Therapeutic biomaterials based on extracellular vesicles: classification of bio-engineering and mimetic preparation routes

References

• Yáñez-Mó M, Siljander PRM, Andreu Z, et al. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015;4:1.
   Web of Science ®Google Scholar
• Lener T, Gimona M, Aigner L, et al. Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper. J Extracell Vesicles. 2015;4:30087.
   PubMed Web of Science ®Google Scholar
• Tran TH, Mattheolabakis G, Aldawsari H, et al. Exosomes as nanocarriers for immunotherapy of cancer and inflammatory diseases. Clin Immunol. 2015;160:46–18.
   PubMed Web of Science ®Google Scholar
• Aline F, Bout D, Amigorena S, et al. Toxoplasma gondii antigen-pulsed-dendritic cell-derived exosomes induce a protective immune response against T. gondii infection. Infect Immun. 2004;74:4127–4137.
   Google Scholar
• Dalal J, Gandy K, Domen J. Role of mesenchymal stem cell therapy in Crohn’s disease. Pediatr Res. 2012;71:445–451.
   PubMed Web of Science ®Google Scholar
• Lamichhane TN, Sokic S, Schardt JS, et al. Emerging roles for extracellular vesicles in tissue engineering and regenerative medicine. Tissue Eng Part B Rev. 2015;21:45–54.
   PubMed Web of Science ®Google Scholar
• Batrakova EV, Kim MS. Using exosomes, naturally-equipped nanocarriers, for drug delivery. J Control Release. 2015;219:396–405.
   PubMed Web of Science ®Google Scholar
• Tan A, Rajadas J, Seifalian AM. Exosomes as nano-theranostic delivery platforms for gene therapy. Adv Drug Deliv Rev. 2013;65:357–367.
   PubMed Web of Science ®Google Scholar
• van Dommelen SM, Vader P, Lakhal S, et al. Microvesicles and exosomes: opportunities for cell-derived membrane vesicles in drug delivery. J Control Release. 2012;161:635–644.
   PubMed Web of Science ®Google Scholar
• Ha D, Yang N, Nadithe V. Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges. Acta Pharm Sin B. 2016;6:287–296.
   PubMed Web of Science ®Google Scholar
• van der Meel R, Fens MHAM, Vader P, et al. Extracellular vesicles as drug delivery systems: lessons from the liposome field. J Control Release. 2014;195:72–85.
   PubMed Web of Science ®Google Scholar
• El Andaloussi S, Lakhal S, Mäger I, et al. Exosomes for targeted siRNA delivery across biological barriers. Adv Drug Deliv Rev. 2013;65:391–397.
   PubMed Web of Science ®Google Scholar
• Kooijmans SAA, Vader P, van Dommelen SM, et al. Exosome mimetics: A novel class of drug delivery systems. Int J Nanomed. 2012;7:1525–1541.
   PubMed Web of Science ®Google Scholar
• Lakhal S, Wood MJA. Exosome nanotechnology: an emerging paradigm shift in drug delivery. Bioessays. 2011;33:737–741.
   PubMed Web of Science ®Google Scholar
• De La Peña H, Madrigal JA, Rusakiewicz S, et al. Artificial exosomes as tools for basic and clinical immunology. J Immunol Methods. 2009;344:121–132.
   Web of Science ®Google Scholar
• Jang SC, Kim OY, Yoon CM, et al. Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors. ACS Nano. 2013;7:7698–7710.
   PubMed Web of Science ®Google Scholar
• Jeong D, Jo W, Yoon J, et al. Nanovesicles engineered from ES cells for enhanced cell proliferation. Biomaterials. 2014;35:9302–9310.
   PubMed Web of Science ®Google Scholar
• Yoon J, Jo W, Jeong D, et al. Generation of nanovesicles with sliced cellular membrane fragments for exogenous material delivery. Biomaterials. 2015;59:12–20.
   PubMed Web of Science ®Google Scholar
• Forterre A, Jalabert A, Berger E, et al. Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: A new paradigm for myoblast-myotube cross talk? PLoS One. 2014;9:e84153.
