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Articles

Levamisole incorporation in fish feed – Ensuring the medication dose and avoidance of leaching into the water

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Pages 1551-1567 | Received 20 Sep 2023, Accepted 10 Nov 2023, Published online: 21 Nov 2023

References

  • Amelin V, Korotkov A, Andoralov A. 2016. Identification and determination of 492 contaminants of different classes in food and feed by high-resolution mass spectrometry using the standard addition method. J AOAC Int. 99(6):1600–1618. doi: 10.5740/jaoacint.16-0069.
  • Anumol T, Lehotay SJ, Stevens J, Zweigenbaum J. 2017. Comparison of veterinary drug residue results in animal tissues by ultrahigh-performance liquid chromatography coupled to triple quadrupole or quadrupole–time-of-flight tandem mass spectrometry after different sample preparation methods, including use of a commercial lipid removal product. Anal Bioanal Chem. 409(10):2639–2653. doi: 10.1007/s00216-017-0208-y.
  • Atta AH, Atta SA, Nasr SM, Mouneir SM. 2022. Current perspective on veterinary drug and chemical residues in food of animal origin. Environ Sci Pollut Res Int. 29(11):15282–15302. doi: 10.1007/s11356-021-18239-y.
  • Azevedo PFO, Martins MA, Blank M, Cardoso L, Bertaglia E de A, Lisboa TR, Jerônimo GT, Furtado WE, Martins ML. 2021. Dietary supplementation of levamisole modulates protein and lipid MALDI-TOF MS profiles of Nile tilapia without causing negative histological alterations. Aquaculture. 533:736177. doi: 10.1016/j.aquaculture.2020.736177.
  • Bader C, Starling DE, Jones DE, Brewer MT. 2019. Use of praziquantel to control platyhelminth parasites of fish. J Vet Pharmacol Ther. 42(2):139–153. doi: 10.1111/jvp.12735.
  • Baralla E, Varoni MV, Nieddu M, Demontis MP, Merella P, Burreddu C, Garippa G, Boatto G. 2020. Determination of praziquantel in Sparus aurata L. After administration of medicated animal feed. Animals (Basel). 10(3):528. doi: 10.3390/ani10030528.
  • Barreto FM, da Silva MR, Braga PAC, Bragotto APA, Hisano H, Reyes FGR. 2018. Evaluation of the leaching of florfenicol from coated medicated fish feed into water. Environ Pollut. 242(Pt B):1245–1252. doi: 10.1016/j.envpol.2018.08.017.
  • Biller-Takahashi JD, Montassier HJ, Takahashi LS, Urbinati EC. 2016. Levamisole promotes an adjuvant effect on the immunity of pacu (Piaractus mesopotamicus) when immunized with Aeromonas hydrophila, even when provided in the diet. Anim Feed Sci Technol. 211:164–173. doi: 10.1016/j.anifeedsci.2015.11.008.
  • Brazil, Ministério da Agricultura, Pecuária e Abastecimento. 2011. Coordenação-Geral de Apoio Laboratorial (CGAL) da Secretaria de Defesa Agropecuária (SDA) do Ministério da Agricultura, Pecuária e Abastecimento (MAPA). 2011. Guia de validação e controle de qualidade: fármacos em produtos para alimentação animal e medicamentos veterinários. Brasília: MAPA/ACS. https://www.gov.br/agricultura/pt-br/assuntos/lfda/arquivos-publicacoes-laboratorio/guia-de-validacao-controle-de-qualidade-analitica.pdf.
  • Brazil, Agência Nacional de Vigilância Sanitária. 2017. Resolução da Diretoria Colegiada RDC n° 166, de 24 de julho de 2017. Guia para Validação de Métodos Analíticos. Dispõe sobre a validação de métodos analíticos e dá outras providências. Diário oficial da união. Edição 141, seção 1, p. 87. http://antigo.anvisa.gov.br/documents/10181/2721567/RDC_166_2017_COMP.pdf/d5fb92b3-6c6b-4130-8670-4e3263763401.
  • Busatto Z, da Silva AFB, de Freitas O, Paschoal JAR. 2017. LC-MS/MS methods for albendazole analysis in feed and its metabolite residues in fish fillet and a leaching study in feed after an alternative procedure for drug incorporation. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 34(4):509–519. doi: 10.1080/19440049.2016.1272008.
  • Busatto Z, de França WG, Cyrino JEP, Paschoal JAR. 2018. Assessment of elimination profile of albendazole residues in fish. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 35(1):77–85. doi: 10.1080/19440049.2017.1400186.
