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Review

Emerging roles of polyunsaturated fatty acid synthesis pathway in colorectal cancer

Pages 61-71 | Received 11 Nov 2022, Accepted 03 Mar 2023, Published online: 20 Mar 2023

References

  • Bae S, Kim MK, Kim HS, Moon YA. 2020. Arachidonic acid induces ER stress and apoptosis in HT-29 human colon cancer cells. Anim Cells Syst. 24(5):260–266.
  • Boot A, Oosting J, van Eendenburg JDH, Kuppen PJK, Morreau H, van Wezel T. 2017. Methylation associated transcriptional repression of ELOVL5 in novel colorectal cancer cell lines. PLoS One. 12(9):e0184900.
  • Bordoni A, Nunzio D, Danesi M, Biagi F, L P. 2006. Polyunsaturated fatty acids: from diet to binding to PPARs and other nuclear receptors. Genes Nutr. 1(2):95–106.
  • Burns JL, Nakamura MT, Ma DWL. 2018. Differentiating the biological effects of linoleic acid from arachidonic acid in health and disease. Prostaglandins Leukot Essent Fatty Acids. 135:1–4.
  • Cai F, Dupertuis YM, Pichard C. 2012. Role of polyunsaturated fatty acids and lipid peroxidation on colorectal cancer risk and treatments. Curr Opin Clin Nutr Metab Care. 15(2):99–106.
  • Cai Q, Gao YT, Chow WH, Shu XO, Yang G, Ji BT, Wen W, Rothman N, Li HL, Morrow JD, et al. 2006. Prospective study of urinary prostaglandin E2 metabolite and colorectal cancer risk. J Clin Oncol. 24(31):5010–5016.
  • Calder PC. 2017. Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochem Soc Trans. 45(5):1105–1115.
  • Centenera MM, Scott JS, Machiels J, Nassar ZD, Miller DC, Zinonos I, Dehairs J, Burvenich IJG, Zadra G, Chetta PM, et al. 2021. ELOVL5 is a critical and targetable fatty acid elongase in prostate cancer. Cancer Res. 81(7):1704–1718.
  • Chambrier C, Bastard J-P, Rieusset J, Chevillotte E, Bonnefont-Rousselot D, Therond P, Hainque B, Riou J-P, Laville M, Vidal H. 2002. Eicosapentaenoic acid induces mRNA expression of peroxisome proliferator-activated receptor γ. Obes Res. 10(6):518–525.
  • Chan AT, Ogino S, Fuchs CS. 2007. Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. N Engl J Med. 356(21):2131–2142.
  • Cinti DL, Cook L, Nagi MN, Suneja SK. 1992. The fatty acid chain elongation system of mammalian endoplasmic reticulum. Prog Lipid Res. 31:1–51.
  • Dannenberg AJ, Altorki NK, Boyle JO, Dang C, Howe LR, Weksler BB, Subbaramaiah K. 2001. Cyclooxygenase 2: a pharmacological target for the prevention of cancer. Lancet Oncol. 2(9):544–551.
  • Deaton AM, Bird A. 2011. Cpg islands and the regulation of transcription. Genes Dev. 25(10):1010–1022.
  • Dentin R, Denechaud P-D, Benhamed F, Girard J, Postic C. 2006. Hepatic gene regulation by glucose and polyunsaturated fatty acids: a role for ChREBP. J Nutr. 136(5):1145–1149.
  • Dierge E, Debock E, Guilbaud C, Corbet C, Mignolet E, Mignard L, Bastien E, Dessy C, Larondelle Y, Feron O. 2021. Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects. Cell Metab. 33(8):1701–1715.e1705.
  • Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, et al. 2012. Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell. 149(5):1060–1072.
  • Dupertuis YM, Meguid MM, Pichard C. 2007. Colon cancer therapy: new perspectives of nutritional manipulations using polyunsaturated fatty acids. Curr Opin Clin Nutr Metab Care. 10(4):427–432.
  • Habbel P, Weylandt KH, Lichopoj K, Nowak J, Purschke M, Wang JD, He CW, Baumgart DC, Kang JX. 2009. Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174 T human colon carcinoma cells. World J Gastroenterol. 15(9):1079–1084.
