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European Clinical Respiratory Journal Volume 10, 2023 - Issue 1
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Short Communication

Nonutility of procalcitonin for diagnosing bacterial pneumonia in patients with severe COVID-19

Avi J. Cohena Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USAORCID Iconhttps://orcid.org/0000-0001-8909-5365View further author information
ORCID Icon,
Laura R. Glicka Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USAView further author information
,
Seohyuk Leea Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USAView further author information
,
Yukiko Kunitomob Johns Hopkins Hospital, Department of Internal Medicine, Section of Pulmonary and Critical Care Medicine, Baltimore, MD, USAView further author information
,
Derek A. Tsanga Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USAView further author information
,
Sarah Pitafia Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USAView further author information
,
Patricia Valda Toroc Department of Internal Medicine, University of California San Francisco, San Francisco, CA, USAView further author information
,
Nicholas R. Ristica Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USAView further author information
,
Ethan Zhanga Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USAView further author information
,
George B. Careya Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USAView further author information
,
Rupak Dattad Veterans Affairs Connecticut Healthcare System, Hospital Epidemiology and Infection Prevention Program, West Haven, CT, USA;e Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, USAView further author information
,
Charles S. Dela Cruza Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA;f Section of Pulmonary, Critical Care, and Sleep Medicine, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA;g Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USAView further author information
&
Samir Gautama Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9443-164XView further author information
ORCID Icon show all
Article: 2174640 | Received 30 Aug 2022, Accepted 26 Jan 2023, Published online: 08 Feb 2023

References

  • Pickens CO, Gao CA, Cuttica MJ, et al. Bacterial superinfection pneumonia in patients mechanically ventilated for COVID-19 pneumonia. Am J Respir Crit Care Med. 2021;204(8):921–4.
  • May M, Chang M, Dietz D, et al. Limited utility of procalcitonin in identifying community-associated bacterial infections in patients presenting with coronavirus disease 2019. Antimicrob Agents Chemother. 2021;65(4). DOI:10.1128/AAC.02167-20
  • Relph KA, Russell CD, Fairfield CJ, et al. Procalcitonin is not a reliable biomarker of bacterial coinfection in people with coronavirus disease 2019 undergoing microbiological investigation at the time of hospital admission. Open Forum Infect Dis. 2022;9(5). DOI:10.1093/ofid/ofac179
  • Pink I, Raupach D, Fuge J, et al. C-reactive protein and procalcitonin for antimicrobial stewardship in COVID-19. Infection. 2021;49(5):935–943.
  • Hughes S, Mughal N, Moore LSP. Procalcitonin to guide antibacterial prescribing in patients hospitalised with covid-19. Antibiotics. 2021;10(9):1119.
  • Atallah NJ, Warren HM, Roberts MB, et al. Baseline procalcitonin as a predictor of bacterial infection and clinical outcomes in COVID-19: a case-control study. PLoS ONE. 2022;17(1):e0262342.
  • Russell CD, Fairfield CJ, Drake TM, et al. Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. Lancet Microbe. 2021;2(8):e354–365. DOI:10.1016/S2666-5247(21)00090-2
  • Shen Y, Cheng C, Zheng X, et al. Elevated procalcitonin is positively associated with the severity of COVID-19: a meta-analysis based on 10 cohort studies. Medicina (Kaunas). 2021;57(6):594.
  • Gautam S, Cohen AJ, Stahl Y, et al. Severe respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia. Thorax. 2020;75(11):974–981.
  • So W, Simon MS, Choi JJ, et al. Characteristics of procalcitonin in hospitalized COVID-19 patients and clinical outcomes of antibiotic use stratified by procalcitonin levels. Intern Emerg Med. 2022;17(5):1405–1412.

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