Phytochemical characterization and multifaceted bioactivity assessment of essential oil from Clinopodium nepeta subsp. ascendens: potential for the food and pharmaceutical sectors

References

• Ait-Sidi-Brahim, M., Markouk, M., & Larhsini, M. (2019). Moroccan medicinal plants as antiinfective and antioxidant agents. In M. S. A. Khan, I. Ahmad & D. Chattopadhyay (Eds.), New look to phytomedicine (pp. 91–9). Elsevier.
   Google Scholar
• Bakkali, F., Averbeck, S., Averbeck, D., & Idaomar, M. (2008). Biological effects of essential oils–a review. Food and Chemical Toxicology, 46(2), 446–475. https://doi.org/10.1016/j.fct.2007.09.106
   PubMed Web of Science ®Google Scholar
• Beddiar, H., Boudiba, S., Benahmed, M., Tamfu, A. N., Ceylan, Ö., Hanini, K., Kucukaydin, S., Elomri, A., Bensouici, C., & Laouer, H. (2021). Chemical composition, anti-quorum sensing, enzyme inhibitory, and antioxidant properties of phenolic extracts of Clinopodium nepeta L. Kuntze. Plants, 10(9), 1955. https://doi.org/10.3390/plants10091955
   Google Scholar
• Benkhaira, N., El Hachlafi, N., Abdnim, M., Jeddi, R., Koraichi, M., Bnouham, S. I., & Fikri-Benbrahim, K. (2023). Unveiling the phytochemical profile, in vitro bioactivities evaluation, in silico molecular docking and ADMET study of essential oil from Clinopodium nepeta grown in Middle Atlas of Morocco. Biocatalysis and Agricultural Biotechnology, 54, 102923. https://doi.org/10.1016/j.bcab.2023.102923
   Web of Science ®Google Scholar
• Boni, G. C., de Feiria, S. N. B., de Laet Santana, P., Anibal, P. C., Boriollo, M. F. G., Buso-Ramos, M. M., Barbosa, J. P., de Oliveira, T. R., & Hofling, J. F. (2016). Antifungal and cytotoxic activity of purified biocomponents as carvone, menthone, menthofuran and pulegone from Mentha spp. African Journal of Plant Science, 10(10), 203–210. https://doi.org/10.5897/AJPS2016.1454
   Google Scholar
• Bourhia, M., Abdelaziz Shahat, A., Mohammed Almarfadi, O., Ali Naser, F., Mostafa Abdelmageed, W., Ait Haj Said, A., El Gueddari, F., Naamane, A., Benbacer, L., & Khlil, N. (2019). Ethnopharmacological survey of herbal remedies used for the treatment of cancer in the greater Casablanca-Morocco. Evidence-Based Complementary and Alternative Medicine, 2019, 1–9. https://doi.org/10.1155/2019/1613457
   Web of Science ®Google Scholar
• Burrell, R. A., & Swanton, C. (2014). Tumour heterogeneity and the evolution of polyclonal drug resistance. Molecular Oncology, 8(6), 1095–1111. https://doi.org/10.1016/j.molonc.2014.06.005
   PubMed Web of Science ®Google Scholar
• Chaudhary, S., Chandrashekar, K. S., Pai, K. S. R., Setty, M. M., Devkar, R. A., Reddy, N. D., & Shoja, M. H. (2015). Evaluation of antioxidant and anticancer activity of extract and fractions of nardostachys jatamansi DC in breast carcinoma. BMC Complementary and Alternative Medicine, 15(1), 1–13. https://doi.org/10.1186/s12906-015-0563-1
   PubMedGoogle Scholar
• Debbabi, H., El Mokni, R., Chaieb, I., Nardoni, S., Maggi, F., Caprioli, G., & Hammami, S. (2020). Chemical composition, antifungal and insecticidal activities of the essential oils from Tunisian Clinopodium nepeta subsp. nepeta and Clinopodium nepeta subsp. glandulosum. Molecules, 25(9), 2137. https://doi.org/10.3390/molecules25092137
