflatoxin-reduction strategies in Africa: case studies in biocontrol and post-harvest interventions

&
Pages 496-509 | Received 12 Jun 2009, Accepted 23 Oct 2009, Published online: 05 Jan 2010

References

  • Abbas , H , Zablotowicz , R , Bruns , HA and Abel , C . 2006 . Biocontrol of aflatoxin in corn by inoculation with non-aflatoxigenic Aspergillus flavus isolates . Biocontrol Sci Tech , 16 : 437 – 449 .
  • Atehnkeng , J , Ojiambo , PS , Ikotun , T , Sikora , RA , Cotty , PJ and Bandyopadhyay , R . 2008 . Evaluation of atoxigenic strains of Aspergillus flavus as potential biocontrol agents for aflatoxin in maize . Food Addit Contam A , 25 : 1254 – 1271 .
  • Azziz-Baumgartner , E , Lindblade , K , Gieseker , K , Schurz Rogers , H , Kieszak , S , Njapau , H , Schleicher , R , McCoy , LF , Misore , A , DeCock , K , Rubin , C , Slutsker , L and Aflatoxin Investigative Group . 2005 . Case-control study of an acute aflatoxicosis outbreak, Kenya, 2004 . Environ Hlth Perspect , 113 : 1779 – 1783 .
  • Bandyopadhyay , R , Kiewnick , S , Atehnkeng , J , Donner , M , Cotty , PJ and Hell , K . Biological control of aflatoxin contamination in maize in Africa . Proceedings of the Conference on International Research for Development . 11–13 October 2005 , Hohenheim, Germany.
  • Bandyopadhyay , R , Kumar , M and Leslie , JF . 2007 . Relative severity of aflatoxin contamination of cereal crops in West Africa . Food Addit Contam , 24 ( 10 ) : 1109 – 1114 .
  • Cotty , PJ , Antilla , L and Wakelyn , PJ . 2007 . “ Competitive exclusion of aflatoxin producers: farmer-driven research and development ” . In Biological control: a global perspective , Edited by: Vincent , C , Goettel , MS and Lazarovits , G . Wallingford (UK) : CAB International .
  • Cotty , PJ and Bhatnagar , D . 1994 . Variability among atoxigenic Aspergillus flavus strains in ability to prevent aflatoxin contamination and production of aflatoxin biosynthetic pathway enzymes . Appl Environ Microbiol , 60 : 2248 – 2251 .
  • Dorner , JW , Cole , RJ and Wicklow , DT . 1999 . Aflatoxin reduction in corn through field application of competitive fungi . J Food Prot , 62 : 650 – 656 .
  • Economy Watch. 2009a. Guinea GDP per capita (PPP), US dollars statistics for year 2009 [Internet]. Economy Watch; [cited 2009 Jun 9]. Available from: http://www.economywatch.com/economic-statistics/Guinea/GDP_Per_Capita_PPP_US_Dollars/year-2009/
  • Economy Watch. 2009b. Nigeria GDP per capita (PPP), US dollars statistics for year 2009 [Internet]. Economy Watch; [cited 2009 Jun 9]. Available from: http://www.economywatch.com/economic-statistics/Nigeria/GDP_Per_Capita_PPP_US_Dollars/year-2009/
  • Ehrlich , KC and Cotty , PJ . 2004 . An isolate of Aspergillus flavus used to reduce aflatoxin contamination in cottonseed has a defective polyketide synthase gene . Appl Microbiol Biotechnol , 65 : 473 – 478 .
  • FAOSTAT. 2009a. Consumption: crops primary equivalent [Internet]. Rome (Italy): Food and Agriculture Organization (FAO); [cited 2009 Jun 9]. Available from: http://faostat.fao.org/
  • FAOSTAT. 2009b. Production: crops [Internet]. Rome (Italy): FAO; [cited 2009 Aug 18]. Available from: http://faostat.fao.org/
  • Forbi , JC , Onyemauwa , N , Gyar , SD , Oyeleye , AO , Entonu , P and Agwale , SM . 2008 . High prevalence of hepatitis B virus among female sex workers in Nigeria . Rev Inst Med Trop Sao Paulo , 50 ( 4 ) : 219 – 221 .
  • Gong , YY , Cardwell , K , Hounsa , A , Egal , S , Turner , PC , Hall , AJ and Wild , CP . 2002 . Dietary aflatoxin exposure and impaired growth in young children from Benin and Togo: cross sectional study . Br Med J , 325 : 20 – 21 .
  • Gong , YY , Turner , PC , Hall , AJ and Wild , CP . 2008 . “ Aflatoxin exposure and impaired child growth in West Africa: an unexplored international public health burden? ” . In Mycotoxins: detection methods, management, public health and agricultural trade , Edited by: Leslie , Jf , Bandyopadhyay , R and Visconti , A . 53 – 65 . Wallingford (UK) : CAB International .