   PubMed Web of Science ®Google Scholar
• Bryniarski K, Ptak W, Jayakumar A, et al. Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity. J Allergy Clin Immunol. 2013;132:170–181.
   PubMed Web of Science ®Google Scholar
• Regente M, Corti-Monzón G, Maldonado AM, et al. Vesicular fractions of sunflower apoplastic fluids are associated with potential exosome marker proteins. FEBS Lett. 2009;583:3363–3366.
   PubMed Web of Science ®Google Scholar
• Prado N, de Dios Alché J, Casado-Vela J, et al. Nanovesicles are secreted during pollen germination and pollen tube growth: A possible role in fertilization. Mol Plant. 2014;7:573–577.
   Web of Science ®Google Scholar
• García-Manrique P, Gutiérrez G, Blanco-López MC. Fully Artificial Exosomes: towards New Theranostic Biomaterials. Trends Biotechnol. Forthcoming.
   Web of Science ®Google Scholar
• Laulagnier K, Motta C, Hamdi S, et al. Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization. Biochem J. 2004;380:161–171.
   PubMed Web of Science ®Google Scholar
• Simpson RJ, Kalra H, Mathivanan S. ExoCarta as a resource for exosomal research. J Extracell Vesicles. 2012;1:18374.
   PubMedGoogle Scholar
• Kim DK, Lee J, Simpson RJ, et al. EVpedia: A community web resource for prokaryotic and eukaryotic extracellular vesicles research. Semin Cell Dev Biol. 2015;40:4–7.
   PubMed Web of Science ®Google Scholar
• Kalra H, Simpson RJ, Ji H, et al. Vesiclepedia: A compendium for extracellular vesicles with continuous community annotation. PLoS Biol. 2012;10:e1001450.
   PubMed Web of Science ®Google Scholar
• Gimona M, Pachler K, Laner-Plamberger S, et al. Manufacturing of human extracellular vesicle-based therapeutics for clinical use. Int J Mol Sci. 2017;18:1190.
   Web of Science ®Google Scholar
• Villarroya-Beltri C, Baixauli F, Gutiérrez-Vázquez C, et al. Sorting it out: regulation of exosome loading. Sem Cancer Biol. 2014;28:3–13.
   PubMed Web of Science ®Google Scholar
• Yeo RWY, Lai RC, Zhang B, et al. Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery. Adv Drug Deliv Rev. 2013;65:336–341.
   PubMed Web of Science ®Google Scholar
• Johnsen KB, Gudbergsson JM, Skov MN, et al. A comprehensive overview of exosomes as drug delivery vehicles—endogenous nanocarriers for targeted cancer therapy. Biochim Biophys Acta Reviews Cancer. 2014;1846:75–87.
   PubMed Web of Science ®Google Scholar
• Lai RC, Yeo RWY, Tan KH, et al. Exosomes for drug delivery—a novel application for the mesenchymal stem cell. Biotechnol Adv. 2013;31:543–551.
   PubMed Web of Science ®Google Scholar
• Lamparski HG, Metha-Damani A, Yao JY, et al. Production and characterization of clinical grade exosomes derived from dendritic cells. J Immunol Methods. 2002;270:211–226.
   PubMed Web of Science ®Google Scholar
• Klippstein R, Pozo D. Nanotechnology-based manipulation of dendritic cells for enhanced immunotherapy strategies. Nanomed Nanotechnol Biol Med. 2010;6:523–529.
   PubMed Web of Science ®Google Scholar
• Bianco NR, Kim SH, Ruffner MA, et al. Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase–positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models. Arthritis Rheumatol. 2009;60:380–389.
   PubMed Web of Science ®Google Scholar
• Hee Kim S, Bianco N, Menon R, et al. Exosomes derived from genetically modified DC expressing FasL are anti-inflammatory and immunosuppressive. Mol Ther. 2006;13:289–300.
   Web of Science ®Google Scholar
• Mahaweni N, Lambers M, Dekkers J, et al. Tumour-derived exosomes as antigen delivery carriers in dendritic cell-based immunotherapy for malignant mesothelioma. J Extracell Vesicles. 2013;2:22492.