   PubMed Web of Science ®Google Scholar
• Dhifi, W., Bellili, S., Jazi, S., Bahloul, N., & Mnif, W. (2016). Essential oils’ chemical characterization and investigation of some biological activities: A critical review. Medicines, 3(4), 25. https://doi.org/10.3390/medicines3040025
   Google Scholar
• Dybing, E., Doe, J., Groten, J., Kleiner, J., O’brien, J., Renwick, A. G., Schlatter, J., Steinberg, P., Tritscher, A., Walker, R., & Younes, M. (2002). Hazard characterisation of chemicals in food and diet: Dose response, mechanisms and extrapolation issues. Food and Chemical Toxicology, 40(2–3), 237–282. https://doi.org/10.1016/S0278-6915(01)00115-6
   PubMed Web of Science ®Google Scholar
• Elbe, H., Yigitturk, G., Cavusoglu, T., Uyanikgil, Y., & Ozturk, F. (2020). Apoptotic effects of thymol, a novel monoterpene phenol, on different types of cancer. Bratislava Medical Journal/Bratislavske Lekarske Listy, 121(2), 122–128. https://doi.org/10.4149/BLL_2020_016
   PubMed Web of Science ®Google Scholar
• Elbouzidi, A., Ouassou, H., Aherkou, M., Kharchoufa, L., Meskali, N., Baraich, A., Mechchate, H., Bouhrim, M., Idir, A., Hano, C., Zrouri, H., & Addi, M. (2022). LC–MS/MS phytochemical profiling, antioxidant activity, and cytotoxicity of the ethanolic extract of atriplex halimus L. against breast cancer cell lines: Computational studies and experimental validation. Pharmaceuticals, 15(9), 1156. https://doi.org/10.3390/ph15091156
   Web of Science ®Google Scholar
• El Guerrouj, B., Taibi, M., Elbouzidi, A., Bouhassoun, S., Loukili, E. H., Moubchir, T., Haddou, M., Hammouti, Y., Khoulati, A., & Addi, M. (2023). The effect of altitude on the chemical composition, antioxidant and antimicrobial activities of eucalyptus globulus Labill. Essential oils. Tropical Journal of Natural Product Research, 7(11), 5279–5285.
   Google Scholar
• El-Mernissi, Y., Zouhri, A., Labhar, A., El Menyiy, N., Salhi, S., El Barkany, A., Hajji, A., Bouyahya, L., & Amhamdi, H. (2023). Indigenous knowledge of the traditional use of aromatic and medicinal plants in Rif Mountains Ketama District. Evidence-Based Complementary and Alternative Medicine, 2023, 1–16. https://doi.org/10.1155/2023/3977622
   Google Scholar
• Fatima, K., Masood, N., Wani, Z. A., Meena, A., & Luqman, S. (2021). Neomenthol prevents the proliferation of skin cancer cells by restraining tubulin polymerization and hyaluronidase activity. Journal of Advanced Research, 34, 93–107. https://doi.org/10.1016/j.jare.2021.06.003
   PubMed Web of Science ®Google Scholar
• Gao, H., Yang, T., Chen, X., & Song, Y. (2021). Changes of lipopolysaccharide-induced acute kidney and liver injuries in rats based on metabolomics analysis. Journal of Inflammation Research, 14, 1807. https://doi.org/10.2147/JIR.S306789
   PubMed Web of Science ®Google Scholar
• Grigoriadou, K., Cheilari, A., Dina, E., Alexandri, S., & Aligiannis, N. (2023). Medicinal and aromatic plants as a source of potential feed and food additives. In G. Arsenos & I. Giannenas Eds.), Sustainable use of feed additives in livestock: Novel ways for animal production (pp. 117–135). Springer.
