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Clinical Research Article

A systematic review and meta-analysis of psychological interventions for comorbid post-traumatic stress disorder and substance use disorder

Una revisión sistemática y meta-análisis de intervenciones psicológicas para la comorbilidad de TEPT y trastorno por uso de sustancias

一项对PTSD 和物质使用障碍共病心理干预的系统综述和元分析

ORCID Icon, ORCID Icon & ORCID Icon
Article: 2041831 | Received 14 Nov 2021, Accepted 29 Jan 2022, Published online: 03 May 2022

References

  • Acosta, M. C., Possemato, K., Maisto, S. A., Marsch, L. A., Barrie, K., Lantinga, L., … Rosenblum, A. (2017). Web-delivered CBT reduces heavy drinking in OEF-OIF veterans in primary care with symptomatic substance use and PTSD. Behavior Therapy, 48(2), 262–276. doi:10.1016/j.beth.2016.09.001
  • American Psychological Association. (2017). Clinical Practice Guideline for the Treatment of Posttraumatic Stress Disorder (PTSD) in Adults. American Psychological Association. Retrieved from www.apa.org/ptsd-guideline
  • Back, S. E., Foa, E. B., Killeen, T. K., Mills, K. L., Teesson, M., Carroll, K. M., et al. (2014). Concurrent treatment of PTSD and substance use disorders using prolonged exposure (COPE): Therapist manual. New York: Oxford University Press.
  • Back, S. E., Killeen, T., Badour, C. L., Flanagan, J. C., Allan, N. P., Ana, E. S., … Brady, K. T. (2019). Concurrent treatment of substance use disorders and PTSD using prolonged exposure: A randomized clinical trial in military veterans. Addictive Behaviors, 90, 369–377. doi:10.1016/j.addbeh.2018.11.032
  • Belleau, E. L., Chin, E. G., Wanklyn, S. G., Zambrano-Vazquez, L., Schumacher, J. A., & Coffey, S. F. (2017). Pre-treatment predictors of dropout from prolonged exposure therapy in patients with chronic posttraumatic stress disorder and comorbid substance use disorders. Behaviour Research and Therapy, 91, 43–50. doi:10.1016/j.brat.2017.01.011
  • Bisson, J. I., Berliner, L., Cloitre, M., Forbes, D., Jensen, T. K., Lewis, C., … Shapiro, F. (2019). The International Society for Traumatic Stress Studies new guidelines for the prevention and treatment of posttraumatic stress disorder: Methodology and development process. Journal of Traumatic Stress, 32(4), 475–483.
  • Blakey, S. M., Dillon, K. H., Wagner, H. R., Simpson, T. L., Beckham, J. C., Calhoun, P. S., & Elbogen, E. B. (2022). Psychosocial well-being among veterans with posttraumatic stress disorder and substance use disorder. Psychological Trauma: Theory, Research, Practice and Policy, 14(3), 421–430. doi:10.1037/tra0001018
  • Boden, M. T., Kimerling, R., Kulkarni, M., Bonn-Miller, M. O., Weaver, C., & Trafton, J. (2014). Coping among military veterans with PTSD in substance use disorder treatment. Journal of Substance Abuse Treatment, 47(2), 160–167. doi:10.1016/j.jsat.2014.03.006
  • Capone, C., Presseau, C., Saunders, E., et al. (2018). Is integrated CBT effective in reducing PTSD symptoms and substance use in Iraq and Afghanistan veterans? Results from a randomized clinical trial. Cognitive Therapy and Research, 42, 735–746. doi:10.1007/s10608-018-9931-8
  • Coffey, S. F., Schumacher, J. A., Nosen, E., Littlefield, A. K., Henslee, A. M., Lappen, A., & Stasiewicz, P. R. (2016). Trauma-focused exposure therapy for chronic posttraumatic stress disorder in alcohol and drug dependent patients: A randomized controlled trial. Psychology of Addictive Behaviors, 30(7), 778–790. doi:10.1037/adb0000201
