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Original Articles

HPLC-ESI-MS/MS assessment of the tetrahydro-metabolites of cortisol and cortisone in bovine urine: promising markers of dexamethasone and prednisolone treatment

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Pages 1175-1189 | Received 29 Mar 2016, Accepted 31 May 2016, Published online: 04 Jul 2016

References

  • Angeletti R, Contiero L, Gallina G, Montesissa C. 2006. The urinary ratio of testosterone to epitestosterone: a good marker of illegal treatment also in cattle? Vet Res Comm. 30:127–131.
  • Antignac JP, Le Bizec B, Monteau F, André F. 2002. Study of natural and artificial corticosteroid phase II metabolites in bovine urine using HPLC-MS/MS. Steroids. 67:873–882.
  • Arioli F, Casati A, Fidani M, Silvestri M, Pompa G. 2012. Prednisolone and prednisone neo-formation in bovine urine after sampling. Animal. 6:1023–1029.
  • Arioli F, Fidani M, Casati A, Fracchiolla ML, Pompa G. 2010. Investigation on possible transformations of cortisol, cortisone and cortisol glucuronide in bovine faecal matter using liquid chromatography–mass spectrometry. Steroids. 75:350–354.
  • Bertocchi L, Dusi G, Ghidelli V, Hathaway T, Nassuato C, Casati A, Fidani M, Pompa G, Arioli F. 2013. Investigation of the origin of prednisolone in urine and adrenal glands of cows. Food Addit Contam A. 30:1055–1062.
  • Cannizzo FT, Capra P, Divari S, Ciccotelli V, Biolatti B, Vincenti M. 2011. Effects of low-dose dexamethasone and prednisolone long-term administration in beef calf: chemical and morphological investigation. Anal Chim Acta. 700:95–104.
  • Cannizzo FT, Crispo M, Divari S, Starvaggi L, Cucuzza M, Biolatti B. 2013. Corticosteroid hormone receptors and prereceptors on hypothalamus-pituitary-adrenal axis of veal calves. LXVII Convegno Nazionale S.ISVet, Società Italiana delle Scienze Veterinarie. Book of abstracts 77.
  • Capolongo F, Tapparo M, Merlanti R, Ravarotto L, Tealdo E, Gallina G, Montesissa C, Dacasto M. 2007. Illicit treatments in cattle and urinary 6beta-hydroxycortisol/cortisol ratio. Anal Chim Acta. 586:228–232.
  • Chiesa L, Nobile M, Panseri S, Sgoifo Rossi CA, Pavlovic R, Arioli F. 2014. Detection of boldenone, its conjugates and androstadienedione, as well as five corticosteroids in bovine bile through a unique immunoaffinity column clean-up and two validated liquid chromatography–tandem mass spectrometry analyses. Anal Chim Acta. 852:137–145.
  • Circular of Ministry of Health, Department of Public and Veterinary Health about the opinion of the Consiglio Superiore di Sanità. Sezione IV. 2012 May 22.
  • Courtney R, Stewart PM, Toh M, Ndongo MN, Calle RA, Hirshberg B. 2008. Modulation of 11β-hydroxysteroid dehydrogenase (11βHSD) activity biomarkers and pharmacokinetics of PF-00915275, a selective 11βHSD1 inhibitor. Clin Endocrinol Metab. 93:550–556.
  • CRL Guidance Paper. 2007. CRL Guidance paper (7 December 2007). CRLs view on state of the art analytical methods for national residue control plans. 8 pp. Available from: http://www.bvl.bund.de/SharedDocs/Downloads/09_Untersuchungen/EURL_Empfehlungen_Konzentrationsauswahl_Methodenvalierungen.pdf?__blob=publicationFile
  • Cuzzola A, Mazzini F, Petri A. 2014. A comprehensive study for the validation of a LC-MS/MS method for the determination of free and total forms of urinary cortisol and its metabolites. J Pharm Biomed Anal. 94:203–209.