   Google Scholar
• Ban JJ, Lee M, Im W, et al. Low pH increases the yield of exosome isolation. Biochem Biophys Res Commun. 2015;461:76–79.
   PubMed Web of Science ®Google Scholar
• Munagala R, Aqil F, Jeyabalan J, et al. Bovine milk-derived exosomes for drug delivery. Cancer Lett. 2016;371:48–61.
   PubMed Web of Science ®Google Scholar
• Zhang M, Viennois E, Xu C, et al. Plant derived edible nanoparticles as a new therapeutic approach against diseases. Tissue Barriers. 2016;4(2):e1134415.
   PubMed Web of Science ®Google Scholar
• Raimondo S, Naselli F, Fontana S, et al. Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death. Oncotarget. 2015;6:19514–19527.
   PubMedGoogle Scholar
• Pérez-Bermúdez P, Blesa J, Soriano JM, et al. Extracellular vesicles in food: experimental evidence of their secretion in grape fruits. Eur J Pharm Sci. 2017;98:40–50.
   Web of Science ®Google Scholar
• Witwer KW, Buzás EI, Bemis LT, et al. Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J Extracell Vesicles. 2013;2:20360.
   Google Scholar
• Sunkara V, Woo HK, Cho YK. Emerging techniques in the isolation and characterization of extracellular vesicles and their roles in cancer diagnostics and prognostics. Analyst. 2016;141:371–381.
   PubMed Web of Science ®Google Scholar
• Liga A, Vliegenthart ADB, Oosthuyzen W, et al. Exosome isolation: A microfluidic road-map. Lab Chip. 2015;15:2388–2394.
   PubMed Web of Science ®Google Scholar
• Andreu Z, Rivas E, Sanguino-Pascual A, et al. Comparative analysis of EV isolation procedures for miRNAs detection in serum samples. J Extracell Vesicles. 2016;5:31655.
   PubMed Web of Science ®Google Scholar
• Lane RE, Korbie D, Anderson W, et al. Analysis of exosome purification methods using a model liposome system and tunable-resistive pulse sensing. Sci Rep. 2015;5:1–7.
   Web of Science ®Google Scholar
• Tauro BJ, Greening DW, Mathias RA, et al. Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes. Methods. 2012;56:293–304.
   PubMed Web of Science ®Google Scholar
• Greening DW, Xu R, Ji H, et al. A protocol for exosome isolation and characterization: evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods. In: Posch A, editor. Proteomic profiling: methods and protocols. New York: Springer; 2015. p. 179–209.
   Google Scholar
• Marcus ME, Leonard JN. FedExosomes: engineering therapeutic biological nanoparticles that truly deliver. Pharmaceuticals. 2013;6:659–680.
   Google Scholar
• Yamada T, Inoshima Y, Matsuda T, et al. Comparison of methods for isolating exosomes from bovine milk. J Vet Med Sci. 2012;74:1523–1525.
   PubMed Web of Science ®Google Scholar
• Böing AN, van der Pol E, Grootemaat AE, et al. Single-step isolation of extracellular vesicles by size-exclusion chromatography. J Extracell Vesicles. 2014;3:23430.
   PubMedGoogle Scholar
• Davies RT, Kim J, Jang SC, et al. Microfluidic filtration system to isolate extracellular vesicles from blood. Lab Chip. 2012;12:5202–5210.
   PubMed Web of Science ®Google Scholar
• He M, Crow J, Roth M, et al. Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology. Lab Chip. 2014;14:3773–3780.
   PubMed Web of Science ®Google Scholar
• Welton JL, Webber JP, Botos LA, et al. Ready-made chromatography columns for extracellular vesicle isolation from plasma. J Extracell Vesicles. 2015;4:27269.
   PubMed Web of Science ®Google Scholar
• Taylor DD, Shah S. Methods of isolating extracellular vesicles impact down-stream analyses of their cargoes. Methods. 2015;87:3–10.
   PubMed Web of Science ®Google Scholar
• Lee J, Lee H, Goh U, et al. Cellular engineering with membrane fusogenic liposomes to produce functionalized extracellular vesicles. ACS Appl Mat Interfaces. 2016;8:6790–6795.