  • Coffey, S. F., Stasiewicz, P. R., Hughes, P. M., & Brimo, M. L. (2006). Trauma-focused imaginal exposure for individuals with comorbid posttraumatic stress disorder and alcohol dependence: Revealing mechanisms of alcohol craving in a cue reactivity paradigm. Psychology of Addictive Behaviors, 20(4), 425–435. doi:10.1037/0893-164X.20.4.425
  • Danielson, C. K., Adams, Z., McCart, M. R., Chapman, J. E., Sheidow, A. J., Walker, J., … de Arellano, M. A. (2020). Safety and efficacy of exposure-based risk reduction through family therapy for co-occurring substance use problems and posttraumatic stress disorder symptoms among adolescents: A randomized clinical trial. JAMA Psychiatry, 77(6), 574–586. doi:10.1001/jamapsychiatry.2019.4803
  • De Jongh, A., Groenland, G. N., Sanches, S., Bongaerts, H., Voorendonk, E. M., & Van Minnen, A. (2020). The impact of brief intensive trauma-focused treatment for PTSD on symptoms of borderline personality disorder. European Journal of Psychotraumatology, 11(1), 1721142. doi:10.1080/20008198.2020.1721142
  • Debell, F., Fear, N. T., Head, M., Batt-Rawden, S., Greenberg, N., Wessely, S., & Goodwin, L. (2014). A systematic review of the comorbidity between PTSD and alcohol misuse. Social Psychiatry and Psychiatric Epidemiology, 49(9), 1401–1425. doi:10.1007/s00127-014-0855-7
  • Degenhardt, L., Whiteford, H. A., Ferrari, A. J., Baxter, A. J., Charlson, F. J., Hall, W. D., … Vos, T. (2013). Global burden of disease attributable to illicit drug use and dependence: Findings from the Global Burden of Disease Study 2010. The Lancet, 382(9904), 1564–1574. doi:10.1016/S0140-6736(13)61530-5
  • Dvorak, R. D., Pearson, M. R., & Day, A. M. (2014). Ecological momentary assessment of acute alcohol use disorder symptoms: Associations with mood, motives, and use on planned drinking days. Experimental and Clinical Psychopharmacology, 22(4), 285–297. doi:10.1037/a0037157
  • Ehlers, A., Hackmann, A., Grey, N., Wild, J., Liness, S., Albert, I., … Clark, D. M. (2014). A randomized controlled trial of 7-day intensive and standard weekly cognitive therapy for PTSD and emotion-focused supportive therapy. The American Journal of Psychiatry, 171(3), 294–304. doi:10.1176/appi.ajp.2013.13040552
  • Foa, E. B., Yusko, D. A., McLean, C. P., Suvak, M. K., Bux, D. A., Jr, Oslin D., … Volpicelli, J. (2013). Concurrent naltrexone and prolonged exposure therapy for patients with comorbid alcohol dependence and PTSD: A randomized clinical trial. JAMA, 310(5), 488–495. https://doi.org/10.1001/jama.2013.8268
  • Ford, J. D., & Russo, E. (2006). Trauma-focused, present-centered, emotional self-regulation approach to integrated treatment for posttraumatic stress and addiction: Trauma Adaptive Recovery Group Education and Therapy (TARGET). American Journal of Psychotherapy, 60(4), 335–355. doi:10.1176/appi.psychotherapy.2006.60.4.335
  • Frisman, L., Ford, J., Lin, H.-J., Mallon, S., & Chang, R. (2008). Outcomes of trauma treatment using the TARGET model. Journal of Groups in Addiction & Recovery, 3(3–4), 285–303. doi:10.1080/15560350802424910
  • Gielen, N., Havermans, R. C., Tekelenburg, M., & Jansen, A. (2012). Prevalence of post-traumatic stress disorder among patients with substance use disorder: It is higher than clinicians think it is. European Journal of Psychotraumatology, 3, 17734. doi:10.3402/ejpt.v3i0.17734