   Google Scholar
• Haddou, M., Taibi, M., Elbouzidi, A., Loukili, E. H., Yahyaoui, M. I., Ou-Yahia, D., Mehane, L., Addi, M., Asehraou, A., Chaabane, K., Bellaouchi, R., & El Guerrouj, B. (2023). Investigating the impact of irrigation water quality on secondary metabolites and chemical profile of mentha piperita essential oil: Analytical profiling, characterization, and potential pharmacological applications. International Journal of Plant Biology, 14(3), 638–657. https://doi.org/10.3390/ijpb14030049
   Google Scholar
• Javanmardi, F., Rahmani, J., Ghiasi, F., Hashemi Gahruie, H., & Mousavi Khaneghah, A. (2019). The association between the preservative agents in foods and the risk of breast cancer. Nutrition and Cancer, 71(8), 1229–1240. https://doi.org/10.1080/01635581.2019.1608266
   PubMed Web of Science ®Google Scholar
• Khalis, M., Diaby, M., Toure, A. B., Charaka, H., Abousselham, L., Belakhel, L., Bendahhou, K., Al Hassani, W., Soliman, A. S., & Nejjari, C. (2021). The past, present, and future of professional cancer education in Morocco. Journal of Cancer Education, 36(Suppl 1), 95–100. https://doi.org/10.1007/s13187-021-02039-6
   PubMed Web of Science ®Google Scholar
• Kumar, K. J. S., Li, J., Vani, M. G., Hsieh, Y.-H., Kuo, Y.-H., & Wang, S.-Y. (2015). Bornyl cinnamate inhibits inflammation-associated gene expression in macrophage cells through suppression of nuclear factor-κB signaling pathway. Planta Medica, 81(1), 39–45. https://doi.org/10.1055/s-0034-1383361
   PubMed Web of Science ®Google Scholar
• Leonti, M., & Casu, L. (2013). Traditional medicines and globalization: Current and future perspectives in ethnopharmacology. Frontiers in Pharmacology, 4, 92. https://doi.org/10.3389/fphar.2013.00092
   PubMed Web of Science ®Google Scholar
• Lin, W.-T., He, Y.-H., Lo, Y.-H., Chiang, Y.-T., Wang, S.-Y., Bezirganoglu, I., & Kumar, K. J. S. (2023). Essential oil from glossogyne tenuifolia inhibits lipopolysaccharide-induced inflammation-associated genes in macro-phage cells via suppression of NF-κB signaling pathway. Plants, 12(6), 1241. https://doi.org/10.3390/plants12061241
   Google Scholar
• Loukili, E. H., Ouahabi, S., Elbouzidi, A., Taibi, M., Yahyaoui, M. I., Asehraou, A., Azougay, A., Saleh, A., Al Kamaly, O., Parvez, M. K., El Guerrouj, B., Touzani, R., & Ramdani, M. (2023). Phytochemical composition and pharmacological activities of three essential oils collected from Eastern Morocco (origanum compactum, Salvia officinalis, and syzygium aromaticum): A comparative study. Plants, 12(19), 3376. https://doi.org/10.3390/plants12193376
   Google Scholar
• Massad, T. J., Fincher, R. M., Smilanich, A. M., & Dyer, L. (2011). A quantitative evaluation of major plant defense hypotheses, nature versus nurture, and chemistry versus ants. Arthropod-Plant Interactions, 5(2), 125–139. https://doi.org/10.1007/s11829-011-9121-z
   Web of Science ®Google Scholar
• Medzhitov, R. (2010). Inflammation 2010: New adventures of an old flame. Cell, 140(6), 771–776. https://doi.org/10.1016/j.cell.2010.03.006
   PubMed Web of Science ®Google Scholar
• Miguel, M. G. (2010). Antioxidant and anti-inflammatory activities of essential oils: A short review. Molecules, 15(12), 9252–9287. https://doi.org/10.3390/molecules15129252
   PubMed Web of Science ®Google Scholar
• Mirza, S. K., Asema, U. K., & Kasim, S. S. (2017). To study the harmful effects of food preservatives on human health. Journal of Medical Chemistry on Drug Discovery, 2(2), 610–616.
   Google Scholar
• Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65(1–2), 55–63. https://doi.org/10.1016/0022-1759(83)90303-4
   PubMed Web of Science ®Google Scholar
• Nathan, C. (2002). Points of control in inflammation. Nature, 420(6917), 846–852. https://doi.org/10.1038/nature01320
   PubMed Web of Science ®Google Scholar
• Noriega, P. (2020). Terpenes in essential oils: Bioactivity and applications. In S. Perveen & A. M. Al-Taweel (Eds.), Terpenes and terpenoids—Recent advances (pp. 142). IntechOpen.
   Google Scholar
• Öztürk, G., YILMAZ, G., Gülnur, E., & DEMİRCİ, B. (2021). Chemical composition and antibacterial activity of Clinopodium nepeta subsp. glandulosum (req.) govaerts essential oil. Natural Volatiles & Essential Oils, 8(3), 75–80. https://doi.org/10.37929/nveo.949959
   Google Scholar
• Pérez, G., Zavala, S., S, M., Arias, G. L., & Ramos, L. M. (2011). Anti-inflammatory activity of some essential oils. Journal of Essential Oil Research, 23(5), 38–44. https://doi.org/10.1080/10412905.2011.9700480
   Web of Science ®Google Scholar
• Quézel, P., & Santa, S. (1962). Nouvelle flore de l’algerie et des regions desertiques meridionales: avec la collab. technique de Mme O. Schotter. Pref. du pr. L. Emberger. Editions du CNRS.
