Virulence gene repression promotes Listeria monocytogenes systemic infection

References

• Cossart P. Illuminating the landscape of host-pathogen interactions with the bacterium Listeria monocytogenes. Proc Natl Acad Sci U S A. 2011;108:19484–19491. doi:10.1073/pnas.1112371108.
   Google Scholar
• EFSA., European Food Safety Authority ECfDPaC. The European Union summary report on trends and sources of zoonoses, zoonotic agents and food-borne outbreaks in 2016. Efsa J 2017;15:5077.
   Google Scholar
• Carvalho F, Sousa S, Cabanes D. How Listeria monocytogenes organizes its surface for virulence. Front Cell Infect Microbiol. 2014;4:48. doi:10.3389/fcimb.2014.00048.
   Google Scholar
• NicAogain K, O’Byrne CP. The role of stress and stress adaptations in determining the fate of the bacterial pathogen Listeria monocytogenes in the food chain. Front Microbiol. 2016;7:1865. doi:10.3389/fmicb.2016.01865.
   Google Scholar
• Chand D, Avinash VS, Yadav Y, Pundle AV, Suresh CG, Ramasamy S. Molecular features of bile salt hydrolases and relevance in human health. Biochim Biophys Acta. 2017;1861:2981–2991. doi:10.1016/j.bbagen.2016.09.024.
   Google Scholar
• Begley M, Gahan CG, Hill C. The interaction between bacteria and bile. FEMS Microbiol Rev. 2005;29:625–651. doi:10.1016/j.femsre.2004.09.003.
   Google Scholar
• Dussurget O, Cabanes D, Dehoux P, Lecuit M, Buchrieser C, Glaser P, Cossart P. Listeria monocytogenes bile salt hydrolase is a PrfA-regulated virulence factor involved in the intestinal and hepatic phases of listeriosis. Mol Microbiol. 2002;45:1095–1106. doi:10.1046/j.1365-2958.2002.03080.x.
   Google Scholar
• Quillin SJ, Schwartz KT, Leber JH. The novel Listeria monocytogenes bile sensor BrtA controls expression of the cholic acid efflux pump MdrT. Mol Microbiol. 2011;81:129–142. doi:10.1111/mmi.2011.81.issue-1.
   Google Scholar
• Camejo A, Carvalho F, Reis O, Leitao E, Sousa S, Cabanes D. The arsenal of virulence factors deployed by Listeria monocytogenes to promote its cell infection cycle. Virulence. 2011;2:379–394. doi:10.4161/viru.2.5.17703.
   Google Scholar
• Begley M, Sleator RD, Gahan CG, Hill C. Contribution of three bile-associated loci, bsh, pva, and btlB, to gastrointestinal persistence and bile tolerance of Listeria monocytogenes. Infect Immun. 2005;73:894–904. doi:10.1128/IAI.73.2.894-904.2005.
   Google Scholar
• Zhang Q, Feng Y, Deng L, Feng F, Wang L, Zhou Q, Luo Q. SigB plays a major role in Listeria monocytogenes tolerance to bile stress. Int J Food Microbiol. 2011;145:238–243. doi:10.1016/j.ijfoodmicro.2010.12.028.
   Google Scholar
• Pombinho R, Camejo A, Vieira A, Reis O, Carvalho F, Almeida MT, Pinheiro JC, Sousa S, Cabanes D. Listeria monocytogenes CadC regulates cadmium efflux and fine-tunes lipoprotein localization to escape the host immune response and promote infection. J Infect Dis. 2017;215:1468–1479. doi:10.1093/infdis/jix118.
   Google Scholar
• Boneca IG, Dussurget O, Cabanes D, Nahori M-A, Sousa S, Lecuit M, Psylinakis E, Bouriotis V, Hugot J-P, Giovannini M, et al. A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system. Proc Natl Acad Sci U S A. 2007;104:997–1002. doi:10.1073/pnas.0609672104.
   Google Scholar
• Dashkevicz MP, Feighner SD. Development of a differential medium for bile salt hydrolase-active Lactobacillus spp. Appl Environ Microbiol. 1989;55:11–16. doi:10.1128/AEM.55.1.11-16.1989.