  • Grant, B. F., Saha, T. D., Ruan, W. J., Goldstein, R. B., Chou, S. P., Jung, J., … Hasin, D. S. (2016). Epidemiology of DSM-5 drug use disorder: Results from the National Epidemiologic Survey on Alcohol and Related Conditions-III. JAMA Psychiatry, 73(1), 39–47. doi:10.1001/jamapsychiatry.2015.2132
  • Grundmann, J., Lotzin, A., Sehner, S., Verthein, U., Hiller, P., Hiersemann, R., … Schäfer, I. (2021). Predictors of attendance in outpatient group treatment for women with posttraumatic stress disorder and substance use disorder. Psychotherapy Research, 31(5), 632–643. doi: 10.1080/10503307.2020.1817604
  • Guyatt, G. H., Oxman, A. D., Schünemann, H. J., Tugwell, P., & Knottnerus, A. (2011). GRADE guidelines: A series of new articles in the Journal of Clinical Epidemiology. Journal of Clinical Epidemiology, 64(4), 380–382. doi:10.1016/j.jclinepi.2010.09.011
  • Haller, M., Norman, S. B., Cummins, K., Trim, R. S., Xu, X., Cui, R., … Tate, S. R. (2016). Integrated cognitive behavioral therapy versus cognitive processing therapy for adults with depression, substance use disorder, and trauma. Journal of Substance Abuse Treatment, 62, 38–48. doi:10.1016/j.jsat.2015.11.005
  • Hien, D. A., Cohen, L. R., Miele, G. M., Litt, L. C., & Capstick, C. (2004). Promising treatments for women with comorbid PTSD and substance use disorders. American Journal of Psychiatry, 161(8), 1426–1432. doi:10.1176/appi.ajp.161.8.1426
  • Hien, D. A., Morgan-Lopez, A. A., Campbell, A. N., Saavedra, L. M., Wu, E., Cohen, L., … Nunes, E. V. (2012). Attendance and substance use outcomes for the Seeking Safety program: Sometimes less is more. Journal of Consulting and Clinical Psychology, 80(1), 29–42. doi:10.1037/a0026361
  • Hien, D. A., Wells, E. A., Jiang, H., Suarez-Morales, L., Campbell, A. N. C., Cohen, L. R., et al. (2009). Multisite randomized trial of behavioral interventions for women with cooccurring PTSD and substance use disorders. Journal of Consulting and Clinical Psychology, 77(4), 607–619. doi:10.1037/a0016227
  • Hien, D., Fitzpatrick, S., Saavedra, L., Ebrahimi, C., Norman, S., Tripp, J., et al. (2022). What’s in a name? A data-driven method to identify optimal psychotherapy classifications to advance treatment research on co-occurring PTSD and substance use disorders. European Journal of Psychotraumatology, 13, 1. doi:10.1080/20008198.2021.2001191
  • Higgins, J. P. T., & Green, S. (2011). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration. Retrieved from www.cochrane-handbook.org
  • International Society for Traumatic Stress Studies. (2018). ISTSS prevention and treatment guidelines (2018). Retrieved from https://www.istss.org/treatingtrauma/new-istss-prevention-and-treatment-guidelines.aspx
  • Jakupcak, M., Conybeare, D., Phelps, L., Hunt, S., Holmes, H. A., Felker, B., … McFall, M. E. (2007). Anger, hostility, and aggression among Iraq and Afghanistan War veterans reporting PTSD and subthreshold PTSD. Journal of Traumatic Stress, 20(6), 945–954. doi:10.1002/jts.20258
  • Jhanjee, S. (2014). Evidence based psychosocial interventions in substance use. Indian Journal of Psychological Medicine, 36(2), 112–118. doi:10.4103/0253-7176.130960
  • Kaysen, D., Stappenbeck, C., Rhew, I., & Simpson, T. (2014). Proximal relationships between PTSD and drinking behavior. European Journal of Psychotraumatology, 5, 26518. doi:10.3402/ejpt.v5.26518
