Advanced search
Publication Cover
Gut Microbes Volume 15, 2023 - Issue 2
Submit an article Journal homepage
2,678
Views
0
CrossRef citations to date
0
Altmetric
Research Paper

Successful weight regain attenuation by autologous fecal microbiota transplantation is associated with non-core gut microbiota changes during weight loss; randomized controlled trial

Omer Kamera Faculty of Health Sciences, Ben-Gurion University of the Negev, The International Center of Health, Innovation & Nutrition On the memory of Manya Igel, Beer-Sheva, IsraelORCID Iconhttps://orcid.org/0009-0003-2486-3898View further author information
ORCID Icon,
Ehud Rinottb Department of Medicine, Hebrew University and Hadassah Medical Center, Jerusalem, IsraelView further author information
,
Gal Tsabana Faculty of Health Sciences, Ben-Gurion University of the Negev, The International Center of Health, Innovation & Nutrition On the memory of Manya Igel, Beer-Sheva, IsraelView further author information
,
Alon Kaplana Faculty of Health Sciences, Ben-Gurion University of the Negev, The International Center of Health, Innovation & Nutrition On the memory of Manya Igel, Beer-Sheva, IsraelView further author information
,
Anat Yaskolka Meira Faculty of Health Sciences, Ben-Gurion University of the Negev, The International Center of Health, Innovation & Nutrition On the memory of Manya Igel, Beer-Sheva, IsraelView further author information
,
Hila Zelichaa Faculty of Health Sciences, Ben-Gurion University of the Negev, The International Center of Health, Innovation & Nutrition On the memory of Manya Igel, Beer-Sheva, IsraelView further author information
,
Dan Knightsc BioTechnology Institute, University of Minnesota, St Paul, USA;d Department of Computer Science and Engineering, University of Minnesota, Minneapolis, USAView further author information
,
Kieran Tuohye Department of Food Quality and Nutrition, Research and Innovation Centre, Fondazione Edmund Mach, Trento, Italy;f School of Food Science & Nutrition, University of Leeds, Leeds, UKView further author information
,
Francesca Favae Department of Food Quality and Nutrition, Research and Innovation Centre, Fondazione Edmund Mach, Trento, ItalyView further author information
,
Matthias Uwe Scholze Department of Food Quality and Nutrition, Research and Innovation Centre, Fondazione Edmund Mach, Trento, ItalyView further author information
,
Oren Zivg Azrieli Faculty of Medicine, Bar Ilan University, Safed, IsraelView further author information
,
Elad Rubing Azrieli Faculty of Medicine, Bar Ilan University, Safed, IsraelView further author information
,
Matthias Blüherh Department of Medicine, University of Leipzig, Leipzig, Germany;i Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, GermanyView further author information
,
Michael Stumvollh Department of Medicine, University of Leipzig, Leipzig, Germany;i Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, GermanyView further author information
,
Uta Ceglarekh Department of Medicine, University of Leipzig, Leipzig, GermanyView further author information
,
Karine Clémentj Inserm, Nutrition and obesities: systemic approaches, nutriOmicsn Research Unit, Nutrition Department, Pitié-Salpêtrière Hospital, Assistance-Publique Hopitaux de Paris, Sorbonne University, Paris, FranceView further author information
,
Omry Koreng Azrieli Faculty of Medicine, Bar Ilan University, Safed, IsraelView further author information
,
Frank B. Huk Harvard T.H. Chan School of Public Health, Boston, USA;l Department of Medicine, Channing Division of Network Medicine, Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, USAView further author information
,
Meir J. Stampferk Harvard T.H. Chan School of Public Health, Boston, USA;l Department of Medicine, Channing Division of Network Medicine, Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, USAView further author information
,
Dong D. Wangk Harvard T.H. Chan School of Public Health, Boston, USAView further author information
,
Ilan Youngsterm Pediatric Division and Center for Microbiome Research, Shamir Medical Center, Be’er Ya’akov, Israel;n Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, IsraelView further author information
&
Iris Shaia Faculty of Health Sciences, Ben-Gurion University of the Negev, The International Center of Health, Innovation & Nutrition On the memory of Manya Igel, Beer-Sheva, Israel;k Harvard T.H. Chan School of Public Health, Boston, USACorrespondence[email protected]
View further author information
 show all
Article: 2264457 | Received 23 Apr 2023, Accepted 25 Sep 2023, Published online: 05 Oct 2023

References

  • Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. The human microbiome project. Nature [Internet]. 2007;449(7164):804–10. [accessed 2022 Aug 5]. doi:10.1038/nature06244.
