A review of the current situation of aflatoxin M₁ in cow’s milk in Serbia: risk assessment and regulatory aspects

References

• Asi MR, Iqbal SZ, Ariño A, Hussain A. 2012. Effect of seasonal variations and lactation times on aflatoxin M1 contamination in milk of different species from Punjab, Pakistan. Food Control. 25:34–38.
   Web of Science ®Google Scholar
• Bartoszek A. 2006. Genotoxic food components. In: Malejka-Giganti D, Bartoszek A, Baer-Dubowska W, editors. Carcinogenic and anticarcinogenic food components. Boca Raton: CRC Taylor & Francis Group; p. 69–96.
   Google Scholar
• Battacone G, Nudda A, Rassu SPG, Decandia M, Pulina G. 2012. Excretion pattern of aflatoxin M1 in milk of goats fed a single dose of aflatoxin B1. J Dairy Sci. 95:2656–2661.
   PubMed Web of Science ®Google Scholar
• Bilandžić N, Božić Đ, Đokić M, Sedak M, Kolanović B, Varenina I, Cvetnić Ž. 2014b. Assessment of aflatoxin M1 contamination in the milk of four dairy species in Croatia. Food Control. 43:18–21.
   Web of Science ®Google Scholar
• Bilandžić N, Božić Đ, Đokić M, Sedak M, Kolanović B, Varenina I, Tanković S, Cvetnić Ž. 2014a. Seasonal effect on aflatoxin M1 contamination in raw and UHT milk from Croatia. Food Control. 40:260–264. ​
   Web of Science ®Google Scholar
• Bilandžić N, Varenina I, Kolanović B, Božić Đ, Đokić M, Sedak M, Tanković S, Potočnjak D, Cvetnić Ž. 2015. Monitoring of aflatoxin M1 in raw milk during four seasons in Croatia. Food Control. 54:331–337.
   Web of Science ®Google Scholar
• Bilandžić N, Varenina I, Solomun B. 2010. Aflatoxin M1 in raw milk in Croatia. Food Control. 21:1279–1281. ​
   Web of Science ®Google Scholar
• Bolzoni G, Zanardi G, Bertocchi L, Delle Donne G. 2013. Risultati delle analisi dell’autocontrollo per la contaminazione da Aflatossina M1 nel latte in Lombardia. Large Anim Rev. 19:251–255.
   Google Scholar
• Bryden WL. 2012. Mycotoxin contamination of the feed supply chain: implications for animal productivity and feed security. Anim Feed Sci Technol. 173:134–158.
   Web of Science ®Google Scholar
• Cano-Sancho G, Marin S, Ramos AJ, Peris-Vicente J, Sanchis V. 2010. Occurrence of aflatoxin M1 and exposure assessment in Catalonia (Spain). Revista Iberoamericana de Micología. 27:130–135.
   PubMed Web of Science ®Google Scholar
• Dimitrieska-Stojković E, Stojanovska-Dimzoska B, Ilievska G, Uzunov R, Stojković G, Hajrulai-Musliu Z, Jankuloski D. 2016. Assessment of aflatoxin contamination in raw milk and feed in Macedonia during 2013. Food Control. 59:201–206.
   Web of Science ®Google Scholar
• Directive 2002/32/EC of the European Parliament and of the Council of 7 May 2002 on undesirable substances in animal feed. 2002. Off J Eur Union (OJ). L 140(30.5):10. http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CONSLEG:2002L0032:20090420:EN:PDF.
   Google Scholar
• Duarte SC, Almeida AM, Teixeira AS, Pereira AL, Falcão AC, Pena A, Lino CM. 2013. Aflatoxin M1 in marketed milk in Portugal: assessment of human and animal exposure. Food Control. 30:411–417.
   Web of Science ®Google Scholar
• [EC] European Commission. 2001. EU Regulation 466/2001. (8 March 2001). Setting maximum levels for certain contaminants in foodstuff. Off J Eur Union (OJ). L077:11–12. ​​​
   Google Scholar
• [EC] European Commission. 2013. Summary report of the standing committee on the food chain and animal health held in Brussels on 21 March 2013–22 March 2013 (section animal nutrition). [accessed 2016 Jul 5 http://ec.europa.eu/food/animals/docs/reg-com_ani-nutrit_20130221_sum.pdf.
   Google Scholar
• [EFSA] European Food Safety Authority. 2004. Opinion of the scientific panel on contaminants in food chain on a request from the commission related to aflatoxin B1 as undesirable substance in animal feed. Request № EFSA-Q-2003-035. EFSA J. 39:1–27.
   Google Scholar
• Fink-Gremmels J. 2008. Mycotoxins in cattle feeds and carry-over to dairy milk: a review. Food Addit Contam. 25:172–180.
