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Original Article

Salivary bacterial shifts in oral leukoplakia resemble the dysbiotic oral cancer bacteriome

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Article: 1857998 | Received 13 Jul 2020, Accepted 17 Nov 2020, Published online: 09 Dec 2020

References

  • Warnakulasuriya S, Ariyawardana A. Malignant transformation of oral leukoplakia: a systematic review of observational studies. J Oral Pathol Med. 2016;45:155–8.
  • Gopinath D. Prevalence of carcinomatous foci in oral leukoplakia: a clinicopathologic study of 546 Indian samples. JCDR. 2016. DOI:https://doi.org/10.7860/JCDR/2016/16815.8305.
  • Speight PM, Khurram SA, Kujan O. Oral potentially malignant disorders: risk of progression to malignancy. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125:612–627.
  • Khurshid Z, Zafar MS, Khan RS, et al. Role of salivary biomarkers in oral cancer detection. Adv Clin Chem. 2018;86:23–70. . Elsevier
  • Gopinath D, Menon RK, Banerjee M, et al. Culture-independent studies on bacterial dysbiosis in oral and oropharyngeal squamous cell carcinoma: a systematic review. Crit Rev Oncol Hematol. 2019;139:31–40.
  • Al-Hebshi NN, Borgnakke WS, Johnson NW. The microbiome of oral squamous cell carcinomas: a functional perspective. Curr Oral Health Rep. 2019;6:145–160.
  • Menon RK, Gopinath D. Eliminating bias and accelerating the clinical translation of oral microbiome research in oral oncology. Oral Oncol. 2018;79:84–85.
  • Kaczor-Urbanowicz KE, Martin Carreras-Presas C, Aro K, et al. Saliva diagnostics – current views and directions. Exp Biol Med (Maywood). 2017;242(5):459–472.
  • Lee W-H, Chen H-M, Yang S-F, et al. Bacterial alterations in salivary microbiota and their association in oral cancer. Sci Rep. 2017;7(1):16540.
  • Lim Y, Fukuma N, Totsika M, et al. The performance of an oral microbiome biomarker panel in predicting oral cavity and oropharyngeal cancers. Front Cell Infect Microbiol. 2018;8:267.
  • Bowman JS, Ducklow HW. Microbial communities can be described by metabolic structure: a general framework and application to a seasonally variable, depth-stratified microbial community from the Coastal West Antarctic Peninsula. PLoS ONE. 2015;10:e0135868.
  • Gopinath D, Kunnath Menon R. Unravelling the molecular signatures in HNSCC: is the homogenous paradigm becoming obsolete? Oral Oncol. 2018Jul;82:195.
  • Callahan BJ, McMurdie PJ, Rosen MJ, et al. DADA2: high-resolution sample inference from Illumina amplicon data. Nat Methods. 2016;13:581–583.
  • Matsen FA, Kodner RB, Armbrust EV. pplacer: linear time maximum-likelihood and Bayesian phylogenetic placement of sequences onto a fixed reference tree. BMC Bioinformatics. 2010;11(1):538.
  • McMurdie PJ, Holmes S. phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. PLoS ONE. 2013;8:e61217.
  • Rohart F, Gautier B, Singh A, et al. mixOmics: an R package for ‘omics feature selection and multiple data integration. PLoS Comput Biol. 2017;13(11):e1005752.
  • Lê Cao K-A, Boitard S, Besse P. Sparse PLS discriminant analysis: biologically relevant feature selection and graphical displays for multiclass problems. BMC Bioinformatics. 2011;12(1):253.
  • Ruiz-Perez D, Guan H, Madhivanan P, et al. So you think you can PLS-DA? BioRxiv. 2020;207225. https://doi.org/https://doi.org/10.1101/207225.
  • Hu X, Zhang Q, Hua H, et al. Changes in the salivary microbiota of oral leukoplakia and oral cancer. Oral Oncol. 2016;56:e6–8.
  • Amer A, Galvin S, Healy CM, et al. The microbiome of potentially malignant oral leukoplakia exhibits enrichment for Fusobacterium, Leptotrichia, Campylobacter, and Rothia species. Front Microbiol. 2017;8:2391.
  • Schmidt BL, Kuczynski J, Bhattacharya A, et al. Changes in abundance of oral microbiota associated with oral cancer. PLoS ONE. 2014;9(6):e98741.
  • Wang H, Funchain P, Bebek G, et al. Microbiomic differences in tumor and paired-normal tissue in head and neck squamous cell carcinomas. Genome Med. 2017;9(1):14.