  • Shade A, Handelsman J. Beyond the venn diagram: the hunt for a core microbiome. Environ Microbiol [Internet]. 2012;14:4–12. [accessed 2022 Aug 5]. doi:10.1111/j.1462-2920.2011.02585.x.
  • Lloyd-Price J, Abu-Ali G, Huttenhower C. The Healthy Human Microbiome Genome Medi [Internet]. 2016;8(1):1–11. [accessed 2022 Jul 27]. doi:10.1186/s13073-016-0307-y.
  • Van Der Gast CJ, Walker AW, Stressmann FA, Rogers GB, Scott P, Daniels TW, Carroll MP, Parkhill J, Bruce KD. Partitioning core and satellite taxa from within cystic fibrosis lung bacterial communities. ISME J [Internet]. 2011;5:780–791. [accessed 2022 Aug 6]. doi:10.1038/ismej.2010.175.
  • Benjamino J, Lincoln S, Srivastava R, Graf J. Low-abundant bacteria drive compositional changes in the gut microbiota after dietary alteration. Microbiome [Internet]. 2018;6(1):86. [accessed 2022 Aug 6]. doi:10.1186/s40168-018-0469-5.
  • Velazquez EM, Nguyen H, Heasley KT, Saechao CH, Gil LM, Rogers AWL, Miller BM, Rolston MR, Lopez CA, Litvak Y, et al. Endogenous Enterobacteriaceae underlie variation in susceptibility to Salmonella infection. Nat microbiol [Internet]. 2019;4(6):1057–1064. [accessed 2022 Aug 6]. doi:10.1038/s41564-019-0407-8.
  • Rinott E, Meir AY, Tsaban G, Zelicha H, Kaplan A, Knights D, Tuohy K, Scholz MU, Koren O, Stampfer MJ, et al. The effects of the green-Mediterranean diet on cardiometabolic health are linked to gut microbiome modifications: a randomized controlled trial. Genome Med. 2022;14(1):14. doi:10.1186/s13073-022-01015-z.
  • Baunwall SMD, Lee MM, Eriksen MK, Mullish BH, Marchesi JR, Dahlerup JF, Hvas CL. Faecal microbiota transplantation for recurrent clostridioides difficile infection: an updated systematic review and meta-analysis. EClinicalMedicine. 2020;29-30:29–30. doi:10.1016/j.eclinm.2020.100642.
  • Craven L, Rahman A, Nair Parvathy S, Beaton M, Silverman J, Qumosani K, Hramiak I, Hegele R, Joy T, Meddings J, et al. Allogenic fecal microbiota transplantation in patients with nonalcoholic fatty liver disease improves abnormal small intestinal permeability: a randomized control trial. Am J Gastroenterol [Internet]. 2020;115(7):1055–1065. [accessed 2022 Aug 7]. doi:10.14309/ajg.0000000000000661.
  • Sokol H, Landman C, Seksik P, Berard L, Montil M, Nion-Larmurier I, Bourrier A, Le Gall G, Lalande V, De Rougemont A, et al. Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study. Microbiome [Internet]. 2020;8(1): [accessed 2022 Aug 7]. doi:10.1186/s40168-020-0792-5.
  • Serrano-Villar S, Talavera-Rodríguez A, Gosalbes MJ, Madrid N, Pérez-Molina JA, Elliott RJ, Navia B, Lanza VF, Vallejo A, Osman M, et al. Fecal microbiota transplantation in HIV: a pilot placebo-controlled study. Nat Commun [Internet]. 2021;12(1): [accessed 2022 Aug 7]. doi:10.1038/s41467-021-21472-1.
  • Costello SP, Hughes PA, Waters O, Bryant RV, Vincent AD, Blatchford P, Katsikeros R, Makanyanga J, Campaniello MA, Mavrangelos C, et al. Effect of fecal microbiota transplantation on 8-week Remission in patients with ulcerative colitis: a randomized clinical trial. JAMA [Internet]. 2019;321:156–164. [accessed 2022 Aug 7]. doi:10.1001/jama.2018.20046.
  • De Groot P, Nikolic T, Pellegrini S, Sordi V, Imangaliyev S, Rampanelli E, Hanssen N, Attaye I, Bakker G, Duinkerken G, et al. Faecal microbiota transplantation halts progression of human new-onset type 1 diabetes in a randomised controlled trial. Gut. 2021;70(1):92–105. doi:10.1136/gutjnl-2020-322630.
  • Davar D, Dzutsev AK, McCulloch JA, Rodrigues RR, Chauvin JM, Morrison RM, Deblasio RN, Menna C, Ding Q, Pagliano O, et al. Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients. Sci [Internet]. 2021;371(1979):595–602. [accessed 2022 Aug 7]. doi:10.1126/science.abf3363.
