Set-up of a multivariate approach based on serum biomarkers as an alternative strategy for the screening evaluation of the potential abuse of growth promoters in veal calves

References

• Biolatti B, Bollo E, Cannizzo FT, Zancanaro G, Tarantola M, Dacasto M, Cantiello M, Carletti M, Biolatti PG, Barbarino G. 2005. Effects of low-dose dexamethasone on thymus morphology and immunological parameters in veal calves. J Vet Med A Physiol Pathol Clin Med. 52:202–208.
   PubMedGoogle Scholar
• Brambilla G, Ballerini A, Civitareale C, Fiori M, Neri B, Cavallina R, Nardoni A, Giannetti L. 2003. Oxidative stress as a bio-marker of estrogen exposure in healthy veal calves. Anal Chim Acta. 483:281–288.
   Web of Science ®Google Scholar
• Cacciatore G, Eisenberg SWF, Situ C, Mooney MH, Delahaut P, Klarenbeek S, Huet AC, Bergwerff AA, Elliott CT. 2009. Effect of growth-promoting 17β-estradiol, 19-nortestosterone and dexamethasone on circulating levels of nine potential biomarker candidates in veal calves. Anal Chim Acta. 637:351–359.
   PubMed Web of Science ®Google Scholar
• Cannizzo FT, Capra P, Divari S, Ciccotelli V, Biolatti B, Vincenti M. 2011. Effects of low-dose dexamethasone and prednisolone long term administration in beef calf: chemical and morphological investigation. Anal Chim Acta. 700:95–104.
   PubMed Web of Science ®Google Scholar
• Cannizzo FT, Miniscalco B, Riondato F, Bollo E, Barbarino G, Giorgi P, Mazzini C, Biolatti B. 2008. Effects of anabolic and therapeutic doses of dexamethasone on thymus morphology and apoptosis in veal calves. Vet Rec. 163:448–452.
   PubMed Web of Science ®Google Scholar
• Cannizzo FT, Pegolo S, Cucuzza LS, Bargelloni L, Divari S, Franch R, Castagnaro M, Biolatti B. 2013. Gene expression profiling of thymus in beef cattle treated with prednisolone. Res Vet Sci. 95:540–547.
   PubMed Web of Science ®Google Scholar
• Cannizzo FT, Zancanaro G, Spada F, Mulasso C, Biolatti B. 2007. Pathology of the testicle and sex accessory glands following the administration of boldenone and boldione as growth promoters in veal calves. J Vet Med Sci. 69:1109–1116.
   PubMed Web of Science ®Google Scholar
• Carletti M, Cantiello M, Giantin M, Nebbia C, Cannizzo FT, Bollo E, Dacasto M. 2007. Serum antioxidant enzyme activities and oxidative stress parameters as possible biomarkers of exposure in veal calves illegally treated with dexamethasone. Toxicol In Vitro. 21:277–283.
   PubMed Web of Science ®Google Scholar
• Carraro L, Ferraresso S, Cardazzo B, Romualdi C, Montesissa C, Gottardo F, Patarnello T, Castagnaro M, Bargelloni L. 2009. Expression profiling of skeletal muscle in young bulls treated with steroidal growth promoters. Physiol Genomics. 38:138–148.
   PubMed Web of Science ®Google Scholar
• Courtheyn D, Le Bizec B, Brambilla G, De Brabander HF, Cobbaert E, De Wiele AV, Vercammen J, De Wasch K. 2002. Recent developments in the use and abuse of growth promoters. Anal Chim Acta. 473:71–82.
   Web of Science ®Google Scholar
• Cunningham RT, Mooney MH, Xia X-L, Crooks S, Matthews D, O’Keeffe M, Li K, Elliott CT. 2009. Feasibility of a clinical chemical analysis approach to predict misuse of growth promoting hormones in cattle. Anal Chem. 81:977–983.
   PubMed Web of Science ®Google Scholar
• De Maesschalck R, Jouan-Rimbaud D, Massart DL. 2000. The Mahalanobis distance. Chemometr Intell Lab Syst. 50:1–18.
   Web of Science ®Google Scholar
• Derde MP, Massart DL. 1986. UNEQ – A class modeling supervised pattern-recognition technique. Mikrochim Acta. 2:139–152.
   Google Scholar
• Divari S, Mulasso C, Uslenghi F, Cannizzo FT, Spada F, De Maria R, Brina N, Biolatti B. 2011. Progesterone receptor up-regulation: a diagnostic tool for the illicit use of oestrogens in adult beef cattle. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 28:1677–1686.
   PubMed Web of Science ®Google Scholar
• Draisci R, Montesissa C, Santamaria B, D’Ambrosio C, Ferretti G, Merlanti R, Ferranti C, De Liguoro M, Cartoni C, Pistarino E, et al. 2007. Integrated analytical approach in veal calves administered the anabolic androgenic steroids boldenone and boldione: urine and plasma kinetic profile and changes in plasma protein expression. Proteomics. 7:3184–3193.
   PubMed Web of Science ®Google Scholar
• Duffour CC, Grandmontagne C. 1990. Evolution of prostate histological pictures after use of new molecules in calf breeding. Rev Med Vet. 141:187–194.
