Determination of pyrrolizidine alkaloids in selected feed materials with gas chromatography-mass spectrometry

References

• Allgaier C, Franz S. 2015. Risk assessment on the use of herbal medicinal products containing pyrrolizidine alkaloids. Regul Toxicol Pharmacol. 73:494–500.
   PubMed Web of Science ®Google Scholar
• Becerra-Jiminez J, Kuschak M, Roeder E, Wiedenfeld H. 2013. Toxic pyrrolizidine alkaloids as undesired contaminants in food and feed: degradation of the PAs from Senecio jacobaea in silage. Pharmazie. 68:636–639.
   PubMed Web of Science ®Google Scholar
• Bodi D, Ronczk S, Gottschalk C, Behr N, Skibba A, Wagner M, Lahrssen-Wiederholt M, Preiss-Weigert A, These A. 2014. Determination of pyrrolizidine alkaloids in tea, herbal drugs and honey. Food Addit Contam Part A. 31:1886–1895.
   PubMed Web of Science ®Google Scholar
• Bolechová M, Čáslavský J, Pospíchalová M, Kosubová P. 2015. UPLC–MS/MS method for determination of selected pyrrolizidine alkaloids in feed. Food Chem. 170:265–270.
   PubMed Web of Science ®Google Scholar
• Boppré M. 2011. The ecological context of pyrrolizidine alkaloids in food, feed and forage: an overview. Food Addit Contam Part A. 28:260–281.
   Google Scholar
• Codex Alimentarius Commission. 2014. Code of practice for weed control to prevent and reduce pyrrolizidine alkaloid contamination in food and feed. Rome: Codex Alimentarius Commission Secretariat.
   Google Scholar
• Cramer L, Beuerle T. 2012. Detection and quantification of pyrrolizidine alkaloids in antibacterial medical honeys. Planta Med. 78:1976–1982.
   PubMed Web of Science ®Google Scholar
• Cramer L, Schiebel H-M, Ernst L, Beuerle T. 2013. Pyrrolizidine alkaloids in the food chain: development, validation, and application of a new HPLC-ESI-MS/MS sum parameter method. J Agric Food Chem. 61:11382–11391.
   PubMed Web of Science ®Google Scholar
• Crews C, Berthiller F, Krska R. 2010. Update on analytical methods for toxic pyrrolizidine alkaloids. Anal Bioanal Chem. 396:327–338.
   PubMed Web of Science ®Google Scholar
• Dübecke A, Beckh G, Lüllmann C. 2011. Pyrrolizidine alkaloids in honey and bee pollen. Food Addit Contam Part A. 28:348–358.
   Web of Science ®Google Scholar
• Edgar JA, Colegate SM, Boppré M, Molyneux RJ. 2011. Pyrrolizidine alkaloids in food: a spectrum of potential health consequences. Food Addit Contam Part A. 28:308–324.
   Web of Science ®Google Scholar
• Edgar JA, Molyneux RJ, Colegate SM. 2015. Pyrrolizidine alkaloids: potential role in the etiology of cancers, pulmonary hypertension, congenital anomalies, and liver disease. Chem Res Toxicol. 28:4–20.
   PubMed Web of Science ®Google Scholar
• European Food Safety Authority, EFSA Panel on Contaminants in the Food Chain (CONTAM). 2011. EFSA scientific opinion on pyrrolizidine alkaloids in food and feed. EFSA J. 9:1–134.
   Google Scholar
• European Union.  2002. EU directive 2002/32/EC on undesirable substances in animal feed. Consolidated document including amendments of the original directive (2002/32/ EC). Brussels, Off J. L. 140:10.
   Google Scholar
• Fu PP, Xia Q, Lin G, Chou MW. 2004. Pyrrolizidine alkaloids—genotoxicity, metabolism enzymes, metabolic activation, and mechanisms. Drug Metab Rev. 36:1–55.
   PubMed Web of Science ®Google Scholar
• Gardner DR, Thorne MS, Molyneux RJ, Pfister JA, Seawright AA. 2006. Pyrrolizidine alkaloids in Senecio madagascariensis from Australia and Hawaii and assessment of possible livestock poisoning. Biochem Syst Ecol. 34:736–744.
   Web of Science ®Google Scholar
• Gottschalk C, Ronczka S, Preiß-Weigert A, Ostertag J, Klaffke H, Schafft H, Lahrssen-Wiederholt M. 2015. Pyrrolizidine alkaloids in natural and experimental grass silages and implications for feed safety. Anim Feed Sci Technol. 207:253–261.
   Web of Science ®Google Scholar
• Griffin CT, Danaher M, Elliott CT, Kennedy DG, Furey A. 2013. Detection of pyrrolizidine alkaloids in commercial honey using liquid chromatography–ion trap mass spectrometry. Food Chem. 136:1577–1583.