  • Ward ZJ, Bleich SN, Cradock AL, Barrett JL, Giles CM, Flax C, Long MW, Gortmaker SL. Projected U.S. State-level prevalence of adult obesity and severe obesity. N Engl J Med [Internet]. 2019;381:2440–2450. [accessed 2022 Aug 7]. doi:10.1056/NEJMsa1909301.
  • Chassaing B, Koren O, Goodrich JK, Poole AC, Srinivasan S, Ley RE, Gewirtz AT. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature [Internet]. 2015;519(7541):92–96. [accessed 2022 Jun 25]. doi:10.1038/nature14232.
  • Thaiss CA, Itav S, Rothschild D, Meijer MT, Levy M, Moresi C, Dohnalová L, Braverman S, Rozin S, Malitsky S, et al. Persistent microbiome alterations modulate the rate of post-dieting weight regain. Nature [Internet]. 2016;540(7634):544–551. [accessed 2022 May 7]. doi:10.1038/nature20796
  • Peters BA, Shapiro JA, Church TR, Miller G, Trinh-Shevrin C, Yuen E, Friedlander C, Hayes RB, Ahn J. A taxonomic signature of obesity in a large study of American adults. Sci Rep [Internet]. 2018;8(1). [accessed 2022 Aug 7]. doi:10.1038/s41598-018-28126-1.
  • Menni C, Jackson MA, Pallister T, Steves CJ, Spector TD, Valdes AM. Gut microbiome diversity and high-fibre intake are related to lower long-term weight gain. Int J Obes. 2017;41(7):1099–1105. doi:10.1038/ijo.2017.66.
  • Kootte RS, Levin E, Salojärvi J, Smits LP, Hartstra AV, Udayappan SD, Hermes G, Bouter KE, Koopen AM, Holst JJ, et al. Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is Driven by baseline intestinal microbiota composition. Cell Metab. 2017;26:611–619.e6. doi:10.1016/j.cmet.2017.09.008.
  • Vrieze A, Van Nood E, Holleman F, Salojärvi J, Kootte RS, Bartelsman JFWM, Dallinga-Thie GM, Ackermans MT, Serlie MJ, Oozeer R, et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology. 2012;143:913–916.e7. doi:10.1053/j.gastro.2012.06.031.
  • Yu EW, Gao L, Stastka P, Cheney MC, Mahabamunuge J, Soto MT, Ford CB, Bryant JA, Henn MR, Hohmann EL, et al. Fecal microbiota transplantation for the improvement of metabolism in obesity: the fmt-trim double-blind placebo-controlled pilot trial. PLoS Med. 2020;17(3):17. doi:10.1371/journal.pmed.1003051.
  • Allegretti JR, Kassam Z, Mullish BH, Chiang A, Carrellas M, Hurtado J, Marchesi JR, McDonald JAK, Pechlivanis A, Barker GF, et al. Effects of fecal microbiota transplantation with oral capsules in obese patients. Clin Gastroenterol Hepatol. 2020;18(4):855–863.e2. doi:10.1016/j.cgh.2019.07.006.
  • Pérez-Matute P, Íñiguez M, de Toro M, Recio-Fernández E, Oteo JA. Autologous fecal transplantation from a lean state potentiates caloric restriction effects on body weight and adiposity in obese mice. Sci Rep [Internet]. 2020;10(1) [accessed 2022 Aug 7] doi:10.1038/s41598-020-64961-x.
  • Rinott E, Youngster I, Yaskolka Meir A, Tsaban G, Zelicha H, Kaplan A, Knights D, Tuohy K, Fava F, Scholz MU, et al. Effects of diet-modulated autologous fecal microbiota transplantation on weight regain. Gastroenterology. 2021;160(1):158–173.e10. doi:10.1053/j.gastro.2020.08.041.
  • Rinott E, Youngster I, Meir AY, Tsaban G, Kaplan A, Zelicha H, Rubin E, Koren O, Shai I. Autologous fecal microbiota transplantation can retain the metabolic achievements of dietary interventions. Eur J Intern Med. 2021;92:17–23. doi:10.1016/j.ejim.2021.03.038.
