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Articles

Development of an LC-MS/MS method for the determination of multiple mycotoxins in human urine

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Pages 917-927 | Received 03 Mar 2023, Accepted 30 May 2023, Published online: 14 Jun 2023

References

  • Al-Jaal BA, Jaganjac M, Barcaru A, Horvatovich P, Latiff A. 2019. Aflatoxin, fumonisin, ochratoxin, zearalenone and deoxynivalenol biomarkers in human biological fluids: a systematic literature review, 2001-2018. Food Chem Toxicol. 129:211–228. doi: 10.1016/j.fct.2019.04.047.
  • Ali N, Blaszkewicz M, Degen GH. 2016. Assessment of deoxynivalenol exposure among Bangladeshi and German adults by a biomarker-based approach. Toxicol Lett. 258:20–28. doi: 10.1016/j.toxlet.2016.06.006.
  • Ali N, Degen GH. 2018. Urinary biomarkers of exposure to the mycoestrogen zearalenone and its modified forms in German adults. Arch Toxicol. 92(8):2691–2700. doi: 10.1007/s00204-018-2261-5.
  • Ali N, Degen GH. 2019. Biomonitoring of zearalenone and its main metabolites in urines of Bangladeshi adults. Food Chem Toxicol. 130:276–283. doi: 10.1016/j.fct.2019.05.036.
  • Benkerroum N. 2020. Aflatoxins: producing-molds, structure, health issues and incidence in Southeast Asian and Sub-Saharan African countries. IJERPH. 17(4):1215. doi: 10.3390/ijerph17041215.
  • Berg T, Kaur L, Risnes A, Havig SM, Karinen R. 2016. Determination of a selection of synthetic cannabinoids and metabolites in urine by UHPSFC-MS/MS and by UHPLC-MS/MS. Drug Test Anal. 8(7):708–722. doi: 10.1002/dta.1844.
  • Cao X, Li X, Li J, Niu Y, Shi L, Fang Z, Zhang T, Ding H. 2018. Quantitative determination of carcinogenic mycotoxins in human and animal biological matrices and animal-derived foods using multi-mycotoxin and analyte-specific high performance liquid chromatography-tandem mass spectrometric methods. J Chromatogr B Analyt Technol Biomed Life Sci. 1073:191–200. doi: 10.1016/j.jchromb.2017.10.006.
  • Carballo D, Pallarés N, Ferrer E, Barba FJ, Berrada H. 2021. Assessment of human exposure to deoxynivalenol, ochratoxin A, zearalenone and their metabolites biomarker in urine samples using LC-ESI-qTOF. Toxins. 13(8):530. doi: 10.3390/toxins13080530.
  • Dasí-Navarro N, Lozano M, Llop S, Esplugues A, Cimbalo A, Font G, Manyes L, Mañes J, Vila-Donat P. 2022. Development and validation of LC-Q-TOF-MS methodology to determine mycotoxin biomarkers in human urine. Toxins. 14(10):651. doi: 10.3390/toxins14100651.
  • De Baere S, Osselaere A, Devreese M, Vanhaecke L, De Backer P, Croubels S. 2012. Development of a liquid-chromatography tandem mass spectrometry and ultra-high-performance liquid chromatography high-resolution mass spectrometry method for the quantitative determination of zearalenone and its major metabolites in chicken and pig plasma. Anal Chim Acta. 756:37–48. doi: 10.1016/j.aca.2012.10.027.
  • Demaegdt H, Daminet B, Evrard A, Scippo ML, Muller M, Pussemier L, Callebaut A, Vandermeiren K. 2016. Endocrine activity of mycotoxins and mycotoxin mixtures. Food Chem Toxicol. 96:107–116. doi: 10.1016/j.fct.2016.07.033.
  • Deng C, Li C, Zhou S, Wang X, Xu H, Wang D, Gong YY, Routledge MN, Zhao Y, Wu Y. 2018. Risk assessment of deoxynivalenol in high-risk area of China by human biomonitoring using an improved high throughput UPLC-MS/MS method. Sci Rep. 8(1):3901. doi: 10.1038/s41598-018-22206-y.
  • Ediage EN, Di Mavungu JD, Song S, Wu A, Van Peteghem C, De Saeger S. 2012. A direct assessment of mycotoxin biomarkers in human urine samples by liquid chromatography tandem mass spectrometry. Anal Chim Acta. 741:58–69. doi: 10.1016/j.aca.2012.06.038.
  • Escrivá L, Font G, Manyes L, Berrada H. 2017. Studies on the presence of mycotoxins in biological samples: an overview. Toxins. 9(8):251. doi: 10.1016/j.aca.2012.06.038.
  • Escrivá L, Manyes L, Font G, Berrada H. 2017. Mycotoxin analysis of human urine by LC-MS/MS: a comparative extraction study. Toxins. 9(10):330. doi: 10.3390/toxins9080251.
