Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador

References

• Berding K, Donovan SM. Microbiome and nutrition in autism spectrum disorder: current knowledge and research needs. Nutr Rev. 2016;74(12):723–736. doi:10.1093/nutrit/nuw048.
   Google Scholar
• Hertz-Picciotto I, Schmidt RJ, Krakowiak P. Understanding environmental contributions to autism: causal concepts and the state of science. Autism Res. 2018;11(4):554–586. doi:10.1002/aur.1938.
   Google Scholar
• Dekkers LMS, Groot NA, Díaz Mosquera EN, Andrade Zúñiga IP, Delfos MF. Prevalence of autism spectrum disorders in Ecuador: a pilot study in Quito. J Autism Dev Disord. 2015;45(12):4165–4173. doi:10.1007/s10803-015-2559-6.
   Google Scholar
• Centers for Disease Control and Prevention. 2018. Data and statistics | autism spectrum disorder (ASD). [accessed 2018 May 4]. https://www.cdc.gov/ncbddd/autism/data.html
   Google Scholar
• Baio J, Wiggins L, Christensen DL, Maenner MJ, Daniels J, Warren Z, … Dowling NF. Prevalence of autism spectrum disorder among children aged 8 years — autism and developmental disabilities monitoring network, 11 sites, United States, 2014. MMWR Surveillance Summaries. 2018;67(6):1–23. doi:10.15585/mmwr.ss6706a1.
   Google Scholar
• Angelidou A, Asadi S, Alysandratos K-D, Karagkouni A, Kourembanas S, Theoharides TC. Perinatal stress, brain inflammation and risk of autism-review and proposal. BMC Pediatr. 2012;12:89. doi:10.1186/1471-2431-12-89.
   Google Scholar
• Finegold SM, Dowd SE, Gontcharova V, Liu C, Henley KE, Wolcott RD, … Green JA. Pyrosequencing study of fecal microflora of autistic and control children. Anaerobe. 2010;16(4):444–453. doi:10.1016/j.anaerobe.2010.06.008.
   Google Scholar
• Gilbert JA, Blaser MJ, Caporaso JG, Jansson JK, Lynch SV, Knight R. Current understanding of the human microbiome. Nat Med. 2018;24(4):392–400. doi:10.1038/nm.4517.
   Google Scholar
• Parracho HMRT, Bingham MO, Gibson GR, McCartney AL. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. J Med Microbiol. 2005;54(Pt 10):987–991. doi:10.1099/jmm.0.46101-0.
   Google Scholar
• Goyal MS, Venkatesh S, Milbrandt J, Gordon JI, Raichle ME. Feeding the brain and nurturing the mind: linking nutrition and the gut microbiota to brain development. Proc Natl Acad Sci. 2015;112(46):14105–14112. doi:10.1073/pnas.1511465112.
   Google Scholar
• Shmaya Y, Eilat-Adar S, Leitner Y, Reif S, Gabis L. Nutritional deficiencies and overweight prevalence among children with autism spectrum disorder. Res Dev Disabil. 2015;38:1–6. doi:10.1016/j.ridd.2014.11.020.
   Google Scholar
• Ranjan S, Nasser JA. Nutritional status of individuals with autism spectrum disorders: do we know enough? Adv Nutr. 2015;6(4):397–407. doi:10.3945/an.114.007914.
   Google Scholar
• Kohane IS, McMurry A, Weber G, MacFadden D, Rappaport L, Kunkel L, … Churchill S. The co-morbidity burden of children and young adults with autism spectrum disorders. PLoS One. 2012;7(4):e33224. doi:10.1371/journal.pone.0033224.
   Google Scholar
• Bresnahan M, Hornig M, Schultz AF, Gunnes N, Hirtz D, Lie KK, … Lipkin WI. Association of maternal report of infant and toddler gastrointestinal symptoms with autism: evidence from a prospective birth cohort. JAMA Psychiatry. 2015;72(5):466–474. doi:10.1001/jamapsychiatry.2014.3034.
   Google Scholar
• Vuong HE, Hsiao EY. Emerging roles for the gut microbiome in autism spectrum disorder. Biol Psychiatry. 2017;81(5):411–423. doi:10.1016/j.biopsych.2016.08.024.
   Google Scholar
• Estes ML, McAllister AK. Immune mediators in the brain and peripheral tissues in autism spectrum disorder. Nat Rev Neurosci. 2015;16(8):469–486. doi:10.1038/nrn3978.