  • Cuzzola A, Petri A, Mazzini F, Salvadori P. 2009. Application of hyphenated mass spectrometry techniques for the analysis of urinary free glucocorticoids. Rapid Commun Mass Spectrom. 23:2975–2982.
  • Divari S, Cannizzo FT, Uslenghi F, Pregel P, Mulasso C, Spada F, De Maria R, Biolatti B. 2011. Corticosteroid hormone receptors and prereceptors as new biomarkers of the illegal use of glucocorticoids in meat production. J Agric Food Chem. 59:2120–2125.
  • Draper N, Stewart PM. 2005. 11beta-hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action. J Endocrinol. 186:251–271.
  • European Commission. 2002. Decision No. 657/2002. Off J Eur Comm Legis. 221:8–36.
  • Famele M, Ferranti C, Palleschi L, Abenavoli C, Fidente R, Pezzolato M, Botta M, Bozzetta E, Draisci R. 2015. Quantification of natural and synthetic glucocorticoids in calf urine following different growth-promoting prednisolone treatments. Steroids. 104:196–202.
  • Ferranti C, delli Quadri F, Palleschi L, Marchiafava C, Pezzolati M, Bozzeta E, Carmelli M, Draisi R. 2011. Studies on the presence of natural and synthetic corticosteroids in bovine urine. Steroids. 76:616–625.
  • Ferranti C, Famele M, Palleschi L, Bozzetta E, Pezzolato M, Draisci R. 2013. Excretion profile of corticosteroids in bovine urine compared with tissue residues after therapeutic and growth-promoting administration of dexamethasone. Steroids. 78:803–812.
  • Główka F, Kosicka K, Karazniewicz-Łada M. 2010. HPLC method for determination of fluorescence derivatives of cortisol, cortisone and their tetrahydro- and allo-tetrahydro-metabolites in biological fluids. J Chromatogr B. 878:283–289.
  • Ljung T, Andersson B, Bengtsson B, Bjorntorp P, Marin P. 1996. Inhibition of cortisol secretion by dexamethasone in relation to body fat distribution: a dose-response study. Obes Res. 4:277–282.
  • Matuszewski BK, Constanzer ML, Chavez-Eng CM. 2003. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal Chem. 75:3019–3030.
  • Mazzarino M, Rossi F, Giacomelli L, Botre’ F. 2006. Effect of the systemic versus inhalatory administration of synthetic glucocorticoids on the urinary steroid profile as studied by gas chromatography–mass spectrometry. Anal Chim Acta. 559:30–36.
  • Mitamura K, Satoh R, Kamibayashi M, Sato K, Iida T, Ikegawa S. 2014. Simultaneous determination of 18 tetrahydrocorticosteroid sulfates in human urine by liquid chromatography/electrospray ionization-tandem mass spectrometry. Steroids. 85:18–29.
  • Möstl E, Messmann S, Bagu E, Robia C, Palme R. 1999. Measurement of glucocorticoid metabolite concentrations in faeces of domestic livestock. Zentralbl Veterinarmed A. 46:621–631.
  • Nebbia C, Capra P, Leporati M, Girolami F, Barbarino G, Gatto S, Vincenti M. 2014. Profile of the urinary excretion of prednisolone and its metabolites in finishing bulls and cows treated with a therapeutic schedule. BMC Vet Res. 10:237.
  • Pavlovic R, Cannizzo FT, Panseri S, Biolatti B, Trutic N, Biondi PA, Chiesa L. 2013. Tetrahydro-metabolites of cortisol and cortisone in bovine urine evaluated by HPLC-ESI-mass spectrometry. J Steroid Biochem Mol Biol. 135:30–35.
  • Pavlovic R, Chiesa LM, Soncin S, Panseri S, Cannizzo FT, Biolatti B, Biondi PA. 2012. Determination of cortisol, cortisone, prednisolone and prednisone in bovine urine by liquid chromatography–electrospray ionisation single quadrupole mass spectrometry. J Liq Chromatogr RT. 35:444–457.
