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Research Article

Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells

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Article: 1324730 | Received 22 Dec 2016, Published online: 06 Jun 2017

References

  • Johnsen KB, Gudbergsson JM, Skov MN, et al. Duroux M. A comprehensive overview of exosomes as drug delivery vehicles - endogenous nanocarriers for targeted cancer therapy. Biochim Biophys Acta. 2014;1846(1):1–11. Epub 2014/04/22.
  • Vlassov AV, Magdaleno S, Setterquist R, et al. Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim Biophys Acta. 2012;1820(7):940–948. Epub 2012/04/17.
  • Valadi H, Ekstrom K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654–659. Epub 2007/05/09.
  • Katakowski M, Buller B, Wang X, et al. Functional microRNA is transferred between glioma cells. Cancer Res. 2010;70(21):8259–8263. Epub 2010/09/16.
  • Mincheva-Nilsson L, Baranov V, Nagaeva O. Isolation and characterization of exosomes from cultures of tissue explants and cell lines. Curr protoc immunol. 2016;115:14 42 1–14 42 21. Epub 2016/11/02.
  • Greening DW, Xu R, Ji H, et al. A protocol for exosome isolation and characterization: evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods. Methods mole biol. 2015;1295:179–209. Epub 2015/03/31.
  • Sun D, Zhuang X, Xiang X, et al. A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes. Mol ther: J Am Soc Gene Ther. 2010;18(9):1606–1614. Epub 2010/06/24.
  • Wang J, Deng Z, Wang Z, et al. MicroRNA-155 in exosomes secreted from helicobacter pylori infection macrophages immunomodulates inflammatory response. Am J Transl Res. 2016;8(9):3700–3709. Epub 2016/10/12.
  • Katakowski M, Buller B, Zheng X, et al. Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth. Cancer Lett. 2013;335(1):201–204. Epub 2013/02/20.
  • Li L, Piontek K, Ishida M, et al.Extracellular vesicles carry microRNA-195 to intrahepatic cholangiocarcinoma and improve survival in a rat model. Hepatology. 2016. 2017;65(2):501–514.
  • Lou G, Song X, Yang F, et al. Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma. J Hematol Oncol. 2015;8:122. Epub 2015/10/31.
  • Ohno S, Kuroda M. Exosome-mediated targeted delivery of miRNAs. Methods mole biol. 2016;1448:261–270. Epub 2016/06/19.
  • Bhatnagar S, Shinagawa K, Castellino FJ, et al. Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo. Blood. 2007;110(9):3234–3244. Epub 2007/08/02.
  • Bhatnagar S, Schorey JS. Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory. J Biol Chem. 2007;282(35):25779–25789. Epub 2007/06/27.
  • Simhadri VR, Reiners KS, Hansen HP, et al. Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function. PloS one. 2008;3(10):e3377. Epub 2008/10/15.
  • Viaud S, Terme M, Flament C. Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15Ralpha. PloS one. 2009;4(3):e4942. Epub 2009/03/26.
  • Buschow SI, van Balkom BW, Aalberts M, et al. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol Cell Biol. 2010;88(8):851–856. Epub 2010/05/12.
  • McLellan AD. Exosome release by primary B cells. Crit Rev Immunol. 2009;29(3):203–217. Epub 2009/06/23.
  • Zhang H, Xie Y, Li W, et al. CD4(+) T cell-released exosomes inhibit CD8(+) cytotoxic T-lymphocyte responses and antitumor immunity. Cell Mol Immunol. 2011;8(1):23–30. Epub 2011/01/05.
  • Brennan FR, Morton LD, Spindeldreher S, et al. Safety and immunotoxicity assessment of immunomodulatory monoclonal antibodies. mAbs. 2010;2(3):233–255. Epub 2010/04/28.
  • Descotes J. Immunotoxicity of monoclonal antibodies. mAbs. 2009;1(2):104–111. Epub 2010/01/12.
  • McBlane JW. Preclinical safety testing for cell-based products using animals. Biol: J Int Assoc Biol Standardization. 2015;43(5):425–428. Epub 2015/06/01.
  • Green TM, Alpaugh ML, Barsky SH, et al. Breast cancer-derived extracellular vesicles: characterization and contribution to the metastatic phenotype. Biomed Res Int. 2015;2015:634865. Epub 2015/11/26.
  • He M, Qin H, Poon TC, et al. Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs. Carcinogenesis. 2015;36(9):1008–1018. Epub 2015/06/10.
  • Nakamura K, Sawada K, Kinose Y, et al. Exosomes promote ovarian cancer cell invasion through transfer of CD44 to peritoneal mesothelial cells. Mole cancer res: MCR. 2016. 2017;15(1):78-92.
  • Pollock K, Stroemer P, Patel S, et al. A conditionally immortal clonal stem cell line from human cortical neuroepithelium for the treatment of ischemic stroke. Exp Neurol. 2006;199(1):143–155. Epub 2006/02/09.
  • Chen TS, Arslan F, Yin Y, et al. Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs. J Transl Med. 2011;9:47. Epub 2011/04/26.
  • Chen C, Ridzon DA, Broomer AJ, et al. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res. 2005;33(20):e179. Epub 2005/11/30.
