737
Views
12
CrossRef citations to date
0
Altmetric
Original Articles

Determination and quantification of the emetic toxin cereulide from Bacillus cereus in pasta, rice and cream with liquid chromatography–tandem mass spectrometry

, &
Pages 911-921 | Received 15 Oct 2014, Accepted 22 Feb 2015, Published online: 20 Mar 2015

References

  • Agata N, Ohta M, Mori M, Isobe M. 1995. A novel dodecadepsipeptide, cereulide, is an emetic toxin of Bacillus cereus. FEMS Microbiol Lett. 129:17–20.
  • Agata N, Ohta M, Yokoyama K. 2002. Production of Bacillus cereus emetic toxin (cereulide) in various foods. Int J Food Microbiol. 73:23–27.
  • Andersson MA, Jääskeläinen EL, Shaheen R, Pirhonen T, Wijnands LM, Salkinoja-Salonen MS. 2004. Sperm bioassay for rapid detection of cereulide-producing Bacillus cereus in food and related environments. Int J Food Microbiol. Jul 15;94:175–183.
  • Andersson MA, Mikkola R, Helin J, Andersson MC, Salkinoja-Salonen M. 1998. A novel sensitivie bioassay for detection of Bacillus cereus emetic toxin and related depsipeptide ionophores. Appl Environ Microbiol. 64:1338–1343.
  • Antignac J-P, Le Bizec B, Monteau F, Andre F. 2003. Validation of analytical methods based on mass spectrometric detection according to the “2002/657/EC” European decision: guideline and application. Anal Chim Acta. Apr;483:325–334.
  • Bauer T, Stark T, Hofmann T, Ehling-Schulz M. 2010. Development of a stable isotope dilution analysis for the quantification of the Bacillus cereus toxin cereulide in foods. J Agric Food Chem. Feb 10;58:1420–1428.
  • Biesta-Peters EG, Reij MW, Blaauw RH, In’t Veld PH, Rajkovic A, Ehling-Schulz M, Abee T. 2010. Quantification of the emetic toxin cereulide in food products by liquid chromatography-mass spectrometry using synthetic cereulide as a standard. Appl Environ Microbiol. Nov;76:7466–7472.
  • Bottone EJ. 2010. Bacillus cereus, a volatile human pathogen. Clin Microbiol Rev. Apr;23:382–398.
  • Burns DT, Danzer K, Townshend A. 2002. Use of the terms “recovery” and “apparent recovery” in analytical procedures (IUPAC Recommendations 2002). Pure Appl Chem. 74:2201–2205.
  • Commission decision of 12 August 2002 implementing Council directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. 2002. Official Journal of the European Communities.2002/657/EC.
  • Delbrassinne L, Andjelkovic M, Rajkovic A, Bottledoorn N, Mahillon J, Van Loco J. 2011. Follow-up of the Bacillus cereus emetic toxin production in penne pasta under household conditions using liquid chromatography coupled with mass spectrometry. Food Microbiol. Aug;28:1105–1109.
  • Delbrassinne L, Andjelkovic M, Rajkovic A, Dubois P, Nguessan E, Mahillon J, Van Loco J. 2012. Determination of Bacillus cereus Emetic Toxin in food products by means of LC–MS². Food Anal Meth. Oct;5:969–979.
  • Dierick K, Van Coillie E, Swiecicka I, Meyfroidt G, Devlieger H, Meulemans A, Hoedemaekers G, Fourie L, Heyndrickx M, Mahillon J. 2005. Fatal family outbreak of Bacillus cereus-associated food poisoning. J Clin Microbiol. Aug;43:4277–4279.
  • Ehling-Schulz M, Fricker M, Grallert H, Rieck P, Wagner M, Scherer S. 2006. Cereulide synthetase gene cluster from emetic Bacillus cereus: structure and location on a mega virulence plasmid related to Bacillus anthracis toxin plasmid pXO1. BMC Microbiol. 6:20.
  • Ehling-Schulz M, Fricker M, Scherer S. 2004. Identification of emetic toxin producing Bacillus cereus strains by a novel molecular assay. FEMS Microbiol Lett. Mar 19;232:189–195.
  • Ehling-Schulz M, Svensson B, Guinebretiere MH, Lindbäck T, Andersson M, Schulz A, Fricker M, Christiansson A, Granum PE, Martlbauer E, et al. 2005. Emetic toxin formation of Bacillus cereus is restricted to a single evolutionary lineage of closely related strains. Microbiology. Jan;151:183–197.
  • Ehling-Schulz M, Vukov N, Schulz A, Shaheen R, Andersson M, Märtlbauer E, Scherer S. 2005. Identification and partial characterization of the nonribosomal peptide synthetase gene responsible for cereulide production in emetic Bacillus cereus. Appl Environ Microbiol. Jan;71:105–113.
  • Finlay WJJ, Logan NA, Sutherland AD. 1999. Semiautomated metabolic staining assay for Bacillus cereus emetic toxin. Appl Environ Mirobiol. 65:1811–1812.
  • Fricker M, Messelhäusser U, Busch U, Scherer S, Ehling-Schulz M. 2007. Diagnostic real-time PCR assays for the detection of emetic Bacillus cereus strains in foods and recent food-borne outbreaks. Appl Environ Microbiol. Mar;73:1892–1898.
