References
- [AOAC] Association of Official Analytical Chemists. 1997. AOAC official method 994.07: ethyl carbamate in alcoholic beverages and soy sauce. In: Official methods of analysis. 17th ed. Gaithersburg (MD): AOAC International; p. 14–15.
- Butzke CE, Bisson LF. 1997. Ethyl carbamate preventative action manual. US Food and Drug Administration. Center for Food Safety and Applied Nutrition.
- Chen D, Ren Y, Zhong Q, Shao Y, Zhao Y, Wu Y. 2017. Ethyl carbamate in alcoholic beverages from China: levels, dietary intake, and risk assessment. Food Control. 72:283–288. doi:https://doi.org/10.1016/j.foodcont.2015.10.047.
- Choi, Jang Y, Koh E. 2018. Determination of ethyl carbamate in soy sauce from Korean market. Food Control. 93:56–60. doi:https://doi.org/10.1016/j.foodcont.2018.05.042.
- Choi, Ryu D, Kim C, Lee J, Choi A, Koh E. 2017. Probabilistic dietary exposure to ethyl carbamate from fermented foods and alcoholic beverages in the Korean population. Food Addit Contam Part A. 34:1885–1892. doi:https://doi.org/10.1080/19440049.2017.1364433.
- [CAC] CODEX Alimentarius Commission. 2001. CXG 37-2001: Harmonized IUPAC guidelines for the use of recovery information in analytical measurement. [accessed 2021 Aug 06]. http://www.fao.org/fao-who-codexalimentarius/committees/committee/related-standards/en/?committee=CCMAS
- Diachenko GW, Canas BJ, Joe FL, DiNovi M. 1992. Ethyl carbamate in alcoholic beverages and fermented foods. 419–428.
- [EFSA] European Food Safety Authority. 2007. Ethyl carbamate and hydrocyanic acid in food and beverages‐scientific opinion of the panel on contaminants. EFSA J. 5:551. doi:https://doi.org/10.2903/j.efsa.2007.551
- [EPA] Environmental Protection Agency. 2005. Guidelines for carcinogen risk assessment. In: Risk assessment forum. Washington, DC: US EPA, 2005.
- Fauhl C, Catsburg R, Wittkowski R, 1993. Determination of ethyl carbamate in soy sauces. Food Chem. 48:313–316.
- [FSA] Food Standards Agency. 2005. Submission to the 64th JECFA meeting: results of the analysis of 100 liquid products and food samples for ethyl carbamate. London: UK FSA.
- [HC] Health Canada, 2020. Health Canada’s maximun levels for chemical contaminants in foods. https://www.canada.ca/en/health-canada/services/food-nutrition/food-safety/chemical-contaminants/maximum-levels-chemical-contaminants-foods.html.
- Huang Z, Pan X-D, Wu P-G, Chen Q, Han J-L, Shen X-H. 2013. Validation (in-house and collaboratory) of the quantification method for ethyl carbamate in alcoholic beverages and soy sauce by GC–MS. Food Chem. 141:4161–4165. doi:https://doi.org/10.1016/j.foodchem.2013.06.128.
- [IARC] International Agency for Research on Cancer. 2007. Alcoholic beverage consumption and ethyl carbamate (urethane). IARC Momographs. 96:1–5.
- [ICH] International Conference on Harmonization. 2005. ICH quality guideline Q2(R1). https://www.ich.org/page/quality-guidelines.
- [JECFA] Joint FAO/WHO Expert Committee on Food Additions. 2006. Joint FAO/WHO expert committee on food additives (2005: rome, Italy) evaluation of certain food contaminants: sixty-fourth report of the joint FAO/WHO expert committee on food additives. WHO Technical Report Series. 930.
- Jung S, Kim S, Kim I, Chung M-S, Moon B, Shin S, Lee J. 2021. Risk assessment of ethyl carbamate in alcoholic beverages in Korea using the margin of exposure approach and cancer risk assessment. Food Control. 124:107867. doi:https://doi.org/10.1016/j.foodcont.2021.107867.
- [KHIDI] Korea Health Industry Development Institute. 2019. Korea National Health and Nutrition Examination Survey (KNHNES). Cheongju: Korea Centers for Disease Control and Prevention.
- Koh E, Kwon H. 2007. Quantification of ethyl carbamate in soy sauce consumed in Korea and estimated daily intakes by age. J Sci Food Agric. 87:98–102. doi:https://doi.org/10.1002/jsfa.2681.
- Lachenmeier DW, Kanteres F, Kuballa T, López MG, Rehm J. 2009. Ethyl carbamate in alcoholic beverages from Mexico (tequila, mezcal, bacanora, sotol) and Guatemala (cuxa): market survey and risk assessment. Int J Environ Res Public Health. 6:349–360. doi:https://doi.org/10.3390/ijerph6010349.
- Lachenmeier DW, Lima MC, Nóbrega IC, Pereira JA, Kerr-Corrêa F, Kanteres F, Rehm J. 2010. Cancer risk assessment of ethyl carbamate in alcoholic beverages from Brazil with special consideration to the spirits cachaça and tiquira. BMC Cancer. 10:1–15. doi:https://doi.org/10.1186/1471-2407-10-266.
