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Research Article

Review of 2,4-Dichlorophenoxyacetic Acid (2,4-D) Epidemiology and Toxicology

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Pages 233-257 | Published online: 29 Sep 2008

References

  • IARC, Occupational exposures to chlorophenoxy herbicides, IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, World Health Organization, Lyon, France, 1986, 357–407.
  • Munro, I.C., Carlo, G.L., Orr, J.C., Sund, K.G., and Wilson, R.M. A comprehensive integrated re-view and evaluation of the scientific evidence relating to the safety of the herbicide 2,4–D. J. Am. Coll. Toxicol. 11(5),559–664. 1992.
  • Hardell, L. and Sandstrom, A. Case-control study: soft-tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols. Br. J. Cancer, 39, 711–717, 1979.
  • Hardell, L., Eriksson, M., Lenner, P., and Lundgren, E. Malignant lymphoma and exposure to chemicals, especially organic solvents, chlorophenols and phenoxy acids: a case-control study. Br. J. Can- cer, 42, 169–176, 1981.
  • Hardell, L. Relation of soft-tissue sarcoma, malig- nant lymphoma and colon cancer to phenoxy acids, chlorophenols and other agents. Scand. J. Work Environ. Health, 7, 119–110, 1981.
  • Hardell, L. Soft-tissue sarcoma, malignant lymphoma, and exposure to phenoxyacids or chlorophenols. Lan- cet, 1408–1409, 1982.
  • Pearce, N.E., Smith, A.H., and Fisher, D.O. Malig- nant lymphoma and multiple myeloma linked with agricultural occupations in a New Zealand cancer reg- istry-based study. Am. J. Epid., 121, 225–237, 1985.
  • Schumacher, M.C. Farming occupations and mortal- ity from non-Hodgkin’s lymphoma in Utah. JOM, 27, 580–584, 1985.
  • Vineis, P., Terracini, B., Ciccone, G., Cignetti, A., and Colombo, E. Phenoxy herbicides and soft-tissue sarcomas in female rice weeders. Scand. J. Work Environ. Health, 13, 9–17, 1986.
  • Riihimaki, H., Asp, S., Pukkala, E., and Hernberg, S. Mortality and cancer morbidity among chlorinated phenoxyacid applicators in Finland. Chemosphere, 12, 779–784, 1983.
  • Lynge, E. A follow-up study of cancer incidence among workers in manufacture of phenoxy herbicides in Denmark. Br. J. Cancer, 52, 259–270, 1985.
  • Hoar, S.K. et al. Agricultural herbicide use and risk of lymphoma and soft-tissue sarcoma. JAMA, 256, 1141–1147, 1986.
  • Frank, R., Campbell, R.A., and Sirons, G.J. For- estry workers involved in aerial application of 2,4– dichlorophenoxyacetic acid (2,4–D): exposure and urinary excretion. Arch. Environ. Contam. Toxicol., 14, 427–435, 1985.
  • Grover, R., Cessna, A.J., Muir, N.I., Riedel, D., and Franklin, C.A. Factors affecting the exposure of ground-rig applicators to 2,4–D dimethylamine salt. Arch. Environ. Contam. Toxicol., 15, 677–686, 1986.
  • Libich, S., To, S.C., Frank, R., and Sirons, G.J. Occupational exposure of herbicide applicators to her- bicides used along electric power transmission line right-of-way. AIHAJ, 45, 56–62, 1984.
  • Berndt, W.O. and Koschier, F. In vitro uptake of 2,4–dichlorophenoxyacetic acid (2,4–D) and 2,4,5– trichlorophenoxyacetic acid (2,4,5–T) by renal corti- cal tissue of rabbits and rats. Toxicol. Appl. Pharmacol. 26, 559–570, 1973.
  • Kim, C.S. and O’Tuama, L.A. Choroid plexus trans- port of 2,4–dichlorophenoxyacetic acid, interaction with the organic acid carrier. Brain Res., 224, 209– 212, 1981.
  • Pritchard, J.B. Accumulation of anionic pesticides by rabbit choroid plexus in vitro. J. Tox. Exp. Therap., 212, 354–359, 1980.
  • Clark, D.E., Palmer, J.S., Radeleff, R.D., Crookshank, H.R., and Farr, F.M. Residues of chlorophenoxy acid herbicides and their phenolic metabolites in tissues of sheep and cattle. J. Agr. Food Chem., 23, 573–578, 1975.
  • Tyynela, K., Elo, H.A., and Ylitalo, P. Distribution of three common chlorophenoxyacetic acid herbicides into the rat brain. Arch. Toxicol., 64, 61–65, 1990.
