Extracellular vesicles from bone marrow-derived mesenchymal stromal cells support ex vivo survival of human antibody secreting cells

References

• Gupta D, Treon SP, Shima Y, et al. Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications. Leukemia. 2001;15(12):1–15.
   Web of Science ®Google Scholar
• Kumar S, Witzig TE, Timm M, et al. Bone marrow angiogenic ability and expression of angiogenic cytokines in myeloma: evidence favoring loss of marrow angiogenesis inhibitory activity with disease progression. Blood. 2004;104(4):1159–1165.
   PubMed Web of Science ®Google Scholar
• Chauhan D, Uchiyama H, Akbarali Y, et al. Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B. Blood. 1996;87(3):1104–1112.
   PubMed Web of Science ®Google Scholar
• Uchiyama H, Barut BA, Mohrbacher AF, et al. Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion. Blood. 1993;82(12):3712–3720.
   PubMed Web of Science ®Google Scholar
• Wang J, Hendrix A, Hernot S, et al. Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells. Blood. 2014;124(4):555–566.
   PubMed Web of Science ®Google Scholar
• Campeau PM, Rafei M, François M, et al. Mesenchymal stromal cells engineered to express erythropoietin induce anti-erythropoietin antibodies and anemia in allorecipients. Mol Ther. 2009;17(2):369–372.
   PubMed Web of Science ®Google Scholar
• Stagg J. Mechanisms of immune modulation by mesenchymal stromal cells and clinical translation. Curr Mol Med. 2013;13(5):856–867.
   PubMed Web of Science ®Google Scholar
• Galipeau J. The mesenchymal stromal cells dilemma–does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road? Cytotherapy. 2013;15(1):2–8.
   PubMed Web of Science ®Google Scholar
• Dalal J, Gandy K, Domen J. Role of mesenchymal stem cell therapy in Crohn’s disease. Pediatr Res. 2012;71(4 Pt 2):445–451.
   Web of Science ®Google Scholar
• Halliley JL, Tipton CM, Liesveld J, et al. Long-lived plasma cells are contained within the CD19(-)CD38(hi)CD138(+) subset in human bone marrow. Immunity. 2015;43(1):132–145.
   PubMed Web of Science ®Google Scholar
• Richardson JD, Nelson A, Zannettino AC, et al. Optimization of the cardiovascular therapeutic properties of mesenchymal stromal/stem cells-taking the next step. Stem Cell Rev. 2013;9(3):281–302.
   Web of Science ®Google Scholar
• Tan SS, Yin Y, Lee T, et al. Therapeutic MSC exosomes are derived from lipid raft microdomains in the plasma membrane. J Extracell Vesicles. 2013;2:22614–22625.
   Google Scholar
• Bonnaure G, Gervais-St-Amour C, Néron S. Bone marrow mesenchymal stem cells enhance the differentiation of human switched memory B lymphocytes into plasma cells in serum-free medium. J Immunol Res. 2016;2016:1–18.
   Web of Science ®Google Scholar
• Roldán E, García-Pardo A, Brieva JA. VLA-4-fibronectin interaction is required for the terminal differentiation of human bone marrow cells capable of spontaneous and high rate immunoglobulin secretion. J Exp Med. 1992;175(6):1739–1747.
   Web of Science ®Google Scholar
• Tabera S, Pérez-Simón JA, Díez-Campelo M, et al. The effect of mesenchymal stem cells on the viability, proliferation and differentiation of B-lymphocytes. Haematologica. 2008;93(9):1301–1309.
   PubMed Web of Science ®Google Scholar
• Dallos T, Krivosikova M, Chorazy-Massalska M, et al. BAFF from bone marrow-derived mesenchymal stromal cells of rheumatoid arthritis patients improves their B-cell viability-supporting properties. Folia Biologica (Praha). 2009;55(5):166–176.
   Web of Science ®Google Scholar
• Roldán E, Rodriguez C, Navas G, et al. Cytokine network regulating terminal maturation of human bone marrow B cells capable of spontaneous and high rate Ig secretion in vitro. J Immunol. 1992;149(7):2367–2371.
   Web of Science ®Google Scholar
• Keller JR, Ortiz M, Ruscetti FW. Steel factor (c-kit ligand) promotes the survival of hematopoietic stem/progenitor cells in the absence of cell division. Blood. 1994;86(5):1757–1764.
