614
Views
20
CrossRef citations to date
0
Altmetric
Original Articles

Development and in-house validation of an LC-MS/MS method for the quantification of the mycotoxins deoxynivalenol, zearalenone, T-2 and HT-2 toxin, ochratoxin A and fumonisin B1 and B2 in vegetable animal feed

, &
Pages 541-549 | Received 11 Sep 2012, Accepted 12 Dec 2012, Published online: 25 Jan 2013

References

  • Bennett , JW and Klich , M . 2003 . Mycotoxins . Clin Microbiol Rev , 16 : 497 – 516 .
  • Binder , EM . 2007 . Managing the risk of mycotoxins in modern feed production . Anim Feed Sci Technol , 133 : 149 – 166 .
  • Burns , DT , Danzer , K and Townshend , A . 2002 . Use of the term “recovery” and “apparent recovery” in analytical procedures (IUPAC Recommendations 2002) . Pure Appl Chem , 74 : 2201 – 2205 .
  • European , Commission . 2002 . Commission Decision 2002/657/EC of 12 August 2002 Implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results . Off J Eur Comm , L221 : 8 – 36 .
  • European , Commission . 2006a . 401/2006. Commission Regulation 401/2006 of 23 February 2006 laying down the methods of sampling and analysis for the official control of the levels of mycotoxins in foodstuffs . Off J Eur Comm , L70 : 12 – 34 .
  • European , Commission . 576/2006. 2006b. Commission Recommendation 2006/576/EC of 17 August 2006 on the presence of deoxynivalenol, zearalenone, ochratoxin A, T-2 and HT-2 and fumonisins in products intended for animal feeding . Off J Eur Comm , L229 7 – 9 .
  • European , Commission . 2006c . 1881/2006. Commission Regulation 1881/2006 EC of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs . Off J Eur Comm , L364 : 5 – 24 .
  • Hussein , HS and Brasel , JM . 2001 . Toxicity, metabolism, and impact of mycotoxins on humans and animals . Toxicology , 167 : 101 – 134 .
  • Kubena , LF , Harvey , RB , Huff , WE , Corrier , DE , Phillips , TD and Rottinghaus , GE . 1989 . Influence of ochratoxin A and T-2 toxin singly and in combination on broiler chickens . Poult Sci , 68 : 867 – 872 .
  • Kubena , LF , Huff , WE , Harvey , RB , Phillips , TD and Rottinghaus , GE . 1989 . Individual and combined toxicity of deoxynivalenol and T-2 toxin in broiler chicks . Poult Sci , 68 : 622 – 626 .
  • Lattanzio , VM , Gatta , SD , Suman , M and Visconti , A . 2011 . Development and in-house validation of a robust and sensitive solid-phase extraction liquid chromatography/tandem mass spectrometry method for the quantitative determination of aflatoxins B1, B2, G1, G2, ochratoxin A, deoxynivalenol, zearalenone, T-2 and HT-2 toxins in cereal-based foods . Rapid Commun Mass Spectrom , 25 : 1869 – 1880 .
  • Lattanzio , VM , Solfrizzo , M , Powers , S and Visconti , A . 2007 . Simultaneous determination of aflatoxins, ochratoxin A and fusarium toxins in maize by liquid chromatography/tandem mass spectrometry after multitoxin immunoaffinity cleanup . Rapid Commun Mass Spectrom , 21 : 3253 – 3261 .
  • Mol , HGJ , Plaza-Bolaños , P , Zomer , P , de Rijk , TC , Stolker , AAM and Mulder , PPJ . 2008 . Toward a generic extraction method for simultaneous determination of pesticides, mycotoxins, plant toxins, and veterinary drugs in feed and food matrixes . Anal Chem , 80 : 9450 – 9459 .
  • Monbaliu , S , Van Poucke , C , Detavernier , C , Dumoulin , F , Van De Velde , M , Schoeters , E , Van Dyck , S , Averkieva , O , Van Peteghem , C and De Saeger , S . 2010 . Occurrence of mycotoxins in feed as analyzed by a multi-mycotoxin LC-MS/MS . J Agric Food Chem , 58 : 66 – 71 .