   PubMed Web of Science ®Google Scholar
• Fuhrmann G, Serio A, Mazo M, et al. Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins. J Control Release. 2015;205:35–44.
   PubMed Web of Science ®Google Scholar
• Hung ME, Leonard JN. A platform for actively loading cargo RNA to elucidate limiting steps in EV-mediated delivery. J Extracell Vesicles. 2016;5:31027.
   PubMed Web of Science ®Google Scholar
• Kim MS, Haney MJ, Zhao Y, et al. Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells. Nanomed Nanotechnol Biol Med. 2016;12(3):655–664.
   PubMed Web of Science ®Google Scholar
• Yim N, Ryu SW, Choi K, et al. Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module. Nat Commun. 2016;7:1–9.
   Web of Science ®Google Scholar
• Stickney Z, Losacco J, McDevitt S, et al. Development of exosome surface display technology in living human cells. Biochem Biophys Res Commun. 2016;472(1):53–59.
   PubMed Web of Science ®Google Scholar
• Delcayre A, Estelles A, Sperinde J, et al. Exosome display technology: applications to the development of new diagnostics and therapeutics. Blood Cells, Mol Dis. 2005;35:158–168.
   PubMed Web of Science ®Google Scholar
• Delcayre A inventor, Le PJB inventor; Methods and compounds for the targeting of protein to exosomes. European patent WO2003016522 A2. 2003.
   Google Scholar
• Zeelenberg IS, Ostrowski M, Krumeich S, et al. Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses. Cancer Res. 2008;68:1228–1235.
   PubMed Web of Science ®Google Scholar
• Hartman ZC, Wei J, Glass OK, et al. Increasing vaccine potency through exosome antigen targeting. Vaccine. 2011;29:9361–9367.
   PubMed Web of Science ®Google Scholar
• Alvarez-Erviti L, Seow Y, Yin H, et al. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol. 2011;29:341–345.
   PubMed Web of Science ®Google Scholar
• Tian Y, Li S, Song J, et al. A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy. Biomaterials. 2014;35:2383–2390.
   PubMed Web of Science ®Google Scholar
• Ohno SI, Takanashi M, Sudo K, et al. Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. Mol Ther. 2013;21:185–191.
   PubMed Web of Science ®Google Scholar
• Bolukbasi MF, Mizrak A, Ozdener GB, et al. miR-1289 and “Zipcode”-like sequence enrich mRNAs in microvesicles. Mol Ther Nucleic Acids. 2012;1:1–10.
   Google Scholar
• Villarroya-Beltri C, Gutiérrez-Vázquez C, Sánchez-Cabo F, et al. Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs. Nat Commun. 2013;4:1–10.
   Web of Science ®Google Scholar
• Lee J, Kim J, Jeong M, et al. Liposome-based engineering of cells to package hydrophobic compounds in membrane vesicles for tumor penetration. Nano Lett. 2015;15:2938–2944.
   PubMed Web of Science ®Google Scholar
• Chang PV, Prescher JA, Sletten EM, et al. Copper-free click chemistry in living animals. Proc Natl Acad Sci USA. 2010;107:1821–1826.
   PubMed Web of Science ®Google Scholar
• Sun D, Zhuang X, Xiang X, et al. A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes. Mol Ther. 2010;18:1606–1614.
   PubMed Web of Science ®Google Scholar
• Zhuang X, Xiang X, Grizzle W, et al. Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol Ther. 2011;19:1769–1779.
   PubMed Web of Science ®Google Scholar
• Aqil F, Kausar H, Agrawal AK, et al. Exosomal formulation enhances therapeutic response of celastrol against lung cancer. Exp Mol Pathol. 2016;101:12–21.
   PubMed Web of Science ®Google Scholar
• Weaver JC. Electroporation: A general phenomenon for manipulating cells and tissues. J Cell Biochem. 1993;51:426–435.
   PubMed Web of Science ®Google Scholar
• Kooijmans SAA, Stremersch S, Braeckmans K, et al. Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles. J Control Release. 2013;172:229–238.
