Lifetime, low-dose ochratoxin A dietary study on renal carcinogenesis in male Fischer rats

References

• Bendele , AM , Carlton , WW , Krogh , P and Lillehoj , EB . 1985 . Ochratoxin A carcinogenesis in the (C57BL/6J × C3H)F1 mouse . J Natl Cancer Inst , 75 : 733 – 742 .
   Google Scholar
• Boorman , GA . 1989. Toxicology and Carcinogenesis Studies of Ochratoxin A (CAS No. 303-47-9) in F344/N Rats (Gavage Studies). National Toxicology Program. Technical Report 358
   Google Scholar
• Brown , AL , Odell , EW and Mantle , PG . 2007 . DNA ploidy distribution in renal tumours induced in male rats by dietary ochratoxin A . Exp Toxicol Pathol. , 54 : 85 – 95 .
   Google Scholar
• Burtis , CA , Ashwood , ER and Bruns , DE editors . 2005 . Tietz: Fundamentals of clinical chemistry , Philadelphia : WB Saunders .
   Google Scholar
• EFSA 2006. Opinion of the scientific panel on contaminants in the food chain on a request from the Commission related to ochratoxin A in food. EFSA J. 365:1-56. Available from: www.efsa.eu.int
   Google Scholar
• Harris , JP and Mantle , PG . 2001 . Biosynthesis of ochratoxin A by Aspergillus ochraceus . Phytochemistry , 58 : 709 – 716 .
   Google Scholar
• Mantle , PG . 2008 . Interpretation of pharmacodynamics of ochratoxin A in blood plasma of rats, during and after acute or chronic ingestion . Food Chem Toxicol , 46 : 1808 – 1816 .
   Google Scholar
• Mantle , PG . 2009 . Minimum tolerable exposure period and maximum threshold dietary intake of ochratoxin A for causing renal cancer in male Dark Agouti rats . Food Chem Toxicol , 47 : 2419 – 2424 .
   Google Scholar
• Mantle , PG and Nagy , J . 2008 . Binding of ochratoxin A to a urinary globulin: A new concept to account for gender difference in rat nephrocarcinogenic responses . Int J Mol Sci , 9 : 719 – 735 .
   Google Scholar
• Mantle , PG and Nolan , CC . 2010 . Pathological outcomes in kidney and brain in male Fischer rats given dietary ochratoxin A, commencing at one year of age . Toxins , 2 : 1100 – 1110 .
   Google Scholar
• Mantle , P , Kulinskaya , E and Nestler , S . 2005 . Renal tumourigenesis in male rats in response to chronic dietary ochratoxin A . Food Addit Contam , 1 : 58 – 64 .
   Google Scholar
• Mantle , PG , Faucet-Marquis , V , Manderville , RM , Squillaci , B and Pfohl-Leszkowicz , A . 2010a . Structures of covalent adducts between DNA and ochratoxin A: a new factor in debate about genotoxicity and human risk assessment . Chem Res Toxicol , 23 : 89 – 98 .
   Google Scholar
• Mantle , PG , Dobrota , M , Gillett , CE , Odell , EW and Pinder , SE . 2010b . Oncological outcomes in rats given nephrocarcinogenic exposure to dietary ochratoxin A, followed by the tumour promoter sodium barbital for life: a pilot study . Toxins , 2 : 552 – 571 .
   Google Scholar
• Miljkovic , A , Pfohl-Leszkowicz , A , Dobrota , M and Mantle , PG . 2003 . Comparative responses to mode of oral administration and dose of ochratoxin A or nephrotoxic extract of Penicillium polonicum in rats . Exp Toxicol Pathol , 54 : 395 – 412 .
   Google Scholar
• Moloney , WC , Boschetti , AE and King , VP . 1970 . Spontaneous leukemia in Fischer rats . Cancer Res , 30 : 41 – 43 .
   Google Scholar
• NTP 2001. Toxicology and carcinogenesis studies of fumonisin B1 in F344/N rats and B6C3F1 mice (feed studies). NTP Technical Report 496, p. 112. Available from: http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr496.pdf
   Google Scholar
• Pinto , AE , Monteiro , P , Silva , G , Ayres , JV and Soares , J . 2005 . Prognostic biomarkers in renal cell carcinoma: relevance of DNA ploidy in predicting disease-related survival . Int J Biol Markers , 20 : 249 – 256 .
   Google Scholar
• Stephens , PJ , McBride , DJ , Lin , ML , Varela , I , Pleasance , ED , Simpson , JT , Stebbings , LA , Leroy , C , Edkins , S Mudie , LJ . 2009 . Complex landscapes of somatic rearrangement in human breast cancer genomes . Nature , 462 : 1005 – 1010 .
   Google Scholar
• Van der Merwe , KJ , Steyn , PS , Fourie , L , Scott , DB and Theron , JJ . 1965 . Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh . Nature , 205 : 1112 – 1113 .
   Google Scholar
• Vettorazzi , A , Gonzalez-Penas , E , Troconiz , IF , Arbillaga , L , Corcuera , LA , Gil , AG and de Cerain Lopez , A . 2009 . A different kinetic profile of ochratoxin A in mature male rats . Food Chem Toxicol , 47 : 1921 – 1927 .
   Google Scholar
• Vettorazzi , A , Troconiz , IF , Gonzalez-Penas , E , Corcuera , LA , Arbillaga , L , Gil , AG , Nagy , JM , Mantle , PG and Lopez de Cerain , A . 2010. Effects of fasting and gender on ochratoxin A toxicokinetics in F344 rats. Food Chem Toxicol., in press
   Google Scholar
• Waddell , WJ . 2006 . Critique of dose response in carcinogenesis . Hum Exp Toxicol , 25 : 413 – 436 .
   Google Scholar