  • Habermann N, Ulrich CM, Lundgreen A, Makar KW, Poole EM, Caan B, Kulmacz R, Whitton J, Galbraith R, Potter JD, et al. 2013. PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer. Genes Nutr. 8(1):115–126.
  • Hall MN, Chavarro JE, Lee I-M, Willett WC, Ma J. 2008. A 22-year prospective study of fish, n-3 fatty acid intake, and colorectal cancer risk in men. Cancer Epidemiol Biomarkers Prev. 17(5):1136–1143.
  • Hannah VC, Ou J, Luong A, Goldstein JL, Brown MS. 2001. Unsaturated fatty acids down-regulate SREBP isoforms 1a and 1c by two mechanisms in HEK-293 cells. J Biol Chem. 276(6):4365–4372.
  • Hardman WE. 2004. (n-3) fatty acids and cancer therapy. J Nutr. 134(12 Suppl):3427s–3430s.
  • Hashemi Goradel N, Najafi M, Salehi E, Farhood B, Mortezaee K. 2019. Cyclooxygenase-2 in cancer: A review. J Cell Physiol. 234(5):5683–5699.
  • Hiraide T, Ikegami K, Sakaguchi T, Morita Y, Hayasaka T, Masaki N, Waki M, Sugiyama E, Shinriki S, Takeda M, et al. 2016. Accumulation of arachidonic acid-containing phosphatidylinositol at the outer edge of colorectal cancer. Sci Rep. 6:29935.
  • Hodge AM, Williamson EJ, Bassett JK, MacInnis RJ, Giles GG, English DR. 2015. Dietary and biomarker estimates of fatty acids and risk of colorectal cancer. Int J Cancer. 137(5):1224–1234.
  • Hofmanová J, Slavík J, Ciganek M, Ovesná P, Tylichová Z, Karasová M, Zapletal O, Straková N, Procházková J, Bouchal J, et al. 2021. Complex alterations of fatty acid metabolism and phospholipidome uncovered in isolated colon cancer epithelial cells. Int J Mol Sci. 22(13):6650.
  • Innes JK, Calder PC. 2018. Omega-6 fatty acids and inflammation. Prostaglandins Leukot Essent Fatty Acids. 132:41–48.
  • Jakobsson A, Westerberg R, Jacobsson A. 2006. Fatty acid elongases in mammals: their regulation and roles in metabolism. Prog Lipid Res. 45(3):237–249.
  • Jara-Gutiérrez Á, Baladrón V. 2021. The role of prostaglandins in different types of cancer. Cells. 10(6):1487.
  • Jump DB. 2009. Mammalian fatty acid elongases. Methods Mol Biol. 579:375–389.
  • Kemiläinen H, Huhtinen K, Auranen A, Carpén O, Strauss L, Poutanen M. 2018. The expression of HSD17B12 is associated with COX-2 expression and is increased in high-grade epithelial ovarian cancer. Oncology. 94(4):233–242.
  • Kim H, Rodriguez-Navas C, Kollipara RK, Kapur P, Pedrosa I, Brugarolas J, Kittler R, Ye J. 2015. Unsaturated fatty acids stimulate tumor growth through stabilization of β-catenin. Cell Rep. 13(3):495–503.
  • Lee J-Y, Nam M, Son HY, Hyun K, Jang SY, Kim JW, Kim MW, Jung Y, Jang E, Yoon S-J, et al. 2020. Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer. Proc Natl Acad Sci U S A. 117(51):32433–32442.
  • Li J, Ma X, Chakravarti D, Shalapour S, DePinho RA. 2021. Genetic and biological hallmarks of colorectal cancer. Genes Dev. 35(11-12):787–820.
  • Lin Y, Meng Y, Zhang J, Ma L, Jiang L, Zhang Y, Yuan M, Ren A, Zhu W, Li S, et al. 2020. Functional genetic variant of HSD17B12 in the fatty acid biosynthesis pathway predicts the outcome of colorectal cancer. J Cell Mol Med. 24(24):14160–14170.
  • May-Wilson S, Sud A, Law PJ, Palin K, Tuupanen S, Gylfe A, Hänninen UA, Cajuso T, Tanskanen T, Kondelin J, et al. 2017. Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis. Eur J Cancer. 84:228–238.
