The Intersection of TNF, IBD and the Microbiome

References

• Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007; 448:427-34; PMID:17653185; http://dx.doi.org/10.1038/nature06005
   PubMed Web of Science ®Google Scholar
• Rubin DC, Shaker A, Levin MS. Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer. Front Immunol 2012; 3:107; PMID:22586430; http://dx.doi.org/10.3389/fimmu.2012.00107
   PubMed Web of Science ®Google Scholar
• Latella G, Papi C. Crucial steps in the natural history of inflammatory bowel disease. World J Gastroenterol 2012; 18:3790-9; PMID:22876029; http://dx.doi.org/10.3748/wjg.v18.i29.3790
   PubMed Web of Science ®Google Scholar
• Strober W. Impact of the gut microbiome on mucosal inflammation. Trends Immunol 2013; 34:423-30; PMID:23957963; http://dx.doi.org/10.1016/j.it.2013.07.001
   PubMed Web of Science ®Google Scholar
• Sartor RB, Mazmanian SK. Intestinal microbes in inflammatory bowel diseases. Am J Gastroenterol Suppl 2012; 1:15-21; http://dx.doi.org/10.1038/ajgsup.2012.4
   Google Scholar
• Jones-Hall YL, Kozik A, Nakatsu C. Ablation of tumor necrosis factor is associated with decreased inflammation and alterations of the microbiota in a mouse model of inflammatory bowel disease. PLoS One 2015; 10:e0119441; PMID:25775453; http://dx.doi.org/10.1371/journal.pone.0119441
   PubMed Web of Science ®Google Scholar
• Abraham C, Cho JH. Inflammatory bowel disease. N Engl J Med 2009; 361:2066-78; PMID:19923578; http://dx.doi.org/10.1056/NEJMra0804647
   PubMed Web of Science ®Google Scholar
• Xu XR, Liu CQ, Feng BS, Liu ZJ. Dysregulation of mucosal immune response in pathogenesis of inflammatory bowel disease. World J Gastroenterol 2014; 20:3255-64; PMID:24695798; http://dx.doi.org/10.3748/wjg.v20.i12.3255
   PubMed Web of Science ®Google Scholar
• Monteleone I, Pallone F, Monteleone G. Th17-related cytokines: new players in the control of chronic intestinal inflammation. BMC Med 2011; 9:122; PMID:22082127; http://dx.doi.org/10.1186/1741-7015-9-122
   PubMed Web of Science ®Google Scholar
• Himmel ME, Yao Y, Orban PC, Steiner TS, Levings MK. Regulatory T-cell therapy for inflammatory bowel disease: more questions than answers. Immunology 2012; 136:115-22; PMID:22348589; http://dx.doi.org/10.1111/j.1365-2567.2012.03572.x
   PubMed Web of Science ®Google Scholar
• Braegger CP, Nicholls S, Murch SH, Stephens S, MacDonald TT. Tumour necrosis factor alpha in stool as a marker of intestinal inflammation. Lancet 1992; 339:89-91; PMID:1345871; http://dx.doi.org/10.1016/0140-6736(92)90999-J
   PubMed Web of Science ®Google Scholar
• Reimund JM, Wittersheim C, Dumont S, Muller CD, Kenney JS, Baumann R, Poindron P, Duclos B. Increased production of tumour necrosis factor-alpha interleukin-1 beta, and interleukin-6 by morphologically normal intestinal biopsies from patients with Crohn's disease. Gut 1996; 39:684-9; PMID:9026483; http://dx.doi.org/10.1136/gut.39.5.684
   PubMed Web of Science ®Google Scholar
• Reimund JM, Wittersheim C, Dumont S, Muller CD, Baumann R, Poindron P, Duclos B. Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis and Crohn's disease. J Clin Immunol 1996; 16:144-50; PMID:8734357; http://dx.doi.org/10.1007/BF01540912
   PubMed Web of Science ®Google Scholar
• Lichtenstein GR. Comprehensive review: antitumor necrosis factor agents in inflammatory bowel disease and factors implicated in treatment response. Therap Adv Gastroenterol 2013; 6:269-93; PMID:23814608; http://dx.doi.org/10.1177/1756283X13479826
   PubMed Web of Science ®Google Scholar
• Kontoyiannis D, Pasparakis M, Pizarro TT, Cominelli F, Kollias G. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 1999; 10:387-98; PMID:10204494; http://dx.doi.org/10.1016/S1074-7613(00)80038-2
   PubMed Web of Science ®Google Scholar
• Neurath MF, Fuss I, Pasparakis M, Alexopoulou L, Haralambous S, Meyer zum Buschenfelde KH, Strober W, Kollias G. Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice. Eur J Immunol 1997; 27:1743-50; PMID:9247586; http://dx.doi.org/10.1002/eji.1830270722
   PubMed Web of Science ®Google Scholar
• Mueller C. Tumour necrosis factor in mouse models of chronic intestinal inflammation. Immunology 2002; 105:1-8; PMID:11849309; http://dx.doi.org/10.1046/j.1365-2567.2002.01329.x
   PubMed Web of Science ®Google Scholar
• Lindebo Holm T, Poulsen SS, Markholst H, Reedtz-Runge S. Pharmacological evaluation of the SCID T cell transfer model of colitis: as a model of crohn's disease. Int J Inflam 2012; 412178:19