   Google Scholar
• Jyonouchi H, Sun S, Le H. Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression. J Neuroimmunol. 2001;120(1–2):170–179. http://www.ncbi.nlm.nih.gov/pubmed/11694332.
   Google Scholar
• Xu N, Li X, Zhong Y. Inflammatory cytokines: potential biomarkers of immunologic dysfunction in autism spectrum disorders. Mediators Inflamm. 2015;2015:1–10. doi:10.1155/2015/531518.
   Google Scholar
• Parr JR, Le Couteur A, Baird G, Rutter M, Pickles A, Fombonne E, and International Molecular Genetic Study of Autism Consortium (IMGSAC) Members. Early developmental regression in autism spectrum disorder: evidence from an international multiplex sample. J Autism Dev Disord. 2011;41(3):332–340. doi:10.1007/s10803-010-1055-2.
   Google Scholar
• Rutter M, Bailey A, Lord C. 2003. Manual the social communication questionnaire. [accessed 2018 May 7]. https://www.wpspublish.com/store/Images/Downloads/Product/SCQ_Manual_Chapter_1.pdf
   Google Scholar
• Guevara DA, Reyes S, López M, Flores N, Aguirre S, Muñoz EB, … Baldeón ME. Impact of milk based micronutrient supplementation in school children in Quito-Ecuador. Nutricion Hospitalaria. 2017;35(1):50–58. http://www.ncbi.nlm.nih.gov/pubmed/29565149
   Google Scholar
• World Health Organization. 2009. WHO anthroplus for personal computers manual software for assessing growth of the world’s children and adolescents. [accessed 2018 May 4]. http://www.who.int/growthref/tools/who_anthroplus_manual.pdf
   Google Scholar
• Baldeón ME, Castro J, Villacrés E, Narváez L, Fornasini M. Hypoglycemic effect of cooked lupinus mutabilis and its purified alkaloids in subjects with type-2 diabetes. Nutricion Hospitalaria. 2012;27:4. doi:10.3305/nh.2012.27.4.5761.
   Google Scholar
• USDA Nutrient Data Laboratory and the Food and Nutrition Information Center and Information Systems Division of the National Agricultural Library. 2018. USDA food composition database. [accessed 2018 May 4]. https://ndb.nal.usda.gov/ndb/
   Google Scholar
• Caporaso JG, Kuczynski J, Stombaugh J, Bittinger K, Bushman FD, Costello EK, … Knight R. QIIME allows analysis of high-throughput community sequencing data. Nat Methods. 2010;7(5):335–336. doi:10.1038/nmeth.f.303.
   Google Scholar
• Edgar RC. Search and clustering orders of magnitude faster than BLAST. Bioinformatics. 2010;26(19):2460–2461. doi:10.1093/bioinformatics/btq461.
   Google Scholar
• McDonald D, Price MN, Goodrich J, Nawrocki EP, DeSantis TZ, Probst A, … Hugenholtz P. An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea. Isme J. 2012;6(3):610–618. doi:10.1038/ismej.2011.139.
   Google Scholar
• DeSantis TZ, Hugenholtz P, Keller K, Brodie EL, Larsen N, Piceno YM, … Andersen GL. NAST: a multiple sequence alignment server for comparative analysis of 16S rRNA genes. Nucleic Acids Res. 2006;34(WebServer issue):W394–9. doi:10.1093/nar/gkl244.
   Google Scholar
• Faith DP, Baker AM. Phylogenetic diversity (PD) and biodiversity conservation: some bioinformatics challenges. Evol Bioinform Online. 2007;2:121–128. http://www.ncbi.nlm.nih.gov/pubmed/19455206.
   Google Scholar
• Jaccard P. Étude comparative de la distribution florale dans une portion des Alpes et des Jura. Bull Del La Sociéte Vaudoise Des Sci Nat. 1901;37:547–579.
   Google Scholar
• Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, … Cani PD. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci USA. 2013;110(22):9066–9071. doi:10.1073/pnas.1219451110.
   Google Scholar
• Mandal S, Van Treuren W, White RA, Eggesbø M, Knight R, Peddada SD. Analysis of composition of microbiomes: a novel method for studying microbial composition. Microb Ecol Health Dis. 2015;26:27663. http://www.ncbi.nlm.nih.gov/pubmed/26028277.
