References
- Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990–2020: global burden of disease study. Lancet. 1997;349(9064):1498–10.
- WHO. Depression and other common mental disorders: global health estimates. Geneva: World Health Organization. 2017.
- Willner P. Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology (Berl). 1997;134(4):319–329.
- Stahl SM. Essential psychopharmacology. 2nd ed. Cambridge: Cambridge University Press; 2000.
- Brunello N, Mendlewicz J, Kasper S, et al. The role of noradrenaline and selective noradrenaline reuptake inhibition in depression. Eur Neuropsychopharmacol. 2002;12(5):461–475.
- Stahl SM, Felker A. Monoamine oxidase inhibitors: a modern guide to an unrequited class of antidepressants. CNS Spectr. 2008;13(10):855–870.
- Vrshek-Schallhorn S, Doane LD, Mineka S, et al. The cortisol awakening response predicts major depression: predictive stability over a 4-year follow-up and effect of depression history. Psychol Med. 2013;43(3):483–493.
- Gold PW, Chrousos GP. The endocrinology of melancholic and atypical depression: relation to neurocircuitry and somatic consequences. Proc Assoc Am Physicians. 1999;111(1):22–34.
- Maric NP, Adzic M. Pharmacological modulation of HPA axis in depression - new avenues for potential therapeutic benefits. Psychiatr Danub. 2013;25(3):299–305.
- Schiepers OJ, Wichers MC, Maes M. Cytokines and major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(2):201–217.
- Krishnadas R, Cavanagh J. Depression: an inflammatory illness? J Neurol Neurosurg Psychiatry. 2012;83(5):495–502.
- Klings ES, Farber HW. Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease. Respir Res. 2001;2(5):280–285.
- Raedler TJ. Inflammatory mechanisms in major depressive disorder. Curr Opin Psychiatry. 2011;24(6):519–525.
- Maes M, De Vos N, Pioli R, et al. Lower serum vitamin E concentrations in major depression. Another marker of lowered antioxidant defenses in that illness. J Affect Disord. 2000;58(3):241–246.
- Bouayed J, Bohn T. Exogenous antioxidants–Double-edged swords in cellular redox state: health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxid Med Cell Longev. 2010;3(4):228–237.
- Takeda H, Tsuji M, Inazu M, et al. Rosmarinic acid and caffeic acid produce antidepressive-like effect in the forced swimming test in mice. Eur J Pharmacol. 2002;449(3):261–267.
- Zafir A, Ara A, Banu N. Invivo antioxidant status: a putative target of antidepressant action. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(2):220–228.
- Dhingra D, Bansal Y. Antidepressant-like activity of beta-carotene in unstressed and chronic unpredictable mild stressed mice. J Funct Foods. 2014;7:425–434.
- MacGillivray S, Arroll B, Hatcher S, et al. Efficacy and tolerability of selective serotonin reuptake inhibitors compared with tricyclic antidepressants in depression treated in primary care: systematic review and meta-analysis. Bmj. 2003;326(7397):1014.
- Zhang XF, Wu L, Wan DJ, et al. Evaluation of the efficacy and safety of vilazodone for treating major depressive disorder. Neuropsychiatr Dis Treat. 2015;11:1957–1965.
- Meeker AS, Herink MC, Haxby DG, et al. The safety and efficacy of vortioxetine for acute treatment of major depressive disorder: a systematic review and meta-analysis. Syst Rev. 2015;4:21.
- Asnis GM, Henderson MA. Levomilnacipran for the treatment of major depressive disorder: a review. Neuropsychiatr Dis Treat. 2015;11:125–135.
- Barnes PM, Powell-Griner E, McFann K, et al. Complementary and alternative medicine use among adults. Adv Data. 2004;343:1–19.
- Baytop T. Türkiyede Bitkiler ile Tedavi. İstanbul Üniversitesi Yayınları. 1984;3255:194–195.
- Sezik E, Aslan M, Yesilada E, et al. Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay-directed fractionation techniques. Life Sci. 2005;76(11):1223–1238.
- Takeda Y, Masuda T, Honda G, et al. Secoiridoid glycosides from Gentiana olivieri. Chem Pharm Bull. 1999;47(9):1338–1340.
- Honda G. A report on traditional medicine of Turkish people (1997, 1998). Kyoto University. 1999. Vol. 43. p. 53,74.