   Google Scholar
• Popivanova BK, Kitamura K, Wu Y, Kondo T, Kagaya T, Kaneko S, Oshima M, Fujii C, Mukaida N. Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest 2008; 118:560-70; PMID:18219394
   PubMed Web of Science ®Google Scholar
• Strober W, Fuss IJ, Blumberg RS. The immunology of mucosal models of inflammation. Annu Rev Immunol 2002; 20:495-549; PMID:11861611; http://dx.doi.org/10.1146/annurev.immunol.20.100301.064816
   PubMed Web of Science ®Google Scholar
• Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, Gill SR, Nelson KE, Relman DA. Diversity of the human intestinal microbial flora. Science 2005; 308:1635-8; PMID:15831718; http://dx.doi.org/10.1126/science.1110591
   PubMed Web of Science ®Google Scholar
• Walters WA, Xu Z, Knight R. Meta-analyses of human gut microbes associated with obesity and IBD. FEBS Lett 2014; 588:4223-33; PMID:25307765; http://dx.doi.org/10.1016/j.febslet.2014.09.039
   PubMed Web of Science ®Google Scholar
• Morgan XC, Tickle TL, Sokol H, Gevers D, Devaney KL, Ward DV, Reyes JA, Shah SA, LeLeiko N, Snapper SB, Bousvaros A, Korzenik J, Sands BE, Xavier RJ, Huttenhower C. Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol 2012; 13:R79; PMID:23013615; http://dx.doi.org/10.1186/gb-2012-13-9-r79
   PubMed Web of Science ®Google Scholar
• Wright EK, Kamm MA, Teo SM, Inouye M, Wagner J, Kirkwood CD. Recent advances in characterizing the gastrointestinal microbiome in Crohn's disease: a systematic review. Inflamm Bowel Dis 2015; 21:1219-28; PMID:25844959
   PubMed Web of Science ®Google Scholar
• Danese S, Sans M, Scaldaferri F, Sgambato A, Rutella S, Cittadini A, Pique JM, Panes J, Katz JA, Gasbarrini A, Fiocchi C. TNF-alpha blockade down-regulates the CD40/CD40L pathway in the mucosal microcirculation: a novel anti-inflammatory mechanism of infliximab in Crohn's disease. J Immunol 2006; 176:2617-24; PMID:16456024; http://dx.doi.org/10.4049/jimmunol.176.4.2617
   PubMed Web of Science ®Google Scholar
• Busquets D, Mas-de-Xaxars T, Lopez-Silas M, Martinez-Medina M, Bahi A, Sabat M, Louvriex R, Miguel-Cusachs O, Garcia-Gil J, Aldeguer X. Anti-TNF treatment with adalimumab induces changes in the microbiota of Crohn's disease. J Crohns Colitis 2015; PMID:26142465
   PubMed Web of Science ®Google Scholar
• Rooks MG, Veiga P, Wardwell-Scott LH, Tickle T, Segata N, Michaud M, Gallini CA, Beal C, van Hylckama-Vlieg JE, Ballal SA, et al. Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission. ISME J 2014; 8:1403-17; PMID:24500617; http://dx.doi.org/10.1038/ismej.2014.3
   PubMed Web of Science ®Google Scholar
• Chiodini RJ, Dowd SE, Davis B, Galandiuk S, Chamberlin WM, Kuenstner JT, McCallum RW, Zhang J. Crohn's disease may be differentiated into 2 distinct biotypes based on the detection of bacterial genomic sequences and virulence genes within submucosal tissues. J Clin Gastroenterol 2013; 47:612-20; PMID:23426447; http://dx.doi.org/10.1097/MCG.0b013e31827b4f94
   PubMed Web of Science ®Google Scholar
• Baumgart M, Dogan B, Rishniw M, Weitzman G, Bosworth B, Yantiss R, Orsi RH, Wiedmann M, McDonough P, Kim SG, et al. Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum. ISME J 2007; 1:403-18; PMID:18043660; http://dx.doi.org/10.1038/ismej.2007.52
   PubMed Web of Science ®Google Scholar
• Darfeuille-Michaud A, Boudeau J, Bulois P, Neut C, Glasser AL, Barnich N, Bringer MA, Swidsinski A, Beaugerie L, Colombel JF. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology 2004; 127:412-21; PMID:15300573; http://dx.doi.org/10.1053/j.gastro.2004.04.061
   PubMed Web of Science ®Google Scholar
• D'Auria G, Peris-Bondia F, Dzunkova M, Mira A, Collado MC, Latorre A, Moya A. Active and secreted IgA-coated bacterial fractions from the human gut reveal an under-represented microbiota core. Sci Rep 2013; 3:3515; PMID:24343271; http://dx.doi.org/10.1038/srep03515
   PubMed Web of Science ®Google Scholar
• Palm NW, de Zoete MR, Cullen TW, Barry NA, Stefanowski J, Hao L, Degnan PH, Hu J, Peter I, Zhang W, et al. Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell 2014; 158:1000-10; PMID:25171403; http://dx.doi.org/10.1016/j.cell.2014.08.006
   PubMed Web of Science ®Google Scholar
• Greenblum S, Turnbaugh PJ, Borenstein E. Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease. Proc Natl Acad Sci U S A 2012; 109:594-9; PMID:22184244; http://dx.doi.org/10.1073/pnas.1116053109
   PubMed Web of Science ®Google Scholar