Prospective study reveals a microbiome signature that predicts the occurrence of post-operative enterocolitis in Hirschsprung disease (HSCR) patients

References

• Baxter KJ, Bhatia AM. Hirschsprung’s disease in the preterm infant: implications for diagnosis and outcome. Am Surg. 2013;79:734–738.
   Google Scholar
• Escobar MA, Grosfeld JL, West KW, Scherer LR, Rouse TM, Engum SA, Rescorla FJ. Long-term outcomes in total colonic aganglionosis: a 32-year experience. J Pediatr Surg. 2005;40:955–961. doi:10.1016/j.jpedsurg.2005.03.043.
   Google Scholar
• Heuckeroth RO. Hirschsprung disease - integrating basic science and clinical medicine to improve outcomes. Nat Rev Gastroenterol Hepatol. 2018;15:152–167. doi:10.1038/nrgastro.2017.149.
   Google Scholar
• Frykman PK, Short SS. Hirschsprung-associated enterocolitis: prevention and therapy. Semin Pediatr Surg. 2012;21:328–335. doi:10.1053/j.sempedsurg.2012.07.007.
   Google Scholar
• Thiagarajah JR, Yildiz H, Carlson T, Thomas AR, Steiger C, Pieretti A, Zukerberg LR, Carrier RL, Goldstein AM. Altered goblet cell differentiation and surface mucus properties in Hirschsprung disease. PLoS One. 2014;9:e99944. doi:10.1371/journal.pone.0099944.
   Google Scholar
• Gosain A, Barlow-Anacker AJ, Erickson CS, Pierre JF, Heneghan AF, Epstein ML, Kudsk KA. Impaired cellular immunity in the murine neural crest conditional deletion of endothelin receptor-B model of Hirschsprung’s disease. PLoS One. 2015;10:e0128822. doi:10.1371/journal.pone.0128822.
   Google Scholar
• Ward NL, Pieretti A, Dowd SE, Cox SB, Goldstein AM. Intestinal aganglionosis is associated with early and sustained disruption of the colonic microbiome. Neurogastroenterol Motil. 2012;24:874–e400.
   Google Scholar
• Li Y, Poroyko V, Yan Z, Pan L, Feng Y, Zhao P, Xie Z, Hong L. Characterization of intestinal microbiomes of Hirschsprung’s disease patients with or without enterocolitis using Illumina-MiSeq high-throughput sequencing. PLoS One. 2016;11:e0162079. doi:10.1371/journal.pone.0162079.
   Google Scholar
• Yan Z, Poroyko V, Gu S, Zhang Z, Pan L, Wang J, Bao N, Hong L. Characterization of the intestinal microbiome of Hirschsprung’s disease with and without enterocolitis. Biochem Biophys Res Commun. 2014;445:269–274. doi:10.1016/j.bbrc.2014.01.104.
   Google Scholar
• Schanler RJ. [In time: human milk is the feeding strategy to prevent necrotizing enterocolitis]. Rev Paul Pediatr. 2015;33:131–133. doi:10.1016/j.rpped.2015.01.001.
   Google Scholar
• Adamkin DH. Mother’s milk, feeding strategies, and lactoferrin to prevent necrotizing enterocolitis. JPEN J Parenter Enteral Nutr. 2012;36:25S–9S. doi:10.1177/0148607111420158.
   Google Scholar
• Rodriguez NA, Caplan MS. Oropharyngeal administration of mother’s milk to prevent necrotizing enterocolitis in extremely low-birth-weight infants: theoretical perspectives. J Perinat Neonatal Nurs. 2015;29:81–90. doi:10.1097/JPN.0000000000000087.
   Google Scholar
• Alshaikh B, Kostecky L, Blachly N, Yee W. Effect of a quality improvement project to use exclusive mother’s own milk on rate of necrotizing enterocolitis in preterm infants. Breastfeed Med. 2015;10:355–361. doi:10.1089/bfm.2015.0042.
   Google Scholar
• Brower-Sinning R, Zhong D, Good M, Firek B, Baker R, Sodhi CP, Hackam DJ, Morowitz MJ. Mucosa-associated bacterial diversity in necrotizing enterocolitis. PLoS One. 2014;9:e105046. doi:10.1371/journal.pone.0105046.
   Google Scholar
• Gregory KE, Samuel BS, Houghteling P, Shan G, Ausubel FM, Sadreyev RI, Walker WA. Influence of maternal breast milk ingestion on acquisition of the intestinal microbiome in preterm infants. Microbiome. 2016;4:68. doi:10.1186/s40168-016-0214-x.
   Google Scholar
• Stewart CJ, Ajami NJ, O’Brien JL, Hutchinson DS, Smith DP, Wong MC, Ross MC, Lloyd RE, Doddapaneni H, Metcalf GA, et al. Temporal development of the gut microbiome in early childhood from the TEDDY study. Nature. 2018;562:583–588. doi:10.1038/s41586-018-0617-x.
   Google Scholar
• Baumann-Dudenhoeffer AM, D’Souza AW, Tarr PI, Warner BB, Dantas G. Infant diet and maternal gestational weight gain predict early metabolic maturation of gut microbiomes. Nat Med. 2018;24:1822–1829. doi:10.1038/s41591-018-0216-2.