   PubMed Web of Science ®Google Scholar
• Hood JL, Scott MJ, Wickline SA. Maximizing exosome colloidal stability following electroporation. Anal Biochem. 2014;448:41–49.
   PubMed Web of Science ®Google Scholar
• Haney MJ, Klyachko NL, Zhao Y, et al. Exosomes as drug delivery vehicles for Parkinson’s disease therapy. J Control Release. 2015;207:18–30.
   PubMed Web of Science ®Google Scholar
• Smyth T, Petrova K, Payton NM, et al. Surface functionalization of exosomes using click chemistry. Bioconjug Chem. 2014;25:1777–1784.
   PubMed Web of Science ®Google Scholar
• Hermanson GT. Zero-length crosslinkers. In: Hermanson GT, editor. Bioconjugate Techniques. 3rd ed. Boston: Academic Press; 2013. p. 259–273.
   Google Scholar
• Sessa G, Freer JH, Colacicco G, et al. Interaction of a lytic polypeptide, melittin, with lipid membrane systems. J Biol Chem. 1969;244:3575–3582.
   PubMed Web of Science ®Google Scholar
• Pan H, Myerson JW, Ivashyna O, et al. Lipid membrane editing with peptide cargo linkers in cells and synthetic nanostructures. Faseb J. 2010;24:2928–2937.
   Web of Science ®Google Scholar
• Sato YT, Umezaki K, Sawada S, et al. Engineering hybrid exosomes by membrane fusion with liposomes. Sci Rep. 2016;6:1–11.
   PubMed Web of Science ®Google Scholar
• Morris GJ, McGrath JJ. The response of multilamellar liposomes to freezing and thawing. Cryobiology. 1981;18:390–398.
   PubMed Web of Science ®Google Scholar
• Jo W, Kim J, Yoon J, et al. Large-scale generation of cell-derived nanovesicles. Nanoscale. 2014;6:12056–12064.
   PubMed Web of Science ®Google Scholar
• Jo W, Jeong D, Kim J, et al. Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers. Lab Chip. 2014;14:1261–1269.
   PubMed Web of Science ®Google Scholar
• Wagner A, Vorauer-Uhl K. Liposome technology for industrial purposes. J Drug Deliv. 2011;2011:1–9.
   Google Scholar
• Mozafari MR. Liposomes: an overview of manufacturing techniques. Cell Mol Biol Lett. 2015;10:711–719.
   Google Scholar
• Szoka JF, Papahadjopoulos D. Comparative properties and methods of preparation of lipid vesicles (liposomes). Annu Rev Biophys Bioeng. 1980;9(1):467–508.
   PubMedGoogle Scholar
• Abdus S, Sultana Y, Aqil M. Liposomal drug delivery systems: an update review. Curr Drug Deliv. 2007;4:297–305.
   Google Scholar
• Antonietti M, Förster S. Vesicles and liposomes: A self-assembly principle beyond lipids. Adv Mat. 2003;15:1323–1333.
   Web of Science ®Google Scholar
• Lasic DD. The mechanism of vesicle formation. Biochem J. 1988;256:1–11.
   PubMed Web of Science ®Google Scholar
• García-Manrique P, Matos M, Gutiérrez G, et al. Using factorial experimental design to prepare size-tuned nanovesicles. Ind Eng Chem Res. 2016;55:9164–9175.
   Web of Science ®Google Scholar
• Gregoriadis G, editor. Entrapment of drugs and other materials into liposomes.Volume II, Liposome Technology. Boca Ratonn: CRC Press; 2007.
   Google Scholar
• Avanti Polar Lipids products. Available from: http://www.avantilipids.com
   Google Scholar
• Sullivan SM, Connor J, Huang L. Immunoliposomes: preparation, properties, and applications. Med Res Rev. 1986;6:171–195.
   PubMed Web of Science ®Google Scholar
• Hermanson GT. The reactions of bioconjugation. In: Hermanson GT, editor. Bioconjugate techniques. 3rd ed. Boston: Academic Press; 2013. p. 229–258.