  • Groopman , JD , Johnson , D and Kensler , TW . 2005 . Aflatoxin and hepatitis B virus biomarkers: a paradigm for complex environmental exposures and risk . Cancer Biomark. , 1 : 5 – 14 .
  • Groopman , JD , Kensler , TW and Wild , CP . 2008 . Protective interventions to prevent aflatoxin-induced carcinogenesis in developing countries . Annu Rev Public Hlth , 29 : 187 – 203 .
  • Havelaar , A . 2007 . Methodological choices for calculating the disease burden and cost-of-illness of foodborne zoonoses in European countries , EU Report No. 07–002, [Internet]. The Netherlands : Med-Vet-Net; [cited 2009 Jun 8]. . Available from: http://www.medvetnet.org/pdf/Reports/Report_07-002.pdf
  • Hedayati , MT , Pasqualotto , AC , Warn , PA , Bowyer , P and Denning , DW . 2007 . Aspergillus flavus: human pathogen, allergen and mycotoxin producers . Microbiology , 153 : 1677 – 1692 .
  • Hell , K , Cardwell , KF , Setamou , M and Poehling , H . 2000 . The influence of storage practices on aflatoxin contamination in maize in four agroecological zones of Benin, West Africa . J Stored Prod Res , 36 ( 4 ) : 365 – 382 .
  • Henry , SH , Bosch , FX , Troxell , TC and Bolger , PM . 1999 . Reducing liver cancer–global control of aflatoxin . Science , 286 : 2453 – 2454 .
  • Ivanov , AP , Ivanova , OE and Pozdnjakov , SV . 1987 . HBsAg carriers in the Republic of Guinea . Ann Soc Belg Med Trop , 67 ( 3 ) : 301
  • Iwalokun , BA , Hodonu , SO , Olaleye , BM and Olabisi , OA . 2006 . Seroprevalence and biochemical features of hepatitis B surface antigenemia in patients with HIV-1 infection in Lagos, Nigeria . Afr J Med Sci , 35 ( 3 ) : 337 – 343 .
  • Jiang , Y , Jolly , PE , Ellis , WO , Wang , JS , Phillips , TD and Williams , JH . 2005 . Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians . Int Immunol , 17 : 807 – 814 .
  • Jiang , Y , Jolly , PE , Preko , P , Wang , JS , Ellis , WO , Phillips , TD and Williams , JH . 2008 . Aflatoxin-related immune dysfunction in health and in human immunodeficiency virus disease . Clin Dev Immunol , 2008 : 1 – 12 .
  • Joint FAO/WHO Expert Committee on Food Additives (JECFA). 1998. Aflatoxins. Safety evaluation of certain food additives and contaminants. Food Additives Series No. 40 [Internet]. The International Programme on Chemical Safety. [cited 2009 Jun 9]. Available from: http://www.inchem.org/documents/jecfa/jecmono/v040je16.htm/
  • Jolly , PE , Jiang , Y , Ellis , WO , Wang , JS , Afriyie-Gyawu , E , Phillips , TD and Williams , JH . 2008 . “ Modulation of the human immune system by aflatoxin ” . In Mycotoxins: detection methods, management, public health and agricultural trade , Edited by: Leslie , JF , Bandyopadhyay , R and Visconti , A . 41 – 52 . Wallingford (UK) : CAB International .
  • Krishnan , S , Manavathu , EK and Chandrasekar , PH . 2009 . Aspergillus flavus: an emerging non-fumigatus Aspergillus species of significance . Mycoses , 52 : 206 – 222 .
  • Lewis , L , Onsongo , M , Njapau , H , Schurz-Rogers , H , Luber , G , Kieszak , S , Nyamongo , J , Backer , L , Dahiye , AM Misore , A . 2005 . Aflatoxin contamination of commercial maize products during an outbreak of acute aflatoxicosis in eastern and central Kenya . Environ Hlth Perspect , 113 : 1763 – 1767 .
  • Lubulwa , ASG and Davis , JS . 1994 . “ Estimating the social costs of the impacts of fungi and aflatoxins in maize and peanuts ” . In Stored product protection: Proceedings of the 6th International Working Conference on Stored-product Protection , Edited by: Highley , E , Wright , EJ , Banks , HJ and Champ , BR . 1017 – 1042 . Wallingford (UK) : CAB International .
  • Mabayoje , VO , Oparinde , DP , Akanni , EO , Taiwo , SS , Muhibi , MA and Adebayo , TO . 2007 . Seroprevalence of hepatitis B and C and of human immunodeficiency virus among blood donors in south-west Nigeria . Br J Biomed Sci , 64 ( 4 ) : 177 – 179 .