   Google Scholar
• Kobayashi M, Bai Y, Dong Y, et al. PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal. Stem Cells. 2014;32(7):1956–1967.
   PubMed Web of Science ®Google Scholar
• Omatsu Y, Sugiyama T, Kohara H, et al. The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity. 2010;33(3):387–399.
   PubMed Web of Science ®Google Scholar
• Balbi C, Piccoli M, Barile L, et al. First characterization of human amniotic fluid stem cell extracellular vesicles as a powerful paracrine tool endowed with regenerative potential. Stem Cells Transl Med. 2017;6:1340–1355.
   PubMed Web of Science ®Google Scholar
• Schmidt O, Teis D. The ESCRT machinery. Curr Biol. 2012;22(4):R116–120.
   PubMed Web of Science ®Google Scholar
• Wen S, Dooner M, Cheng Y, et al. Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells. Leukemia. 2016;30(11):2221–2231.
   PubMed Web of Science ®Google Scholar
• Battiwalla M, Barrett A. Bone marrow mesenchymal stromal cells to treat complications following allogeneic stem cell transplantation. Tissue Eng Part B Rev. 2014;20(3):211–217.
   PubMed Web of Science ®Google Scholar
• Nicolay NH, Sommer E, Lopez R, et al. Mesenchymal stem cells retain their defining stem cell characteristics after exposure to ionizing radiation. Int J Radiat Oncol Biol Phys. 2013;87(5):1171–1178.
   Web of Science ®Google Scholar
• Fekete N, Erle A, Amann EM, et al. Effect of high-dose irradiation on human bone-marrow-derived mesenchymal stromal cells. Tissue Eng Part C Methods. 2015;21(2):112–122.
   Web of Science ®Google Scholar
• Halliley JL, Kyu S, Kobie JJ, et al. Peak frequencies of circulating human influenza-specific antibody secreting cells correlate with serum antibody response after immunization. Vaccine. 2010;28(20):3582–3587.
   PubMed Web of Science ®Google Scholar
• Castro AR, Morrill WE, Pope V. Lipid removal from human serum samples. Clin Diagn Lab Immunol. 2000;7(2):197–199.
   Google Scholar
• Megger DA, Padden J, Rosowski K, et al. One sample, one shot - evaluation of sample preparation protocols for the mass spectrometric proteome analysis of human bile fluid without extensive fractionation. J Proteomics. 2017;154:13–21.
   Web of Science ®Google Scholar
• Helwa I, Cai J, Drewry MD, et al. A comparative study of serum exosome isolation using differential ultracentrifugation and three commercial reagents. PLoS One. 2017;12(1):e0170628.
   PubMed Web of Science ®Google Scholar
• Madrigal M, Rao K, Riordan NH. A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods. J Transl Med. 2014;12(1):s12967-014–0260-8.
   Google Scholar
• Nong K, Wang W, Niu X, et al. Hepatoprotective effect of exosomes from human-induced pluripotent stem cell-derived mesenchymal stromal cells against hepatic ischemia-reperfusion injury in rats. Cytotherapy. 2016;18(12):1548–1559.
   PubMed Web of Science ®Google Scholar
• Sze SK, De Kleijn DPV, Lai RC, et al. Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells. Mol Cell Proteomics. 2007;6(10):1680–1689.
   PubMed Web of Science ®Google Scholar
• Mutschelknaus L, Azimzadeh O, Heider T, et al. Radiation alters the cargo of exosomes released from squamous head and neck cancer cells to promote migration of recipient cells. Sci Rep. 2017;7(1):12423.
   PubMed Web of Science ®Google Scholar
• An M, Lohse I, Tan Z, et al. Quantitative proteomic analysis of serum exosomes from patients with locally advanced pancreatic cancer undergoing chemoradiotherapy. J Proteome Res. 2017;16(4):1763–1772.
   PubMed Web of Science ®Google Scholar
• Yentrapalli R, Merl-Pham J, Azimzadeh O, et al. Quantitative changes in the protein and miRNA cargo of plasma exosome-like vesicles after exposure to ionizing radiation. Int J Radiat Biol. 2017;93(6):569–580.
   PubMed Web of Science ®Google Scholar
• Li T, Yan Y, Wang B, et al. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis. Stem Cells Dev. 2013;22(6):845–854.