  • Eiseman, J. The pharmokinetics evaluation of 14C- labelled 2,4–D in the mouse. Hazelton Laboratories America Inc., Vienna, VA, USA, 1984.
  • Pelletier, O., Ritter, L., Caron, J., and Somers, D. Disposition of 2,4–dichlorophenoxyacetic acid dimethylamine salt by fischer 344 rats dosed orally and dermally. J. Toxicol. Environ. Health, 28, 221– 234, 1989.
  • Smith, F. A., Nolan, R. J., Hermann, E. A., and Ramsey, J. C. Pharmacokinetics of 2,4–dichloropenoxyacetic acid (2,4–D) in Fischer 344 rats, The Dow Chemical Com- pany, Midland, Michigan, USA, 1990.
  • Timchalk, C, Dryzga, M. D., and Brzak, K. A. 2,4– Dichlorophenoxycetic acid, tissue distribution and metabolism of 14–C-labelled 2,4–D in Fischer 344 rats, The Dow Chemical Company, Midland, Michi- gan, USA, 1990.
  • World Health Organization. Pesticide residues in food — 1996. Report of the joint meeting of theFAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Expert Group on Pes- ticide Residues., World Health Organization, Rome, Italy, 9–16–1996, 1–38.
  • Dryzga, M. D., Brzak, K. A., and Nolan, R. J. 2,4– Dichlorophenoxyacetate 2–ethylhexyl ester: metabo- lism in Fischer 344 rats, The Dow Chemical Com- pany, Midland, Michigan, USA, 1992.
  • Dryzga, M. D., Brzak, K. A., and Nolan, R. J. 2,4– Dichlorophenoxyacetate 2–ethylhexyl ester: Metabo- lism in Fischer 344 rats, The Dow Chemical Com- pany, Midland, Michigan, USA, 1992.
  • Moody, R.P., Franklin, C.A., Ritter, L., and Maibach, H.I. Dermal absorption of the phenoxy herbicides 2,4–d, 2,4–d amine, 2,4–d isooctyl, and 2,4,5–t in rabbits, rats, rhesus monkeys, and humans: a cross-species comparison. J. Toxicol. Environ. Health, 29, 237–245, 1990.
  • Guo, M. and Stewart, S. Metabolism of 14–C-ring labelled 2,4–D in lactating goats. ABC Laboratories Inc., Columbia, Missouri, USA, 1993.
  • Elo, H.A. and Ylitalo, P. Substantial increase in the levels of chlorophenoxyacetic acids in the CNS of rats as a result of severe intoxication. Acta Pharmacol. Toxicol., 41, 280–284, 1977.
  • Ylitalo, P., Narhi, U., and Elo, H.A. Increase in the acute toxicity and brain concentrations of chlorophenoxyacetic acids by probenecid in rats. Gen. Pharmacol., 21, 811– 814, 1990.
  • Elo, H.A., Hervonen, H., and Ylitalo, P. Compara- tive study on cerebrovascular injuries by three chlorophenoxyacetic acids (2,4–D, 2,4,5–T, and MCPA). Comp. Biochem. Physiol., 90C, 65–68, 1988.
  • Sauerhoff, M.W., Braun, W.H., Blau, G.E., and Gehring, P.J. The fate of 2,4–dichlorophenoxyacetic acid (2,4–D) following oral administration to man. Toxicology, 8, 3–11, 1977.
  • Grunow, W. and Bohme, C.H.R. Uber den stoffwechsel von 2,4,5–T und 2,4–D bei ratten und mausen. Arch. Toxikol., 32, 217–225, 1974.
  • Kohli, J.D., Khanna, R.N., and Gupta, B.N. Ab- sorption and excretion of 2,4–dichlorophenoxyacetic acid in man. Xenobiotica, 4, 97–100, 1974.
  • Charles, J.M., Hanley, T.R., Wilson, R.D., van Ravenzwaay, B., and Bus, J.S. Developmental tox- icity studies in rats and rabbits on 2,4–dichlorophe- noxyacetic acid and its forms. Toxicol. Sci., 60, 121– 131, 2001.
  • Sandberg, J.A. et al. Distribution of 2,4–dichlorophe- noxyacetic acid (2,4–D) in maternal and fetal rabbits. J. Toxicol. Environ. Health, 49, 497–509, 1996.
  • Charles, J.M., Cunny, H.C., Wilson, R.D., and Bus, J.S. Comparative subchronic studies on 2,4–dichlo- rophenoxyacetic acid, amine, and ester in rats. Funda- m. Appl. Toxicol., 33, 161–165, 1996.