  • Häggblom MM, Apetroaie C, Andersson MA, Salkinoja-Salonen MS. 2002. Quantitative analysis of Cereulide, the Emetic Toxin of Bacillus cereus, produced under various conditions. Appl Environ Microbiol. 68:2479–2483.
  • Hormazabal V, Østensvik Ø, O’Sullivan K, Granum PE. 2004. Quantification of Bacillus cereus emetic toxin (cereulide) in figs using LC/MS. J Liq Chrom Rel Technol. 27:2531–2538.
  • Jääskeläinen EL, Häggblom MM, Andersson MA, Vanne L, Salkinoja-Salonen MS. 2003. Potential of Bacillus cereus for producing an emetic toxin, cereulide, in bakery products: quantitative analysis by vhemical and biological methods. J Food Prot. 66:1047–1054.
  • Jääskeläinen EL, Teplova V, Andersson MA, Andersson LC, Tammela P, Andersson MC, Pirhonen TI, Saris N-EL, Vuorela P, Salkinoja-Salonen MS. 2003. In vitro assay for human toxicity of cereulide, the emetic mitochondrial toxin produced by food poisoning Bacillus cereus. Toxicol in Vitro. Oct–Dec;17:737–744.
  • Kim J-B, Kim J-M, Kim S-Y, Kim J-H, Park Y-B, Choi N-J, Oh D-H. 2010. Comparison of enterotoxin production and phenotypic characteristics between emetic and enterotoxic Bacillus cereus. J Food Prot. 73:1219–1224.
  • Lücking G, Dommel MK, Scherer S, Fouet A, Ehling-Schulz M. 2009. Cereulide synthesis in emetic Bacillus cereus is controlled by the transition state regulator AbrB, but not by the virulence regulator PlcR. Microbiology. Mar;155:922–931.
  • Mahler H, Pasi A, Kramer JM, Schulte P, Scoging AC, Bär W, Krähenbühl S. 1997. Fulminant liver failure in association with the Emetic Toxin of Bacillus cereus. New Engl J Med. 336:1142–1148.
  • Mellegård H, Rønning HT, Osborg EJ, Østensvik Ø. 2014. Bacillus cereus emetisk matforgiftning. Norsk Veterinærtidsskrift. 6:543–547
  • Messelhäusser U, Frenzel E, Blöchinger C, Zucker R, Kämpf P, Ehling-Schulz M. 2014. Emetic Bacillus cereus are more volatile than thought: recent foodborne outbreaks and prevalence studies in Bavaria (2007–2013). Biomed Res Int. 2014:1–9.
  • Mikkola R, Saris N-EL, Grigoriev PA, Andersson MA, Salkinoja-Salonen MS. 1999. Ionophoretic properties and mitochondrial effects of cereulide the emetic toxin of B. cereus. Eur J Biochem. 263:112–117.
  • Naranjo M, Denayer S, Botteldoorn N, Delbrassinne L, Veys J, Waegenaere J, Sirtaine N, Driesen RB, Sipido KR, Mahillon J, Dierick K. 2011. Sudden death of a young adult associated with Bacillus cereus food poisoning. J Clin Microbiol. Dec;49:4379–4381.
  • Rau J, Perz R, Klittich G, Contzen M. 2009. Cereulidebildende präsumptive Bacillus cereus aus Lebensmitteln - Differenzierende Untersuchungen mittles kultureller Methoden, LC-MS/MS, PCR und Infrarotspektroskopie unter Berücksichtigung thermotoleranter Vertreter. Berliner und Münchener Tierärztliche Wochenschrift. 122:25–36.
  • Røssvoll E, Rønning HT, Granum PE, Møretrø T, Hjerpekjøn MR, Langsrud S. 2014. Toxin production and growth of pathogens subjected to temperature fluctuations simulating consumer handling of cold cuts. Int J Food Microbiol. Aug 18;185:82–92.
  • Shaheen R, Andersson MA, Apetroaie C, Schulz A, Ehling-Schulz M, Ollilainen VM, Salkinoja-Salonen MS. 2006. Potential of selected infant food formulas for production of Bacillus cereus emetic toxin, cereulide. Int J Food Microbiol. Apr 1;107:287–294.
  • Shiota M, Saitou K, Mizumoto H, Matsusaka M, Agata N, Nakayama M, Kage M, Tatsumi S, Okamoto A, Yamaguchi S, et al. 2010. Rapid detoxification of cereulide in Bacillus cereus food poisoning. Pediatrics. Apr;125:e951–e955.
  • Stark T, Marxen S, Rütschle A, Lücking G, Scherer S, Ehling-Schulz M, Hofmann T. 2013. Mass spectrometric profiling of Bacillus cereus strains and quantitation of the emetic toxin cereulide by means of stable isotope dilution analysis and HEp-2 bioassay. Anal Bioanal Chem. Jan;405:191–201.
  • Thorsen L, Hansen BM, Nielsen KF, Hendriksen NB, Phipps RK, Budde BB. 2006. Characterization of emetic Bacillus weihenstephanensis, a new cereulide-producing bacterium. Appl Environ Microbiol. Jul;72:5118–5121.
  • Ueda S, Nakajima H, Iwase M, Shinagawa K, Kuwabara Y. 2012. LC-MS analysis of the emetic toxin, cereulide, produced by Bacillus cereus. Biocontrol Sci. 17:191–195.
  • Ueda S, Yamaguchi M, Iwase M, Kuwabara Y. 2013. Detection of emetic Bacillus cereus by real-time PCR in foods. Biocontrol Sci. 18:227–232.
  • Yamaguchi M, Kawai T, Kitagawa M, Kumeda Y. 2013. A new method for rapid and quantitative detection of the Bacillus cereus emetic toxin cereulide in food products by liquid chromatography-tandem mass spectrometry analysis. Food Microbiol. May;34:29–37.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.