Circulating extracellular vesicle content reveals de novo DNA methyltransferase expression as a molecular method to predict septic shock

References

• Bird A. DNA methylation patterns and epigenetic memory. Genes Dev. 2002;16(1):6–17.
   PubMed Web of Science ®Google Scholar
• Robertson KD. DNA methylation and human disease. Nat Rev Genet. 2005;6(8):597–610.
   PubMed Web of Science ®Google Scholar
• Fatemi M, Hermann A, Gowher H, et al. Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA. Eur J Biochem. 2002;269(20):4981–4984.
   PubMedGoogle Scholar
• Allis CD1, Jenuwein T2. The molecular hallmarks of epigenetic control. Nat Rev Genet. 2016 Aug;17(8):487–500. doi: 10.1038/nrg.2016.59.
   Google Scholar
• Robertson KD. DNA methylation and chromatin - Unraveling the tangled web. Oncogene. 2002;21(35REV. ISS. 3):5361–5379.
   Web of Science ®Google Scholar
• Ashapkin VV, Kutueva LI, Vanyushin BF. Dnmt2 is the most evolutionary conserved and enigmatic cytosine DNA methyltransferase in eukaryotes. Russ J Genet. 2016;52(3):237–248.
   Web of Science ®Google Scholar
• Bourc’his D. Dnmt3L and the establishment of maternal genomic imprints. Science. 2001;294(5551):2536–2539.
   PubMed Web of Science ®Google Scholar
• Théry C, Zitvogel L, Amigorena S. Exosomes: composition, biogenesis and function. Nat Rev Immunol. 2002;2(8):569–579.
   PubMed Web of Science ®Google Scholar
• Redman CWG, Sargent IL. Microparticles and immunomodulation in pregnancy and pre-eclampsia. J Reprod Immunol. 2007;76(1–2):61–67.
   Web of Science ®Google Scholar
• Pap E, Pállinger É, Pásztói M, et al. Highlights of a new type of intercellular communication: microvesicle-based information transfer. Inflamm Res. 2009;58(1):1–8.
   PubMed Web of Science ®Google Scholar
• Zhang YN, Vernooij F, Ibrahim I, et al. Extracellular vesicle proteins associated with systemic vascular events correlate with heart failure: an observational study in a dyspnoea cohort. PLoS One. 2016;11(1). DOI:10.1371/journal.pone.0148073
   Web of Science ®Google Scholar
• Becker A, Thakur BK, Weiss JM, et al. Extracellular vesicles in cancer: cell-to-cell mediators of metastasis. Cancer Cell. 2016;30(6):836–848.
   PubMed Web of Science ®Google Scholar
• Ismail N, Wang Y, Dakhlallah D, et al. Macrophage microvesicles induce macrophage differentiation and miR-223 transfer. Blood. 2013;121(6):984–995.
   PubMed Web of Science ®Google Scholar
• Sakr Y, Jimenez E, Njimi H, et al. Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit. Lancet Respir Med. 2014;2(5):380–386.
   Web of Science ®Google Scholar
• Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the USA: analysis of incidence, outcome, and associated costs of care. CritCareMed. 2001;29(7):1303–1310.
   Web of Science ®Google Scholar
• Ramachandran G. Gram-positive and gram-negative bacterial toxins in sepsis: a brief review. Virulence. 2013;5(1):27024.
   Web of Science ®Google Scholar
• Bone RC. American college of chest physicians/society of critical care medicine consensus conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest J. 1992;20(6):1644.
   Web of Science ®Google Scholar
• Karlsson S, Varpula M, Ruokonen E, et al. Incidence, treatment, and outcome of severe sepsis in ICU-treated adults in Finland: the finnsepsis study. Intensive Care Med. 2007;33(3):435–443.
   PubMed Web of Science ®Google Scholar
• Kaukonen K-M-M, Bailey M, Pilcher D, et al. Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med. 2015;372(17):1629–1638.
   PubMed Web of Science ®Google Scholar
• Hotchkiss RS, Monneret G, Payen D. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol. 2013;13(12):862–874.
   PubMed Web of Science ®Google Scholar
• Boulanger CM, Scoazec A, Ebrahimian T, et al. Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction. 2001;2649–2652. DOI:10.1161/hc4701.100516.
   Google Scholar
• Trappenburg MC, Van Schilfgaarde M, Marchetti M, et al. Elevated procoagulant microparticles expressing endothelial and platelet markers in essential thrombocythemia. Haematologica. 2009;94(7):911–918.
   Web of Science ®Google Scholar
• Diamant M, Nieuwland R, Pablo RF, et al. Elevated numbers of tissue-factor exposing microparticles correlate with components of the metabolic syndrome in uncomplicated type 2 diabetes mellitus. Circulation. 2002;106(19):2442–2447.
