2,088
Views
2
CrossRef citations to date
0
Altmetric
Original Article

Dysbiotic human oral microbiota alters systemic metabolism via modulation of gut microbiota in germ-free mice

, , , , , , , , & ORCID Icon show all
Article: 2110194 | Received 01 May 2022, Accepted 03 Aug 2022, Published online: 11 Aug 2022

References

  • Qin N, Yang F, Li A, et al. Alterations of the human gut microbiome in liver cirrhosis. Nature. 2014;513(7516):59–14. Epub 2014/08/01. PubMed PMID: 25079328
  • Read E, Curtis MA, Neves JF.The role of oral bacteria in inflammatory bowel disease.Nat Rev Gastroenterol Hepatol.2021;18(10):731–742; Epub 2021/08/18. PubMed PMID: 34400822;
  • Yachida S, Mizutani S, Shiroma H, et al. Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer. Nat Med. 2019;25(6):968–976. Epub 2019/06/07. PubMed PMID: 31171880
  • Schmidt TS, Hayward MR, Coelho LP, et al. Extensive transmission of microbes along the gastrointestinal tract. Elife. Epub 2019/02/13. 10.7554/eLife.42693. PubMed PMID: 30747106; PubMed Central PMCID: PMCPMC6424576. 2019;8
  • Kageyama S, Takeshita T, Asakawa M, et al. Relative abundance of total subgingival plaque-specific bacteria in salivary microbiota reflects the overall periodontal condition in patients with periodontitis. PLoS One. 2017;12(4):e0174782. Epub 2017/04/04. PubMed PMID: 28369125; PubMed Central PMCID: PMCPMC5378373
  • Arimatsu K, Yamada H, Miyazawa H, et al. Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota. Sci Rep. 2014;4(1):4828. Epub 2014/05/07. srep04828 [pii]. PubMed PMID: 24797416; PubMed Central PMCID: PMC4010932.
  • Kato T, Yamazaki K, Nakajima M, et al. Oral administration of porphyromonas gingivalis alters the gut microbiome and serum metabolome. mSphere. Epub 2018/10/20. 10.1128/mSphere.00460-18. PubMed PMID: 30333180; PubMed Central PMCID: PMCPMC6193602. 2018;3(5)
  • Yamazaki K, Kato T, Tsuboi Y, et al. Oral Pathobiont-Induced Changes in Gut Microbiota Aggravate the Pathology of Nonalcoholic Fatty Liver Disease in Mice. Front Immunol. 2021;12:766170. Epub 2021/10/29. PubMed PMID: 34707622; PubMed Central PMCID: PMCPMC8543001
  • Yamazaki K, Sato K, Tsuzuno T, et al. Orally administered pathobionts and commensals have comparable and innocuous systemic effects on germ-free mice. Microb Pathog. 2020;140:103962. Epub 2020/01/07. PubMed PMID: 31904448.
  • Iwasawa K, Suda W, Tsunoda T, et al. Dysbiosis of the salivary microbiota in pediatric-onset primary sclerosing cholangitis and its potential as a biomarker. Sci Rep. 2018;8(1):5480. Epub 2018/04/05. PubMed PMID: 29615776; PubMed Central PMCID: PMCPMC5882660
  • Atarashi K, Suda W, Luo C, et al. Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation. Science. 2017;358(6361):359–365. Epub 2017/10/21. PubMed PMID: 29051379; PubMed Central PMCID: PMCPMC5682622
  • Kozich JJ, Westcott SL, Baxter NT, et al.Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform.Appl Environ Microbiol.2013;79(17):5112–5120; Epub 2013/06/25. AEM.01043-13 [pii]. PubMed PMID: 23793624; PubMed Central PMCID: PMC3753973.;
  • Callahan BJ, McMurdie PJ, Rosen MJ, et al.DADA2: high-resolution sample inference from Illumina amplicon data.Nat Methods.2016;13(7):581–583; Epub 2016/05/24. PubMed PMID: 27214047; PubMed Central PMCID: PMCPMC4927377;
  • Quast C, Pruesse E, Yilmaz P, et al. The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Nucleic Acids Res. 2013;41( Database issue):D590–6. Epub 2012/11/30. PubMed PMID: 23193283; PubMed Central PMCID: PMCPMC3531112