  • Charles, J.M. et al. Chronic dietary toxicity/oncoge- nicity studies on 2,4–dichlorophenoxyacetic acid in rodents. Fundam. Appl. Toxicol., 33, 166–172, 1996.
  • Charles, J.M. et al. comparative subchronic and chronic dietary toxicity studies on 2,4–dichlorophe- noxyacetic acid, amine, and ester in the dog. Fundam. Appl. Toxicol., 29, 78–85, 1996.
  • IARC. Polychlorinated dibenzo-para-dioxins and poly- chlorinated dibenzofurans., IARC, IARC Monographs on the Evaluation of Carcinogenic Risk to Humans. International Agency for Research on Cancer, Lyon, France, 1997, 1–639.
  • Charles, J.M., Dalgard, D.W., Cunny, H.C., Wil- son, R.D., and Bus, J.S. Comparative subchronic and chronic dietary toxicity studies on 2,4–dichlorophe- noxyacetic acid amine, and ester in the dog. Fundam. Appl. Toxicol., 29, 78–85, 1996.
  • Hayes, H.M. et al. Case-control study of canine ma- lignant lymphoma: positive association with dog owner’s use of 2,4–dichlorophenoxyacetic acid herbi- cides. J. Natl. Cancer Inst., 83, 1226–1231, 1991.
  • Kaneene, J.B. and Miller, R.A. Reanalysis of 2,4–D use and the occurrence of canine malignant lymphoma. Vet. Hum. Toxicol., 41, 164–170, 1999.
  • Gollapudi, B.B., Charles, J.M., Linscombe, V.A., Day, S.J., and Bus, J.S. Evaluation of the genotoxicity of 2,4–dichlorophenoxyacetic acid and Its derivatives in mammalian cell cultures. Mutat. Res., 444, 217– 225, 1999.
  • Charles, J.M. et al. Ames assays and unscheduled DNA synthesis assays on 2,4–dichlorophenoxyacetic acid and its derivatives. Mutat. Res., 444, 207–216, 1999.
  • Charles, J.M. et al. In vivo micronucleus assays on 2,4–dichlorophenoxyacetic acid and its derivatives. Mutat. Res., 444, 227–234, 1999.
  • US Environmental Protection Agency. Memoran- dum on 2,4–dichlorophenoxyacetic acid. 5–16–1996.
  • Charles, J., Bond, D.M., Jeffries, T.K., Yano, B.L., and Stott, W.T. Chronic dietary toxicity/oncogenic- ity studies on 2,4–dichlorophenoxyacetic acid in ro- dents. Fundam. Appl. Toxicol., 33, 166–172, 1996.
  • Steiss, J.E., Braund, K.G., and Clark, E.G. Neuro- muscular effects of acute 2,4–dichlorophenoxyacetic acid (2,4–D) exposure in dogs. J. Neurolog. Sci., 78, 295–301, 1987.
  • Arnold, E.K., Beasley, V.R., Parker, A.J., and Stedelin, J.R. 2,4–D toxicosis. II. A pilot study of clinical pathologic and electroencephalographic ef- fects and residues of 2,4–D in orally dosed dogs. Vet. Hum. Toxicol., 33, 446–449, 1991.
  • Beasley, V.R., Arnold, E.K., and Lovell, R.A. 2,4– D toxicosis I: a pilot study of 2,4–dichlorophenoxy- acetic acid- and dicamba-induced myotonia in experi- mental dogs. Vet. Hum. Toxicol., 33, 435–449, 1991.
  • Kwiecinski, H. Myotonia induced by chemical agents. CRC Crit. Rev. Toxicol., 8, 279, 1981.
  • Elo, H.A. and MacDonald, E. Effects of 2,4–dichlo- rophenoxyacetic acid (2,4–D) on biogenic amines and their acidic metabolites in brain and cerebrospinal fluid of rats. Arch. Toxikol., 63, 127–130, 1989.
  • Podolak, M. Dose dependence of the effects caused by acute intoxication with 2,4–D. I. Biogenic amines. Bromat. Chem. Toksykol., 14, 17–22, 1981.
  • Podolak, M. Dose dependence of the effects caused by acute intoxication with 2,4–D. II. Oxidative phos- phorylation. Bromat. Chem. Toksykol., 14, 165–175, 1981.