   PubMed Web of Science ®Google Scholar
• Tomasoni S, Longaretti L, Rota C, et al. Transfer of growth factor receptor mRNA via exosomes unravels the regenerative effect of mesenchymal stem cells. Stem Cells Dev. 2013;22(5):772–780.
   PubMed Web of Science ®Google Scholar
• Chinnadurai R, Ng S, Velu V, et al. Challenges in animal modelling of mesenchymal stromal cell therapy for inflammatory bowel disease. World J Gastroenterol. 2015;21(16):4779–4787.
   Web of Science ®Google Scholar
• Chinnadurai R, Garcia M, Sakurai Y, et al. Actin cytoskeletal disruption following cryopreservation alters the biodistribution of human mesenchymal stromal cells in vivo. Stem Cell Reports. 2014;3(1):60–72.
   Web of Science ®Google Scholar
• Sze SK, de Kleijn D, Lai RC, et al. Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells. Mol Cell Proteomics. 2007;6(10):1680–1689.
   PubMed Web of Science ®Google Scholar
• Mulcahy LA, Pink RC, Carter DR. Routes and mechanisms of extracellular vesicle uptake. J Extracell Vesicles. 2014;3:24641.
   Google Scholar
• Malhotra S, Kovats S, Zhang W, et al. B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin. J Biol Chem. 2009;284(36):24088–24097.
   Web of Science ®Google Scholar
• Wols HAM, Underhill G, Kansas GS, et al. The role of bone marrow-derived stromal cells in the maintenance of plasma cell longevity. J Immunol. 2002;169:4213–4221.
   Web of Science ®Google Scholar
• Munir H, McGettrick MH. Mesenchymal stem cell therapy for autoimmune disease: risks and rewards. Stem Cells Dev. 2015;24(18):2091–2100.
   Web of Science ®Google Scholar
• Introna M, Rambaldi A. Mesenchymal stromal cells for prevention and treatment of graft-versus-host disease: successes and hurdles. Curr Opin Organ Transplant. 2015;20(1):72–78.
   Google Scholar
• Méndez-Ferrer S, Michurina TV, Ferraro F, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2010;466(7308):829–834.
   PubMed Web of Science ®Google Scholar
• Lattanzio R, Piantelli M, Falasca M. Role of phospholipase C in cell invasion and metastasis. Adv Biol Regul. 2013;53(3):309–318.
   PubMedGoogle Scholar
• Shirakawa R, Horiuchi H. Ral GTPases: crucial mediators of exocytosis and tumourigenesis. J Biochem. 2015;157(5):285–299.
   Web of Science ®Google Scholar
• Burbage M, Keppler S, Gasparrini F, et al. Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity. J Exp Med. 2015;212(1):53–72.
   PubMed Web of Science ®Google Scholar
• Gerasimcik N, Dahlberg C, Baptista MAP, et al. The Rho GTPase Cdc42 is essential for the activation and function of mature B cells. J Immunol. 2015;194:4750–4758.
   Web of Science ®Google Scholar
• Chinnadurai R, Copland IB, Garcia MA, et al. Cryopreserved mesenchymal stromal cells are susceptible to T-cell mediated apoptosis which is partly rescued by IFNγ licensing. Stem Cells. 2016;34(9):2429–2442.
   PubMed Web of Science ®Google Scholar
• Liao Z, Muth DC, Eitan E, et al. Serum extracellular vesicle depletion processes affect release and infectivity of HIV-1 in culture. Sci Rep. 2017;7(1):2558.
   Web of Science ®Google Scholar
• Szatanek R, Baran J, Siedlar M, et al. Isolation of extracellular vesicles: determining the correct approach (Review). Int J Mol Med. 2015;36(1):11–17.
   PubMed Web of Science ®Google Scholar
• Chen WX, Smeekens J, Wu RH. Enhancing the mass spectrometric identification of membrane proteins by combining chemical and enzymatic digestion methods. J Proteome Res. 2014;13:1466–1473.
   Google Scholar
• Eng JK, McCormack A, Yates JR. An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J Am Soc Mass Spectrom. 1994;5(11):976–989.
   PubMed Web of Science ®Google Scholar
• Elias JE, Gygi S. Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Nat Methods. 2007;4(3):207–214.
   PubMed Web of Science ®Google Scholar
• Käll L, Canterbury J, Weston J, et al. Semi-supervised learning for peptide identification from shotgun proteomics datasets. Nat Methods. 2007;4(11):923–925.
   PubMed Web of Science ®Google Scholar