  • Kehle-Forbes, S. M., Chen, S., Polusny, M. A., Lynch, K. G., Koffel, E., Ingram, E., … Oslin, D. W. (2019). A randomized controlled trial evaluating integrated versus phased application of evidence-based psychotherapies for military veterans with comorbid PTSD and substance use disorders. Drug and Alcohol Dependence, 205, 107647. doi:10.1016/j.drugalcdep.2019.107647
  • Kessler, R. C., Aguilar-Gaxiola, S., Alonso, J., Benjet, C., Bromet, E. J., Cardoso, G., … Koenen, K. C. (2017). Trauma and PTSD in the WHO World Mental Health Surveys. European Journal of Psychotraumatology, 8(sup5), 1353383. doi:10.1080/20008198.2017.1353383
  • Kline, A. C., Panza, K. E., Harlé, K. M., Angkaw, A. C., Trim, R. S., Back, S. E., & Norman, S. B. (2021). Within-treatment clinical markers of dropout risk in integrated treatments for comorbid PTSD and alcohol use disorder. Drug and Alcohol Dependence, 221, 108592. doi:10.1016/j.drugalcdep.2021.108592
  • Kline, A. C., Straus, E., Lyons, R. C., Angkaw, A. C., Davis, B. C., Haller, M., … Norman, S. B. (2021). Substance use predictors of attendance among veterans in integrated PTSD and alcohol use disorder treatment. Journal of Substance Abuse Treatment, 124, 108278. doi:10.1016/j.jsat.2021.108278
  • Langdon, K. J., Fox, A. B., King, L. A., King, D. W., Eisen, S., & Vogt, D. (2016). Examination of the dynamic interplay between posttraumatic stress symptoms and alcohol misuse among combat-exposed Operation Enduring Freedom (OEF)/Operation Iraqi Freedom (OIF) veterans. Journal of Affective Disorders, 196, 234–242. doi:10.1016/j.jad.2016.02.048
  • Langendam, M. W., Akl, E. A., Dahm, P., Glasziou, P., Guyatt, G., & Schünemann, H. J. (2013). Assessing and presenting summaries of evidence in Cochrane reviews. Systematic Reviews, 23(2), 81. doi:10.1186/2046-4053-2-81
  • Leeies, M., Pagura, J., Sareen, J., & Bolton, J. M. (2010). The use of alcohol and drugs to self-medicate symptoms of posttraumatic stress disorder. Depression and Anxiety, 27(8), 731–736. doi:10.1002/da.20677
  • Leeman, R. F., Hefner, K., Frohe, T., Murray, A., Rosenheck, R. A., Watts, B. V., & Sofuoglu, M. (2017). Exclusion of participants based on substance use status: Findings from randomized controlled trials of treatments for PTSD. Behaviour Research and Therapy, 89, 33–40. doi:10.1016/j.brat.2016.10.006
  • Lewis, C. E., Roberts, N. P., Gibson, S., & Bisson, J. I. (2020). Dropout from psychological therapies for post-traumatic stress disorder (PTSD) in adults: Systematic review and meta-analysis. European Journal of Psychotraumatology, 11(1), 1709709. doi:10.1080/20008198.2019.1709709
  • Lewis, C., Roberts, N. P., Andrew, M., Starling, E., & Bisson, J. I. (2020). Psychological therapies for post-traumatic stress disorder in adults: Systematic review and meta-analysis. European Journal of Psychotraumatology, 11(1), 1729633. doi:10.1080/20008198.2020.1729633
  • López-Castro, T., Zhao, Y., Fitzpatrick, S., Ruglass, L. M., & Hien, D. A. (2021). Seeing the forest for the trees: Predicting attendance in trials for co-occurring PTSD and substance use disorders with a machine learning approach. Journal of Consulting and Clinical Psychology, 89(10), 869–884. doi:10.1037/ccp0000688
  • McGovern, M. P., Lambert-Harris, C., Alterman, A. I., Xie, H., & Meier, A. (2011). A randomized controlled trial comparing integrated cognitive behavioral therapy versus individual addiction counseling for co-occurring substance use and posttraumatic stress disorders. Journal of Dual Diagnosis, 7(4), 207–227. doi:10.1080/15504263.2011.620425