  • Fan K, Xu J, Jiang K, Liu X, Meng J, Di Mavungu JD, Guo W, Zhang Z, Jing J, Li H, et al. 2019. Determination of multiple mycotoxins in paired plasma and urine samples to assess human exposure in Nanjing, China. Environ Pollut. 248:865–873. doi: 10.1016/j.envpol.2019.02.091.
  • Foerster C, Ríos-Gajardo G, Gómez P, Muñoz K, Cortés S, Maldonado C, Ferreccio C. 2021. Assessment of mycotoxin exposure in a rural county of Chile by urinary biomarker determination. Toxins. 13(7):439. doi: 10.3390/toxins13070439.
  • Food and Drug Administration. 2018. Bioanalytical method validation guidance for industry. [updated 2022; accessed]. https://www.fda.gov/files/drugs/published/Bioanalytical-Method-Validation-Guidance-for-Industry.pdf.
  • Fromme H, Gareis M, Völkel W, Gottschalk C. 2016. Overall internal exposure to mycotoxins and their occurrence in occupational and residential settings–an overview. Int J Hyg Environ Health. 219(2):143–165. doi: 10.1016/j.ijheh.2015.11.004.
  • Gerding J, Ali N, Schwartzbord J, Cramer B, Brown DL, Degen GH, Humpf HU. 2015. A comparative study of the human urinary mycotoxin excretion patterns in Bangladesh, Germany, and Haiti using a rapid and sensitive LC-MS/MS approach. Mycotoxin Res. 31(3):127–136. doi: 10.1007/s12550-015-0223-9.
  • Gratz SW, Richardson AJ, Duncan G, Holtrop G. 2014. Annual variation of dietary deoxynivalenol exposure during years of different Fusarium prevalence: a pilot biomonitoring study. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 31(9):1579–1585. doi: 10.1080/19440049.2014.937772.
  • Huang Q, Jiang K, Tang Z, Fan K, Meng J, Nie D, Zhao Z, Wu Y, Han Z. 2021. Exposure assessment of multiple mycotoxins and cumulative health risk assessment: a biomonitoring-based study in the Yangtze River Delta, China. Toxins. 13(2):103. doi: 10.3390/toxins13020103.
  • Kai F, Fang J, JianHong X, MingRong Q, JinSheng D, DongXia N, ZhanMin T, ZhiHui Z, JianRong S, Zheng H. 2021. Natural occurrence and characteristic analysis of 40 mycotoxins in agro-products from Yangtze Delta region. Scientia Agricultura Sinica. 54(13):2870–2884. doi: 10.3864/j.issn.0578-1752.2021.13.015.
  • Kyei NNA, Cramer B, Humpf H-U, Degen GH, Ali N, Gabrysch S. 2022. Assessment of multiple mycotoxin exposure and its association with food consumption: a human biomonitoring study in a pregnant cohort in rural Bangladesh. Arch Toxicol. 96(7):2123–2138. doi: 10.1007/s00204-022-03288-0.
  • Lauwers M, De Baere S, Letor B, Rychlik M, Croubels S, Devreese M. 2019. Multi LC-MS/MS and LC-HRMS Methods for Determination of 24 Mycotoxins including Major Phase I and II Biomarker Metabolites in Biological Matrices from Pigs and Broiler Chickens. Toxins. 11(3):171. doi: 10.3390/toxins11030171.
  • Li C, Deng C, Zhou S, Zhao Y, Wang D, Wang X, Gong YY, Wu Y. 2018. High-throughput and sensitive determination of urinary zearalenone and metabolites by UPLC-MS/MS and its application to a human exposure study. Anal Bioanal Chem. 410(21):5301–5312. doi: 10.1007/s00216-018-1186-4.
  • Liu Z, Zhao X, Wu L, Zhou S, Gong Z, Zhao Y, Wu Y. 2020. Development of a sensitive and reliable UHPLC-MS/MS method for the determination of multiple urinary biomarkers of mycotoxin exposure. Toxins. 12(3):193. doi: 10.3390/toxins12030193.
  • Martins C, Vidal A, De Boevre M, De Saeger S, Nunes C, Torres D, Goios A, Lopes C, Assunção R, Alvito P. 2019. Exposure assessment of Portuguese population to multiple mycotoxins: the human biomonitoring approach. Int J Hyg Environ Health. 222(6):913–925. doi: 10.1016/j.ijheh.2019.06.010.
  • Matuszewski BK, Constanzer ML, Chavez-Eng CM. 2003. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC − MS/MS. Anal Chem. 75(13):3019–3030. doi: 10.1021/ac020361s.
  • Ndossi DG, Frizzell C, Tremoen NH, Fæste CK, Verhaegen S, Dahl E, Eriksen GS, Sørlie M, Connolly L, Ropstad E. 2012. An in vitro investigation of endocrine disrupting effects of trichothecenes deoxynivalenol (DON), T-2 and HT-2 toxins. Toxicol Lett. 214(3):268–278. doi: 10.1016/j.toxlet.2012.09.005.