  • Mokhtari K, Mahdevar M, Hajipour M, Esmaeili M, Peymani M, Mirzaei S, Nasr-Esfahani MH, Hashemi M, Hushmandi K, Ghaedi K. 2022. Title: involvement of unsaturated fatty acid biosynthesis in CRC progression based on in vitro and in silico studies. Biomed Pharmacother. 153:113338.
  • Moon YA, Hammer RE, Horton JD. 2009. Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice. J Lipid Res. 50(3):412–423.
  • Moon YA, Horton JD. 2003. Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade. J Biol Chem. 278(9):7335–7343.
  • Mutoh M, Takahashi M, Wakabayashi K. 2006. Roles of prostanoids in colon carcinogenesis and their potential targeting for cancer chemoprevention. Curr Pharm Des. 12(19):2375–2382.
  • Nagasaki S, Suzuki T, Miki Y, Akahira J-i, Kitada K, Ishida T, Handa H, Ohuchi N, Sasano H. 2009. 17β-Hydroxysteroid dehydrogenase type 12 in human breast carcinoma: A prognostic factor via potential regulation of fatty acid synthesis. Cancer Res. 69(4):1392–1399.
  • Nikulin S, Zakharova G, Poloznikov A, Raigorodskaya M, Wicklein D, Schumacher U, Nersisyan S, Bergquist J, Bakalkin G, Astakhova L, et al. 2021. Effect of the expression of ELOVL5 and IGFBP6 genes on the metastatic potential of breast cancer cells. Front Genet. 12:662843.
  • Nitta S, Kandori S, Tanaka K, Sakka S, Siga M, Nagumo Y, Negoro H, Kojima T, Mathis BJ, Shimazui T, et al. 2022. ELOVL5-mediated fatty acid elongation promotes cellular proliferation and invasion in renal cell carcinoma. Cancer Sci. 113(8):2738–2752.
  • Ogino S, Chan AT, Fuchs CS, Giovannucci E. 2011. Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field. Gut. 60(3):397–411.
  • Patel MI, Kurek C, Dong Q. 2008. The arachidonic acid pathway and its role in prostate cancer development and progression. J Urol. 179(5):1668–1675.
  • Paweł K, Maria Małgorzata S. 2022. Cpg island methylator phenotype- A hope for the future or a road to nowhere? Int J Mol Sci. 23(2):830.
  • Peck B, Schulze A. 2016. Lipid desaturation – the next step in targeting lipogenesis in cancer? The FEBS J. 283(15):2767–2778.
  • Pender-Cudlip MC, Krag KJ, Martini D, Yu J, Guidi A, Skinner SS, Zhang Y, Qu X, He C, Xu Y, et al. 2013. Delta-6-desaturase activity and arachidonic acid synthesis are increased in human breast cancer tissue. Cancer Sci. 104(6):760–764.
  • Phipps AI, Passarelli MN, Chan AT, Harrison TA, Jeon J, Hutter CM, Berndt SI, Brenner H, Caan BJ, Campbell PT, et al. 2015. Common genetic variation and survival after colorectal cancer diagnosis: a genome-wide analysis. Carcinogenesis. 37(1):87–95.
  • Pot GK, Geelen A, van Heijningen EM, Siezen CL, van Kranen HJ, Kampman E. 2008. Opposing associations of serum n-3 and n-6 polyunsaturated fatty acids with colorectal adenoma risk: an endoscopy-based case-control study. Int J Cancer. 123(8):1974–1977.
  • Romanuik TL, Ueda T, Le N, Haile S, Yong TMK, Thomson T, Vessella RL, Sadar MD. 2009. Novel biomarkers for prostate cancer including noncoding transcripts. Am J Pathol. 175(6):2264–2276.
  • Rossen NS, Hansen AJ, Selhuber-Unkel C, Oddershede LB. 2011. Arachidonic acid randomizes endothelial cell motion and regulates adhesion and migration. PLoS One. 6(9):e25196.
  • Rothwell PM, Wilson M, Elwin CE, Norrving B, Algra A, Warlow CP, Meade TW. 2010. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet. 376(9754):1741–1750.