   Google Scholar
• Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc. 1995. WileyRoyal Statistical Society. doi:10.2307/2346101.
   Google Scholar
• Vezzani A, Viviani B. Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability. Neuropharmacology. 2015;96(Pt A):70–82. doi:10.1016/j.neuropharm.2014.10.027.
   Google Scholar
• Herndon AC, DiGuiseppi C, Johnson SL, Leiferman J, Reynolds A. Does nutritional intake differ between children with autism spectrum disorders and children with typical development? J Autism Dev Disord. 2009;39(2):212–222. doi:10.1007/s10803-008-0606-2.
   Google Scholar
• Berding K, Donovan SM. Diet can impact microbiota composition in children with autism spectrum disorder. Front Neurosci. 2018;12:515. doi:10.3389/fnins.2018.00515.
   Google Scholar
• Marí-Bauset S, Zazpe I, Mari-Sanchis A, Llopis-González A, Morales-Suárez-Varela M. Food selectivity in autism spectrum disorders. J Child Neurol. 2014;29(11):1554–1561. doi:10.1177/0883073813498821.
   Google Scholar
• Ashwood P, Wills S, Van de Water J. The immune response in autism: a new frontier for autism research. J Leukoc Biol. 2006;80(1):1–15. doi:10.1189/jlb.1205707.
   Google Scholar
• Suzuki K, Matsuzaki H, Iwata K, Kameno Y, Shimmura C, Kawai S, … Mori N. Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders. PLoS One. 2011;6(5):e20470. doi:10.1371/journal.pone.0020470.
   Google Scholar
• Pardo CA, Farmer CA, Thurm A, Shebl FM, Ilieva J, Kalra S, Swedo S. Serum and cerebrospinal fluid immune mediators in children with autistic disorder: a longitudinal study. Mol Autism. 2017;8(1):1. doi:10.1186/s13229-016-0115-7.
   Google Scholar
• Singh VK. Plasma increase of interleukin-12 and interferon-gamma. Pathological significance in autism. J Neuroimmunol. 1996;66(1–2):143–145. http://www.ncbi.nlm.nih.gov/pubmed/8964908.
   Google Scholar
• Li X, Chauhan A, Sheikh AM, Patil S, Chauhan V, Li X-M, … Malik M. Elevated immune response in the brain of autistic patients. J Neuroimmunol. 2009;207(1–2):111–116. doi:10.1016/j.jneuroim.2008.12.002.
   Google Scholar
• Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol. 2005;57(1):67–81. doi:10.1002/ana.20315.
   Google Scholar
• Ashwood P, Enstrom A, Krakowiak P, Hertz-Picciotto I, Hansen RL, Croen LA, … Van de Water J. Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes. J Neuroimmunol. 2008;204(1–2):149–153. doi:10.1016/j.jneuroim.2008.07.006.
   Google Scholar
• Okada K, Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, … Mori N. Decreased serum levels of transforming growth factor-beta1 in patients with autism. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(1):187–190. doi:10.1016/j.pnpbp.2006.08.020.
   Google Scholar
• De Angelis M, Piccolo M, Vannini L, Siragusa S, De Giacomo A, Serrazzanetti DI, … Francavilla R. Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified. PLoS One. 2013;8(10):e76993. doi:10.1371/journal.pone.0076993.
   Google Scholar
• Kang D-W, Park JG, Ilhan ZE, Wallstrom G, Labaer J, Adams JB, Krajmalnik-Brown R. Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children. PLoS One. 2013;8(7):e68322. doi:10.1371/journal.pone.0068322.
   Google Scholar
• Argou-Cardozo I, Zeidán-Chuliá F. Clostridium bacteria and autism spectrum conditions: a systematic review and hypothetical contribution of environmental glyphosate levels. Med Sci (Basel, Switzerland). 2018;6(2):29. doi:10.3390/medsci6020029.
   Google Scholar
• Kang D-W, Adams JB, Gregory AC, Borody T, Chittick L, Fasano A, … Krajmalnik-Brown R. Microbiota transfer therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome. 2017;5(1):10. doi:10.1186/s40168-016-0225-7.
   Google Scholar
• Rose DR, Yang H, Serena G, Sturgeon C, Ma B, Careaga M, … Ashwood P. Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms. Brain Behav Immun. 2018;70:354–368. doi:10.1016/j.bbi.2018.03.025.
   Google Scholar