- Lachenmeier DW, Przybylski MC, Rehm J. 2012. Comparative risk assessment of carcinogens in alcoholic beverages using the margin of exposure approach. Int J Cancer. 131:E995–E1003. doi:https://doi.org/10.1002/ijc.27553.
- Le Kim Y-K, Koh E, Chung H-J, Kwon H. 2000. Determination of ethyl carbamate in some fermented Korean foods and beverages. Food Addit Contam. 17:469–475. doi:https://doi.org/10.1080/02652030050034055.
- Lee K-G. 2013. Analysis and risk assessment of ethyl carbamate in various fermented foods. Eur Food Res Technol. 236:891–898. doi:https://doi.org/10.1007/s00217-013-1953-6.
- Li G, Zhong Q, Wang D, Gao H. 2017. A survey of ethyl carbamate in beer from Chinese market. Food Control. 79:254–257. doi:https://doi.org/10.1016/j.foodcont.2017.03.039.
- Lim H-S, Lee K-G. 2011. Development and validation of analytical methods for ethyl carbamate in various fermented foods. Food Chem. 126:1373–1379. doi:https://doi.org/10.1016/j.foodchem.2010.11.110.
- Matsudo T, Aoki T, Abe K, Fukuta N, Higuchi T, Sasaki M, Uchida K. 1993. Determination of ethyl carbamate in soy sauce and its possible precursor. J Agric Food Chem. 41:352–356. doi:https://doi.org/10.1021/jf00027a003.
- [MFDS] Ministry of Food and Drug Safety. 2021. Food additives code. https://www.foodsafetykorea.go.kr/foodcode/03_02.jsp?idx=32.
- [MAFRA] Ministry of Agriculture, Food and Rural Affairs, 2020. 2020 Alcoholic beverage market trend report. https://www.atfis.or.kr/article/M001040000/view.do?articleId=3683&boardId=3&page=&searchKey=subject&searchString=&searchCategory.
- Noh I-W, Ha M-S, Han E-M, Jang I-S, An Y-J, Ha S-D, Park S-K, Bae D-H. 2006. Assessment of the human risk by an intake of ethyl carbamate present in major Korean fermented foods. J Microbiol Biotechnol. 16:1961–1967.
- Park S-R, Ha S-D, Yoon J-H, Lee S-Y, Hong K-P, Lee E-H, Yeom H-J, Yoon N-G, Bae D-H. 2009. Exposure to ethyl carbamate in alcohol-drinking and nondrinking adults and its reduction by simple charcoal filtration. Food Control. 20:946–952. doi:https://doi.org/10.1016/j.foodcont.2009.02.006.
- Ryu D, Choi B, Kim N, Koh E. 2016. Validation of analytical methods for ethyl carbamate in nine food matrices. Food Chem. 211:770–775. doi:https://doi.org/10.1016/j.foodchem.2016.05.131.
- Schlatter J, Lutz WK. 1990. The carcinogenic potential of ethyl carbamate (urethane): risk assessment at human dietary exposure levels. Food Chem Toxicol. 28:205–211. doi:https://doi.org/10.1016/0278-6915(90)90008-B.
- Stevens D, Ough C. 1993. Ethyl carbamate formation: reaction of urea and citrulline with ethanol in wine under low to normal temperature conditions. Am J Enol Vitic. 44:309–312.
- Sulaiman J, Gan HM, Yin W-F, Chan K-G. 2014. Microbial succession and the functional potential during the fermentation of Chinese soy sauce brine. Front Microbiol. 5:556. doi:https://doi.org/10.3389/fmicb.2014.00556.
- Tang A, Chung S, Kwong K, Xiao Y, Chen M, Ho Y, Ma S. 2011. Ethyl carbamate in fermented foods and beverages: dietary exposure of the Hong Kong population in 2007–2008. Food Addit Contam Part B. 4:195–204. doi:https://doi.org/10.1080/19393210.2011.605524.
- Wu P, Pan X, Wang L, Shen X, Yang D. 2012. A survey of ethyl carbamate in fermented foods and beverages from Zhejiang, China. Food Control. 23:286–288. doi:https://doi.org/10.1016/j.foodcont.2011.07.014.
- Zhang J, Fang F, Chen J, Du G. 2014. The arginine deiminase pathway of koji bacteria is involved in ethyl carbamate precursor production in soy sauce. FEMS Microbiol Lett. 358:91–97. doi:https://doi.org/10.1111/1574-6968.12542.
- Zhao, Du G, Zou H, Fu J, Zhou J, Chen J. 2013. Progress in preventing the accumulation of ethyl carbamate in alcoholic beverages. Trends Food Sci Technol. 32:97–107. doi:https://doi.org/10.1016/j.tifs.2013.05.009.
- Zimmerli B, Schlatter J. 1991. Ethyl carbamate: analytical methodology, occurrence, formation, biological activity and risk assessment. Mutat Res Genet Toxicol Environ Mutagen. 259:325–350. doi:https://doi.org/10.1016/0165-1218(91)90126-7.