  • Cao D, Li Q, Sun X, Wang Y, Zhao X, Cakmak E, Liang W, Anderson A, Ozcan S, Zhu H. 2021. Amphipathic binder integrating ultrathin and highly ion-conductive sulfide membrane for cell-level high-energy-density all-solid-state batteries. Adv Mater. 33(52):e2105505. doi: 10.1002/adma.202105505.
  • Castilla-Fernández D, Moreno-González D, Beneito-Cambra M, Molina-Díaz A. 2019. Critical assessment of two sample treatment methods for multiresidue determination of veterinary drugs in milk by UHPLC-MS/MS. Anal Bioanal Chem. 411(7):1433–1442. doi: 10.1007/s00216-019-01582-y.
  • Chang SH, Lai YH, Huang CN, Peng GJ, Liao CD, Kao YM, Tseng SH, Wang DY. 2019. Multi-residue analysis using liquid chromatography-tandem mass spectrometry for detection of 20 coccidiostats in poultry, livestock, and aquatic tissues. J Food Drug Anal. 27(3):703–716. doi: 10.1016/j.jfda.2019.02.004.
  • European Commission. 2021. Commission Implementing Regulation (EU) 2021/808 of 22 March 2021 on the performance of analytical methods for residues of pharmacologically active substances used in food-producing animals and on the interpretation of results as well as on the methods to be used for sampling and repealing decisions 2002/657/EC and 98/179/EC. Off J Eur Union. 180:84–109. https://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32021R0808&rid=10.
  • Cordeiro RP, Braga PAC, Rocha MJS, Chagas EC, Reyes FG. 2021. Depletion study and estimation of the withdrawal period for albendazole in tambaqui (Colossoma macropomum) parasitised by acanthocephalan (Neoechinorhynchus buttnerae) treated with albendazole-containing feed. Food Addit Contam Part A. 38(11):1883–1896. doi: 10.1080/19440049.2021.1954700.
  • Cortese M, Gigliobianco MR, Magnoni F, Censi R, Di Martino P. 2020. Compensate for or minimize matrix effects? Strategies for overcoming matrix effects in liquid chromatography-mass spectrometry technique: a tutorial review. Molecules. 25(13):3047. doi: 10.3390/molecules25133047.
  • Cuesta A, Esteban MA, Meseguer J. 2002. Levamisole is a potent enhancer of gilthead seabream natural cytotoxic activity. Vet Immunol Immunopathol. 89(3–4):169–174. doi: 10.1016/S0165-2427(02)00220-9.
  • Davis A, Sharp J. 2020. Rethinking One Health: emergent human, animal and environmental assemblages. Soc Sci Med. 258(2020):113093. doi: 10.1016/j.socscimed.2020.113093.
  • Economou A, Botitsi H, Antoniou S, Tsipi D. 2009. Determination of multi-class pesticides in wines by solid-phase extraction and liquid chromatography-tandem mass spectrometry. J Chromatogr A. 1216(31):5856–5867. doi: 10.1016/j.chroma.2009.06.031.
  • Fais AP, Franco RSB, da Silva AFB, de Freitas O, Paschoal JAR. 2017. LC-MS/MS methods for sulfadimethoxine and ormetoprim analysis in feed and fish fillet and a leaching study for feed after alternative procedures for the incorporation of drugs. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 34(4):501–508. doi: 10.1080/19440049.2016.1267875.
  • Feitoza da Silva A, Pahor Filho E, Gonçalves LU, Silva TFA, Urbinati EC. 2021. Levamisole modulates cortisol and innate immunity responses in tambaqui (Colossoma macropomum) parasitized with Neoechinorhynchus buttnerae. Aquac Res. 52(11):5920–5924. doi: 10.1111/are.15442.
  • Fiorentin TR, Fogarty M, Limberger RP, Logan BK. 2019. Determination of cutting agents in seized cocaine samples using GC–MS, GC–TMS and LC–MS/MS. Forensic Sci Int. 295:199–206. doi: 10.1016/j.forsciint.2018.12.016.
  • Fraccarolli Neto P, da Silva AFB, Moro EB, Pilarski F, de Freitas O, Mooney MH, Paschoal JAR. 2019. Emamectin benzoate in tilapia: alternative method for drug incorporation into feed and associated residual depletion study. Food Res Int. 119:524–529. doi: 10.1016/j.foodres.2019.01.033.