  • Meenakshi , JV , Johnson , N , Manyong , VM , De Groote , H , Javelosa , J , Yanggen , D , Naher , F , Gonzalez , C , Garcia , J and Meng , E . 2007 . “ How cost-effective is biofortification in combating micronutrient malnutrition? an ex-ante assessment ” . HarvestPlus Working Paper No. 2 Washington (DC) : Harvest Plus .
  • National Research Council (NRC) . 2008 . Science and decisions: advancing risk assessment , Washington (DC) : National Academy Press .
  • Onakewhor , JU , Offor , E and Okonofua , FE . 2001 . Maternal and neonatal seroprevalence of hepatitis B surface antigen (HBsAg) in Benin City, Nigeria . J Obstet Gynaecol , 21 ( 6 ) : 583 – 586 .
  • Pitt , JI and Hocking , AD . 2006 . Mycotoxins in Australia: biocontrol of aflatoxin in groundnuts . Mycopathologia , 162 : 233 – 243 .
  • Qian , GS , Ross , RK , Yu , MC , Yuan , JM , Gao , YT , Henderson , BE , Wogan , GN and Groopman , JD . 1994 . A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China . Cancer Epidemiol Biomarkers Prev , 3 : 3 – 10 .
  • Shephard , GS . 2008 . Risk assessment of aflatoxins in food in Africa . Food Addit Contam A , 25 : 1246 – 1256 .
  • Stein , AJ , Sachdev , HPS and Qaim , M . 2008 . Genetic engineering for the poor: golden rice in public health in India . World Develop , 36 : 144 – 158 .
  • Strosnider , H , Azziz-Baumgartner , E , Banziger , M , Bhat , RV , Breiman , R , Brune , M , DeCock , K , Dilley , A , Groopman , J Hell , K . 2006 . Workgroup report: public health strategies for reducing aflatoxin exposure in developing countries . Environ Hlth Perspect , 114 : 1989 – 1903 .
  • Turner , PC , Moore , SE , Hall , AJ , Prentice , AM and Wild , CP . 2003 . Modification of immune function through exposure to dietary aflatoxin in Gambian children . Environ Hlth Perspect , 111 : 217 – 220 .
  • Turner , PC , Sylla , A , Gong , YY , Diallo , MS , Sutcliffe , AE , Hall , AJ and Wild , CP . 2005 . Reduction in exposure to carcinogenic aflatoxins by post-harvest intervention measures in west Africa: a community-based intervention study . Lancet , 365 ( 9475 ) : 1950 – 1956 .
  • Uneke , CJ , Ogbu , O , Inyama , PU , Anyanwu , GI , Njoku , MO and Idoko , JH . 2005 . Prevalence of hepatitis-B surface antigen among blood donors and human immunodeficiency virus-infected patients in Jos, Nigeria . Mem Inst Oswaldo Cruz , 100 ( 1 ) : 13 – 16 .
  • University of Georgia. 2003. World geography of the peanut: Guinea. Griffin (GA): University of Georgia. Available from: http://www.lanra.uga.edu/peanut/knowledgebase/countries/guinea.cfm/
  • US Central Intelligence Agency (CIA) . 2009 . The world factbook , Washington (DC) : US Central Intelligence Agency .
  • Wild , CP and Hall , AJ . 2000 . Primary prevention to hepatocellular carcinoma in developing countries . Mutat Res , 462 : 381 – 393 .
  • Williams , JH . 2008 . “ Institutional stakeholders in mycotoxin issues–past, present and future ” . In Mycotoxins: detection methods, management, public health and agricultural trade , Edited by: Leslie , JF , Bandyopadhyay , R and Visconti , A . 349 – 58 . Wallingford (UK) : CAB International .
  • Williams , JH , Phillips , TD , Jolly , PE , Stiles , JK , Jolly , CM and Aggarwal , D . 2004 . Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions . Am J Clin Nutr , 80 : 1106 – 1122 .
  • World Health Organization (WHO). 2001. Macroeconomics and health: investing in health for economic development. Report of the WHO Commission on Macroeconomics and Health. Geneva (Switzerland): WHO
  • World Health Organization (WHO). 2008. The global burden of disease: 2004 update. Geneva (Switzerland): WHO
  • Wu , F . 2004 . Mycotoxin risk assessment for the purpose of setting international regulatory standards . Environ Sci Tech , 38 : 4049 – 4055 .
  • Wu , F , Liu , Y and Bhatnagar , D . 2008 . Cost-effectiveness of aflatoxin control methods: economic incentives . Tox Rev , 27 : 203 – 225 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.