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Original Articles

Identification of a new tadalafil analogue in commercial dietary supplements: isopropylnortadalafil

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Pages 162-169 | Received 13 Sep 2016, Accepted 19 Nov 2016, Published online: 22 Dec 2016

References

  • Bortolini C, Pivato A, Bogialli S, Pastore P. 2015. One-shot analysis of PDE-5inhibitors and analogues in counterfeit herbal natural products using an LC-DAD-QTOF system. Anal Bioanal Chem. 407:6207–6216.
  • Gilard V, Balayssac S, Tinaugus A, Martins N, Martino R, Malet-Martino M. 2015. Detection, identification and quantification by 1H NMR of adulterants in 150 herbal dietary supplements marketed for improving sexual performance. J Pharm Biomed Anal. 102:476–493.
  • Huang YC, Lee HC, Lin YL, Lu CY, Tsai CF, Cheng WF. 2016. Separation and identification of a novel tadalafil analogue adulterant in a dietary supplement. Food Addit Contam Part A. 33:179–185.
  • Kern S, Lorenz L, Lanzarotta A, Nickum E, Litzau J. 2015. Isolation and structural characterization of a new tadalafil analog (chloropropanoylpretadalafil) found in a dietary supplement. J Pharm Biomed Anal. 103:99–103.
  • Lebel P, Gagnon J, Furtos A, Waldron KC. 2014. A rapid, quantitative liquid chromatography-mass spectrometry screening method for 71 active and 11 natural erectile dysfunction ingredients present in potentially adulterated or counterfeit products. J Chromatogr A. 1343:143–151.
  • Lee JH, Kim HJ, Noh E, Kim JY, Cho SH, Do JA, Yoon CY, Cho S, Kim WS. 2014. Identification and screening of a tadalafil analogue found in adulterated herbal products t. J Pharm Biomed Anal. 103:80–84.
  • Lee JH, Park HN, Ganganna B, Jeong JH, Park S-K, Lee J, Baek SY. 2016. Isolation and structural elucidation of a new tadalafil analogue in health supplements: bisprenortadalafil. Food Addit Contam Part A. 33:945–952.
  • Low M-Y, Zeng Y, Li L, Ge X-W, Lee R, Bloodworth B-C, Koh H-L. 2009. Safety and quality assessment of 175 illegal sexual enhancement products seized in red-light districts in Singapore. Drug Saf. 32:1141–1146.
  • Patel DN, Li L, Kee CL, Ge X, Low MY, Koh HL. 2014. Screening of syntheticPDE-5 inhibitors and their analogues as adulterants: analytical techniques and challenges. J Pharm Biomed Anal. 87:176–190.
  • Patel DN, Low W-L, Tan LL, Tan -M-MB, Zhang Q, Low MY, Chan C-L, Koh H-L. 2012. Adverse events associated with the use of complementary medicine and health supplements: an analysis of reports in the Singapore Pharmacovigilance database from 1998 to 2009. Clin Toxicol. 50:481–489.
  • Praveen K, Antoni R, Francesc C, Merce G, Nuria C, Josep C, Ramon C. 2013. Targeted fanalysis with benchtop quadrupole-Orbitrap hybrid mass spectrometer: application to determination of synthetic hormones in animal urine. Anal Chim Acta. 780:65–73.
  • Shi F, Guo C, Gong L, Li J, Dong P, Zhang J, Cui P, Jiang S, Zhao Y, Zeng S. 2014. Application of a high resolution benchtop quadrupole-Orbitrap mass spectrometry for the rapid screening, confirmation and quantification of illegal adulterated phosphodiesterase-5 inhibitors in herbal medicines and dietary supplements. J Chromatogr A. 1344:91–98.
  • Vaclavik L, Schmitz JR, Halbardier J-F, Mastovska K. 2016. Single-laboratory validation study of a method for screening and identification of phosphodiesterase type 5 inhibitors in dietary ingredients and supplements using liquid chromatography/quadrupole-orbital ion trap mass spectrometry: first action 2015.12. J AOAC. 99:55–72.
  • Vaysse J, Gilard V, Balayssac S, Zedde C, Martino R. 2012. Identification of a novelsildenafil analogue in an adulterated herbal supplement. J Pharm Biomed Anal. 59:58–66.
  • Wollein U, Eisenreich W, Schramek N. 2011. Identification of novelsildenafil-analogues in an adulterated herbal food supplement. J Pharm Biomed Anal. 56:705–712.
  • Xu Y, Kee C-L, Ge X, Low M-Y, Koh H-L. 2016. Isolation and characterization of a tadalafil analogue, N-cyclopentylnortadalafil in health supplement. J Pharm Biomed Anal. 118:235–241.

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