   Google Scholar
• Camejo A, Buchrieser C, Couve E, Carvalho F, Reis O, Ferreira P, Sousa S, Cossart P, Cabanes D, et al. In vivo transcriptional profiling of Listeria monocytogenes and mutagenesis identify new virulence factors involved in infection. PLoS Pathog. 2009;5:e1000449. doi:10.1371/journal.ppat.1000449.
   Google Scholar
• Toledo-Arana A, Dussurget O, Nikitas G, Sesto N, Guet-Revillet H, Balestrino D, Loh E, Gripenland J, Tiensuu T, Vaitkevicius K, et al. The Listeria transcriptional landscape from saprophytism to virulence. Nature. 2009;459:950–956. doi:10.1038/nature08080.
   Google Scholar
• Ooi LG, Liong MT. Cholesterol-lowering effects of probiotics and prebiotics: a review of in vivo and in vitro findings. Int J Mol Sci. 2010;11:2499–2522. doi:10.3390/ijms11062499.
   Google Scholar
• Yamamoto T, Hara H, Tsuchiya K, Sakai S, Fang R, Matsuura M, Nomura T, Sato F, Mitsuyama M, Kawamura I, et al. Listeria monocytogenes strain-specific impairment of the TetR regulator underlies the drastic increase in cyclic di-AMP secretion and beta interferon-inducing ability. Infect Immun. 2012;80:2323–2332. doi:10.1128/IAI.06162-11.
   Google Scholar
• Crimmins GT, Herskovits AA, Rehder K, Sivick KE, Lauer P, Dubensky TW Jr., Portnoy DA. Listeria monocytogenes multidrug resistance transporters activate a cytosolic surveillance pathway of innate immunity. Proc Natl Acad Sci U S A. 2008;105:10191–10196. doi:10.1073/pnas.0804170105.
   Google Scholar
• Schwartz KT, Carleton JD, Quillin SJ, Rollins SD, Portnoy DA, Leber JH, Camilli A. Hyperinduction of host beta interferon by a Listeria monocytogenes strain naturally overexpressing the multidrug efflux pump MdrT. Infect Immun. 2012;80:1537–1545. doi:10.1128/IAI.06286-11.
   Google Scholar
• Personnic N, Bruck S, Nahori MA, Toledo-Arana A, Nikitas G, Lecuit M, Dussurget O, Cossart P, Bierne H. The stress-induced virulence protein InlH controls interleukin-6 production during murine listeriosis. Infect Immun. 2010;78:1979–1989. doi:10.1128/IAI.01096-09.
   Google Scholar
• Cummins J, Casey PG, Joyce SA, Gahan CG, Bereswill S. A mariner transposon-based signature-tagged mutagenesis system for the analysis of oral infection by Listeria monocytogenes. PLoS One. 2013;8:e75437. doi:10.1371/journal.pone.0075437.
   Google Scholar
• Seifart Gomes C, Izar B, Pazan F, Mohamed W, Mraheil MA, Mukherjee K, Billion A, Aharonowitz Y, Chakraborty T, Hain T, et al. Universal stress proteins are important for oxidative and acid stress resistance and growth of Listeria monocytogenes EGD-e in vitro and in vivo. PLoS One. 2011;6:e24965. doi:10.1371/journal.pone.0024965.
   Google Scholar
• Hain T, Hossain H, Chatterjee SS, Machata S, Volk U, Wagner S, et al. Temporal transcriptomic analysis of the Listeria monocytogenes EGD-e sigmaB regulon. BMC Microbiol. 2008;8:20.
   Google Scholar
• Sue D, Fink D, Wiedmann M, Boor KJ. sigmaB-dependent gene induction and expression in Listeria monocytogenes during osmotic and acid stress conditions simulating the intestinal environment. Microbiology. 2004;150:3843–3855. doi:10.1099/mic.0.27257-0.
   Google Scholar
• Oliver HF, Orsi RH, Wiedmann M, Boor KJ. Listeria monocytogenes sigmaB has a small core regulon and a conserved role in virulence but makes differential contributions to stress tolerance across a diverse collection of strains. Appl Environ Microbiol. 2010;76:4216–4232. doi:10.1128/AEM.00031-10.