   Google Scholar
• EFSA. 2013. Scientific Opinion on the public health hazards to be covered by inspection of meat (bovine animals). EFSA J. 11:261.
   Google Scholar
• Ferranti C, Famele M, Palleschi L, Bozzetta E, Pezzolato M, Draisci R. 2013. Excretion profile of corticosteroids in bovine urine compared with tissue residues after therapeutic and growth-promoting administration of dexamethasone. Steroids. 78:803–812.
   PubMed Web of Science ®Google Scholar
• Forina M, Lanteri S, Sarabia L. 1995. Distance and class space in the uneq class-modeling technique. J Chemom. 9:69–89.
   Web of Science ®Google Scholar
• Forina M, Oliveri P, Lanteri S, Casale M. 2008. Class-modeling techniques, classic and new, for old and new problems. Chemometr Intell Lab Syst. 93:132–148.
   Web of Science ®Google Scholar
• Gardini G, Del Boccio P, Colombatto S, Testore G, Corpillo D, Di Ilio C, Urbani A, Nebbia C. 2006. Proteomic investigation in the detection of the illicit treatment of calves with growth-promoting agents. Proteomics. 6:2813–2822.
   PubMed Web of Science ®Google Scholar
• Godfrey RW, Lunstra DD, Schanbacher BD. 1992. Effect of implanting bull calves with testosterone propionate, dihydrotestosterone propionate or oestradiol-17  prepubertally on the pituitary-testicular axis and on postpubertal social and sexual behaviour. J Reprod Fertil. 94:57–69.
   PubMedGoogle Scholar
• Groot MJ, Biolatti B. 2004. Histopathological effects of boldenone in cattle. J Vet Med A Physiol Pathol Clin Med. 51:58–63.
   PubMedGoogle Scholar
• Groot MJ, Denhartog JMP, Arts CJM, Ossenkoppele JS, Gruys E. 1990. Histological-changes in the prostate of veal calves after the administration of natural hormones. Arch Lebensmittelhyg. 41:37–42.
   Web of Science ®Google Scholar
• Groot MJ, Schilt R, Ossenkoppele JS, Berende PLM, Haasnoot W. 1998. Combinations of growth promoters in veal calves: consequences for screening and confirmation methods. J Vet Med A Physiol Pathol Clin Med. 45:425–440.
   Google Scholar
• Hotelling H. 1947. Multivariate quality control. In: Eisenhart C., Mw H., Wa W., editors. Techniques of statistical analysis. New York (NY): McGraw-Hill; p. 111–184.
   Google Scholar
• Imbimbo P, Castigliego L, Armani A, Biolatti B, Cannizzo FT, Gianfaldoni D, Guidi A. 2012. A histologic study on growth promoter target organs of slaughtered beef in Molise region (Italy). J Vet Med Sci. 74:1253–1259.
   PubMed Web of Science ®Google Scholar
• Lee AJ, Hodges S, Eastell R. 2000. Measurement of osteocalcin. Ann Clin Biochem. 37:432–446.
   PubMed Web of Science ®Google Scholar
• Marini F. 2013. Chemometrics in food chemistry. In: Marini F., editor. Data handling in science and technology. Cambridge (UK): Elsevier; p. 1–512.
   Google Scholar
• Marini F, Bucci R, Magrì AL, Magrì AD. 2006. Authentication of Italian CDO wines by class-modeling techniques. Chemometr Intell Lab Syst. 84:164–171.
   Web of Science ®Google Scholar
• Marini F, Magrì AL, Bucci R, Balestrieri F, Marini D. 2006. Class-modeling techniques in the authentication of Italian oils from Sicily with a Protected Denomination of Origin (PDO). Chemometr Intell Lab Syst. 80:140–149.
   Web of Science ®Google Scholar
• Matsuo A, Togashi A, Sasaki K, Devkota B, Hirata T-I, Yamagishi N. 2014. Diurnal Variation of Plasma Bone Markers in Japanese Black Calves. J Vet Med Sci. 76:1029–1032.
   PubMed Web of Science ®Google Scholar
• Matsuzaki S, Uenoyama Y, Okuda K, Watanabe G, Kitamura N, Taya K, Cruzana MBC, Yamada J. 2001. Prepubertal changes in immunoreactive inhibin concentration in blood serum and testicular tissue in Holstein bull calves. J Vet Med Sci. 63:1303–1307.
   PubMed Web of Science ®Google Scholar
• Mooney MH, Le Bizec B, Elliott CT. 2009. Combining biomarker screening and mass-spectrometric analysis to detect hormone abuse in cattle. Trends Analyt Chem. 28:665–675.
   Web of Science ®Google Scholar
• Mooney MH, Situ C, Cacciatore G, Hutchinson T, Elliott C, Bergwerff AA. 2008. Plasma biomarker profiling in the detection of growth promoter use in calves. Biomarkers. 13:246–256.
   PubMed Web of Science ®Google Scholar
• Mosher RA, Wang C, Allen PS, Coetzee JF. 2013. Comparative effects of castration and dehorning in series or concurrent castration and dehorning procedures on stress responses and production in Holstein calves. J Anim Sci. 91:4133–4145.