   Web of Science ®Google Scholar
• Golge OA. 2014. survey on the occurrence of aflatoxin M1 in raw milk produced in Adana province of Turkey. Food Control. 45:150–155.
   Web of Science ®Google Scholar
• Groopman JD, Kensler TW, Wild CP. 2008. Protective interventions to prevent aflatoxin-induced Carcinogenesis in developing countries. Annu Rev Public Health. 29:187–203.
   PubMed Web of Science ®Google Scholar
• Hassani A-C, Mojemmi B, Mouane N. 2016. Occurrence and levels of mycotoxins and their metabolites in human breast milk associated to dietary habits and other factors: A systematic literature review, 1984–2015. Trends Food Sci Technol. 50:56–69.
   Web of Science ®Google Scholar
• [IARC] International Agency for Research Some traditional herbal medicines, some mycotoxins, naphthalene and styrene. In: IARC monograph on the evaluation of carcinogenic risks to humans. Lyon: World Health Organization; vol. 82; p. 1–556. ​​​
   Google Scholar
• Ilic M, Putnik S, Prvulovic-Bunovic N, Vojinovic-Miloradov M, Mihajlovic I, Turk-Sekulic M, Radonic J. 2016. Hepatocellular carcinoma and impact of aflatoxin difuranocoumarin derivative system: A case report. Srpski arhiv za celokupno lekarstvo. 144(11–12):661–663.
   Web of Science ®Google Scholar
• Institute of Public Health of Serbia. 2014. “Dr Milan Jovanović Batut”. 2016. Cancer Incidence and Mortality In Central Serbia. Cancer Registry of Central Serbia. Report number 16. ​​​
   Google Scholar
• [IPCS] - International Programme on Chemical Safety. 2009. Dietary exposure assessment of chemicals in food. In: Principles and methods for the risk assessment of chemicals in food. Genève (Switzerland): World Health Organization. ​​​
   Google Scholar
• Iqbal SZ, Jinap S, Pirouz AA, Ahmad, Faizal AR. 2015. Aflatoxin M1 in milk and dairy products, occurrence and recent challenges: A review. Trends Food Sci Technol. 46(1):110–119.
   Web of Science ®Google Scholar
• Ismail A, Riaz M, Levin RE, Akhtar S, Gong YY, Hameed A. 2016. Seasonal prevalence level of aflatoxin M1 and its estimated daily intake in Pakistan. Food Control. 60:461–465.
   Web of Science ®Google Scholar
• Jakovac-Strajn B, Tavčar-Kalcher G, Ujčič Vrhovnik I, Pavšič Vrtač K, Fon Tacer K, Vengušt A. 2012. Aflatoxins in Slovene milk and feed samples. Vet Clin Pathology. 41(4):E23, 40.
   Google Scholar
• Jaksic S, Zivkov-Balos M, Prica N, Masic Z, Nesic K, Jajic I, Abramovic B. 2015. The influence of climatic factors in Serbia on mycotoxin production. In: Proceedings of the First International Symposium of Veterinary Medicine ISVM2015), Hotel “Premier Aqua”–Vrdnik; May 21–23. 166–172. ​
   Google Scholar
• [JECFA] Joint FAO/WHO Expert Committee on Food Additives. 2002. Evaluation of certain mycotoxins in food. Fifty sixth report of the Joint FAO/WHO expert committee on food additives. Geneva: World Health Organization.
   Google Scholar
• Kew M. 2012. Hepatocellular carcinoma in developing countries: prevention, diagnosis and treatment. World J Hepatol. 4(3):99–104. doi:10.4254/wjh.v4.i3.99. [PMID: 22489262].
   PubMedGoogle Scholar
• Kos J, Lević J, Đuragić O, Kokić B, Miladinović I. 2014. Occurrence and estimation of aflatoxin M1 exposure in milk in Serbia. Food Control. 38:41–46.
   Web of Science ®Google Scholar
• Kos J, Mastilović J, Hajnal EJ, Šarić B. 2013. Natural occurrence of aflatoxins in maize harvested in Serbia during 2009-2012. Food Control. 34:31–34.
   Web of Science ®Google Scholar
• Kuiper-Goodman T. 1990. Uncertainties in the risk assessment of three mycotoxins: aflatoxin, ochratoxin, and zearalenone. Can J Physiol Pharmacol. 68(7):1017–1024.
   PubMed Web of Science ®Google Scholar
• Mahmoudi R, Norian R. 2015. Aflatoxin B1 and M1 contamination in cow feeds and milk from Iran. Food Agric Immunol. 26:131–137.
   Web of Science ®Google Scholar
• Milićević D, Nastasijevic I, Petrovic Z. 2016. Mycotoxin in the food supply chain—implications for public health program. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 34(4):293–319.