  • Fu Q, Meyer C, Patrick M, Kosfeld V, Rüdel H, Koschorreck J, Hollender J. 2022. Comprehensive screening of polar emerging organic contaminants including PFASs and evaluation of the trophic transfer behavior in a freshwater food web. Water Res. 218(2022):118514. doi: 10.1016/j.watres.2022.118514.
  • Gao P, Zhang P, Guo Y, He Z, Dong Y, Tang Y, Guan F, Zhang T, Xie K. 2021. Determination of levamisole and mebendazole and its two metabolite residues in three poultry species by HPLC-MS/MS. Foods. 10(11):2841. doi: 10.3390/foods10112841.
  • Girmatsion M, Mahmud A, Abraha B, Xie Y, Cheng Y, Yu H, Yao W, Guo Y, Qian H. 2021. Rapid detection of antibiotic residues in animal products using surface-enhanced Raman Spectroscopy: a review. Food Control. 126:108019. doi: 10.1016/j.foodcont.2021.108019.
  • Guardone L, Tinacci L, Armani A, Trevisani M. 2022. Residues of veterinary drugs in fish and fish products: an analysis of RASFF data over the last 20 years. Food Control. 135(2022):108780. doi: 10.1016/j.foodcont.2021.108780.
  • Guidi LR, Santos FA, Ribeiro ACSR, Fernandes C, Silva LHM, Gloria MBA. 2018. Quinolones and tetracyclines in aquaculture fish by a simple and rapid LC-MS/MS method. Food Chem. 245:1232–1238. doi: 10.1016/j.foodchem.2017.11.094.
  • Guidi LR, Tette PAS, Gloria MBA, Fernandes C. 2018. A simple and rapid LC–MS/MS method for the determination of amphenicols in Nile tilapia. Food Chem. 262:235–241. doi: 10.1016/j.foodchem.2018.04.087.
  • Gutiérrez E, Lozano S, Guillén J. 2020. Efficiency data analysis in EU aquaculture production. Aquaculture. 520:734962. doi: 10.1016/j.aquaculture.2020.734962.
  • Hashimoto JC, Paschoal JAR, de Queiroz JF, Reyes FGR. 2011. Considerations on the use of malachite green in aquaculture and analytical aspects of determining the residues in fish: a review. J Aquat Food Prod. 20(3):273–294. doi: 10.1080/10498850.2011.569643.
  • Hossain A, Habibullah-Al-Mamun M, Nagano I, Masunaga S, Kitazawa D, Matsuda H. 2022. Antibiotics, antibiotic-resistant bacteria, and resistance genes in aquaculture: risks, current concern, and future thinking. Environ Sci Pollut Res Int. 29(8):11054–11075. doi: 10.1007/s11356-021-17825-4.
  • Julinta RB, Abraham TJ, Roy A, Singha J, Bardhan A, Sar TK, Patil PK, Kumar KA. 2020. Safety of emamectin benzoate administered in feed to Nile tilapia Oreochromis niloticus (L.). Environ Toxicol Pharmacol. 75:103348. doi: 10.1016/j.etap.2020.103348.
  • Kafeenah HIS, Osman R, Bakar NKA. 2019. Effect of mobile phase pH on the electrospray ionization efficiency and qualitative analysis of pharmaceuticals in ESI + LC-MS/MS. J Chromatogr Sci. 57(9):847–854. doi: 10.1093/chromsci/bmz061.
  • Kang J, Fan CL, Chang QY, Bu MN, Zhao ZY, Wang W, Pang GF. 2014. Simultaneous determination of multi-class veterinary drug residues in different muscle tissues by modified QuEChERS combined with HPLC-MS/MS. Anal Methods. 6(16):6285–6293. doi: 10.1039/C4AY00589A.
  • Kim J, Suh JH, Cho HD, Kang W, Choi YS, Han SB. 2016. Analytical method for fast screening and confirmation of multi-class veterinary drug residues in fish and shrimp by LC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 33(3):420–432. doi: 10.1080/19440049.2016.1139752.
  • Liu C, Huang J, Zheng X, Liu S, Lu K, Tang K, Liu J. 2020. Heat sealable soluble soybean polysaccharide/gelatin blend edible films for food packaging applications. Food Packag Shelf Life. 24:100485. doi: 10.1016/j.fpsl.2020.100485.
  • Liu Y, Deng L, Zhang C, Chen K, Feng F, Zhang H. 2018. Comparison of ethyl cellulose–gelatin composite films fabricated by electrospinning versus solvent casting. J Appl Poly Sci. 135(46):46824. doi: 10.1002/app.46824.