  • Schulze, G.E. and Dougherty, J.A. Neurobehavioral toxicity of 2,4–D-n-Butyl Ester (2,4–D Ester): toler- ance and lack of cross-tolerance. Neurotoxicol. Teratol., 10, 75–79, 1988.
  • de Duffard, A.M.E., de Alderete, M.N., and Duffard, R. Changes in brain serotonin and 5– hydroxyindolacetic acid levels induced by 2,4–dichlo- rophenoxyacetic butyl ester. Toxicology, 64, 265–270, 1990.
  • de Duffard, A.M.E., Orta, C., and Duffard, R. Behavioral changes in rats fed a diet containing 2,4– dichlorophenoxyacetic butyl ester. Neuro, 11, 563– 572, 1990.
  • Tyynela, K., Elo, H.A., Ylitalo, P., and Hervonen, H. The central nervous system toxicity of chlorophenoxyacetic acid herbicides. Archiv. Toxicol. Suppl., 9, 355, 1986.
  • Kim, C.S., Keizer, R.F., and Pritchard, J.B. 2,4– dichlorophenoxyacetic acid intoxication increases its accumulation within the brain. Brain Res., 440, 216– 226, 1988.
  • Mattsson, J.L. et al. Single-dose and chronic dietary neurotoxicity screening studies on 2,4–dichlorophe- noxyacetic acid in rats. Fundam. Appl. Toxicol., 40, 111–119, 1997.
  • Reuber, M.D. Carcinogenicity and toxicity of 2,4– dichlorophenoxyacetic acid. Sci. Total Environ., 31, 203–218, 1983.
  • Green, L.M. Suicide and exposure to phenoxy acid herbicides. Scand. J. Work Environ. Health, 13, 460, 1987.
  • Lathrop, G. D. Epidemiologic investigation of health effects in Air Force personnel following exposure to herbicides: study protocol, US Air Force, Surgeon General, Washington, DC, 1982.
  • Singer, R., Moses, M., Valciukas, J., Lilis, R., and Selikoff, I.J. Nerve conduction velocity studies of workers employed in the manufacture of phenoxy herbicides. Environ. Res., 29, 297–311, 1982.
  • Buslovich, S.I.U. and Pichugin, U.I.U. Electromyo- graphic characteristics of acute poisonings with chlo- rine derivatives of phenoxy acids. Farmakol. I. Toksikol., 46, 99–101, 1983.
  • Clement Associates. 2,4–D. Analyses of recent lit- erature on health effects. Veterans Administration, Washington, DC, 1985.
  • Clement Associates. 2,4–D. Analysis of recent litera- ture on health effects. Volume XIV. Annotated bibli- ography of recent literature on health effects. Depart- ment of Veterans Affairs, Washington, DC, 1989.
  • Clement Associates. 2,4–D. Analysis of recent litera- ture on health effects. Volume XVI. Annotated bibli- ography of recent literature on health effects. Depart- ment of Veterans Affairs, Washington, DC, 1990.
  • Levy, C.J. Agent Orange exposure and posttraumatic stress disorder. J. Nervous Mental Dis. 176, 242–245, 1988.
  • IARC. Occupational exposures to chlorophenoxy herbicides., IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Interna- tional Agency for Research on Cancer, Lyon, France, 1986, 357–407.
  • US Environmental Protection Agency. Carcinoge- nicity peer review (4th) of 2,4–Dichlorophenoxyace- tic acid (2,4–D). 1–29–1997.
  • Shifrin, E., Workshop finds 2,4–D cancer link “far from established”, Harvard University School of Pub- lic Health, Department of Health Policy and Manage- ment, Boston, Massachusetts, 1990, 1–27.
  • Acquavella, J.F., Olsen, G.W., Cole, P., Ireland, B., and Kaneene, J.B. Cancer among farmers: a meta- analysis. Annal. Epidemiol., 8, 64–74, 1998.
  • Blair, A., Cantor, K.P., and Zahm, S.H. Non- Hodgkin’s lymphoma and agricultural use of the in- secticide lindane. Am. J. Indust. Med., 33, 82–87, 1998.
  • Cantor, K.P., Everett, G., Blair, A., and Gibson, R. Farming and non-Hodgkin’s lymphoma. Society for Epidemiologic Research: Abstracts, 535–536. 1998.
  • Keller-Byrne, J.E., Khuder, S.A., Schaub, E.A., and McAfee, O. A meta-analysis of non-hodgkin’s lymphoma among farmers in the central United States. Am. J Indust. Med., 31, 442–444, 1997.
  • Amadori, D. et al. Chronic lymphocytic leukaemias and non-Hodgkin’s lymphomas by histological typein farming-animal breeding workers: a population case- control study based on job titles. Occupat. Environ. Med., 52, 374–379, 1995.
