313
Views
0
CrossRef citations to date
0
Altmetric
Articles

Validation of a LC-MS/MS method for the quantitative analysis of four antibiotics in pig tissues and plasma to assess the risk of transfer of residues to edible matrices after exposure to cross-contaminated feed

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, , & ORCID Icon show all
Pages 1818-1827 | Received 30 Jun 2022, Accepted 13 Sep 2022, Published online: 04 Oct 2022

References

  • French Agency for Food, Environmental and Occupational Health & Safety (Anses), French Agency for Veterinary Medicinal Products (ANMV), Urban D, Chevance A, Moulin G. 2019. Sales survey of veterinary medicinal products containing antimicrobials in France in 2018.
  • Barbosa Da Silva A, Back M, Daguer H, Palmeira M, Antunes De S, Ploencio L, Molognoni L, Peripolli V, Bianchi I. 2019. Carry-over and contamination of veterinary drugs in feed production lines for poultry and pigs. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 36(5):740–751. doi:10.1080/19440049.2019.1585580
  • Borràs S, Companyó R, Granados M, Guiteras J, Pérez-Vendrell AM, Brufau J, Medina M, Bosch J. 2011. Analysis of antimicrobial agents in animal feed. Trends Anal Chem. 30(7):1042–1064. doi:10.1016/j.trac.2011.02.012
  • [EC] European Commission. 2002. Commission Decision of 12 August 2002 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. Off J Eur Commun. L221:8–36.
  • [EC] European Commission. 2003. Regulation (EC) No 1831/2003 of the European Parliament and f the Council of 22 September 2003 on additives for use in animal nutrition. Off J Eur Union. L268:29–43.
  • [EC] European Commission. 2018. European Commission. 2018. Regulation (EU) 2019/4 of the European Parliament and of the Council of 11 December 2018 on the manufacture, placing on the market and use of medicated feed, amending Regulation (EC) No 183/2005 of the European Parliament and of the Council and repealing Council Directive 90/167/EEC. Off J Eur Union. L4:1–23.
  • French Ministry of Agriculture and Fisheries. 2007. Décision du 12 février 2007 relative aux bonnes pratiques de fabrication et de distribution en gros des aliments médicamenteux. J Off Républ Franç. 20.
  • Gaugain M, Fourmond MP, Fuselier R, Verdon E, Roudaut B, Pessel D. 2020. Control of antimicrobials in feed using liquid chromatography-tandem mass spectrometry: assessment of cross-contamination rates at the farm level. J Agric Food Chem. 68(34):9033–9042. doi:10.1021/acs.jafc.0c02999
  • Gullberg E, Cao S, Berg OG, Ilback C, Sandegren L, Hughes D, Andersson DI. 2011. Selection of resistant bacteria at very low antibiotic concentrations. PLoS Pathog. 7(7):e1002158. doi:10.1371/journal.ppat.1002158
  • Hazards EPoB, Koutsoumanis K, Allende A, Alvarez-Ordóñez A, Bolton D, Bover-Cid S, Chemaly M, Davies R, De Cesare A, Herman L, et al. 2021. Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 1: Methodology, general data gaps and uncertainties. EFSA J. 19(10):e06852. doi:10.2903/j.efsa.2021.6852
  • Holman DB, Chénier MR. 2013. Impact of subtherapeutic administration of tylosin and chlortetracycline on antimicrobial resistance in farrow-to-finish swine. FEMS Microbiol Ecol. 85(1):1–13. doi:10.1111/1574-6941.12093
  • Hubert P, Nguyen-Huu JJ, Boulanger B, Chapuzet E, Chiap P, Cohen N, Compagnon PA, Dewé W, Feinberg M, Lallier M, et al. 2007. Harmonization of strategies for the validation of quantitative analytical procedures: a SFSTP proposal – Part II. J Pharm Biomed Anal. 45(1):70–81. doi:10.1016/j.jpba.2007.06.013