   PubMed Web of Science ®Google Scholar
• Milićević DR, Škrinjar MM, Baltić T. 2010. Real and perceived risks for mycotoxin contamination in foods and feeds: challenges for food safety control. Toxins. 2(4):572–592.
   PubMed Web of Science ®Google Scholar
• Miocinovic J, Keskic T, Miloradovic Z, Kos A, Tomasevic I, Pudja P. 2017. The aflatoxin M1 crisis in the Serbian dairy sector: the year after. Food Addit Contam: Part B: Surveillance Commun. 10(1):1–4.
   PubMed Web of Science ®Google Scholar
• Murphy PA, Hendrich S, Landgren C, Bryant CM. 2006. Food mycotoxins: an update. J Food Sci. 71:R51–R65.
   Web of Science ®Google Scholar
• Nachtmann C, Gallina S, Rastelli M, Ferro GL, Decastelli L. 2007. Regional monitoring plan regarding the presence of aflatoxin M1 in pasteurized and UHT milk in Italy. Food Control. 18:623–629. ​​​
   Web of Science ®Google Scholar
• Official Gazette of SRY (Official Bulletin of the Republic of Serbia). 1992. Maximum allowed contents of contaminants in food. 92/5. ​​​
   Google Scholar
• Pleadin J, Vulić A, Perši N, Škrivanko M, Capek B, Cvetnić Ž. 2014. Aflatoxin B1 occurrence in maize sampled from Croatian farms and feed factories during 2013. Food Control. 40:286–291.
   Web of Science ®Google Scholar
• Polovinski Horvatovic M, Glamocic D, Jajic I, Krstovic S, Guljaš D, Gjorgjievsk S. 2016. Aflatoxin M1 in raw milk in the region of Vojvodina. Mljekarstvo. 66(3):239–245.
   Web of Science ®Google Scholar
• Polovinski-Horvatović M, Jurić V, Glamočić D. 2009a. The frequency of occurrence of Aflatoxin M1 in milk on the territory of Vojvodina. Proc Nat Sci, Matica Srpska Novi Sad. 116:75—80.
   Google Scholar
• Polovinski-Horvatović M, Jurić V, Glamočić D. 2009b. Two-year study of incidence of aflatoxin M1 in milk in the region of Serbia. Biotechnol Anim Husbandry. 25(5–6):713–718.
   Google Scholar
• Rama A, Latifi F, Bajraktari D, Ramadani N. 2015. Assessment of aflatoxin M1 levels in pasteurized and UHT milk consumed in Prishtina, Kosovo. Food Control. 57:351–354.
   Web of Science ®Google Scholar
• Rama A, Montesissa C, Lucatello L, Galina G, Benetti C, Bajraktari D. 2016. A study on the occurrence of aflatoxin M1 in milk consumed in Kosovo during 2009–2010. Food Control. 62:52–55.
   Web of Science ®Google Scholar
• Rastogi S, Dwivedi PD, Khanna SK, Das M. 2004. Detection of aflatoxin M1 contamination in milk and infant milk products from Indian markets by ELISA. Food Control. 15:287–290.
   Web of Science ®Google Scholar
• Samson RA, Visagie CM, Houbraken J, Hong S-B, Hubka V, Klaassen CHW, Perrone G, Seifert KA, Susca A, Tanney JB, et al. 2014. Phylogeny, identification and nomenclature of the genus Aspergillus. Stud Mycol. 78:141–173.
   PubMed Web of Science ®Google Scholar
• Sarica DY, Has O, Tasdelen S, Ezer Ü. 2015. Occurrence of aflatoxin M1 in milk, white cheese and yoghurt from Ankara, Turkey markets. J Biol Chem Res. 2015: 36–49. ​​​
   Google Scholar
• Scholl PF, Groopman JD. 2008. Long-term stability of human aflatoxin B1 albumin adducts assessed by isotope dilution mass spectrometry and high-performance liquid chromatography-fluorescence. Cancer Epidemiol Biomarkers Prev. 17:1436–1439. ​​​
   PubMed Web of Science ®Google Scholar
• Serbian Regulation. 2011. Maximum allowed contents of contaminants in food and feed, 28/11. Belgrade: Official Bulletin of the Republic Serbia; p. 2–7. ​​​
   Google Scholar
• Serbian Regulation. 2013. Amendment on Serbian regulation 2011 “Maximum allowed contents of contaminants in food and feed”, 20/13. Belgrade: Official Bulletin of the Republic Serbia. ​​​
   Google Scholar
• Serbian Regulation. 2014. Amendment on Serbian regulation 2011 “Maximum allowed contents of contaminants in food and feed”, 29/14. Belgrade: Official Bulletin of the Republic Serbia. ​​​
   Google Scholar
• Serbian Regulation. 2015. Amendment on Serbian regulation 2011 “Maximum allowed contents of contaminants in food and feed”, 84/15. Belgrade: Official Bulletin of the Republic of Serbia. ​​​
   Google Scholar
• Sirot V, Fremy J-M, Leblanc J-C. 2013. Dietary exposure to mycotoxins and health risk assessment in the second French total diet study. Food Chem Toxicol. 52:1–11. ​​​ ​
   PubMed Web of Science ®Google Scholar
• Škrbić B, Živančev J, Antić I, Godula M. 2014. Levels of aflatoxin M1 in different types of milk collected in Serbia: assessment of human and animal exposure. Food Control. 40:113–119. ​​​
   Web of Science ®Google Scholar
• Sørensen LK, Elbæk TH. 2005. Determination of mycotoxins in bovine milk by liquid chromatography tandem mass spectrometry. J Chromatogr B. 820:183–196.