   Google Scholar
• Kazmierczak MJ, Wiedmann M, Boor KJ. Contributions of Listeria monocytogenes sigmaB and PrfA to expression of virulence and stress response genes during extra- and intracellular growth. Microbiology. 2006;152:1827–1838.
   Google Scholar
• Gray MJ, Freitag NE, Boor KJ. How the bacterial pathogen Listeria monocytogenes mediates the switch from environmental Dr. Jekyll to pathogenic Mr. Hyde. Infect Immun. 2006;74:2505–2512. doi:10.1128/IAI.74.5.2505-2512.2006.
   Google Scholar
• Sauer JD, Sotelo-Troha K, von Moltke J, Monroe KM, Rae CS, Brubaker SW, et al. The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect Immun. 2011;79:688–694.
   Google Scholar
• Auerbuch V, Brockstedt DG, Meyer-Morse N, O’Riordan M, Portnoy DA. Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes. J Exp Med. 2004;200:527–533. doi:10.1084/jem.20040976.
   Google Scholar
• O’Connell RM, Saha SK, Vaidya SA, Bruhn KW, Miranda GA, Zarnegar B, Perry AK, Nguyen BO, Lane TF, Taniguchi T, et al. Type I interferon production enhances susceptibility to Listeria monocytogenes infection. J Exp Med. 2004;200:437–445. doi:10.1084/jem.20040712.
   Google Scholar
• Kamisango K, Fujii H, Okumura H, Saiki I, Araki Y, Yamamura Y, Azuma I. Structural and immunochemical studies of teichoic acid of Listeria monocytogenes. J Biochem. 1983;93:1401–1409. doi:10.1093/oxfordjournals.jbchem.a134275.
   Google Scholar
• Gopal S, Berg D, Hagen N, Schriefer E-M, Stoll R, Goebel W, Kreft J. Maltose and maltodextrin utilization by Listeria monocytogenes depend on an inducible ABC transporter which is repressed by glucose. PLoS One. 2010;5:e10349. doi:10.1371/journal.pone.0010349.
   Google Scholar
• Schnupf P, Hofmann J, Norseen J, Glomski IJ, Schwartzstein H, Decatur AL. Regulated translation of listeriolysin O controls virulence of Listeria monocytogenes. Mol Microbiol. 2006;61:999–1012. doi:10.1111/mmi.2006.61.issue-4.
   Google Scholar
• Arnaud M, Chastanet A, Debarbouille M. New vector for efficient allelic replacement in naturally nontransformable, low-GC-content, gram-positive bacteria. Appl Environ Microbiol. 2004;70:6887–6891. doi:10.1128/AEM.70.11.6887-6891.2004.
   Google Scholar
• Carvalho F, Atilano ML, Pombinho R, Covas G, Gallo RL, Filipe SR, Sousa S, Cabanes D. L-rhamnosylation of Listeria monocytogenes wall teichoic acids promotes resistance to antimicrobial peptides by delaying interaction with the membrane. PLoS Pathog. 2015;11:e1004919. doi:10.1371/journal.ppat.1004919.
   Google Scholar
• Pinheiro J, Lisboa J, Pombinho R, Carvalho F, Carreaux A, Brito C, Pöntinen A, Korkeala H, Dos Santos NMS, Morais-Cabral JH, et al. MouR controls the expression of the Listeria monocytogenes Agr system and mediates virulence. Nucleic Acids Res. 2018;46:9338–9352. doi:10.1093/nar/gky624.
   Google Scholar
• Cabanes D, Lecuit M, Cossart P. Animal models of Listeria infection. Curr Protoc Microbiol. 2008;Chapter 9:Unit9B1.
   Google Scholar
• Glaser P, Frangeul L, Buchrieser C, Rusniok C, Amend A, Baquero F, Berche P, Bloecker H, Brandt P, Chakraborty T, et al. Comparative genomics of Listeria species. Science. 2001;294:849–852. doi:10.1126/science.1063447.
   Google Scholar