- Orhan N, Hocbac S, Orhan DD, et al. Enzyme inhibitory and radical scavenging effects of some antidiabetic plants of Turkey. Iran J Basic Med Sci. 2014;17(6):426–432.
- Singh S, Yadav CPS, Noolvi MN. Immunomodulatory activity of butanol fraction of Gentiana olivieri Griseb. on Balb/C mice. Asian Pac J Tropical Biomedicine. 2012;2(6):433–437.
- Mansoor A, Zaidi MI, Hyder M, et al. Antihypertensive effect of Gentiana olivieri. J Med Sci. 2004;4:176–178.
- Orhan DD, Aslan M, Aktay G, et al. Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacute administration and isolation of active principle. Life Sci. 2003;72(20):2273–2283.
- Aslan M, Orhan DD, Orhan N. Effect of Gentiana olivieri on experimental epilepsy models. Pharmacogn Mag. 2011;7(28):344–349.
- Muscat R, Sampson D, Willner P. Dopaminergic mechanism of imipramine action in an animal model of depression. Biol Psychiatry. 1990;28(3):223–230.
- Sakar M, Taner M Fitokimyasal Analizler. Ankara Üniversitesi Eczacılık Fakültesi Yayınları. 1991. p. 67.
- Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248–254.
- Bahramsoltani R, Farzaei MH, Farahani MS, et al. Phytochemical constituents as future antidepressants: a comprehensive review. Rev Neurosci. 2015;26(6):699–719.
- Wen TN, Prasad KN, Yang B. et al. Bioactive substance contents and antioxidant capacity of raw and blanched vegetables. Innov Food Sci Emerg Technol. 2010;11(3):464–469.
- Tomic M, Tovilovic G, Butorovic B, et al. Neuropharmacological evaluation of diethylether extract and xanthones of Gentiana kochiana. Pharmacol Biochem Behav. 2005;81(3):535–542.
- Wainwright SR, Workman JL, Tehrani A, et al. Testosterone has antidepressant-like efficacy and facilitates imipramine-induced neuroplasticity in male rats exposed to chronic unpredictable stress. Horm Behav. 2016;79:58–69.
- Farooq RK, Isingrini E, Tanti A, et al. Is unpredictable chronic mild stress (UCMS) a reliable model to study depression-induced neuroinflammation? Behav Brain Res. 2012;231(1):130–137.
- Laconi E, Tomasi C, Curreli F, et al. Early exposure to restraint stress enhances chemical carcinogenesis in rat liver. Cancer Lett. 2000;161(2):215–220.
- Butterweck V, Böckers T, Korte B, et al. Long-term effects of St. John’s wort and hypericin on monoamine levels in rat hypothalamus and hippocampus. Brain Res. 2002;930(1):21–29.
- Elhwuegi AS. Central monoamines and their role in major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28(3):435–451.
- Jans LA, Riedel WJ, Markus CR, et al. Serotonergic vulnerability and depression: assumptions, experimental evidence and implications. Mol Psychiatry. 2007;12(6):522–543.
- Nemeroff CB. Fostering foster care outcomes: quality of intervention matters in overcoming early adversity. Arch Gen Psychiatry. 2008;65(6):623–624.
- Mello AF, Juruena MF, Pariante CM, et al. Depression and stress: is there an endophenotype? Rev Bras Psiquiatr. 2007;29(Suppl 1):13–18.
- Tyrka AR, Mello AF, Mello MF, et al. Temperament and hypothalamic-pituitary-adrenal axis function in healthy adults. Psychoneuroendocrinology. 2006;31(9):1036–1045.
- Habib M, Shaker S, El-Gayar N, et al. The effects of antidepressants “fluoxetine and imipramine” on vascular abnormalities and Toll like receptor-4 expression in diabetic and non-diabetic rats exposed to chronic stress. PloS One. 2015;10(3):e0120559.
- O’Brien SM, Scully P, Fitzgerald P, et al. Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy. J Psychiatr Res. 2007;41(3–4):326–331.
- Ortmann CF, Reus GZ, Ignacio ZM, et al. Enriched flavonoid fraction from cecropia pachystachya trecul leaves exerts antidepressant-like behavior and protects brain against oxidative stress in rats subjected to chronic mild stress. Neurotox Res. 2016;29(4):469–483.