  • McGovern, M. P., Lambert-Harris, C., Xie, H., Meier, A., McLeman, B., & Saunders, E. (2015). A randomized controlled trial of treatments for co-occurring substance use disorders and post-traumatic stress disorder. Addiction, 110(7), 1194–1204. https://doi.org/10.1111/add.12943
  • Mills, K. L., Barrett, E., Back, S. E., Cobham, V. E., Bendall, S., Perrin, S., … Teesson, M. (2020). Randomised controlled trial of integrated trauma-focused psychotherapy for traumatic stress and substance use among adolescents: Trial protocol. BMJ Open, 10(11), e043742. doi:10.1136/bmjopen-2020-043742
  • Mills, K. L., Teeson, M., Back, S. E., Brady, K. T., Baker, A. L., Hopwood, S., et al. (2012). Integrated exposure based therapy for co-occurring posttraumatic stress disorder and substance dependence. Journal of the American Medical Association, 308(7), 690–699. doi:10.1001/jama.2012.9071
  • Mills, K. L., Teeson, M., Ross, J., & Peters, L. (2006). Trauma, PTSD, and substance use disorders: Findings from the Australian National Survey of Mental Health and Well-Being. American Journal of Psychiatry, 163(4), 652–658. doi:10.1176/appi.ajp.163.4.652
  • Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & PRISMA Group (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Medicine, 6(7), e1000097. doi:10.1371/journal.pmed.1000097
  • Mueser, K. T., Rosenburg, S. D., Xie, H., Jankowski, M. K., Bolton, E. E., Lu, W., et al. (2008). A randomized controlled trial of cognitive–behavioral treatment for posttraumatic stress disorder in severe mental illness. Journal of Consulting and Clinical Psychology, 76(2), 259–271. doi:10.1037/0022-006X.76.2.259
  • Myers, U. S., Browne, K. C., & Norman, S. B. (2015). Treatment engagement: Female survivors of intimate partner violence in treatment for PTSD and alcohol use disorder. Journal of Dual Diagnosis, 11(3-4), 238–247. doi:10.1080/15504263.2015.1113762
  • Najavits, L. M. (2002). Seeking safety: A treatment manual for PTSD and substance abuse. New York, NY: Guilford Press.
  • Najavits, L. M., Gallop, R. J., & Weiss, R. D. (2006). Seeking Safety therapy for adolescent girls with PTSD and substance use disorder: A randomized controlled trial. Journal of Behavioral Health Services and Research, 33(4), 453–463. doi:10.1007/s11414-006-9034-2
  • Najavits, L. M., Gastfriend, D. R., Barber, J. P., Reif, S., Muenz, L. R., Blaine, J., et al. (1998). Cocaine dependence with and without PTSD among subjects in the National Institute on Drug Abuse Collaborative Cocaine Treatment Study. American Journal of Psychiatry, 155, 214–219.
  • Najavits, L. M., Krinsley, K., Waring, M. E., Gallagher, M. W., & Skidmore, C. (2018). A randomized controlled trial for veterans with PTSD and substance use disorder: Creating change versus seeking safety. Substance Use & Misuse, 53(11), 1788–1800. doi:10.1080/10826084.2018.1432653
  • NICE. (2007). Drug misuse in over 16s: psychosocial interventions. National Institute for Health and Care Excellence. Retrieved from www.nice.org.uk/guidance/cg51
  • NICE. (2018). Post-traumatic stress disorder. National Institute for Health and Care Excellence. Retrieved from www.nice.org.uk/guidance/ng116
  • NIDA. (2020). Behavioral Therapies. Retrieved from https://www.drugabuse.gov/publications/principles-drug-addiction-treatment-research-based-guide-third-edition/evidence-based-approaches-to-drug-addiction-treatment/behavioral-therapies on 2021, August 1.