  • Lin H, Peddada SD.Analysis of compositions of microbiomes with bias correction.Nat Commun.2020;11(1):3514; Epub 2020/07/16. PubMed PMID: 32665548; PubMed Central PMCID: PMCPMC7360769;
  • Ohashi Y, Hirayama A, Ishikawa T, et al. Depiction of metabolome changes in histidine-starved Escherichia coli by CE-TOFMS. Mol Biosyst. 2008;4(2):135–147. Epub 2008/01/24. PubMed PMID: 18213407
  • Ooga T, Sato H, Nagashima A, et al. Metabolomic anatomy of an animal model revealing homeostatic imbalances in dyslipidaemia. Mol Biosyst. 2011;7(4):1217–1223. Epub 2011/01/25. PubMed PMID: 21258713
  • Sugimoto M, Wong DT, Hirayama A, et al.Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles.Metabolomics.2010;6(1):78–95; Epub 2010/03/20. PubMed PMID: 20300169; PubMed Central PMCID: PMCPMC2818837;
  • Yamamoto H, Fujimori T, Sato H, et al.Statistical hypothesis testing of factor loading in principal component analysis and its application to metabolite set enrichment analysis.BMC Bioinformatics.2014;15(1):51; Epub 2014/02/22. PubMed PMID: 24555693; PubMed Central PMCID: PMCPMC4015128;
  • Junker BH, Klukas C, Schreiber F.VANTED: a system for advanced data analysis and visualization in the context of biological networks.BMC Bioinformatics.2006;7(1):109; Epub 2006/03/08. PubMed PMID: 16519817; PubMed Central PMCID: PMCPMC1413562;
  • Saran AR, Dave S, Zarrinpar A.Circadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease.Gastroenterology.2020;158(7):1948–66 e1; Epub 2020/02/18. PubMed PMID: 32061597; PubMed Central PMCID: PMCPMC7279714;
  • Kashiwagi Y, Aburaya S, Sugiyama N, et al. Porphyromonas gingivalis induces entero-hepatic metabolic derangements with alteration of gut microbiota in a type 2 diabetes mouse model. Sci Rep. 2021;11(1):18398. Epub 2021/09/17. PubMed PMID: 34526589; PubMed Central PMCID: PMCPMC8443650
  • Kitamoto S, Nagao-Kitamoto H, Jiao Y, et al. The intermucosal connection between the mouth and gut in commensal pathobiont-driven colitis. Cell. 2020;182(2):447–62 e14. Epub 2020/08/08. PubMed PMID: 32758418; PubMed Central PMCID: PMCPMC7414097
  • Komazaki R, Katagiri S, Takahashi H, et al. Periodontal pathogenic bacteria, Aggregatibacter actinomycetemcomitans affect non-alcoholic fatty liver disease by altering gut microbiota and glucose metabolism. Sci Rep. 2017;7(1):13950. doi:Epub 2017/10/27. PubMed PMID: 29066788; PubMed Central PMCID: PMCPMC5655179
  • Li J, Morrow C, Barnes S, et al. Gut microbiome composition and serum metabolome profile among individuals with spinal cord injury and normal glucose tolerance or prediabetes/Type 2 Diabetes. Arch Phys Med Rehabil. 2021. Epub 2021/06/15. doi: 10.1016/j.apmr.2021.03.043. PubMed PMID: 34126067
  • Sato K, Takahashi N, Kato T, et al. Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system. Sci Rep. 2017;7(1):6955. Epub 2017/08/02. 10.1038/s41598-017-07196-7 [pii]. PubMed PMID: 28761156; PubMed Central PMCID: PMC5537233
  • Sohn J, Li L, Zhang L, et al. Porphyromonas gingivalis indirectly elicits intestinal inflammation by altering the gut microbiota and disrupting epithelial barrier function through IL9-producing CD4(+) T cells. Mol Oral Microbiol. 2021. Epub 2021/12/28. doi: 10.1111/omi.12359. PubMed PMID: 34958712
  • Jin SS, Lin CJ, Lin XF, et al.Silencing lncRNA NEAT1 reduces nonalcoholic fatty liver fat deposition by regulating the miR-139-5p/c-Jun/SREBP-1c pathway.Ann Hepatol.2021;27(2):100584; Epub 2021/11/23. PubMed PMID: 34808393;
  • Hu MJ, Long M, Dai RJ.Acetylation of H3K27 activated lncRNA NEAT1 and promoted hepatic lipid accumulation in non-alcoholic fatty liver disease via regulating miR-212-5p/GRIA3.Mol Cell Biochem.2022;477(1):191–203; Epub 2021/10/16. PubMed PMID: 34652536; PubMed Central PMCID: PMCPMC8517567;