   Web of Science ®Google Scholar
• Lin Z-B, Ci H-B, Li Y, et al. Endothelial microparticles are increased in congenital heart diseases and contribute to endothelial dysfunction. J Transl Med. 2017;15(1):4.
   PubMed Web of Science ®Google Scholar
• VanWijk MJ, Nieuwland R, Boer K, et al. Microparticle subpopulations are increased in preeclampsia: possible involvement in vascular dysfunction? Am J Obstet Gynecol. 2002;187(2):450–456.
   Web of Science ®Google Scholar
• Perel A, Segal E, Khurana A, et al. Management of Sepsis. N Engl J Med. 2007;356(11):1178–1182.
   Google Scholar
• Berckmans RJ, Nieuwland R, Böing AN, et al. Cell-derived microparticles circulate in healthy humans and support low grade thrombin generation. Thromb Haemost. 2001;85(4):639–646.
   PubMed Web of Science ®Google Scholar
• Gasser O, Schifferli JA. Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis. Blood. 2004;104(8):2543–2548.
   PubMed Web of Science ®Google Scholar
• Dignat-George F, Boulanger CM. The many faces of endothelial microparticles. Arterioscler Thromb Vasc Biol. 2011;31(1):27–33.
   PubMed Web of Science ®Google Scholar
• George FD. Microparticles in vascular diseases. Thromb Res. 2008;122(SUPPL.1). DOI:10.1016/S0049-3848(08)70020-3
   Web of Science ®Google Scholar
• Joop K, Berckmans RJ, Nieuwland R, et al. Microparticles from patients with multiple organ dysfunction syndrome and sepsis support coagulation through multiple mechanisms. Thromb Haemost. 2001;85(5):810–820.
   Web of Science ®Google Scholar
• Ratajczak J, Miekus K, Kucia M, et al. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia. 2006;20(5):847–856.
   PubMed Web of Science ®Google Scholar
• Barry OP, Praticò D, Lawson JA, et al. Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles. J Clin Invest. 1997;99(9):2118–2127.
   PubMed Web of Science ®Google Scholar
• Mesri M, Altieri DC. Endothelial cell activation by leukocyte microparticles. J Immunol. 1998;161(8):4382–4387.
   PubMed Web of Science ®Google Scholar
• Cai Y, Xu M-J, Koritzinsky EH, et al. Mitochondrial DNA–enriched microparticles promote acute-on-chronic alcoholic neutrophilia and hepatotoxicity. JCI Insight. 2017;2(14). DOI:10.1172/jci.insight.92634
   Web of Science ®Google Scholar
• Nieuwland R, Berckmans RJ, McGregor S, et al. Cellular origin and procoagulant properties of microparticles in meningococcal sepsis. Blood. 2000;95(3):930–935.
   PubMed Web of Science ®Google Scholar
• Hunter MP, Ismail N, Zhang X, et al. Detection of microRNA expression in human peripheral blood microvesicles. PLoS One. 2008;3(11). DOI:10.1371/journal.pone.0003694
   Web of Science ®Google Scholar
• Yokoi A, Yoshioka Y, Yamamoto Y, et al. Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer. Nat Commun. 2017;8. DOI:10.1038/ncomms14470.
   Web of Science ®Google Scholar
• Cardoso MC, Leonhardt H. DNA methyltransferase is actively retained in the cytoplasm during early development. J Cell Biol. 1999;147(1):25–32.
   Web of Science ®Google Scholar
• Guiducci S, Distler JHW, Jüngel A, et al. The relationship between plasma microparticles and disease manifestations in patients with systemic sclerosis. Arthritis Rheum. 2008;58(9):2845–2853.
   PubMed Web of Science ®Google Scholar
• Amore E, Ferraro M, Manca ML, et al. Mucoadhesive solid lipid microparticles for controlled release of a corticosteroid in the chronic obstructive pulmonary disease treatment. Nanomedicine. 2017;12(19):2287–2302.
   Web of Science ®Google Scholar
• Horvath S. Erratum to: DNA methylation age of human tissues and cell types. Genome Biol. 2015;16(1):96.
   Web of Science ®Google Scholar
• Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10). DOI:10.1186/gb-2013-14-10-r115
   PubMed Web of Science ®Google Scholar
• Ratajczak J, Wysoczynski M, Hayek F, et al. Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication. Leukemia. 2006;20(9):1487–1495.
   PubMed Web of Science ®Google Scholar
• Faix JD. Biomarkers of sepsis. Crit Rev Clin Lab Sci. 2013;50(1):23–36.
   PubMed Web of Science ®Google Scholar
• Cho SY, Choi JH. Biomarkers of Sepsis. Infect Chemother. 2014;46(1):1–12.
   PubMedGoogle Scholar
• Trahtemberg U, Mevorach D. Apoptotic cells induced signaling for immune homeostasis in macrophages and dendritic cells. Front Immunol. 2017;8:1356.
