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Original Articles

A novel approach to simultaneous screening and confirmation of regulated pharmaceutical compounds in dietary supplements by LC/MS/MS with an information-dependent acquisition method

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Pages 396-407 | Received 25 Oct 2010, Accepted 02 Jan 2011, Published online: 16 Mar 2011

References

  • Aroma , IO . 2006 . The impact of food regulation on the food supply chain . Toxicology , 221 : 119 – 127 .
  • Azucena , G and Tiaziana , M . 2008 . The demand for organic foods in the South of Italy: A discrete choice model . Food Policy , 33 ( 5 ) : 386 – 396 .
  • Barreira , MJ , Alvito , PC and Almeida , CMM . 2010 . Occurrence of Patulin in apple-based-foods in Portugal . Food Chem , 121 : 653 – 658 .
  • Choi , D . 2008 . Structure elucidation and determination of illegal compounds (Anti-impotence drug analogues) in foods . Anal Sci Technol , 21 : 65 – 83 .
  • Choi , D , Im , M , Lee , K , Kwon , K , Jeong , J , Park , G , Hong , M and Lee , C . 2004 . Determining anti-impotence drug-like compounds in food . Anal Sci Technol , 17 : 520 – 526 .
  • Cox , DM , Zhong , F , Du , M , Duchoslav , E , Sakuma , T and McDermott , JC . 2005 . Multiple Reaction Monitoring as a Method for Identifying Protein Posttranslational Modifications . J Biomol Tech , 16 ( 2 ) : 83 – 90 .
  • Deepananda , H , John , C and Spencer , H . 2008 . Who consumes functional foods and nutraceuticals in Canada?: Results of cluster analysis of the (2006) survey of Canadian's Demand for Food Products Supporting Health and Wellness . Appetite , 51 ( 2 ) : 256 – 265 .
  • Dresen , S , Gergov , M , Politi , L and Weinmann , W . 2006 . Inter-instrument comparison an ESI-MS/MS library of drugs for targeted and general-unknown analysis . International mass spectrometry conference . 2006 , Prague, Czech Republic.
  • Gratz , SR , Flurer , CL and Wolnik , KA . 2004 . Analysis of undeclared synthetic phosphodiesterase-5 inhibitors in DSs and herbal matrices by LC–ESI–MS and LC–UV . J Pharm Biomed Anal , 36 : 525 – 533 .
  • Gratz , SR , Zeller , M , Mincey , DW and Flurer , CL . 2009 . Structural characterization of sulfoaildenafil, an analog of sildenafil . J Pharm Biomed Anal , 50 : 228 – 231 .
  • Hernando , MD , Suarez-Barcena , JM , Bueno , MJM , Garcia-Reyes , JF and Ferenandez-Alba , AR . 2007 . Fast separation liquid chromatography-tandem mass spectrometry for the confirmation and quantitative analysis of avermectin residues in food . J Chromatogr A , 1155 : 62 – 73 .
  • Huang , B , Han , Z , Cai , Z , Wu , Y and Ren , Y . 2010 . Simultaneous determination of aflatoxins B1, B2, G1, G2, M1 and M2 in peanuts and their derivative products by ultra-high-performance liquid chromatography–tandem mass spectrometry . Anal Chim Acta , 662 : 62 – 68 .
  • Kim , D-K , Ryu , DH , Lee , N , Lee , JY , Kim , J-S , Lee , S , Choi , J-Y , Ryu , J-H , Kim , N-H Im , G-J . 2001 . Synthesis and phosphodiesterase 5 inhibitory activity of new 5-phenyl-1,6-dihydro-7H-pyrazolo(4,3-d)pyrimidin-7-one derivatives containing an N-acylamido group on a phenyl ring . Bioorg Med Chem , 9 : 1895 – 1899 .
  • Klaus , M . 2001 . Market and marketing of functional food in Europe . J Food Eng , 56 : 181 – 188 .
  • Lam , Y-H , Poon , W-T , Lai , C-K , Chan , AY-W and Mak , TW-L . 2008 . Identification of a novel vardenafil analogue in herbal product . J Pharm Biomed Anal , 46 : 804 – 807 .
  • Lee , H-M , Kim , CS , Jang , YM , Kwon , SW and Lee , B-J . 2011 . Separation and structural elucidation of a novel analogue of vardenafil included as an adulterant in a dietary supplement by liquid chromatography–electrospray ionization mass spectrometry, infrared spectroscopy and nuclear magnetic resonance spectroscopy . J Pharm Biomed Anal , 54 : 491 – 496 .
  • Orsi , DD , Pellegrini , M , Marchei , E , Nebuloni , P , Gallinella , B , Scaravelli , G , Martufi , A , Gagliardi , L and Pichini , S . 2009 . High performance liquid chromatography–diode array and electrospray–mass spectrometry analysis of vardenafil, sildenafil, tadalafil, testosterone and local anesthetics in cosmetic creams sold on the Internet web sites . J Pharm Biomed Anal , 50 ( 3 ) : 362 – 369 .
  • Politi , L , Morini , L and Polettini , A . 2007 . A direct screening procedure for diuretics in human urine by liquid chromatography–tandem mass spectrometry with information dependent acquisition . Clin Chim Acta , 386 : 46 – 52 .
  • Qiao , J-P , Abliz , Z , Chu , F-M , Hou , P-L , Liang , F , Chang , Y and Guo , Z-R . 2004 . Application of a novel quadrupole linear ion trap mass spectrometer to study the metabolism of 6-aminobutylphthalide in rat brains . Rapid Commun Mass Spectrom , 18 : 3142 – 3147 .
  • Ramakrishna , NVS , Vishwottam , KN , Puran , S , Koteshwara , M , Manoj , S and Santosh , M . 2004 . Quantitation of tadalafil in human plasma by liquid chromatography–tandem mass spectrometry with electrospray ionization . J Chromatogr B , 809 ( 2 ) : 243 – 249 .
  • Scholz , K , Dekant , W , Volkel , W and Pahler , A . 2005 . Rapid detection and identification of N-acetyk-L-cysteine thioethers using constant neutral loss and theoretical multiple reaction monitoring combined with enhanced product-ion scans on a linear ion trap mass . J Am Soc Mass Spectrom , 16 : 1976 – 1984 .
  • Singh , S , Prasad , B , Savaliya , AA , Shah , RP , Gohil , VM and Kaur , A . 2009 . Strategies for characterizing sildenafil, vardenafil, tadalafil and their analogues in herbal DSs, and detecting these drugs . Trends Anal Chem , 28 : 13 – 28 .
  • Wang , J , Jiang , Y , Wang , Y , Zhao , X , Cui , Y and Gu , J . 2007 . Liquid chromatography tandem mass spectrometry assay to determine the pharmacokinetics of aildenafil in human plasma . J Pharm Biomed Anal , 44 : 231 – 235 .
  • Zhu , X , Xiao , S , Chen , B , Zhang , F , Yao , S , Wan , Z , Yang , D and Han , H . 2005 . Simultaneous determination of sildenafil, vardenafil and tadalafil as forbidden components in natural DSs for male sexual potency by high-performance liquid chromatography–electrospray ionization mass spectrometry . J Chromatogr A , 1066 : 89 – 95 .
  • Zou , P , Oh , SS , Hou , P , Low , MY and Koh , HL . 2006 . Simultaneous determination of synthetic phosphodiesterase-5 inhibitors found in a dietary supplement and pre-mixed bulk powders for DSs using high-performance liquid chromatography with diode array detection and liquid chromatography–electrospray ionization tandem mass spectrometry . J Chromatogr A , 1104 : 113 – 122 .

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