Witnessed sleep apneas together with elevated plasma glucose are predictors of COPD exacerbations

References

• Lundbäck B, Bakke P, Ingebrigtsen TS, et al. Chronic obstructive pulmonary disease. In: Annesi-Maesona I, Lundbäck B, Viegi G, editors. Respiratory epidemiology. European Respiratory Society Publications; 2014;Chapter 1: 1–17.
   Google Scholar
• Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD executive summary. Am J Respir Crit Care Med. 2017;195(5):557–8. .
   PubMed Web of Science ®Google Scholar
• Thomsen M, Ingebrigtsen TS, Marott JL, et al. Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease. JAMA. 2013;309(22):2353–2361. .
   PubMed Web of Science ®Google Scholar
• Robichaud-Halle L, Beaudry M, Fortin M. Obstructive sleep apnea and multimorbidity. BMC Pulm Med. 2012;12:60.
   Web of Science ®Google Scholar
• Marshall NS, Wong KK, Liu PY, et al. Sleep apnea as an independent risk factor for all-cause mortality: the busselton health study. Sleep. 2008;31(8):1079–1085.
   PubMed Web of Science ®Google Scholar
• Soler X, Gaio E, Powell FL, et al. High prevalence of obstructive sleep apnea in patients with moderate to severe chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2015;12(8):1219–1225.
   PubMed Web of Science ®Google Scholar
• McNicholas WT. COPD-OSA overlap syndrome: evolving evidence regarding epidemiology, clinical consequences, and management. Chest. 2017;152(6):1318–1326.
   PubMed Web of Science ®Google Scholar
• Schreiber A, Cemmi F, Ambrosino N, et al. Prevalence and predictors of obstructive sleep apnea in patients with chronic obstructive pulmonary disease undergoing inpatient pulmonary rehabilitation. COPD. 2018;15(3):265–270.
   PubMedGoogle Scholar
• Marin JM, Soriano JB, Carrizo SJ, et al. Outcomes in patients with chronic obstructive pulmonary disease and obstructive sleep apnea: the overlap syndrome. Am J Respir Crit Care Med. 2010;182(3):325–331.
   PubMed Web of Science ®Google Scholar
• Kent BD, Grote L, Bonsignore MR, et al. Sleep apnoea severity independently predicts glycaemic health in nondiabetic subjects: the ESADA study. Eur Respir J. 2014;44(1):130–139.
   PubMed Web of Science ®Google Scholar
• Calvin AD, Albuquerque FN, Lopez-Jimenez F, et al. Obstructive sleep apnea, inflammation, and the metabolic syndrome. Metab Syndr Relat Disord. 2009;7(4):271–278.
   PubMed Web of Science ®Google Scholar
• Baker EH, Janaway CH, Philips BJ, et al. Hyperglycaemia is associated with poor outcomes in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonary disease. Thorax. 2006;61(4):284–289.
   PubMed Web of Science ®Google Scholar
• Islam EA, Limsuwat C, Nantsupawat T, et al. The association between glucose levels and hospital outcomes in patients with acute exacerbations of chronic obstructive pulmonary disease. Ann Thorac Med. 2015;10(2):94–99.
   Web of Science ®Google Scholar
• Esposito K, Nappo F, Marfella R, et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation. 2002;106(16):2067–2072.
   PubMed Web of Science ®Google Scholar
• Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest. 2005;115(5):1111–1119.
   PubMed Web of Science ®Google Scholar
• Wu Y, Wu T, Wu J, et al. Chronic inflammation exacerbates glucose metabolism disorders in C57BL/6J mice fed with high-fat diet. J Endocrinol. 2013;219(3):195–204.
   PubMed Web of Science ®Google Scholar
• Gyurko R, Siqueira CC, Caldon N, et al. Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice. J Immunol. 2006;177(10):7250–7256.
   PubMed Web of Science ®Google Scholar
• Bhat TA, Panzica L, Kalathil SG, et al. Immune dysfunction in patients with chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2015;12(Suppl 2):S169–75.