  • Leeman WR, Van Den Berg KJ, Houben GF. 2007. Transfer of chemicals from feed to animal products: the use of transfer factors in risk assessment. Food Addit Contam. 24(1):1–13. doi:10.1080/02652030600815512
  • McEvoy JDG. 2002. Contamination of animal feedingstuffs as a cause of residues in food: a review of regulatory aspects, incidence and control. Anal Chim Acta. 473(1–2):3–26. doi:10.1016/S0003-2670(02)00751-1
  • Mevius DJ, Vellenga L, Breukink HJ, Nouws JF, Vree TB, Driessens F. 1986. Pharmacokinetics and renal clearance of oxytetracycline in piglets following intravenous and oral administration. Vet Q. 8(4):274–284. doi:10.1080/01652176.1986.9694056
  • Nielsen P, Gyrd-Hansen N. 1996. Bioavailability of oxytetracycline, tetracycline and chlortetracycline after oral administration to fed and fasted pigs. J Vet Pharmacol Ther. 19(4):305–311. doi:10.1111/j.1365-2885.1996.tb00054.x
  • Peeters LE, Daeseleire E, Devreese M, Rasschaert G, Smet A, Dewulf J, Heyndrickx M, Imberechts H, Haesebrouck F, Butaye P, et al. 2016. Residues of chlortetracycline, doxycycline and sulfadiazine-trimethoprim in intestinal content and feces of pigs due to cross-contamination of feed. BMC Vet Res. 12(1):209. doi:10.1186/s12917-016-0803-8
  • Peeters LEJ, Croubels S, Rasschaert G, Imberechts H, Daeseleire E, Dewulf J, Heyndrickx M, Butaye P, Haesebrouck F, Smet A. 2018. Effect of residual doxycycline concentrations on resistance selection and transfer in porcine commensal Escherichia coli. Int J Antimicrob Agents. 51(1):123–127. doi:10.1016/j.ijantimicag.2017.04.018
  • Przeniosło-Siwczyńska M, Patyra E, Grelik A, Chyłek-Purchała M, Kozak B, Kwiatek K. 2020. Contamination of animal feed with undeclared tetracyclines-confirmatory analysis by liquid chromatography-mass spectrometry after microbiological plate test. Molecules (Basel, Switzerland). 25(9):2162. doi:10.3390/molecules25092162
  • Robert C, Brasseur PY, Dubois M, Delahaut P, Gillard N. 2016. Development and validation of rapid multiresidue and multi-class analysis for antibiotics and anthelmintics in feed by ultra-high-performance liquid chromatography coupled to tandem mass spectrometry. Food Addit Contam Part A. 33(8):1–12. doi:10.1080/19440049.2016.1207808
  • Rozet E, Wascotte V, Lecouturier N, Préat V, Dewé W, Boulanger B, Hubert P. 2007. Improvement of the decision efficiency of the accuracy profile by means of a desirability function for analytical methods validation: Application to a diacetyl-monoxime colorimetric assay used for the determination of urea in transdermal iontophoretic extracts. Anal Chim Acta. 591(2):239–247. doi:10.1016/j.aca.2007.04.002
  • Sandegren L. 2014. Selection of antibiotic resistance at very low antibiotic concentrations. UPS J Med Sci. 119(2):103–107. doi:10.3109/03009734.2014.904457
  • Segato G, Benetti C, Angeletti R, Montesissa C, Biancotto G. 2011. Doxycycline and sulfadimethoxine transfer from cross-contaminated feed to chicken tissues. Food Addit Contam Part A. 28(7):860–868. doi:10.1080/19440049.2011.569574
  • Stolker AA, Manti V, Zuidema T, van Egmond H, Deckers ER, Herbes R, Hooglugt J, Olde Heuvel E, de Jong J. 2013. Carry-over of veterinary drugs from medicated to non-medicated feeds in commercial feed manufacturing plants. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 30(6):1100–1107. doi:10.1080/19440049.2013.794308

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.