  • Norman, S. B., Trim, R., Haller, M., Davis, B. C., Myers, U. S., Colvonen, P. J., … Mayes, T. (2019). Efficacy of integrated exposure therapy vs integrated coping skills therapy for comorbid posttraumatic stress disorder and alcohol use disorder: A randomized clinical trial. JAMA Psychiatry, 76(8), 791–799. doi:10.1001/jamapsychiatry.2019.0638
  • Phoenix Australia. (2020). The Australian guidelines for the prevention and treatment of acute stress disorder (ASD), posttraumatic stress disorder (PTSD) and complex PTSD. Retrieved from https://www.phoenixaustralia.org/australian-guidelines-for-ptsd/.
  • Possemato, K., Johnson, E. M., Emery, J. B., Wade, M., Acosta, M. C., Marsch, L. A., … Maisto, S. A. (2019). A pilot study comparing peer supported web-based CBT to self-managed web CBT for primary care veterans with PTSD and hazardous alcohol use. Psychiatric Rehabilitation Journal, 42(3), 305–313. doi:10.1037/prj0000334
  • Review Manager (RevMan) [Computer program]. Version 5.4.1 Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration. (2020).
  • Reynolds, M., Hinchliffe, K., Asamoah, V., & Kouimtsidis, C. (2011). Trauma and post-traumatic stress disorder in a drug treatment community service. The Psychiatrist, 35(7), 256–260. doi:10.1192/pb.bp.110.030379
  • Reynolds, M., Mezey, G., Chapman, M., Wheeler, M., Drummond, C., & Baldacchino, A. (2005). Co-morbid post-traumatic stress disorder in a substance misusing clinical population. Drug and Alcohol Dependence, 77(3), 251–258. doi:10.1016/j.drugalcdep.2004.08.017
  • Roberts, N. P., Roberts, P. A., Jones, N., & Bisson, J. I. (2015). Psychological interventions for post-traumatic stress disorder and comorbid substance use disorder: A systematic review and meta-analysis. Clinical Psychology Review, 38, 25–38. doi:10.1016/j.cpr.2015.02.007
  • Roberts, N. P., Roberts, P. A., Jones, N., & Bisson, J. I. (2016). Psychological therapies for post-traumatic stress disorder and comorbid substance use disorder. Cochrane Database of Systematic Reviews, 2016(4), CD010204. doi:10.1002/14651858.CD010204.pub2
  • Roberts, N. P., Back, S. E., Mueser, K. T., & Murray, L. (2020). Treatment considerations for PTSD comorbidities. In D. Forbes, J. I. Bisson, C. Monson, & L. Berliner (Eds.), Effective treatments for PTSD: Practice guidelines from the International Society for Traumatic Stress Studies (3rd ed., pp. 417–450). New York, NY: Guilford Press.
