Advanced search
Publication Cover
Food Additives & Contaminants: Part A Volume 28, 2011 - Issue 2
Submit an article Journal homepage
191
Views
21
CrossRef citations to date
0
Altmetric
Original Articles

Ultra-high performance liquid chromatography coupled to triple quadrupole mass spectrometry detection of naturally occurring thiouracil in urine of untreated livestock, domesticated animals and humans

J. Vanden Bussche Ghent University, Faculty of Veterinary Medicine, Research Group of Veterinary Public Health and Zoonoses, Laboratory of Chemical Analysis, Salisburylaan 133, B-9820 Merelbeke, BelgiumCorrespondence[email protected]
,
L. Vanhaecke Ghent University, Faculty of Veterinary Medicine, Research Group of Veterinary Public Health and Zoonoses, Laboratory of Chemical Analysis, Salisburylaan 133, B-9820 Merelbeke, Belgium
,
Y. Deceuninck ONIRIS, USC 2013, LABERCA Atlanpole-La Chantrerie, F-44307, Nantes, France
,
K. Wille Ghent University, Faculty of Veterinary Medicine, Research Group of Veterinary Public Health and Zoonoses, Laboratory of Chemical Analysis, Salisburylaan 133, B-9820 Merelbeke, Belgium
,
K. Bekaert Ghent University, Faculty of Veterinary Medicine, Research Group of Veterinary Public Health and Zoonoses, Laboratory of Chemical Analysis, Salisburylaan 133, B-9820 Merelbeke, Belgium
,
B. Le Bizec ONIRIS, USC 2013, LABERCA Atlanpole-La Chantrerie, F-44307, Nantes, France
&
H.F. De Brabander Ghent University, Faculty of Veterinary Medicine, Research Group of Veterinary Public Health and Zoonoses, Laboratory of Chemical Analysis, Salisburylaan 133, B-9820 Merelbeke, Belgium
 show all
Pages 166-172 | Received 22 Sep 2010, Accepted 25 Nov 2010, Published online: 24 Jan 2011

References

  • Courtheyn , D , Le Bizec , B , Brambilla , G , De Brabander , HF , Cobbaert , E , de Wiele , AV , Vercammen , J and De Wasch , K . 2002 . Recent developments in the use and abuse of growth promoters . Anal Chim Acta , 473 : 71 – 82 .
  • De Brabander HF. 1984. Bepalingsmethoden voor thyreostatica in biologisch materiaal [thesis]. [Ghent]: Ghent University.
  • Derblom , H , Johansson , H and Nylander , G . 1963 . Thyroid hormone activity and gastrointestinal function, an experimental study in the rat . Acta Chir Scand , 10 : 1 – 5 .
  • European Community . 1981 . Council Directive 81/602/EC . Off J Eur Comm. L , 222 : 32 – 33 .
  • European Community . 2002 . Council Decision (2002)/657/EC . Off J Eur Comm. L , 221 : 8 – 36 .
  • European Union of Reference Laboratory (EURL) 2007. EURL guidance document: EURL's view on state of the art analytical methods for national residue control plans. Available from: http://www.rivm.nl/bibliotheek/digitaaldepot/crlguidance2007.pdf/
  • Getahun , SM and Chung , FL . 1999 . Conversion of glucosinolates to isothiocyanates in humans after ingestion of cooked watercress . Cancer Epidemiol Biomarkers Prev , 8 : 447 – 451 .
  • Heeremans , A , Ermens , L , De Wasch , KK , Van Peteghem , C and De Brabander , HF . 1998 . Elimination profile of methylthiouracil in cows after oral administration . Analyst , 123 : 2629 – 2632 .
  • International Agency for Research on Cancer (IARC). 2010. IARC monographs on the evaluation of carcinogenic risks to humans. Last updated August 2010. Available from: http://monographs.iarc.fr/ENG/Classification/index.php/
  • Kotter , L , Terplan , G and Schulz , J . 1959 . Biological demonstration of inhibitors in foodstuff of animal origin . Arch Lebensmittelhyg , 10 : 145 – 152 .
  • Lõhmus , M , Kallaste , K and Le Bizec , B . 2009 . Determination of thyreostats in urine and thyroid gland by ultra high performance liquid chromatography tandem mass spectrometry . J Chromatogr A , 1216 : 8080 – 8089 .
  • Mackenzie , CG and Mackenzie , JB . 1943 . Effect of sulfonamides and thioureas on the thyroid gland and basal metabolism . Endocrinology , 32 : 185 – 193 .
  • Pinel , G , Bichon , E , Pouponneau , K , Maume , D , Andre , F and Le Bizec , B . 2005 . Multi-residue method for the determination of thyreostats in urine samples using liquid chromatography coupled to tandem mass spectrometry after derivatisation with 3-iodobenzylbromide . J Chromatogr A , 1085 : 247 – 252 .
  • Pinel , G , Mathieu , S , Cesbron , N , Maume , D , De Brabander , HF , Andre , F and Le Bizec , B . 2006 . Evidence that urinary excretion of thiouracil in adult bovine submitted to a cruciferous diet can give erroneous indications of the possible illegal use of thyreostats in meat production . Food Addit Contam A , 23 : 974 – 980 .
  • Ross , MM , Sterk , SS , Verhagen , H , Stalenhoef , AFH and De Jong , N . 2007 . Phytosterol consumption and the anabolic steroid boldenone in humans: a hypothesis piloted . Food Addit Contam A , 24 : 679 – 684 .
  • Rouzaud , G , Young , SA and Duncan , AJ . 2004 . Hydrolysis of glucosinolates to isothiocyanates after ingestion of raw or microwaved cabbage by human volunteers . Cancer Epidemiol Biomarkers Prev , 13 : 125 – 131 .
  • Vanden Bussche , J , Noppe , H , Verheyden , K , Wille , K , Pinel , G , Le Bizec , B and De Brabander , HF . 2009 . Analysis of thyreostats: a history of 35 years . Anal Chim Acta , 637 : 2 – 12 .
  • Vanden Bussche , J , Vanhaecke , L , Deceuninck , Y , Verheyden , K , Wille , K , Bekaert , K , Le Bizec , B and De Brabander , HF . 2010 . Development and validation of an ultra-high-performance liquid chromatography tandem mass spectrometry method for quantifying thyreostats in urine without derivatisation . J Chromatogr A , 1217 : 4285 – 4293 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.