  • Segata N, Haake S, Mannon P, et al. Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples. Genome Biol. 2012;13(6):R42.
  • Hooper SJ, Crean S-J, Fardy MJ, et al. A molecular analysis of the bacteria present within oral squamous cell carcinoma. J Med Microbiol. 2007;56:1651–1659.
  • Börnigen D, Ren B, Pickard R, et al. Alterations in oral bacterial communities are associated with risk factors for oral and oropharyngeal cancer. Sci Rep. 2017;7(1):17686.
  • Zhao H, Chu M, Huang Z, et al. Variations in oral microbiota associated with oral cancer. Sci Rep. 2017;7(1):11773.
  • Pushalkar S, Mane SP, Ji X, et al. Microbial diversity in saliva of oral squamous cell carcinoma. FEMS Immunol Med Microbiol. 2011;61(3):269–277.
  • Vesty A, Gear K, Biswas K, et al. Microbial and inflammatory-based salivary biomarkers of head and neck squamous cell carcinoma. Clin Exp Dent Res. 2018;4(6):255–262.
  • Mughini-Gras L, Schaapveld M, Kramers J, et al. Increased colon cancer risk after severe Salmonella infection. PLoS ONE. 2018;13:e0189721.
  • Oh HY, Kim B-S, Seo -S-S, et al. The association of uterine cervical microbiota with an increased risk for cervical intraepithelial neoplasia in Korea. Clin Microbiol Infect. 2015;21:674.e1–674.e9.
  • Baker JL, Hendrickson EL, Tang X, et al. Klebsiella and Providencia emerge as lone survivors following long-term starvation of oral microbiota. Proc Natl Acad Sci USA. 2019;116:8499–8504.
  • Wang C-Z, Kazmierczak RA, Eisenstark A. Strains, mechanism, and perspective: Salmonella -based cancer therapy. Int J Microbiol. 2016;2016:1–10.
  • Xu L, Chen X, Wang Y, et al. Dynamic alterations in salivary microbiota related to dental caries and age in preschool children with deciduous dentition: a 2-year follow-up study. Front Physiol. 2018;9:342.
  • Marrazzo JM, Fiedler TL, Srinivasan S, et al. Extravaginal reservoirs of vaginal bacteria as risk factors for incident bacterial vaginosis. J Infect Dis. 2012;205(10):1580–1588.
  • Audirac-Chalifour A, Torres-Poveda K, Bahena-Román M, et al. Cervical microbiome and cytokine profile at various stages of cervical cancer: a pilot study. PLoS ONE. 2016;11(4):e0153274.
  • Sodhani P, Gupta S, Gupta R, et al. Bacterial vaginosis and cervical intraepithelial neoplasia: is there an association or is co-existence incidental? APJCP. 2017;18. DOI:https://doi.org/10.22034/APJCP.2017.18.5.1289
  • Gannot G, Gannot I, Vered H, et al. Increase in immune cell infiltration with progression of oral epithelium from hyperkeratosis to dysplasia and carcinoma. Br J Cancer. 2002;86(9):1444–1448.
  • Mashhadiabbas F, Fayazi-Boroujeni M. Correlation of vascularization and inflammation with severity of oral leukoplakia. Iran J Pathol. 2017;12:225–230.
  • Syafriadi M, Cheng J, Jen KY, et al. Two-phase appearance of oral epithelial dysplasia resulting from focal proliferation of parabasal cells and apoptosis of prickle cells. J Oral Pathol Med. 2005;34(3):140–149.
  • Athié-Morales V, O’Connor GM, Gardiner CM. Activation of human NK cells by the bacterial pathogen-associated molecular pattern muramyl dipeptide. J Immunol. 2008;180:4082–4089.
  • Guerrero-Preston R, Godoy-Vitorino F, Jedlicka A, et al. 16S rRNA amplicon sequencing identifies microbiota associated with oral cancer, human papilloma virus infection and surgical treatment. Oncotarget. 2016;7(32):51320–51334.
  • Wolf A, Moissl-Eichinger C, Perras A, et al. The salivary microbiome as an indicator of carcinogenesis in patients with oropharyngeal squamous cell carcinoma: a pilot study. Sci Rep. 2017;7(1):5867.
  • Yang C-Y, Yeh Y-M, Yu H-Y, et al. Oral microbiota community dynamics associated with oral squamous cell carcinoma staging. Front Microbiol. 2018;9:862.
  • Knights D, Costello EK, Knight R. Supervised classification of human microbiota. FEMS Microbiol Rev. 2011;35(2):343–359.
  • Gopinath D, Kunnath Menon RK, Veettil S, et al. Periodontal diseases as putative risk factors for head and neck cancer: systematic review and meta-analysis. Cancers (Basel). 2020;12(7):1893.