  • Luo Q, Hossen MA, Zeng Y, Dai J, Li S, Qin W, Liu Y. 2022. Gelatin-based composite films and their application in food packaging: a review. J Food Eng. 313:110762. doi: 10.1016/j.jfoodeng.2021.110762.
  • Mahotra M, Yu H, Xu Q, Liew WC, Kharel S, Tan LSE, Loo SCJ. 2022. Solid Lipid Microparticles as leaching free, slow-release encapsulation system for Methionine in aquaculture. Aquaculture. 557:738342. doi: 10.1016/j.aquaculture.2022.738342.
  • Marques TV, Paschoal JAR, Barone RSC, Cyrino JEP, Rath S. 2018. Depletion study and estimation of withdrawal periods for florfenicol and florfenicol amine in pacu (Piaractus mesopotamicus). Aquac Res. 49(1):111–119. doi: 10.1111/are.13439.
  • Monteiro SH, Francisco JG, Campion TF, Pimpinato RF, Moura Andrade GCR, Garcia F, Tornisielo VL. 2015. Multiresidue antimicrobial determination in Nile tilapia (Oreochromis Niloticus) cage farming by liquid chromatography tandem mass spectrometry. Aquaculture. 447:37–43. doi: 10.1016/j.aquaculture.2015.07.002.
  • Moran A, Patel M, Talu O. 2018. Axial dispersion effects with small diameter adsorbent particles. Adsorption. 24(3):333–344. doi: 10.1007/s10450-018-9944-3.
  • Muckoya VA, Nomngongo PN, Ngila JC. 2020. Factorial design optimisation of solid phase extraction for preconcentration of parabens in wastewater using ultra-high performance liquid chromatography triple quadrupole mass spectrometry. CAC. 16(4):436–446. doi: 10.2174/1573411014666180627150854.
  • Nogueira JN, Santos GG, Tavares-Dias M. 2019. High concentration of levamisole in the diet of Colossoma macropomum (Pisces: serrasalmidae) is effective for controlling monogenean parasites. Rev Bras Parasitol Vet. 28(4):708–712. doi: 10.1590/s1984-29612019095.
  • Oliveira LCD, Majolo C, Brandão FR, Farias CFS, Oliveira MIB, Santos WB, Monteiro PC, Rocha MJS, Chagas EC, Tavares-Dias M. 2019. Avermectins, praziquantel and levamisole have in vitro efficacy against Neoechinorhynchus buttnerae (Neoechinorhynchidae) in Colossoma macropomum: a Serrasalmidae from the Amazon. J Fish Dis. 42(5):765–772. doi: 10.1111/jfd.12980.
  • Oliveira LCD, Brasiliense ARP, Dias MKR, Yoshioka ETO, Tavares-Dias M. 2019. Toxicological, hematological and immunological effects of levamisole and ivermectin diet supplementation on Colossoma macropomum (Serrasalmidae). Dis Aquat Organ. 136(3):255–263. doi: 10.3354/dao03413.
  • Pahor-Filho E, Castillo ASC, Pereira NL, Pilarski F, Urbinati EC. 2017. Levamisole enhances the innate immune response and prevents increased cortisol levels in stressed pacu (Piaractus mesopotamicus). Fish Shellfish Immunol. 65:96–102. doi: 10.1016/j.fsi.2017.04.003.
  • Portela ACV, Silveira JGF, Damaceno MA, da Silva AFB, de Jesus RB, Pilarski F, Gadaj A, Mooney MH, Paschoal JAR. 2020. Food safety evaluation for the use of albendazole in fish: residual depletion profile and withdrawal period estimation. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 37(4):596–606. doi: 10.1080/19440049.2020.1719285.
  • National Library of Medicine (US), National Center for Biotechnology Information. 2004. PubChem compound summary for CID 27944, levamisole hydrochloride [accessed 2023 October 25] https://pubchem.ncbi.nlm.nih.gov/compound/Levamisole-Hydrochloride.
  • Ramakrishna UV, Sunder SR, Kumar RK, Sinha SN. 2020. Method development and validation for rapid identification of epigallocatechin gallate using ultra-high performance liquid chromatography. PLOS One. 15(1):e0227569. doi: 10.1371/journal.pone.0227569.
  • Riviere JE, Papich MG. 2018. Veterinary pharmacology & therapeutics. 10th ed. Hoboken: John Wiley & Sons Inc.
  • Robert C, Gillard N, Brasseur PY, Pierret G, Ralet N, Dubois M, Delahaut P. 2013. Rapid multi-residue and multi-class qualitative screening for veterinary drugs in foods of animal origin by UHPLC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 30(3):443–457. doi: 10.1080/19440049.2012.751632.
