1,203
Views
0
CrossRef citations to date
0
Altmetric
Original Article

Effects of intermittent fasting on the histology and mRNA expression of major drug-metabolizing cyp450s in the liver of diabetic mice

, , , , , , , , , & show all
Article: 2270188 | Received 15 Jun 2023, Accepted 09 Oct 2023, Published online: 26 Oct 2023

References

  • Muntane J. Regulation of drug metabolism and transporters. Curr Drug Metab. 2009 Oct;10(8):932–11. doi: 10.2174/138920009790274595
  • Almazroo OA, Miah MK, Venkataramanan R. Drug metabolism in the liver. Clin Liver Dis. 2017 Feb;21(1):1–20. doi: 10.1016/j.cld.2016.08.001
  • Jarrar Y, Lee SJ. The functionality of UDP-Glucuronosyltransferase genetic variants and their association with drug responses and human diseases. J Pers Med. 2021 Jun 14;11(6):554. doi: 10.3390/jpm11060554
  • Westervelt P, Cho K, Bright DR, et al. Drug-gene interactions: inherent variability in drug maintenance dose requirements. P T. 2014 Sep;39(9):630–637.
  • Abdullah S, Jarrar Y, Alhawari H, et al. The influence of endothelial nitric oxide synthase (eNOS) genetic polymorphisms on cholesterol blood levels among type 2 diabetic patients on atorvastatin therapy. Endocr Metab Immune Disord Drug Targets. 2021;21(2):352–359. doi: 10.2174/1871530320666200621174858
  • Abed E, Jarrar Y, Alhawari H, et al. How the cytochrome 7a1 (CYP7A1) and ATP-binding cassette G8 (ABCG8) genetic variants affect atorvastatin response among type 2 diabetic patients attending the University of Jordan hospital. Int J Clin Pharmacol Ther. 2021 Feb;59(2):99–108. doi: 10.5414/CP203779
  • Alhawari H, Jarrar Y, AlKhatib MA, et al. The association of 3-Hydroxy-3-Methylglutaryl-CoA reductase, apolipoprotein E, and solute carrier organic anion genetic variants with atorvastatin response among Jordanian patients with type 2 diabetes. Life. 2020 Oct 5;10(10):232. doi: 10.3390/life10100232
  • American Diabetes A. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2009 Jan;1(Suppl 1):S62–7. 32 Suppl.
  • Hammad AM, Al-Qerem W, Alassi A, et al. Effect of type 2 diabetes mellitus and diabetic medication on pulmonary function. Curr Respir Med Rev. 2020;16(4):213–219. doi: 10.2174/1573398X17666210121141412
  • Irshaid YM, Al-Hadidi HF, Abuirjeie MA, et al. N-acetylation phenotyping using dapsone in a Jordanian population. Br J Clin Pharmacol. 1991 Sep;32(3):289–293. doi: 10.1111/j.1365-2125.1991.tb03901.x
  • Balasmeh R, Jarrar Y, Al-Sheikh I, et al. Effects of fasting and Phoenix dactylifera on the expression of major drug- metabolizing enzymes in the mouse livers. Curr Drug Metab. 2022;23(8):666–676. doi: 10.2174/1389200223666220820105330
  • Zouhal H, Saeidi A, Salhi A, et al. Exercise training and fasting: current insights. Open Access J Sports Med. 2020;11:1–28. doi: 10.2147/OAJSM.S224919
  • Tinsley GM, La Bounty PM. Effects of intermittent fasting on body composition and clinical health markers in humans. Nutr Rev. 2015;73(10):661–674. doi: 10.1093/nutrit/nuv041
  • Alkandari JR, Maughan RJ, Roky R, et al. The implications of Ramadan fasting for human health and well-being. J Sports Sci. 2012;30(sup1):S9–S19. doi: 10.1080/02640414.2012.698298
  • Patterson RE, Sears DD. Metabolic effects of intermittent fasting. Annu Rev Nutr. 2017;37(1):371–393. doi: 10.1146/annurev-nutr-071816-064634
  • Abdelrahim D, Faris ME, Hassanein M, et al. Impact of Ramadan diurnal intermittent fasting on hypoglycemic events in patients with type 2 diabetes: a systematic review of randomized controlled trials and observational studies. Front Endocrinol. 2021;12:624423. doi: 10.3389/fendo.2021.624423
  • Olfert ED, Cross BM, McWilliam AA. Guide to the care and use of experimental animalsVol. 1. Canadian Council on Animal Care; 1993.
  • Jarrar YB, Al-Essa L, Kilani A, et al. Alterations in the gene expression of drug and arachidonic acid-metabolizing Cyp450 in the livers of controlled and uncontrolled insulin-dependent diabetic mice. Diabetes Metab Syndr Obes. 2018;11:483–492. doi: 10.2147/DMSO.S172664
  • Orsolic N, Sirovina D, Koncic MZ, et al. Effect of Croatian propolis on diabetic nephropathy and liver toxicity in mice. BMC Complement Altern Med. 2012 Aug 6;12(1):117. doi: 10.1186/1472-6882-12-117
  • Jarrar YB, Jarrar Q, Abed A, et al. Effects of nonsteroidal anti-inflammatory drugs on the expression of arachidonic acid-metabolizing Cyp450 genes in mouse hearts, kidneys and livers. Prostaglandins Other Lipid Mediat. 2019 Apr;141:14–21.
  • Wilfinger WW, Mackey K, Chomczynski P. Effect of pH and ionic strength on the spectrophotometric assessment of nucleic acid purity. Biotechniques. 1997;22(3):474–481. doi: 10.2144/97223st01
  • Hart SN, Cui Y, Klaassen CD, et al. Three patterns of cytochrome P450 gene expression during liver maturation in mice. Drug Metab Dispos. 2009;37(1):116–121. doi: 10.1124/dmd.108.023812