  • Pallarés N, Carballo D, Ferrer E, Rodríguez-Carrasco Y, Berrada H. 2022. High-throughput determination of major mycotoxins with human health concerns in urine by LC-Q TOF MS and its application to an exposure study. Toxins. 14(1):42. doi: 10.3390/toxins14010042.
  • Peters FT, Drummer OH, Musshoff F. 2007. Validation of new methods. Forensic Sci Int. 165(2–3):216–224. doi: 10.1016/j.forsciint.2006.05.021.
  • Schmidt J, Lindemann V, Olsen M, Cramer B, Humpf HU. 2021. Dried urine spots as sampling technique for multi-mycotoxin analysis in human urine. Mycotoxin Res. 37(2):129–140. doi: 10.1007/s12550-021-00423-1.
  • Slobodchikova I, Vuckovic D. 2018. Liquid chromatography–high resolution mass spectrometry method for monitoring of 17 mycotoxins in human plasma for exposure studies. J Chromatogr A. 1548:51–63. doi: 10.1016/j.chroma.2018.03.030.
  • Solfrizzo M, Gambacorta L, Lattanzio VM, Powers S, Visconti A. 2011. Simultaneous LC-MS/MS determination of aflatoxin M1, ochratoxin A, deoxynivalenol, de-epoxydeoxynivalenol, α and β-zearalenols and fumonisin B1 in urine as a multi-biomarker method to assess exposure to mycotoxins. Anal Bioanal Chem. 401(9):2831–2841. doi: 10.1007/s00216-011-5354-z.
  • Tkaczyk A, Jedziniak P. 2021. Development of a multi-mycotoxin LC-MS/MS method for the determination of biomarkers in pig urine. Mycotoxin Res. 37(2):169–181. doi: 10.1007/s12550-021-00428-w.
  • Tolosa J, Font G, Mañes J, Ferrer E. 2016. Multimycotoxin analysis in water and fish plasma by liquid chromatography-tandem mass spectrometry. Chemosphere. 145:402–408. doi: 10.1016/j.chemosphere.2015.11.085.
  • Turner PC, White KL, Burley VJ, Hopton RP, Rajendram A, Fisher J, Cade JE, Wild CP. 2010. A comparison of deoxynivalenol intake and urinary deoxynivalenol in UK adults. Biomarkers. 15(6):553–562. doi: 10.3109/1354750X.2010.495787.
  • Wallin S, Gambacorta L, Kotova N, Lemming EW, Nälsén C, Solfrizzo M, Olsen M. 2015. Biomonitoring of concurrent mycotoxin exposure among adults in Sweden through urinary multi-biomarker analysis. Food Chem Toxicol. 83:133–139. doi: 10.1016/j.fct.2015.05.023.
  • Wang X, Liang J, Cao P, Zhou S, Wu A, Gao P, Xu H, Liu Z, Gong Y. 2019. Biomonitoring study of deoxynivalenol exposure in Chinese inhabitants. Int J Environ Rescher Public Health. 16(12): 2169. doi: 10.3390/ijerph16122169.
  • Wang X, Yang D, Qin M, Xu H, Zhang L, Zhang L. 2020. Risk assessment and spatial analysis of deoxynivalenol exposure in Chinese population. Mycotoxin Res. 36(4):419–427. doi: 10.1007/s12550-020-00406-8.
  • Wang XD, Yang X, Xu HB, Cao P, Gao P, Liang J. 2019. Exposure status and health risk assessment of deoxynivalenol from cereals in Chinese population in different regions. Chinese J Prevent Med. 53(4):394–397. doi: 10.3760/cma.j.issn.0253-9624.2019.04.012.
  • Warth B, Sulyok M, Berthiller F, Schuhmacher R, Krska R. 2013. New insights into the human metabolism of the Fusarium mycotoxins deoxynivalenol and zearalenone. Toxicol Lett. 220(1):88–94. doi: 10.1016/j.toxlet.2013.04.012.
  • Xia L, Routledge MN, Rasheed H, Ismail A, Dong Y, Jiang T, Gong YY. 2020. Biomonitoring of aflatoxin B(1) and deoxynivalenol in a rural Pakistan population using ultra-sensitive LC-MS/MS method. Toxins. 12(9):591. doi: 10.3390/toxins12090591.
  • Xinyuan C, Fei D, Linli Z, Deliang W, Shufang W, Jianhong X, Guizhen M, Jianrong S. 2021. Contamination pattern of Fusarium toxins in cereals in Sichuan Province. J Sichuan Agric Univ. 39(02):141–148 + 172. doi: 10.16036/j.issn.1000-2650.2021.02.002.
  • Zhou H, Xu A, Liu M, Yan Z, Qin L, Liu H, Wu A, Liu N. 2022. Mycotoxins in wheat flours marketed in Shanghai, China: occurrence and dietary risk assessment. Toxins. 14(11):748. doi: 10.3390/toxins14110748.
  • Zinedine A, Soriano JM, Moltó JC, Mañes J. 2007. Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin. Food Chem Toxicol. 45(1):1–18. doi: 10.1016/j.fct.2006.07.030.

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