   Google Scholar
• Brown BP, Jaspan HB. Compositional analyses reveal correlations between taxon-level gut bacterial abundance and peripheral T cell marker expression in African infants. Gut Microbes. 2019;1–8. doi:10.1080/19490976.2019.1643673.
   Google Scholar
• Lu YC, Yeh WC, Ohashi PS. LPS/TLR4 signal transduction pathway. Cytokine. 2008;42:145–151. doi:10.1016/j.cyto.2008.01.006.
   Google Scholar
• Underhill DM, Ozinsky A. Toll-like receptors: key mediators of microbe detection. Curr Opin Immunol. 2002;14:103–110. doi:10.1016/S0952-7915(01)00304-1.
   Google Scholar
• He Y, Liu S, Kling DE, Leone S, Lawlor NT, Huang Y, Feinberg SB, Hill DR, Newburg DS. The human milk oligosaccharide 2ʹ-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation. Gut. 2016;65:33–46. doi:10.1136/gutjnl-2014-307544.
   Google Scholar
• Frykman PK, Nordenskjold A, Kawaguchi A, Hui TT, Granstrom AL, Cheng Z, Tang J, Underhill DM, Iliev I, Funari VA, et al. Characterization of bacterial and fungal microbiome in children with Hirschsprung disease with and without a history of enterocolitis: A multicenter study. PLoS One. 2015;10:e0124172. doi:10.1371/journal.pone.0124172.
   Google Scholar
• Neuvonen MI, Korpela K, Kyrklund K, Salonen A, de Vos W, Rintala RJ, Pakarinen MP. Intestinal microbiota in Hirschsprung Disease. J Pediatr Gastroenterol Nutr. 2018;67:594–600. doi:10.1097/MPG.0000000000001999.
   Google Scholar
• Patel RM, Underwood MA. Probiotics and necrotizing enterocolitis. Semin Pediatr Surg. 2018;27:39–46. doi:10.1053/j.sempedsurg.2017.11.008.
   Google Scholar
• Shen DH, Shi CR, Chen JJ, Yu SY, Wu Y, Yan WB. Detection of intestinal bifidobacteria and lactobacilli in patients with Hirschsprung’s disease associated enterocolitis. World J Pediatr. 2009;5:201–205. doi:10.1007/s12519-009-0038-x.
   Google Scholar
• Wang X, Li Z, Xu Z, Wang Z, Feng J. Probiotics prevent Hirschsprung’s disease-associated enterocolitis: a prospective multicenter randomized controlled trial. Int J Colorectal Dis. 2015;30:105–110. doi:10.1007/s00384-014-2054-0.
   Google Scholar
• El-Sawaf M, Siddiqui S, Mahmoud M, Drongowski R, Teitelbaum DH. Probiotic prophylaxis after pullthrough for Hirschsprung disease to reduce incidence of enterocolitis: a prospective, randomized, double-blind, placebo-controlled, multicenter trial. J Pediatr Surg. 2013;48:111–117. doi:10.1016/j.jpedsurg.2012.10.028.
   Google Scholar
• Demehri FR, Frykman PK, Cheng Z, Ruan C, Wester T, Nordenskjold A, Kawaguchi A, Hui TT, Granström AL, Funari V, et al. Altered fecal short chain fatty acid composition in children with a history of Hirschsprung-associated enterocolitis. J Pediatr Surg. 2016;51:81–86. doi:10.1016/j.jpedsurg.2015.10.012.
   Google Scholar
• Ronco C. Lipopolysaccharide (LPS) from the cellular wall of Gram-negative bacteria, also known as endotoxin, is a key molecule in the pathogenesis of sepsis and septic shock. Preface Blood Purif. 2014;37(Suppl 1):1. doi:10.1159/000357412.
   Google Scholar
• Sweeney RP, Lowary TL. New insights into lipopolysaccharide assembly and export. Curr Opin Chem Biol. 2019;53:37–43. doi:10.1016/j.cbpa.2019.07.004.
   Google Scholar
• Gupta VK, Paul S, Dutta C. Geography, ethnicity or subsistence-specific variations in human microbiome composition and diversity. Front Microbiol. 2017;8:1162. doi:10.3389/fmicb.2017.01162.
   Google Scholar
• Pastor AC, Osman F, Teitelbaum DH, Caty MG, Langer JC. Development of a standardized definition for Hirschsprung’s-associated enterocolitis: a Delphi analysis. J Pediatr Surg. 2009;44:251–256. doi:10.1016/j.jpedsurg.2008.10.052.
   Google Scholar
• Zhu-Shimoni J, Yu C, Nishihara J, Wong RM, Gunawan F, Lin M, Krawitz D, Liu P, Sandoval W, Vanderlaan M. Host cell protein testing by ELISAs and the use of orthogonal methods. Biotechnol Bioeng. 2014;111:2367–2379. doi:10.1002/bit.25327.
   Google Scholar
• Spiegelman D, Hertzmark E. Easy SAS calculations for risk or prevalence ratios and differences. Am J Epidemiol. 2005;162:199–200. doi:10.1093/aje/kwi188.
   Google Scholar