   PubMedGoogle Scholar
• Schnohr P, Jensen G, Lange P, et al. The copenhagen city heart study - Østerbroundersøgelsen. Tables with data from the third examination 1991-1994. Eur Heart J. 2001;3(supplH):H1–H83.
   Google Scholar
• Andersen TF, Madsen M, Jorgensen J, et al. The Danish National Hospital Register. A valuable source of data for modern health sciences. Dan Med Bull. 1999;46(3):263–268.
   PubMed Web of Science ®Google Scholar
• Lynge E, Sandegaard JL, Rebolj M. The danish national patient register. Scand J Public Health. 2011;39(7 Suppl):30–33.
   PubMed Web of Science ®Google Scholar
• Lin DY, Wei LJ, Ying Z. Checking the cox model with cumulative sums of martingale-based residuals. Biometrika. 1993;80(3):557–572.
   Web of Science ®Google Scholar
• R Core Team. R: A language and environment for statistical computing. Vienna (Austria): R Foundation for Statistical Computing. [cited 2020 Apr 27]. Available from: www.R-project.org.
   Google Scholar
• Cizza G, Piaggi P, Lucassen EA, et al. Obstructive sleep apnea is a predictor of abnormal glucose metabolism in chronically sleep deprived obese adults. PLoS One. 2013;8(5):e65400. .
   Web of Science ®Google Scholar
• Bakker JP, Weng J, Wang R, et al. Associations between obstructive sleep apnea, sleep duration, and abnormal fasting glucose. The multi-ethnic study of atherosclerosis. Am J Respir Crit Care Med. 2015;192(6):745–753.
   PubMed Web of Science ®Google Scholar
• Cebron Lipovec N, Beijers RJ, van den Borst B, et al. The prevalence of metabolic syndrome in chronic obstructive pulmonary disease: a systematic review. COPD. 2016;13(3):399–406.
   PubMedGoogle Scholar
• Kupeli E, Ulubay G, Ulasli SS, et al. Metabolic syndrome is associated with increased risk of acute exacerbation of COPD: a preliminary study. Endocrine. 2010;38(1):76–82.
   Web of Science ®Google Scholar
• Fleming WE, Holty JC, Bogan RK, et al. Use of blood biomarkers to screen for obstructive sleep apnea. Nat Sci Sleep. 2018;10:159–167.
   Web of Science ®Google Scholar
• Wei YF, Tsai YH, Wang CC, et al. Impact of overweight and obesity on acute exacerbations of COPD - subgroup analysis of the Taiwan obstructive lung disease cohort. Int J Chron Obstruct Pulmon Dis. 2017;12:2723–2729.
   Web of Science ®Google Scholar
• Julius S, Valentini M, Palatini P. Overweight and hypertension: a 2-way street? Hypertension. 2000;35(3):807–813.
   PubMed Web of Science ®Google Scholar
• McNicholas WT. Diagnosis of obstructive sleep apnea in adults. Proc Am Thorac Soc. 2008;5(2):154–160.
   PubMedGoogle Scholar
• Thomsen RW, Lange P, Hellquist B, et al. Validity and underrecording of diagnosis of COPD in the danish national patient registry. Respir Med. 2011;105(7):1063–1068. .
   PubMed Web of Science ®Google Scholar
• Yang D, Liu Z, Yang H, et al. Effects of continuous positive airway pressure on glycemic control and insulin resistance in patients with obstructive sleep apnea: a meta-analysis. Sleep Breath. 2013;17(1):33–38.
   Web of Science ®Google Scholar
• Loachimescu OC, Anthony J Jr., Constantin T, et al. VAMONOS (Veterans affairs’ metabolism, obstructed and non-obstructed sleep) study: effects of CPAP therapy on glucose metabolism in patients with obstructive sleep apnea. J Clin Sleep Med. 2017;13(3):455–466.
   Web of Science ®Google Scholar