  • Sakai M, Kakutani S, Horikawa C, Tokuda H, Kawashima H, Shibata H, Okubo H, Sasaki S. 2012. Arachidonic acid and cancer risk: a systematic review of observational studies. BMC Cancer. 12:606.
  • Sano H, Kawahito Y, Wilder RL, Hashiramoto A, Mukai S, Asai K, Kimura S, Kato H, Kondo M, Hla T. 1995. Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res. 55(17):3785–3789.
  • Sasazuki S, Inoue M, Iwasaki M, Sawada N, Shimazu T, Yamaji T, Takachi R, Tsugane S, ftJPHCBPS G. 2011. Intake of n-3 and n-6 polyunsaturated fatty acids and development of colorectal cancer by subsite: Japan public health center–based prospective study. Int J Cancer. 129(7):1718–1729.
  • Saxonov S, Berg P, Brutlag DL. 2006. A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters. Proc Natl Acad Sci U S A. 103(5):1412–1417.
  • Shkurnikov MY, Poloznikov AA, Nikulin SV, Schumacher U, Wicklein D, Stürken C, Galatenko VV, BY A. 2019. Transcriptome guided drug combination suppresses proliferation of breast cancer cells. Bull Exp Biol Med. 166(5):656–660.
  • Spector AA, Kim HY. 2015. Discovery of essential fatty acids. J Lipid Res. 56(1):11–21.
  • Szajnik M, Szczepanski MJ, Elishaev E, Visus C, Lenzner D, Zabel M, Glura M, DeLeo AB, Whiteside TL. 2012. 17β hydroxysteroid dehydrogenase type 12 (HSD17B12) is a marker of poor prognosis in ovarian carcinoma. Gynecol Oncol. 127(3):587–594.
  • Tang C, Cho HP, Nakamura MT, Clarke SD. 2003. Regulation of human Δ-6 desaturase gene transcription: identification of a functional direct repeat-1 element. J Lipid Res. 44(4):686–695.
  • Thanikachalam K, Khan G. 2019. Colorectal cancer and nutrition. Nutrients. 11(1):164.
  • Tsachaki M, Strauss P, Dunkel A, Navrátilová H, Mladenovic N, Odermatt A. 2020. Impact of 17β-HSD12, the 3-ketoacyl-CoA reductase of long-chain fatty acid synthesis, on breast cancer cell proliferation and migration. Cell Mol Life Sci. 77(6):1153–1175.
  • Van Blarigan EL, Fuchs CS, Niedzwiecki D, Ye X, Zhang S, Song M, Saltz LB, Mayer RJ, Mowat RB, Whittom R, et al. 2018. Marine ω-3 polyunsaturated fatty acid and fish intake after colon cancer diagnosis and survival: CALGB 89803 (alliance). Cancer Epidemiol Biomarkers Prev. 27(4):438–445.
  • Wang D, Fu L, Sun H, Guo L, DuBois RN. 2015. Prostaglandin E2 promotes colorectal cancer stem cell expansion and metastasis in mice. Gastroenterology. 149(7):1884–1895.
  • Wang D, Mann JR, DuBois RN. 2005. The role of prostaglandins and other eicosanoids in the gastrointestinal tract. Gastroenterology. 128(5):1445–1461.
  • Wang Q, Morris RJ, Bode AM, Zhang T. 2022. Prostaglandin pathways: opportunities for cancer prevention and therapy. Cancer Res. 82(6):949–965.
  • WHO. 2022. Cancer. World Health Organizaion; [accessed 2022 2022 Nov 02]. https://www.who.int/news-room/fact-sheets/detail/cancer.
  • Yamashita Y, Nishiumi S, Kono S, Takao S, Azuma T, Yoshida M. 2017. Differences in elongation of very long chain fatty acids and fatty acid metabolism between triple-negative and hormone receptor-positive breast cancer. BMC Cancer. 17(1):589.
  • Yoshikawa T, Shimano H, Yahagi N, Ide T, Amemiya-Kudo M, Matsuzaka T, Nakakuki M, Tomita S, Okazaki H, Tamura Y, et al. 2002. Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements. J Biol Chem. 277(3):1705–1711.