   PubMed Web of Science ®Google Scholar
• Finkielsztein A, Mascarenhas L, Butin-Israeli V, et al. Isolation and characterization of neutrophil-derived microparticles for functional studies. J Vis Exp. 2018;(133). DOI:10.3791/56949.
   Web of Science ®Google Scholar
• Hainsworth AH, Yeo NE, Weekman EM, et al. Homocysteine, hyperhomocysteinemia and vascular contributions to cognitive impairment and dementia (VCID). Biochim Biophys Acta - Mol Basis Dis. 2016;1862(5):1008–1017.
   PubMed Web of Science ®Google Scholar
• Prattichizzo F, Micolucci L, Cricca M, et al. Exosome-based immunomodulation during aging: a nano-perspective on inflamm-aging. Mech Ageing Dev. 2017;168:44–53.
   PubMed Web of Science ®Google Scholar
• Mbagwu S, Walch M, Filgueira L, et al. Production and characterization of extracellular vesicles in malaria. Extracell Vesicles Methods Protoc. 2017;1660:377–388.
   Google Scholar
• Bellingham SA, Guo BB, Coleman BM, et al. Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases? Front Physiol. 2012 May 3. DOI:10.3389/fphys.2012.00124.
   Web of Science ®Google Scholar
• Kowal J, Primdal-Bengtson B, Dingli F, et al. Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes. Proc Natl Acad Sci. 2016;113(8):E968–E977.
   PubMed Web of Science ®Google Scholar
• Hellum M, Øvstebø R, Brusletto BS, et al. Microparticle-associated tissue factor activity correlates with plasma levels of bacterial lipopolysaccharides in meningococcal septic shock. Thromb Res. 2014;133:507–514.
   Web of Science ®Google Scholar
• Schertzer JW, Whiteley M. Bacterial outer membrane vesicles in trafficking, communication and the host-pathogen interaction. US Natl Libr Med. 2013;23:118–130.
   Google Scholar
• Jiang Y, Gao M, Wang W, et al. Sinomenine hydrochloride protects against polymicrobial sepsis via autophagy. Int J Mol Sci. 2015;16(2):2559–2573.
   PubMed Web of Science ®Google Scholar
• Bueno V, Sant’Anna OA, Lord JM. Ageing and myeloid-derived suppressor cells: possible involvement in immunosenescence and age-related disease. Age (Dordr). 2014;36(6):9729.
   Google Scholar
• Tyml K, Swarbreck S, Pape C, et al. Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice. Crit Care. 2017;21(1):210.
   PubMed Web of Science ®Google Scholar
• Saman S, Kim WH, Raya M, et al. Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early alzheimer disease. J Biol Chem. 2012;287(6):3842–3849.
   PubMed Web of Science ®Google Scholar
• Soldan A, Pettigrew C, Cai Q, et al. Cognitive reserve and long-term change in cognition in aging and preclinical alzheimer’s disease. Neurobiol Aging. 2017;60:164–172.
   Web of Science ®Google Scholar
• Takahashi K, Sugi Y, Nakano K, et al. Epigenetic control of the host gene by commensal bacteria in large intestinal epithelial cells. J Biol Chem. 2011;286(41):35755–35762.
   PubMed Web of Science ®Google Scholar
• Niwa T, Tsukamoto T, Toyoda T, et al. Inflammatory processes triggered by helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res. 2010;70(4):1430–1440.
   PubMed Web of Science ®Google Scholar
• Thangavel J, Malik AB, Elias HK, et al. Combinatorial therapy with acetylation and methylation modifiers attenuates lung vascular hyperpermeability in endotoxemia-induced mouse inflammatory lung injury. Am J Pathol. 2014;184(8):2237–2249.
   Web of Science ®Google Scholar
• Bierne H, Hamon M, Cossart P. Epigenetics and bacterial infections. Cold Spring Harb Perspect Med. 2012;2(12). DOI:10.1101/cshperspect.a010272
   Web of Science ®Google Scholar
• Sánchez-Romero MA, Cota I, Casadesús J. DNA methylation in bacteria: from the methyl group to the methylome. Curr Opin Microbiol. 2015;25:9–16.
   PubMed Web of Science ®Google Scholar
• Shalova IN, Lim JY, Chittezhath M, et al. Human monocytes undergo functional re-programming during sepsis mediated by hypoxia inducible factor 1. Immunity. 2015;42(3):484–498.
   Web of Science ®Google Scholar
• Dakhlallah D, Batte K, Wang Y, et al. Epigenetic regulation of mir-17∼92 contributes to the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med. 2013;187(4):397–405.
   Web of Science ®Google Scholar
• Dakhlallah D, Zhang J, Yu L, et al. MicroRNA-133a engineered mesenchymal stem cells augment cardiac function and cell survival in the infarct heart. J Cardiovasc Pharmacol. 2015;65(3):241–251.
   Web of Science ®Google Scholar