  • Wang Q, Wei S, Li L, et al. miR-139-5p sponged by LncRNA NEAT1 regulates liver fibrosis via targeting -catenin/SOX9/TGF-1 pathway. Cell Death Discov. 2021;7(1):243. Epub 2021/09/18. PubMed PMID: 34531378; PubMed Central PMCID: PMCPMC8446030
  • Xu X, Zhang Y, Wang X, et al.Substrate Stiffness Drives Epithelial to Mesenchymal Transition and Proliferation through the NEAT1-Wnt/-Catenin Pathway in Liver Cancer.Int J Mol Sci.2021;22(21):12066; Epub 2021/11/14. PubMed PMID: 34769497; PubMed Central PMCID: PMCPMC8584463;
  • Wang JX, Zeng Q, Chen L, et al. SPINDLIN1 promotes cancer cell proliferation through activation of WNT/TCF-4 signaling. Mol Cancer Res. 2012;10(3):326–335. Epub 2012/01/20. PubMed PMID: 22258766
  • Liu H, Fergusson MM, Wu JJ, et al. Wnt signaling regulates hepatic metabolism. Sci Signal. 2011;4(158):ra6. Epub 2011/02/03. PubMed PMID: 21285411; PubMed Central PMCID: PMCPMC3147298
  • Sato M, Kawakami T, Kondoh M, et al. Development of high-fat-diet-induced obesity in female metallothionein-null mice. FASEB J. 2010;24(7):2375–2384. Epub 2010/03/12. PubMed PMID: 20219986
  • Ge Q, Feng F, Liu L, et al. RNA-Seq analysis of the pathogenesis of STZ-induced male diabetic mouse liver. J Diabetes Complications. 2020;34(2):107444. Epub 2019/11/24. PubMed PMID: 31757765
  • Seiki S, Frishman WH.Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia.Cardiol Rev.2009;17(2):70–76; Epub 2009/04/16. PubMed PMID: 19367148;
  • Soga T, Baran R, Suematsu M, et al. Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. J Biol Chem. 2006;281(24):16768–16776. Epub 2006/04/13. PubMed PMID: 16608839
  • Sato K, Yamazaki K, Kato T, et al. Obesity-Related Gut Microbiota Aggravates Alveolar Bone Destruction in Experimental Periodontitis through Elevation of Uric Acid. mBio. 2021;12(3):e0077121. Epub 2021/06/02. PubMed PMID: 34061595; PubMed Central PMCID: PMCPMC8262938
  • Li X, Xu Z, Lu X, et al. Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry for metabonomics: biomarker discovery for diabetes mellitus. Anal Chim Acta. 2009;633(2):257–262. Epub 2009/01/27. PubMed PMID: 19166731
  • Elliott P, Posma JM, Chan Q, et al. Urinary metabolic signatures of human adiposity. Sci Transl Med. 2015;7(285):285ra62. Epub 2015/05/01. PubMed PMID: 25925681; PubMed Central PMCID: PMCPMC6598200
  • Tsoukalas D, Fragoulakis V, Papakonstantinou E, et al. Prediction of autoimmune diseases by targeted metabolomic assay of urinary organic acids. Metabolites. 2020;10(12):502. Epub 2020/12/12. PubMed PMID: 33302528; PubMed Central PMCID: PMCPMC7764183
  • Afroz R, Tanvir EM, Karim N, et al. Sundarban Honey Confers Protection against Isoproterenol-Induced Myocardial Infarction in Wistar Rats. Biomed Res Int. 2016;2016:6437641. Epub 2016/06/14. PubMed PMID: 27294126; PubMed Central PMCID: PMCPMC4886051.
  • Schwartz JL, Pena N, Kawar N, et al. Old age and other factors associated with salivary microbiome variation. BMC Oral Health. 2021;21(1):490. Epub 2021/10/05. PubMed PMID: 34602059; PubMed Central PMCID: PMCPMC8489047
  • Feres M, Teles F, Teles R, et al. The subgingival periodontal microbiota of the aging mouth. Periodontol. 2016;72(1):30–53. Epub 2016/08/09. PubMed PMID: 27501490; PubMed Central PMCID: PMCPMC5141605 2000
  • Arrieta MC, Walter J, Finlay BB.Human Microbiota-Associated Mice: a Model with Challenges.Cell Host Microbe.2016;19(5):575–578; Epub 2016/05/14. PubMed PMID: 27173924;