   PubMed Web of Science ®Google Scholar
• Spirić MD, Stefanović MS, Radičević MT, Đinović Stojanović JM, Janković VV, Velebit BM, Janković DS. 2015. Study of aflatoxins incidence in cow feed and milk in Serbia during 2013. Hemijska Industrija. 69(6):651–656.
   Web of Science ®Google Scholar
• Statistical Yearbook of Serbia. 2016. Belgrade: Statistical Office of the Republic of Serbia. ​​​
   Google Scholar
• Stefanović S. 2014. Comparative investigation of aflatoxin B1 presence in feed and aflatoxin M1 presence in milk [Doctoral thesis]. Belgrade: Faculty of veterinary medicine.
   Google Scholar
• Stefanovic S, Spiric D, Petronijevic R, Nedeljkovic Trailovic J, Milicevic D, Nikolic D, Jankovic S. 2015. Comparison of two analytical methods (ELISA and LC-MS/MS) for determination of aflatoxin B1 in corn and aflatoxin M1 in milk. Procedia Food Sci. 5:270–273.
   Google Scholar
• Tankovic S. 2015. The development, validation and comparison of methods for the detection and quantification of aflatoxin M1 residues in milk [Doctoral thesis]. Bosnia and Herzegovina: Faculty of Veterinary Medicine in University of Sarajevo.
   Google Scholar
• Tomašević I, Petrović J, Jovetić M, Raičević S, Milojević M, Miočinović J. 2015. Two-year survey on the occurrence and seasonal variation of aflatoxin M1 in milk and milk products in Serbia. Food Control. 56:64–70.
   Web of Science ®Google Scholar
• Torovic L. 2015. Aflatoxin M1 in processed milk and infant formulae and corresponding exposure of adult population in Serbia in 2013–2014. Food Addit Contam: Part B. 8(4):235–244.
   PubMed Web of Science ®Google Scholar
• Tsakiris IN, Tzatzarakis MN, Alegakis AK, Vlachou M,I, Renieri EA, Tsatsakis AM. 2013. Risk assessment scenarios of children’s exposure to aflatoxin M1 residues in different milk types from the Greek market. Food Chem Toxicol. 56:261–265.
   PubMed Web of Science ®Google Scholar
• Van der Spiegel M, Van der Fels-Klerx HJ, Marvin HJP. 2012. Effects of climate change on food safety hazards in the dairy production chain. Food Res Int. 46:201–208.
   Web of Science ®Google Scholar
• Walte H-G, Schwake-Anduschus C, Geisen R, Fritsche J. 2016. J Consumer Prot Food Saf. 11:295–297. doi:10.1007/s00003-016-1059-8
   Web of Science ®Google Scholar
• [USDA] United States Department of Agriculture. 2014. Gain report number Rb1403. Serbia-Grain and Feed Annual [accessed 2016 Jul 12]. http://gain.fas.usda.gov/Recent%20GAIN%20Publications/Grain%20and%20 Feed%20Annual_Belgrade_Serbia_3-31-2014.pdf.
   Google Scholar
• Williams, J.H., Phillips TD, Jolly PE, Stiles JK, Jolly CM, Aggarwal D. 2004. Human aflatoxicosis in developing countries: areview of toxicology, exposure, potential health onsequences, and interventions. Am J Clin Nutr. 80:1106–1122.
   PubMed Web of Science ®Google Scholar
• [WCRFI] World Cancer Research Fund International/American Institute for Cancer Research. 2015. Continuous update project report: diet, nutrition, physical activity and liver cancer. London. ​​​
   Google Scholar
• Zinedine A, González-Osnaya L, Soriano JM, Moltó JC, Idrissi L, Mañes J. 2007. Presence of aflatoxin M1 in pasteurized milk from Morocco. Int J Food Microbiol. 114:25–29.
   PubMed Web of Science ®Google Scholar