  • Oksanen J, Simpson G, Blanchet F, Kindt R, Legendre P, Minchin P, O’Hara R, Solymos P, Stevens M, Szoecs E, et al. The vegan: Community ecology package. R package version 2.6-4. 2013. https://CRAN.R-project.org/package=vegan
  • Shai I, Schwarzfuchs D, Henkin Y, Shahar DR, Witkow S, Greenberg I, Golan R, Fraser D, Bolotin A, Vardi H, et al. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N Engl J Med [Internet]. 2008;359:229–241. [accessed 2022 Aug 8]. doi:10.1056/nejmoa0708681.
  • Gepner Y, Shelef I, Schwarzfuchs D, Zelicha H, Tene L, Meir AY, Tsaban G, Cohen N, Bril N, Rein M, et al. Effect of distinct lifestyle interventions on mobilization of fat storage pools CENTRAL magnetic resonance imaging randomized controlled trial. Circulation [Internet]. 2018;137:1143–1157. [accessed 2022 Jun 21]. doi:10.1161/CIRCULATIONAHA.117.030501.
  • Falony G, Joossens M, Vieira-Silva S, Wang J, Darzi Y, Faust K, Kurilshikov A, Bonder MJ, Valles-Colomer M, Vandeputte D, et al. Population-level analysis of gut microbiome variation. Sci [Internet]. 2016;352(6285):560–564. [accessed 2022 Oct 31]. doi:10.1126/science.aad3503.
  • Risely A, Tate A. Applying the core microbiome to understand host–microbe systems. J Animal Eco. 2020;89(7):1549–1558. doi:10.1111/1365-2656.13229.
  • Neu AT, Allen EE, Roy K. Defining and quantifying the core microbiome: challenges and prospects. Proc Natl Acad Sci USA [Internet]. 2021;118(51). [accessed 2022 Jun 1]. doi:10.1073/pnas.2104429118.
  • Pust MM, Tümmler B. Bacterial low-abundant taxa are key determinants of a healthy airway metagenome in the early years of human life. Comput Struct Biotechnol J. 2022;20:175–186. doi:10.1016/j.csbj.2021.12.008.
  • Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M, Magris M, Hidalgo G, Baldassano RN, Anokhin AP, et al. Human gut microbiome viewed across age and geography. Nature. 2012;486(7402):222–227. doi:10.1038/nature11053.
  • Palmas V, Pisanu S, Madau V, Casula E, Deledda A, Cusano R, Uva P, Vascellari S, Loviselli A, Manzin A, et al. Gut microbiota markers associated with obesity and overweight in Italian adults. Sci Rep [Internet]. 2021;11(1):1–14. [accessed 2022 Nov 21]. doi:10.1038/s41598-021-84928-w.
  • Jian C, Silvestre MP, Middleton D, Korpela K, Jalo E, Broderick D, de Vos WM, Fogelholm M, Taylor MW, Raben A, et al. Gut microbiota predicts body fat change following a low-energy diet: a PREVIEW intervention study. Genome Med [Internet]. 2022;14:1–18. [accessed 2022 Jun 16]. doi:10.1186/s13073-022-01053-7.
  • Jie Z, Yu X, Liu Y, Sun L, Chen P, Ding Q, Gao Y, Zhang X, Yu M, Liu Y, et al. The baseline gut microbiota directs dieting-induced weight loss trajectories. Gastroenterology [Internet]. 2021;160(6):2029–2042.e16. [accessed 2022 May 21]. doi:10.1053/j.gastro.2021.01.029.
  • Magne F, Gotteland M, Gauthier L, Zazueta A, Pesoa S, Navarrete P, Balamurugan R. The firmicutes/bacteroidetes ratio: a relevant marker of gut dysbiosis in obese patients? Nutrients. 2020;12:1474. doi:10.3390/nu12051474.
  • Meir AY, Rinott E, Tsaban G, Zelicha H, Kaplan A, Rosen P, Shelef I, Youngster I, Shalev A, Blüher M, et al. Effect of green-Mediterranean diet on intrahepatic fat: the DIRECT plus randomised controlled trial. Gut. 2021;70(11):2085–2095. doi:10.1136/gutjnl-2020-323106.
  • O’Leary NA, Wright MW, Brister JR, Ciufo S, Haddad D, McVeigh R, Rajput B, Robbertse B, Smith-White B, Ako-Adjei D, et al. Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation. Nucleic Acids Res [Internet]. 2016;44(D1):D733–45. [accessed 2022 Oct 28]. doi:10.1093/nar/gkv1189.
  • Seabold S, Perktold J Statsmodels: econometric and Statistical modeling with Python [Internet]. 2010. http://statsmodels.sourceforge.net/
  • Vallat R. Pingouin: statistics in Python. J Open Source Softw [Internet]. 2018;3(31):1026. [accessed 2022 Oct 2]. doi:10.21105/joss.01026.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.