  • Monbaliu , S , Van Poucke , C , Van Peteghem , C , Van Poucke , K , Heungens , K and De Saeger , S . 2009 . Development of a multi-mycotoxin liquid chromatography/tandem mass spectrometry method for sweet pepper analysis . Rapid Commun Mass Spectrom , 23 : 3 – 11 .
  • Nilsson A, Stensiö K-E, Lundgren B. 2000. Validering av kemiska analysmetoder [Validation of chemical analytical methods]. SWEDAC DOC 00:32, ISSN 1400-6138. [cited 2013 Jan 14]; 1–29. http://www.swedac.se/sv/Dokument/foreskrifter-och-dokument (http://www.swedac.se/sv/Dokument/foreskrifter-och-dokument)
  • Plattner , RD . 1999 . HPLC/MS analysis of fusarium mycotoxins, fumonisins and deoxynivalenol . Nat Toxins , 7 : 365 – 370 .
  • Rasmussen , RR , Storm , IM , Rasmussen , PH , Smedsgaard , J and Nielsen , KF . 2010 . Multi-mycotoxin analysis of maize silage by LC-MS/MS . Anal Bioanal Chem , 397 : 765 – 776 .
  • Razzazi-Fazeli , E , Rabus , B , Cecon , B and Böhm , J . 2002 . Simultaneous quantification of A-trichothecene mycotoxins in grains using liquid chromatography–atmospheric pressure chemical ionisation mass spectrometry . J Chromatogr A , 968 : 129 – 142 .
  • Ren , Y , Zhang , Y , Shao , S , Cai , Z , Feng , L , Pan , H and Wang , Z . 2007 . Simultaneous determination of multi-component mycotoxin contaminants in foods and feeds by ultra-performance liquid chromatography tandem mass spectrometry . J Chromatogr A , 1143 : 48 – 64 .
  • Spanjer , MC , Rensen , PM and Scholten , JM . 2008 . LC–MS/MS multi-method for mycotoxins after single extraction, with validation data for peanut, pistachio, wheat, maize, cornflakes, raisins and figs . Food Addit Contam Part A Chem Anal Control Expo Risk Assess , 25 : 472 – 489 .
  • Speijers , GJA and Speijers , MHM . 2004 . Combined toxic effects of mycotoxins . Toxicol Lett , 153 : 91 – 98 .
  • Sørensen , LK and Elbæk , TH . 2005 . Determination of mycotoxins in bovine milk by liquid chromatography tandem mass spectrometry . J Chromatogr B , 820 : 183 – 196 .
  • Sulyok , M , Berthiller , F , Krska , R and Schuhmacher , R . 2006 . Development and validation of a liquid chromatography/tandem mass spectrometric method for the determination of 39 mycotoxins in wheat and maize . Rapid Commun Mass Spectrom , 20 : 2649 – 2659 .
  • van Bennekom , EO , Brouwer , L , Laurant , EHM , Hooijerink , H and Nielen , MWF . 2002 . Confirmatory analysis method for zeranol, its metabolites and related mycotoxins in urine by liquid chromatography-negative ion electrospray tandem mass spectrometry . Anal Chim Acta , 473 : 151 – 160 .
  • Varga , E , Glauner , T , Koppen , R , Mayer , K , Sulyok , M , Schuhmacher , R , Krska , R and Berthiller , F . 2012 . Stable isotope dilution assay for the accurate determination of mycotoxins in maize by UHPLC-MS/MS . Anal Bioanal Chem , 402 : 2675 – 2686 .
  • Völkel , I , Schröer-Merker , E and Czerny , C-P . 2011 . The carry-over of mycotoxins in products of animal origin with special regard to its implications for the European Food Safety Legislation . Food Nutr Sci , 2 : 852 – 867 .
  • Zöllner , P and Mayer-Helm , B . 2006 . Trace mycotoxin analysis in complex biological and food matrices by liquid chromatography–atmospheric pressure ionisation mass spectrometry . J Chromatogr A , 1136 : 123 – 169 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.