  • Sajid M, Płotka-Wasylka J. 2022. Green analytical chemistry metrics: a review. Talanta. 238(Pt 2):123046. doi: 10.1016/j.talanta.2021.123046.
  • Sebastião FA, Souza Rocha MJ, Rodrigues Brandão F, Braga de Oliveira MI, de Melo Souza DC, Carlos do Nascimento Barbosa B, Castro Monteiro P, Majolo C, Crescêncio R, Tavares-Dias M, et al. 2022. Evaluation of the clinical safety and efficacy of fenbendazole and levamisole in the control of Neoechinorhynchus buttnerae in Colossoma macropomum: acanthocephalosis treatments. Aquacult Int. 30(3):1341–1351. doi: 10.1007/s10499-022-00854-2.
  • Sherif AH, Mahfouz ME. 2019. Immune status of Oreochromis niloticus experimentally infected with Aeromonas hydrophila following feeding with 1,3 β-glucan and levamisole immunostimulants. Aquaculture. 509:40–46. doi: 10.1016/j.aquaculture.2019.05.016.
  • Shinn A, Pratoomyot J, Bron J, Paladini G, Brooker E, Brooke A. 2015. Economic impacts of aquatic parasites on global finfish production. Glob Aquacult Advocate. 1:58–61. [accessed 2023 November 16]. https://www.globalseafood.org/advocate/economic-impacts-of-aquatic-parasites-on-global-finfish-production/.
  • Silva RO, de Menezes MGG, de Castro RC, d. A, Nobre C, Milhome MAL, do Nascimento RF. 2019. Efficiency of ESI and APCI ionization sources in LC-MS/MS systems for analysis of 22 pesticide residues in food matrix. Food Chem. 297:124934. doi: 10.1016/j.foodchem.2019.06.001.
  • Skilton DC, Saunders RJ, Hutson KS. 2020. Parasite attractants: identifying trap baits for parasite management in aquaculture. Aquaculture. 516:734557. doi: 10.1016/j.aquaculture.2019.734557.
  • Tang EKY, Partridge GJ, Woolley LD, Pilmer L, Lim LY. 2022. Effects of formulation on the palatability and efficacy of in-feed praziquantel medications for marine finfish aquaculture. Mar Drugs. 20(5):323. doi: 10.3390/md20050323.
  • Taylor MJ, Giela A, Sharp EA, Senior CC, Vyas DS. 2019. A rapid multi-class, multi-residue UHPLC-MS/MS method for the simultaneous determination of anticoagulant rodenticides, pesticides and veterinary medicines in wild animals, pets and livestock. Anal Methods. 11(8):1087–1101. doi: 10.1039/C8AY02367K.
  • Tomasini D, Sampaio MRF, Caldas SS, Buffon JG, Duarte FA, Primel EG. 2012. Simultaneous determination of pesticides and 5-hydroxymethylfurfural in honey by the modified QuEChERS method and liquid chromatography coupled to tandem mass spectrometry. Talanta. 99:380–386. doi: 10.1016/j.talanta.2012.05.068.
  • Veigure R, Lossmann K, Hecht M, Parman E, Born R, Leito I, Herodes K, Kipper K. 2020. Retention of acidic and basic analytes in reversed phase column using fluorinated and novel eluent additives for liquid chromatography-tandem mass spectrometry. J Chromatogr A. 1613:460667. doi: 10.1016/j.chroma.2019.460667.
  • Whelan M, Chirollo C, Furey A, Cortesi ML, Anastasio A, Danaher M. 2010. Investigation of the persistence of levamisole and oxyclozanide in milk and fate in cheese. J Agric Food Chem. 58(23):12204–12209. doi: 10.1021/jf102725b.
  • Xu N, Dong J, Yang Y, Liu Y, Yang Q, Ai X. 2018. Development of a liquid chromatography–tandem mass spectrometry method with modified QuEChERS extraction for the quantification of mebendazole and its metabolites, albendazole and its metabolites, and levamisole in edible tissues of aquatic animals. Food Chem. 269:442–449. doi: 10.1016/j.foodchem.2018.07.017.
  • Zhou FZ, Yu XH, Luo DH, Yang XQ, Yin SW. 2023. Pickering water in oil emulsions prepared from biocompatible gliadin/ethyl cellulose complex particles. Food Hydrocoll. 134:108050. doi: 10.1016/j.foodhyd.2022.108050.

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