  • Ruglass, L. M., Lopez-Castro, T., Papini, S., Killeen, T., Back, S. E., & Hien, D. A. (2017). Concurrent treatment with prolonged exposure for co-occurring full or subthreshold posttraumatic stress disorder and substance use disorders: A randomized clinical trial. Psychotherapy and Psychosomatics, 86(3), 150–161. doi:10.1159/000462977
  • Saavedra, L. M., Morgan-López, A. A., Hien, D. A., López-Castro, T., Ruglass, L. M., Back, S. E., … CAST, the Consortium on Addictions, Stress and Trauma (2021). Evaluating treatments for posttraumatic stress disorder, alcohol and other drug use disorders using meta-analysis of individual patient data: Design and methodology of a virtual clinical trial. Contemporary Clinical Trials, 107, 106479. doi:10.1016/j.cct.2021.106479
  • Sannibale, C., Teesson, M., Creamer, M., Sitharthan, T., Bryant, R. A., Sutherland, K., et al. (2013). Randomized controlled trial of cognitive behaviour therapy for comorbid post-traumatic stress disorder and alcohol use disorders. Addiction, 108(8), 1397–1410. doi:10.1111/add.12167
  • Schacht, R. L., Brooner, R. K., King, V. L., Kidorf, M. S., & Peirce, J. M. (2017). Incentivizing attendance to prolonged exposure for PTSD with opioid use disorder patients: A randomized controlled trial. Journal of Consulting and Clinical Psychology, 85(7), 689–701. doi:10.1037/ccp0000208
  • Schäfer, I., Langeland, W., Hissbach, J., Luedecke, C., Ohlmeier, M. D., Chodzinski, C., … TRAUMAB-Study group (2010). Childhood trauma and dissociation in patients with alcohol dependence, drug dependence, or both – A multi-center study. Drug and Alcohol Dependence, 109(1-3), 84–89. doi:10.1016/j.drugalcdep.2009.12.012
  • Schäfer, I., & Lotzin, A. (2018). Psychosocial support to tackle trauma-related symptoms and related substance use disorders. Co-operation Group to Combat Drug Abuse and Illicit Trafficking in Drugs, Council of Europe. Retrieved from https://www.drugsandalcohol.ie/30825/
  • Schäfer, I., Lotzin, A., Hiller, P., Sehner, S., Driessen, M., Hillemacher, T., … Grundmann, J. (2019). A multisite randomized controlled trial of seeking safety vs. relapse prevention training for women with co-occurring posttraumatic stress disorder and substance use disorders. European Journal of Psychotraumatology, 10(1), 1577092. doi:10.1080/20008198.2019.1577092
  • Schäfer, I., & Najavits, L. M. (2007). Clinical challenges in the treatment of patients with posttraumatic stress disorder and substance abuse. Current Opinion in Psychiatry, 20, 614–618. doi:10.1097/YCO.0b013e3282f0ffd9
  • Seal, K. H., Cohen, G., Waldrop, A., Cohen, B. E., Maguen, S., & Ren, L. (2011). Substance use disorders in Iraq and Afghanistan veterans in VA healthcare, 2001-2010: Implications for screening, diagnosis and treatment. Drug and Alcohol Dependence, 116(1-3), 93–101. doi:10.1016/j.drugalcdep.2010.11.027
  • Simpson, T. L., Lehavot, K., & Petrakis, I. L. (2017). No wrong doors: Findings from a critical review of behavioral randomized clinical trials for individuals with co-occurring alcohol/drug problems and posttraumatic stress disorder. Alcoholism, Clinical and Experimental Research, 41(4), 681–702. doi:10.1111/acer.13325
  • Simpson, T. L., Stappenbeck, C. A., Luterek, J. A., Lehavot, K., & Kaysen, D. L. (2014). Drinking motives moderate daily relationships between PTSD symptoms and alcohol use. Journal of Abnormal Psychology, 123(1), 237–247. doi:10.1037/a0035193
  • Stappenbeck, C. A., Luterek, J. A., Kaysen, D., Rosenthal, C. F., Gurrad, B., & Simpson, T. L. (2015). A controlled examination of two coping skills for daily alcohol use and PTSD symptom severity among dually diagnosed individuals. Behaviour Research and Therapy, 66, 8–17. doi:10.1016/j.brat.2014.12.013
  • Straus, E., Haller, M., Lyons, R. C., & Norman, S. B. (2018). Functional and psychiatric correlates of comorbid post-traumatic stress disorder and alcohol use disorder. Alcohol Research: Current Reviews, 39(2), 121–129.