  • Martin-Jaular L, de Menezes-Neto A, Monguio-Tortajada M, et al. Corrigendum: Spleen-dependent immune protection elicited by CpG adjuvanted reticulocyte-derived exosomes from malaria infection is associated with changes in T cell subsets’ distribution. Front cell dev biol. 2016;4:153. Epub 2017/01/20.
  • Li J, Chen X, Yi J, et al. Identification and characterization of 293T cell-derived exosomes by profiling the protein, mRNA and microRNA components. PloS one. 2016;11(9):e0163043. Epub 2016/09/21.
  • Wiklander OP, Nordin JZ, O’Loughlin A, et al. Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting. J extracellular vesicles. 2015;4:26316. Epub 2015/04/23.
  • Kim JH, Badawi M, Park JK, et al. Anti-invasion and anti-migration effects of miR-199a-3p in hepatocellular carcinoma are due in part to targeting CD151. Int J Oncol. 2016;49(5):2037–2045. Epub 2016/10/26.
  • Lo A, Lin CT, Wu HC. Hepatocellular carcinoma cell-specific peptide ligand for targeted drug delivery. Mol Cancer Ther. 2008;7(3):579–589. Epub 2008/03/19.
  • Li Y, Hu Y, Xiao J, et al. Investigation of SP94 peptide as a specific probe for hepatocellular carcinoma imaging and therapy. Sci Rep. 2016;6:33511. Epub 2016/09/22.
  • Alvarez-Erviti L, Seow Y, Yin H, et al. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol. 2011;29(4):341–345. Epub 2011/03/23.
  • Sutaria DS, Jiang J, Elgamal OA, et al. Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA delivery. J Extracellular Vesicles. Forthcoming 2017.
  • Rosas LE, Elgamal OA, Mo X, et al. In vitro immunotoxicity assessment of culture-derived extracellular vesicles in human monocytes. J Immunotoxicol. 2016;13(5):652–665. Epub 2016/04/15.
  • Toomey CB, Cauvi DM, Hamel JC, et al. Cathepsin B regulates the appearance and severity of mercury-induced inflammation and autoimmunity. Toxicol sci: off j Soc Toxicol. 2014;142(2):339–349. Epub 2014/09/23.
  • Livak KJ. Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402–408. Epub 2002/02/16.
  • Jia JZ, Shen YW, Xue AM, et al. Immunohistochemical analysis of cardiac troponin inhibitor in an experimental model of acute myocardial infarction experimental model and in human tissues. Pathol Res Pract. 2015;211(6):456–461. Epub 2015/03/22.
  • Jaeger LB, Dohgu S, Sultana R, et al. Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer’s disease. Brain Behav Immun. 2009;23(4):507–517. Epub 2009/06/03.
  • Syama S, Gayathri V, Mohanan PV. Assessment of immunotoxicity of dextran coated ferrite nanoparticles in albino mice. Mol Biol Int. 2015;2015:518527. Epub 2015/11/18.
  • Ha D, Yang N, Nadithe V. Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges. Acta pharm Sin B. 2016;6(4):287–296. Epub 2016/07/30.
  • Martin-Jaular L, de Menezes-Neto A, Monguio-Tortajada M, et al. Spleen-dependent immune protection elicited by CpG adjuvanted reticulocyte-derived exosomes from malaria infection is associated with changes in T cell subsets’ distribution. Front cell dev biol. 2016;4:131. Epub 2016/12/03.
  • Cloutier N, van Eyll O, Janelle ME, et al. Flamand L. Increased tumorigenicity of cells carrying recombinant human herpesvirus 8. Arch Virol. 2008;153(1):93–103. Epub 2007/10/19.
  • Bucala R. Polyclonal activation of B lymphocytes by lipopolysaccharide requires macrophage-derived interleukin-1. Immunology. 1992;77(4):477–482. Epub 1992/12/01.
  • Xu H, Liew LN, Kuo IC, et al. The modulatory effects of lipopolysaccharide-stimulated B cells on differential T-cell polarization. Immunology. 2008;125(2):218–228. Epub 2008/03/22.
  • Imai T, Takahashi Y, Nishikawa M, et al. Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice. J extracellular vesicles. 2015;4:26238. Epub 2015/02/12.
  • Yuksel M, Laukens D, Heindryckx F, et al. Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis. Int J Exp Pathol. 2014;95(5):309–320. Epub 2014/08/13.
  • Dabydeen SA, Furth PA. Genetically engineered ERalpha-positive breast cancer mouse models. Endocr Relat Cancer. 2014;21(3):R195–R208. Epub 2014/02/01.
  • Scattoni ML, Crawley J, Ricceri L. Ultrasonic vocalizations: a tool for behavioural phenotyping of mouse models of neurodevelopmental disorders. Neurosci Biobehav Rev. 2009;33(4):508–515. Epub 2008/09/06.
  • Yang Z, Xie J, Zhu J, et al. Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation. J controlled release: off j Controlled Release Soc. 2016;243:160–171. Epub 2016/11/05.
  • Qu Z, Wu J, Wu J, et al. Exosomes derived from HCC cells induce sorafenib resistance in hepatocellular carcinoma both in vivo and in vitro. J exp clin cancer res: CR. 2016;35(1):159. Epub 2016/10/08.
  • Geiger A, Walker A, Nissen E. Human fibrocyte-derived exosomes accelerate wound healing in genetically diabetic mice. Biochem Biophys Res Commun. 2015;467(2):303–309. Epub 2015/10/11.
  • Tao SC, Yuan T, Rui BY, et al. Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2 signal pathway. Theranostics. 2017;7(3):733–750. Epub 2017/03/04.