   Google Scholar
• Rodenak-Kladniew, B., Castro, M. A., Gambaro, R. C., Girotti, J., Cisneros, J. S., Viña, S., Padula, G., Crespo, R., Castro, G. R., & Gehring, S. (2023). Cytotoxic screening and enhanced anticancer activity of lippia alba and clinopodium nepeta essential oils-loaded biocompatible lipid nanoparticles against lung and colon cancer cells. Pharmaceutics, 15(8), 2045. https://doi.org/10.3390/pharmaceutics15082045
   PubMed Web of Science ®Google Scholar
• Roy, A., Park, H.-J., Abdul, Q. A., Jung, H. A., & Choi, J. S. (2018). Pulegone exhibits anti-inflammatory activities through the regulation of NF-κB and nrf-2 signaling pathways in LPS-stimulated RAW 264.7 cells. Natural Product Sciences, 24(1), 28–35. https://doi.org/10.20307/nps.2018.24.1.28
   Google Scholar
• Taban, B. M., Stavropoulou, E., Winkelströter, L. K., & Bezirtzoglou, E. (2021). Value-added effects of using aromatic plants in foods and human therapy. Food Science and Technology, 42, e43121. https://doi.org/10.1590/fst.43121
   Web of Science ®Google Scholar
• Taibi, M., Elbouzidi, A., Haddou, M., Baraich, A., Loukili, E. H., Moubchir, T., Allali, A., Asehraou, R., Bellaouchi, A., & Addi, M. (2024). Phytochemical characterization and multifaceted bioactivity assessment of essential oil from ptychotis verticillata Duby: Anti-diabetic, anti-tyrosinase, and anti-inflammatory activity. Heliyon, 10(8), e29459. https://doi.org/10.1016/j.heliyon.2024.e29459
   PubMed Web of Science ®Google Scholar
• Taibi, M., Elbouzidi, A., Haddou, M., Loukili, E. H., Bellaouchi, R., Asehraou, A., Douzi, Y., Addi, M., Salamatullah, A. M., & Nafidi, H.-A. (2024). Chemical profiling, antibacterial efficacy, and synergistic actions of ptychotis verticillata duby essential oil in combination with conventional antibiotics. Natural Product Communications, 19(1), 1934578X231222785. https://doi.org/10.1177/1934578X231222785
   Web of Science ®Google Scholar
• Taibi, M., Elbouzidi, A., Ouahhoud, S., Loukili, E. H., Ou-Yahya, D., Ouahabi, S., Alqahtani, A. S., Noman, O. M., Addi, M., Bellaouchi, R., Asehraou, A., Saalaoui, E., El Guerrouj, B., & Chaabane, K. (2023). Evaluation of antioxidant activity, cytotoxicity, and genotoxicity of ptychotis verticillata essential oil: Towards novel breast cancer therapeutics. Life, 13(7), 1586. https://doi.org/10.3390/life13071586
   PubMedGoogle Scholar
• Taibi, M., Elbouzidi, A., Ou-Yahia, D., Dalli, M., Bellaouchi, R., Tikent, A., Roubi, M., Gseyra, N., Asehraou, A., Hano, C., Addi, M., El Guerrouj, B., & Chaabane, K. (2023). Assessment of the antioxidant and antimicrobial potential of ptychotis verticillata duby essential oil from Eastern Morocco: An in vitro and in silico analysis. Antibiotics, 12(4), 655. https://doi.org/10.3390/antibiotics12040655
   Google Scholar
• Tomko, A. M., Whynot, E. G., Ellis, L. D., & Dupré, D. J. (2020). Anti-cancer potential of cannabinoids, terpenes, and flavonoids present in cannabis. Cancers, 12(7), 1985. https://doi.org/10.3390/cancers12071985
   PubMed Web of Science ®Google Scholar
• Xu, X., Liu, A., Hu, S., Ares, I., Martínez-Larrañaga, M.-R., Wang, X., Martínez, M., Anadón, A., & Martínez, M.-A. (2021). Synthetic phenolic antioxidants: Metabolism, hazards and mechanism of action. Food Chemistry, 353, 129488. https://doi.org/10.1016/j.foodchem.2021.129488
   PubMed Web of Science ®Google Scholar
• Zhao, H., Ren, S., Yang, H., Tang, S., Guo, C., Liu, M., Tao, Q., Ming, T., & Xu, H. (2022). Peppermint essential oil: Its phytochemistry, biological activity, pharmacological effect and application. Biomedicine & Pharmacotherapy, 154, 113559. https://doi.org/10.1016/j.biopha.2022.113559
   PubMed Web of Science ®Google Scholar