   PubMed Web of Science ®Google Scholar
• Nebbia C, Cantiello M, Giuliano Albo A, Gusson F, Dacasto M, Bellino C, Gardini G. 2003. Serum antioxidant status and oxidative stress parameters as biomarkers for illicit treatments with growth promoting agents in veal calves. J Vet Pharmacol Ther. 26:1.
   Google Scholar
• Nebbia C, Urbani A, Carletti M, Gardini G, Balbo A, Bertarelli D, Girolami F. 2011. Novel strategies for tracing the exposure of meat cattle to illegal growth-promoters. Vet J. 189:34–42.
   PubMed Web of Science ®Google Scholar
• Neve A, Corrado A, Cantatore FP. 2013. Osteocalcin: Skeletal and extra-skeletal effects. J Cell Physiol. 228:1149–1153.
   PubMed Web of Science ®Google Scholar
• O’Brien CA, Jia D, Plotkin LI, Bellido T, Powers CC, Stewart SA, Manolagas SC, Weinstein RS. 2004. Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. Endocrinology. 145:1835–1841.
   PubMed Web of Science ®Google Scholar
• Oliveri P, Casolino MC, Forina M. 2010. Chemometric brains for artificial tongues. Adv Food Nutr Res. 61:57–117.
   PubMedGoogle Scholar
• Oliveri P, Downey G. 2012. Multivariate class modeling for the verification of food-authenticity claims. Trends Analyt Chem. 35:74–86.
   Web of Science ®Google Scholar
• Pezzolato M, Richelmi GB, Maurella C, Pitardi D, Varello K, Caramelli M, Bozzetta E. 2013. Histopathology as a simple and reliable method to detect 17β-oestradiol illegal treatment in male calves. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 30:1096–1099.
   PubMed Web of Science ®Google Scholar
• Pirro V, Oliveri P, Sciutteri B, Salvo R, Salomone A, Lanteri S, Vincenti M. 2013. Multivariate strategies for screening evaluation of harmful drinking. Bioanalysis. 5:687–699.
   PubMed Web of Science ®Google Scholar
• PNR. 2013. [Internet]. [cited 2014 Aug 11]. Available from: http://www.regione.calabria.it/sanita/allegati/dpgr_2013/dpgr_2013/all._dpgr_n._5_-_pnr_2013.pdf.
   Google Scholar
• Pottgiesser T, Schumacher YO. 2013. Current strategies of blood doping detection. Anal Bioanal Chem. 405:9625–9639.
   PubMed Web of Science ®Google Scholar
• Preston RL, Bartle SJ, Kasser TR, Day JW, Veenhuizen JJ, Baile CA. 1995. Comparative effectiveness of somatotropin and anabolic-steroids in feedlot steers. J Anim Sci. 73:1038–1047.
   PubMed Web of Science ®Google Scholar
• Regione Piemonte. 2009. [Internet]. [cited 2014 September 16] Available from: http://www.regione.piemonte.it/sanita/cms2/documentazione/category/97-2010?download=978:area-c-piano-regionale-di-controllo-dei-residui-indesiderati-nelle-carni-e-negli-animali-allevati-pdf-180.49-kb
   Google Scholar
• Scarth J, Akre C, Van Ginkel L, Le Bizec B, De Brabander H, Korth W, Points J, Teale P, Kay J. 2009. Presence and metabolism of endogenous androgenic-anabolic steroid hormones in meat-producing animals: a review. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 26:640–671.
   PubMed Web of Science ®Google Scholar
• Schilt R, Groot MJ, Berende PLM, Ramazza V, Ossenkoppele JS, Haasnoot W, Van Bennekom EO, Brouwer L, Hooijerink H. 1998. Pour on application of growth promoters in veal calves: analytical and histological results. Analyst. 123:2665–2670.
   PubMed Web of Science ®Google Scholar
• Seasholtz MB, Kowalski B. 1993. The parsimony principle applied to multivariate calibration. Anal Chim Acta. 277:165–177.
   Web of Science ®Google Scholar
• Stephany RW. 2010. Hormonal growth promoting agents in food producing animals. Handb Exp Pharmacol. 2010:355–367.
   Google Scholar
• Suresh PS, Rajan T, Tsutsumi R. 2011. New targets for old hormones: inhibins clinical role revisited [Review]. Endocr J. 58:223–235.
   PubMed Web of Science ®Google Scholar
• Vascellari M, Capello K, Stefani A, Biancotto G, Moro L, Stella R, Pozza G, Mutinelli F. 2012. Evaluation of thymus morphology and serum cortisol concentration as indirect biomarkers to detect low-dose dexamethasone illegal treatment in beef cattle. BMC Vet Res. 8:129.
   PubMed Web of Science ®Google Scholar
• Vascellari M, Pozza G, Poppi L, Capello K, Angeletti R, Ravarotto L, Andrighetto I, Mutinelli F. 2008. Evaluation of indirect biomarkers for detecting corticosteroids used as illegal growth promoters in beef cattle. Vet Rec. 163:147–152.
   PubMed Web of Science ®Google Scholar