Comparison of correct technique and preference for Spiromax®, Easyhaler® and Turbuhaler®: a single-site, single-visit, crossover study in inhaler-naïve adult volunteers

References

• European Respiratory Society (ERS) White book. Chapter 1: the burden of lung disease. 2013:1–11. Available from: http://www.erswhitebook.org/chapters/the-burden-of-lung-disease/.
   Google Scholar
• Lötvall J, Ekerljung L, Rönmark EP, et al. West Sweden Asthma Study: prevalence trends over the last 18 years argues no recent increase in asthma. Respir Res. 2009;10:94.
   PubMed Web of Science ®Google Scholar
• Lindberg A, Jonsson AC, Rönmark E, et al. Prevalence of chronic obstructive pulmonary disease according to BTS, ERS, GOLD and ATS criteria in relation to doctor’s diagnosis, symptoms, age, gender, and smoking habits. Respiration. 2005;72:471–479.
   PubMed Web of Science ®Google Scholar
• Global Initiative For Asthma. Pocket guide for asthma management and prevention (for adults and children older than 5 years). A pocket guide for physicians and nurses. Updated 2015. Available from: http://www.ginasthma.org/wp-content/uploads/2016/01/GINA_Pocket_2015.pdf.
   Google Scholar
• Global Initiative for Asthma. Global strategy for asthma management and prevention. Updated 2017. Available from: http://www.ginasthma.org/2017-gina-report-global-strategy-for-asthma-management-and-prevention.
   Google Scholar
• Lavorini F, Magnan A, Dubus JC, et al. Effect of incorrect use of dry powder inhalers on management of patients with asthma and COPD. Respir Med. 2008;102:593–604.
   PubMed Web of Science ®Google Scholar
• Molimard M, Raherison C, Lignot S, et al. Chronic obstructive pulmonary disease exacerbation and inhaler device handling: real-life assessment of 2935 patients. Eur Respir J. 2017;49:1601794.
   PubMed Web of Science ®Google Scholar
• Herland K, Akselsen JP, Skjønsberg OH, et al. How representative are clinical study patients with asthma or COPD for a larger “real life” population of patients with obstructive lung disease? Respir Med. 2005;99:11–19.
   PubMed Web of Science ®Google Scholar
• Bjermer L. The importance of continuity in inhaler device choice for asthma and chronic obstructive pulmonary disease. Respiration. 2014;88:346–352.
   PubMed Web of Science ®Google Scholar
• Mäkelä MJ, Backer V, Hedegaard M, et al. Adherence to inhaled therapies, health outcomes and costs in patients with asthma and COPD. Respir Med. 2013;107:1481–1490.
   PubMed Web of Science ®Google Scholar
• Melani AS, Bonavia M, Cilenti V, et al. Inhaler mishandling remains common in real life and is associated with reduced disease control. Respir Med. 2011;105:930–938.
   PubMed Web of Science ®Google Scholar
• Schulte M, Osseiran K, Betz R, et al. Handling of and preferences for available dry powder inhaler systems by patients with asthma and COPD. J Aerosol Med Pulm Drug Deliv. 2008;21:321–328.
   PubMed Web of Science ®Google Scholar
• Sandler N, Holländer J, Långström D, et al. Evaluation of inhaler handling-errors, inhaler perception and preference with Spiromax, Easyhaler and Turbuhaler devices among healthy Finnish volunteers: a single site, single visit crossover study (Finhaler). BMJ Open Resp Res. 2016;3:e000119.
   PubMed Web of Science ®Google Scholar
• Chrystyn H, Safioti G, Keegstra JR, et al. Effect of inhalation profile and throat geometry on predicted lung deposition of budesonide and formoterol (BF) in COPD: an in-vitro comparison of Spiromax with Turbuhaler. Int J Pharm. 2015;491:268–276.
   PubMed Web of Science ®Google Scholar
• Cazzola M, Ora J, Di Paolo A, et al. Onset of action of budesonide/formoterol Spiromax® compared with budesonide/formoterol Turbuhaler® in patients with COPD. Pulm Pharmacol Ther. 2016;39:48–53.
   Web of Science ®Google Scholar
• Meakin BJ, Cainey JM, Woodcock PM. Simulated ‘in-use’ and ‘mis-use’ aspects of the delivery of terbutaline sulphate from Bricanyl TurbohalerTM dry powder inhalers. Int J Pharmaceutics. EMJ Respir. 1995;119:103–108.
   Google Scholar
• Molimard M, Raherison C, Lignot S, et al. Assessment of handling of inhaler devices in real life: An observational study in 3811 patients in primary care. J Aerosol Med. 2003;16:249–254.
   Google Scholar
• Price D, Bosnic-Anticevich, Briggs A, et al. Inhaler competence in asthma: Common errors, barriers to use and recommended solutions. Resp Med. 2013;107:37–46.
   Web of Science ®Google Scholar
• Basheti IA, Bosnic-Anticevich SZ, Armour CL, et al. Checklists for power inhaler technique: A review and recommendations. Respir Care. 2014;59:1140–1154.
   Web of Science ®Google Scholar
• Mahon J, Fitzgerald A, Glanville J, et al. Misuse and/or treatment delivery failure of inhalers among patients with asthma or COPD: A review and recommendations for the conduct of future research. Respir Med. 2017;129:98–116.
   Web of Science ®Google Scholar
• Dekhuijzen R, Wong G, Virchow JC, et al. Inhaler devices: the past, the present, and the future. EMJ Respir. 2015;3:49–54.
   Google Scholar
• Virchow JC, Rodriguez-Roisin R, Papi A, et al. A randomized, double-blinded, double-dummy efficacy and safety study of budesonide-formoterol Spiromax® compared to budesonide-formoterol Turbuhaler® in adults and adolescents with persistent asthma. BMC Pulm Med. 2016;16:42.
   PubMed Web of Science ®Google Scholar
• Chrystyn H, Dekhuijzen R, Rand C, et al. Evaluation of inhaler technique mastery for budesonide formoterol Spiromax® compared with Symbicort Turbohaler® in adult patients with asthma primary results from the easy low instruction over time [ELIOT] study. Thorax. 2015;70(Suppl 3):A154–A155.
   Google Scholar
• Taffet GE, Donohue JF, Altman PR. Considerations for managing chronic obstructive pulmonary disease in the elderly. Clin Interv Aging. 2014;9:23–30.
   Web of Science ®Google Scholar
• Lavorini F, Braido F, Baiardini I, et al. SIAAC-SIMER. Asthma and COPD: interchangeable use of inhalers. A document of Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC) & Italian Society of Respiratory Medicine (SIMeR). Pulm Pharmacol Ther. 2015;34:25–30.
   PubMed Web of Science ®Google Scholar
• Melani AS, Paleari D. Maintaining control of chronic obstructive airway disease: adherence to inhaled therapy and risks and benefits of switching devices. Copd. 2016;13:241–250.
   PubMedGoogle Scholar
• Ekberg-Jansson A, Svenningsson I, Rågdell P, et al. Budesonide inhaler device switch patterns in an asthma population in Swedish clinical practice (ASSURE). Int J Clin Pract. 2015;69:1171–1178.
   PubMed Web of Science ®Google Scholar