  • Straus, E., Worley, M. J., Lyons, R., Kline, A. C., Tripp, J. C., Davis, B. C., … Norman, S. B. (2022). Examining attendance patterns across integrated therapies for posttraumatic stress disorder and alcohol use disorder. Journal of Anxiety Disorders, 85, 102498. Advance online publication. doi:10.1016/j.janxdis.2021.102498
  • Szafranski, D. D., Gros, D. F., Acierno, R., Brady, K. T., Killeen, T. K., & Back, S. E. (2019). Heterogeneity of treatment dropout: PTSD, depression, and alcohol use disorder reductions in PTSD and AUD/SUD treatment noncompleters. Clinical Psychology & Psychotherapy, 26(2), 218–226. doi:10.1002/cpp.2344
  • Szafranski, D. D., Snead, A., Allan, N. P., Gros, D. F., Killeen, T., Flanagan, J., … Back, S. E. (2017). Integrated, exposure-based treatment for PTSD and comorbid substance use disorders: Predictors of treatment dropout. Addictive Behaviors, 73, 30–35. doi:10.1016/j.addbeh.2017.04.005
  • Torchalla, I., Nosen, L., Rostam, H., & Allen, P. (2012). Integrated treatment programs for individuals with concurrent substance use disorders and trauma experiences: A systematic review and meta-analysis. Journal of Substance Abuse Treatment, 42(1), 65–77. doi:10.1016/j.jsat.2011.09.001
  • Tripp, J. C., Worley, M. J., Straus, E., Angkaw, A. C., Trim, R. S., & Norman, S. B. (2020). Bidirectional relationship of posttraumatic stress disorder (PTSD) symptom severity and alcohol use over the course of integrated treatment. Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors, 34(4), 506–511. doi:10.1037/adb0000564
  • VA/DOD. (2017). Clinical practice guideline for the management of posttraumatic stress disorder and acute stress disorder: Clinician summary. Retrieved from https://www.healthquality.va.gov/guidelines/mh/ptsd/
  • van Dam, D., Vedel, E., Ehring, T., & Emmelkamp, P. M. (2012). Psychological treatments for concurrent posttraumatic stress disorder and substance use disorder: A systematic review. Clinical Psychology Review, 32(3), 202–214. doi:10.1016/j.cpr.2012.01.004
  • Voorendonk, E. M., De Jongh, A., Rozendaal, L., & Van Minnen, A. (2020). Trauma-focused treatment outcome for complex PTSD patients: Results of an intensive treatment programme. European Journal of Psychotraumatology, 11(1), 1783955. doi:10.1080/20008198.2020.1783955
  • Vujanovic, A. A., Smith, L. J., Green, C. E., Lane, S. D., & Schmitz, J. M. (2018). Development of a novel, integrated cognitive-behavioral therapy for co-occurring posttraumatic stress and substance use disorders: A pilot randomized clinical trial. Contemporary Clinical Trials, 65, 123–129. doi:10.1016/j.cct.2017.12.013
  • World Health Organization. (2011). Global Status report on alcohol and health. Retrieved from www.who.int/substance_abuse/publications/global_alcohol_report/msbgsruprofiles.pdf (accessed 1 August 2021).
  • Zandberg, L. J., Rosenfield, D., Alpert, E., McLean, C. P., & Foa, E. B. (2016). Predictors of dropout in concurrent treatment of posttraumatic stress disorder and alcohol dependence: Rate of improvement matters. Behaviour Research and Therapy, 80, 1–9. doi:10.1016/j.brat.2016.02.005
  • Zlotnick, C., Johnson, J., & Najavits, L. M. (2009). Randomized controlled pilot study of cognitive-behavioral therapy in a sample of incarcerated women with substance use disorder and PTSD. Behavior Therapy, 40(4), 325–336. doi:10.1016/j.beth.2008.09.004
  • Zoet, H. A., Wagenmans, A., van Minnen, A., & de Jongh, A. (2018). Presence of the dissociative subtype of PTSD does not moderate the outcome of intensive trauma-focused treatment for PTSD. European Journal of Psychotraumatology, 9(1), 1468707. doi:10.1080/20008198.2018.1468707