  • Pegolo S, Di Camillo B, Montesissa C, Cannizzo FT, Biolatti B, Bargelloni L. 2015. Toxicogenomic markers for corticosteroid treatment in beef cattle: integrated analysis of transcriptomic data. Food Chem Toxicol. 77:1–11.
  • Pleadin J, Terzić S, Perši N, Vulić A. 2011. Evaluation of steroid hormones anabolic use in cattle in Croatia. Biotechnol Anim Husb. 7:147–158.
  • Pompa G, Arioli F, Cassati A, Fidani M, Bertocchi L, Dusi G. 2011. Investigation of the origin of prednisolone in cow urine. Steroids. 76:104–110.
  • Pirro V, Girolami F, Spalenza V, Gardini G, Badino P, Nebbia C. 2015. Set-up of a multivariate approach based on serum biomarkers as an alternative strategy for the screening evaluation of the potential abuse of growth promoters in veal calves. Food Addit Contam Part A. 32:702–711.
  • Quinkler M, Stewart PM. 2003. Hypertension and the cortisol-cortisone shuttle. J Clin Endocrinol Metab. 88:2384–2392.
  • Raffaelli A, Saba A, Vignali E, Marcocci C, Salvadori P. 2006. Direct determination of the ratio of tetrahydrocortisol + allo-tetrahydrocortisol to tetrahydrocortisone in urine by LC-MS–MS. J Chromatogr B. 830:278–285.
  • Savu SR, Silvestro L, Haag A, Sörgel F. 1996. A confirmatory HPLC-MS/MS method for ten synthetic corticosteroids in bovine urines. J Mass Spectrom. 31:1651–1363.
  • Tomlinson JW, Sherlock M, Hughes B, Hughes SV, Kilvington F, Barlett W, Courtney R, Rejto P, Carley W, Stewart PM. 2007. Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis. J Clin Endocrinol Metab. 92:857–864.
  • Turpeinen U, Markkanen H, Sane T, Hämäläinen E. 2006. Determination of free tetrahydrocortisol and tetrahydrocortisone ratio in urine by liquid chromatography-tandem mass spectrometry. Scand J Clin Lab Invest. 66:147–159.
  • US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM). May 2001. BP. Guidance for Industry Bioanalytical methods validation [online]. Available from: http://www.fda.gov/downloads/Drugs/Guidances/ucm070107.pdf.
  • Vascellari M, Capello K, Stefani A, Biancotto G, Moro L, Stella R, Pozza G, Mutinelli F. 2012. Evaluation of thymus morphology and serum cortisol concentration as indirect biomarkers to detect low-dose dexamethasone illegal treatment in beef cattle. BMC Vet Res. 8:129.
  • Vierhapper H. 2000. The stress of being a doctor: steroid excretion rates in internal medicine residents on and off duty. Am J Med. 109:492–494.
  • Vincenti M, Girolami F, Capra P, Pazzi M, Carletti M, Gardini G, Nebbia C. 2009. Dexamethasone urinary excretion in cattle. J Agric Food Chem. 57:1299–1306.
  • Vincenti M, Leporati M, Capra P, Gatto S, Attucci A, Barbarino G, Nebbia C. 2012. A field survey on the presence of prednisolone and prednisone in urine samples from untreated cows. Food Addit Contam Part A. 29:1893–1900.
  • White PC. 2001. Synthesis and metabolism of corticosteroids. In: Becker KL, editor. Principles and practice of endocrinology and metabolism. Philadelphia (PA): Lippincott Williams & Wilkins; p. 704–719.
  • Zhai X, Chen F, Zhu C, Lu Y. 2015. A simple LC-MS/MS method for the determination of cortisol cortisone and tetrahydro-metabolites in human urine: Assay development, validation and application in depression patients. J Pharm Biomed Anal. 107:450–455.

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