  • Pokreisz P, Fleming I, Kiss L, et al. Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling. Hypertension. 2006;47(4):762–770. doi: 10.1161/01.HYP.0000208299.62535.58
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2− ΔΔCT method. Methods. 2001;25(4):402–408. doi: 10.1006/meth.2001.1262
  • Oliveira WH, Nunes AK, França MER, et al. Effects of metformin on inflammation and short-term memory in streptozotocin-induced diabetic mice. Brain Res. 2016;1644:149–160. doi: 10.1016/j.brainres.2016.05.013
  • Ahmed S, Zhou Z, Zhou J, et al. Pharmacogenomics of drug metabolizing enzymes and transporters: relevance to precision Medicine. Int J Genomics Proteomics. 2016 Oct;14(5):298–313. doi: 10.1016/j.gpb.2016.03.008
  • Caldwell J, Gardner I, Swales N. An introduction to drug disposition: the basic principles of absorption, distribution, metabolism, and excretion. Toxicol Pathol. 1995;23(2):102–114. doi: 10.1177/019262339502300202
  • Jensen TL, Kiersgaard M, Sørensen DB, et al. Fasting of mice: a review. Lab Anim. 2013;47(4):225–240. doi: 10.1177/0023677213501659
  • Pak HH, Haws SA, Green CL, et al. Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice. Nat Metab. 2021 Oct;3(10):1327–1341. doi: 10.1038/s42255-021-00466-9
  • Grams J, Garvey WT. Weight loss and the Prevention and Treatment of type 2 diabetes using lifestyle therapy, pharmacotherapy, and bariatric surgery: mechanisms of action. Curr Obes Rep. 2015 Jun;4(2):287–302. doi: 10.1007/s13679-015-0155-x
  • Fernando HA, Zibellini J, Harris RA, et al. Effect of Ramadan fasting on weight and body composition in healthy non-athlete adults: a systematic review and meta-analysis. Nutrients. 2019;11(2):478. doi: 10.3390/nu11020478
  • Dietze S, Lees KR, Fink H, et al. Food deprivation, body weight loss and anxiety-related behavior in rats. Animals (Basel). 2016 Jan 7;6(1):4. doi: 10.3390/ani6010004
  • Jensen TL, Kiersgaard MK, Sorensen DB, et al. Fasting of mice: a review. Lab Anim. 2013 Oct;47(4):225–240. doi: 10.1177/0023677213501659
  • Sokolović M, Wehkamp D, Sokolović A, et al. Fasting induces a biphasic adaptive metabolic response in murine small intestine. BMC Genomics. 2007;8(1):1–18. doi: 10.1186/1471-2164-8-361
  • Kolb H, Kempf K, Rohling M, et al. Ketone bodies: from enemy to friend and guardian angel. BMC Med. 2021 Dec 9;19(1):313. doi: 10.1186/s12916-021-02185-0
  • Zafar M, Naqvi S-U-H, Ahmed M, et al. Altered liver morphology and enzymes in Streptozotocin induced diabetic rats. Int J Morphol. 2009;27(3):719–725. doi: 10.4067/S0717-95022009000300015
  • Longo VD, Mattson MP. Fasting: molecular mechanisms and clinical applications. Cell Metab. 2014;19(2):181–192. doi: 10.1016/j.cmet.2013.12.008
  • Cobbina E, Akhlaghi F. Non-alcoholic fatty liver disease (NAFLD)–pathogenesis, classification, and effect on drug metabolizing enzymes and transporters. Drug Metab Rev. 2017;49(2):197–211. doi: 10.1080/03602532.2017.1293683
  • Jarrar Y, Al-Doaiss A, Alfaifi M, et al. The influence of five metallic nanoparticles on the expression of major drug-metabolizing enzyme genes with correlation of inflammation in mouse livers. Environ Toxicol Pharmacol. 2020 Nov;80:103449.
  • Elbekai RH, Korashy HM, El-Kadi AO. The effect of liver cirrhosis on the regulation and expression of drug metabolizing enzymes. Curr Drug Metab. 2004;5(2):157–167. doi: 10.2174/1389200043489054
  • Klein M, Thomas M, Hofmann U, et al. A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and HepaRG cells. Drug Metab Dispos. 2015;43(2):273–283. doi: 10.1124/dmd.114.060962
  • Ding X, Lichti K, Kim I, et al. Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha. J Biol Chem. 2006 Sep 8;281(36):26540–26551. doi: 10.1074/jbc.M600931200
  • Gao J, Xie W. Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism. Drug Metab Dispos. 2010 Dec;38(12):2091–2095. doi: 10.1124/dmd.110.035568
  • Alsaad AM, Zordoky BN, El-Sherbeni AA, et al. Chronic doxorubicin cardiotoxicity modulates cardiac cytochrome P450-mediated arachidonic acid metabolism in rats. Drug Metab Dispos. 2012 Nov;40(11):2126–2135. doi: 10.1124/dmd.112.046631
  • Zordoky BN, Anwar-Mohamed A, Aboutabl ME, et al. Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats. Toxicol Appl Pharmacol. 2010 Jan 1;242(1):38–46. doi: 10.1016/j.taap.2009.09.012
  • Velez-Bermudez IC, Schmidt W. The conundrum of discordant protein and mRNA expression. Are plants special? Front Plant Sci. 2014;5:619. doi: 10.3389/fpls.2014.00619
  • Zerdes I, Karafousia V, Mezheyeuski A, et al. Discordance of PD-L1 expression at the protein and RNA levels in early breast cancer. Cancers (Basel). 2021 Sep 16;13(18):4655. doi: 10.3390/cancers13184655