862
Views
15
CrossRef citations to date
0
Altmetric
Original Articles

Quantification of pyrrolizidine alkaloids in North American plants and honey by LC-MS: single laboratory validation

, &
Pages 2068-2074 | Received 04 Jun 2015, Accepted 20 Sep 2015, Published online: 20 Oct 2015

References

  • AOAC. 2013. Appendix K: guidelines for dietary supplements and botanicals. Official methods of analysis Gaithersburg: AOAC International, Appendix K; p. 1–32.
  • Betteridge K, Cao Y, Colegate SM. 2005. Improved method for extraction and LC-MS analysis of pyrrolizidine alkaloids and their N-oxides in honey: application to Echium vulgare honeys. J Agric Food Chem. 53:1894–1902.
  • Betz JM, Brown PN, Roman MC. 2011. Accuracy, precision, and reliability of chemical measurements in natural products research. Fitoterapia. 82:44–52.
  • Beuerle T, Benford D, Brimer L, Cottrill B, Doerge D, Dusemund B, Farmer P, Fürst P, Humpf H-U MP. 2011. Scientific opinion on pyrrolizidine alkaloids in food and feed: EFSA panel on contaminants in the food chain (CONTAM). Efsa J. 9:1–134.
  • Colegate SM, Edgar JA, Knill AM, Lee ST. 2005. Solid-phase extraction and HPLC-MS profiling of pyrrolizidine alkaloids and their N-oxides: a case study of Echium plantagineum. Phytochem Anal. 16:108–119.
  • Cramer L, Beuerle T. 2012. Detection and quantification of pyrrolizidine alkaloids in antibacterial medical honeys. Planta Med. 78:1976–1982.
  • Crews C, Berthiller F, Krska R. 2010. Update on analytical methods for toxic pyrrolizidine alkaloids. Anal Bioanal Chem. 396:327–338.
  • Edgar JA, Colegate SM, Boppre M, Molyneux RJ. 2011. Pyrrolizidine alkaloids in food: a spectrum of potential health consequences. Food Addit Contam: Part A. 28:308–324.
  • Edgar JA, Roeder E, Molyneux RJ. 2002. Honey from plants containing pyrrolizidine alkaloids: a potential threat to health. J Agric Food Chem. 50:2719–2730.
  • GPO. 2014. Guidelines establishing test procedures for the analysis of pollutants; procedures for detection and quantification. 2002, 40 CFR pt. 136, Appendix B, rev. 1.11. [ cited 2014 March 11]. Available from: http://www.ecfr.gov/cgi-bin/text-idx?SID=962dadc08ba42d97a8c94764cd97dc08& node=40:24.0.1.1.1.0.1.8.2&rgn=div9
  • Griffin CT, Danaher M, Elliott CT, Kennedy DG, Furey A. 2013. Detection of pyrrolizidine alkaloids in commercial honey using liquid chromatography–ion trap mass spectrometry. Food Chem. 136:1577–1583.
  • Joosten L, Mulder PP, Vrieling K, Van Veen JA, Klinkhamer PG. 2010. The analysis of pyrrolizidine alkaloids in Jacobaea vulgaris; a comparison of extraction and detection methods. Phytochem Anal. 21:197–204.
  • Kempf M, Beuerle T, Bühringer M, Denner M, Trost D, Von Der Ohe K, Bhavanam VB, Schreier P. 2008. Pyrrolizidine alkaloids in honey: risk analysis by gas chromatography‐mass spectrometry. Mol Nutr Food Res. 52:1193–1200.
  • Liu F, Wan SY, Jiang Z, Li SFY, Ong ES, Osorio JCC. 2009. Determination of pyrrolizidine alkaloids in comfrey by liquid chromatography–electrospray ionization mass spectrometry. Talanta. 80:916–923.
  • Mattocks AR. 1986. Chemistry and toxicology of pyrrolizidine alkaloids. London: Academic Press.
  • Molyneux RJ, Gardner DL, Colegate SM, Edgar JA. 2011. Pyrrolizidine alkaloid toxicity in livestock: a paradigm for human poisoning? Food Addit Contam: Part A. 28:293–307.
  • Pauli GF, Jaki BU, Lankin DC. 2005. Quantitative 1H NMR: development and potential of a method for natural products analysis. J Nat Prod. 68:133–149.
  • Peters FT, Drummer OH, Musshoff F. 2007. Validation of new methods. Forensic Sci Int. 165:216–224.
  • Reinhard A, Janke M, Von Der Ohe W, Kempf M, Theuring C, Hartmann T, Schreier P, Beuerle T. 2009. Feeding deterrence and detrimental effects of pyrrolizidine alkaloids fed to honey bees (Apis mellifera). J Chem Ecol. 35:1086–1095.
  • Smith LW, Culvenor CCJ. 1981. Plant sources of hepatotoxic pyrrolizidine alkaloids. J Nat Prod. 44:129–152.
  • Wiedenfeld H. 2011. Plants containing pyrrolizidine alkaloids: toxicity and problems. Food Addit Contam: Part A. 28:282–292.
  • Williams MT, Warnock BJ, Betz JM, Beck JJ, Gardner DR, Lee ST, Molyneux RJ, Colegate SM. 2011. Detection of high levels of Pyrrolizidine-N-oxides in the endangered plant Cryptantha crassipes (Terlingua Creek Cat’s-eye) Using HPLC-ESI-MS. Phytochem Anal. 22:532–540.
  • Witte L, Rubiolo P, Bicchi C, Hartmannt T. 1992. Comparative analysis of pyrrolizidine alkaloids from natural sources by gas chromatography-mass spectrometry. Phytochemistry. 32:187–196.
  • Wood R. 1999. How to validate analytical methods. TrAC Trends Anal Chem. 18:624–632.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.