   Google Scholar
• Nobs L, Buchegger F, Gurny R, et al. Current methods for attaching targeting ligands to liposomes and nanoparticles. J Pharm Sci. 2004;93:1980–1992.
   PubMed Web of Science ®Google Scholar
• Schuber F. Chemistry of ligand-coupling to liposomes. In: Schuber F, Philippot JR, editors. Liposomes as tools in basic research and industry. Boca Raton: CRC Press; 1995. p. 21–39.
   Google Scholar
• Martinez-Lostao L, García-Alvarez FC, Basáñez G, et al. Liposome-bound APO2L/TRAIL is an effective treatment in a rabbit model of rheumatoid arthritis. Arthritis Rheum. 2010;62:2272–2282.
   PubMed Web of Science ®Google Scholar
• Li K, Chang S, Wang Z, et al. A novel micro-emulsion and micelle assembling method to prepare DEC205 monoclonal antibody coupled cationic nanoliposomes for simulating exosomes to target dendritic cells. Int J Pharm. 2015;491:105–112.
   Google Scholar
• Chandler WL, Yeung W, Tait JF. A new microparticle size calibration standard for use in measuring smaller microparticles using a new flow cytometer. J Throm Haemost. 2011;9:1216–1224.
   PubMed Web of Science ®Google Scholar
• Gardiner C, Shaw M, Hole P, et al. Measurement of refractive index by nanoparticle tracking analysis reveals heterogeneity in extracellular vesicles. J Extracell Vesicles. 2014;3:25361.
   PubMedGoogle Scholar
• De Miguel D, Basáñez G, Sánchez D, et al. Liposomes decorated with Apo2L/TRAIL overcome chemoresistance of human hematologic tumor cells. Mol Pharm. 2013;10:893–904.
   Web of Science ®Google Scholar
• de Miguel D, Gallego-Lleyda A, Galan-Malo P, et al. Immunotherapy with liposome-bound TRAIL overcomes partial protection to soluble TRAIL-induced apoptosis offered by down-regulation of Bim in leukemic cells. Clin Trans Oncol. 2015;17:657–667.
   Web of Science ®Google Scholar
• Pagnan G, Stuart DD, Pastorino F, et al. Delivery of c-myb antisense oligodeoxynucleotides to human neuroblastoma cells via disialoganglioside GD2-Targeted immunoliposomes: antitumor effects. J Natl Cancer Inst. 2000;92:253–261.
   PubMed Web of Science ®Google Scholar
• Pastorino F, Brignole C, Marimpietri D, et al. Doxorubicin-loaded Fab′ fragments of anti-disialoganglioside immunoliposomes selectively inhibit the growth and dissemination of human neuroblastoma in nude mice. Cancer Res. 2003;63:86–92.
   PubMed Web of Science ®Google Scholar
• Marianecci C, Di Marzio L, Rinaldi F, et al. Niosomes from 80s to present: the state of the art. Adv Colloid Interface Sci. 2014;205:187–206.
   PubMed Web of Science ®Google Scholar
• Moghassemi S, Hadjizadeh A. Nano-niosomes as nanoscale drug delivery systems: an illustrated review. J.Control Release. 2014;185:22–36.
   PubMed Web of Science ®Google Scholar
• Capretto L, Carugo D, Mazzitelli S, et al. Microfluidic and lab-on-a-chip preparation routes for organic nanoparticles and vesicular systems for nanomedicine applications. Adv Drug Deliv Rev. 2013;65:1496–1532.
   PubMed Web of Science ®Google Scholar
• Birnbaumer G, Kupcu S, Jungreuthmayer C, et al. Rapid liposome quality assessment using a lab-on-a-chip. Lab Chip. 2011;11:2753–2762.
   PubMed Web of Science ®Google Scholar
• Bhise NS, Ribas J, Manoharan V, et al. Organ-on-a-chip platforms for studying drug delivery systems. J Control Release. 2014;190:82–93.
   PubMed Web of Science ®Google Scholar
• Hu CMJ, Fang RH, Wang KC, et al. Nanoparticle biointerfacing by platelet membrane cloaking. Nature. 2015;526:118–121.
   PubMed Web of Science ®Google Scholar