   PubMed Web of Science ®Google Scholar
• Hoogenboom LA, Mulder PP, Zeilmaker MJ, van den Top HJ, Remmelink GJ, Brandon EF, Klijnstra M, Meijer GA, Schothorst R, Van Egmond HP. 2011. Carry-over of pyrrolizidine alkaloids from feed to milk in dairy cows. Food Addit Contam Part A. 28:359–372.
   Web of Science ®Google Scholar
• Hösch G, Wiedenfeld H, Dingermann T, Röder E. 1996. A new high performance liquid chromatography method for the simultaneous quantitative analysis of pyrrolizidine alkaloids and their N-oxides in plant material. Phytochem Anal. 7:284–288.
   Web of Science ®Google Scholar
• Huybrechts B, Callebaut A. 2015. Pyrrolizidine alkaloids in food and feed on the Belgian market. Food Addit Contam Part A. 32:1939–1951.
   PubMed Web of Science ®Google Scholar
• Kempf M, Beuerle T, Bühringer M, Denner M, Trost D, von der Ohe K, Bhavanam VBR, Schreier P. 2008. Pyrrolizidine alkaloids in honey: risk analysis by gas chromatography-mass spectrometry. Mol Nutr Food Res. 52:1193–1200.
   PubMed Web of Science ®Google Scholar
• Lebada R, Schreier A, Scherz S, Resch C, Krenn L, Kop B. 2000. Quantitative analysis of the pyrrolizidine alkaloids senkirkine and senecionine in Tussilago farfara L. by capillary electrophoresis. Phytochem Anal. 11:366–369.
   Web of Science ®Google Scholar
• Mroczek T, Glowniak K, Wlaszczyk A. 2002. Simultaneous determination of N-oxides and free bases of pyrrolizidine alkaloids by cation-exchange solid-phase extraction and ion-pair high-performance liquid chromatography. J Chromatogr A. 949:249–262.
   PubMed Web of Science ®Google Scholar
• Mulder PPJ, Beumer B, Oosterink E, de Jong J. 2009. Dutch survey pyrrolizidine alkaloids in animal forage. RIKILT Report 2009.018. Wageningen: RIKILT – Institute of Food Safety, p. 1–45.
   Google Scholar
• Muzquiz M, Cuadrado C, Ayet G, de la Cuadra C, Burbano C, Osagie A. 1994. Variation of alkaloid components of lupin seeds in 49 genotypes of Lupinus albus from different countries and locations. J Agric Food Chem. 42:1447–1450.
   Web of Science ®Google Scholar
• Pelser PB, de Vos H, Theuring C, Beuerle T, Vrieling K, Hartmann T. 2005. Frequent gain and loss of pyrrolizidine alkaloids in the evolution of Senecio section Jacobaea (Asteraceae). Phytochemistry. 66:1285–1295.
   PubMed Web of Science ®Google Scholar
• SANTE/11945/2015 Guidance document on analytical quality control and method validation procedures for pesticides residues analysis in food and feed.
   Google Scholar
• Schulz M, Meins J, Diemert S, Zagermann-Muncke P, Goebelm R, Schrenkm D, Schubert-Zsilaveczm M, Abdel-Tawabm M. 2015. Detection of pyrrolizidine alkaloids in German licensed herbal medicinal teas. Phytomedicine. 22:648–656.
   PubMed Web of Science ®Google Scholar
• Stegelmeier BL, Edgar JA, Colegate SM, Gardner DR, Schoch TK, Coulombe RA, Molyneux RJ. 1999. Pyrrolizidine alkaloid plants, metabolism and toxicity. J Nat Toxins. 8:95–116.
   PubMedGoogle Scholar
• Valese AC, Molognoni L, de Sá Ploêncio LA, de Lima FG, Gonzaga LV, Górniak SL, Daguer H, Barreto F, Costa ACO. 2016. A fast and simple LC-ESI-MS/MS method for detecting pyrrolizidine alkaloids in honey with full validation and measurement uncertainty. Food Control. 67:183–191.
   Web of Science ®Google Scholar
• Van Raamsdonk LWD, Ozinga WA, Hoogenboom LAP, Mulder PPJ, Mol JGJ, Groot MJ, van der Fels-Klerx HJ, de Nijs M. 2015. Exposure assessment of cattle via roughages to plants producing compounds of concern. Food Chem. 189:27–37.
   PubMed Web of Science ®Google Scholar
• Wiedenfeld H, Edgar J. 2011. Toxicity of pyrrolizidine alkaloids to humans and ruminants. Phytochem Rev. 10:137–151.
   Web of Science ®Google Scholar