  • Linet, M.S. et al. Occupation and hematopoetic and lymphoproliferative malignancies among women: a linked registry study. JOM, 36, 1187–1198, 1994.
  • Morrison, H.I., Semenciw, R.M., Wilkins, K., Mao, Y., and Wigle, D.T. Non-Hodgkin’s lymphoma and agricultural practices in the prairie provinces of Canada. Scand. J. Work Environ. Health, 20, 42–47, 1994.
  • Semenciw, R.M., Morrison, H.I., Morison, D., and Mao, Y. Leukemia mortality and farming in the prai- rie provinces of Canada. Canad. J. Public Health, 85, 208–211, 1994.
  • Blair, A., Dosemeci, M., and Heineman, E.F. Can- cer and other causes of death among male and female farmers from twenty-three states. Am. J. Indust. Med., 23, 729–742, 1993.
  • Morrison, H.I., Savitz, D.A., and Semenciw, R.M. Farming and prostate cancer mortality. Am. J. Epid., 137, 270–280, 1993.
  • Persson, B., Fredriksson, M., Olsen, K., Boeryd, B., and Axelson, O. Some occupational exposures as risk factors for malignant lymphomas. Cancer, 72, 1773–1778, 1993.
  • Viel, J.-F. and Richardson, S.T. Lymphoma, mul- tiple myeloma and leukaemia among French farmers in relation to pesticide exposure. Soc. Sci. Med., 37, 771–777, 1993.
  • Blair, A. et al. Evaluation of risks for non-Hodgkin’s lym- phoma by occupation and industry exposures from a case- control study. Am. J. Indust. Med., 23, 301–312, 1993.
  • Ronco, G., Costa, G., and Lynge, E. Cancer risk among Danish and Italian farmers. Br. J. Indust. Med., 49, 220–225, 1992.
  • Blair, A. and Zahm, S.H. Cancer among farmers. Occupational Medicine: State of the Art Reviews, 6, 335–354, 1991.
  • Vineis, P., Faggiano, F., Tedeschi, M., and Ciccone, G. Incidence rates of lymphomas and soft-tissue sar- comas and environmental measurements of phenoxy herbicides. J. Natl. Cancer Inst., 83, 362–363, 1991.
  • Weisenburger, D.D. Environmental epidemiology of non-Hodgkin’s lymphoma in eastern Nebraska. Am. J. Indust. Med., 18, 303–305, 1990.
  • Wigle, D.T. et al. Mortality study of Canadian male farm operators: non-Hodgkin’s lymphoma mortality and agricultural practices in Saskatchewan. J. Nat. Cancer Inst., 82, 575–582, 1990.
  • Blair, A. et al., Principles of health and safety in agriculture. Dosman, J.A. and Cockcroft, D.W., Eds., pp. 276–278, CRC Press, Boca Raton, 1989.
  • Burmeister, L.F., Principles of health and safety in agriculture. Dosman, J.A. and Cockcroft, D.W., Eds., pp. 268–273, CRC Press, Boca Raton, 1989.
  • La Vecchia, C., Negri, E., D’Avanzo, B., and Franceschi, S. Occupation and lymphoid neoplasms. Br. J. Cancer, 60, 385–388, 1989.
  • Morrison, H.I., Mao, Y., Ritter, L., and Wigle, D.T., Principles of health and safety in agriculture. Dosman, J.A. and Cockcroft, D.W., Eds., pp. 280– 282, CRC Press, Boca Raton, 1989.
  • Woods, J.S. and Polissar, L. Non-Hodgkin’s lym- phoma among phenoxy herbicide-exposed farm work- ers in western Washington State. Chemosphere, 18, 401–406, 1989.
  • Bohigian, G.M., Kennedy, W.R., Numann, P.J., and Scott, W.C. Cancer risk of pesticides in agricul- tural workers. JAMA, 260, 959–966, 1988.
  • Wiklund, K., Linderfors, B.M., and Holm, L.E. Risk of malignant lymphoma in Sweden agricultural and forestry workers. Br. J. Indust. Med., 45, 19–24, 1988.
  • Dubrow, R., Paulson, J.O., and Windian, R. Farm- ing and malignant lymphoma in Hancock County, Ohio. Br. J. Indust. Med., 45, 25–28, 1988.
  • Schumacher, M.C. and Delzell, E. A death certifi- cate case-control study on non-Hodgkin’s lymphoma and occupation in men in North Carolina. Am. J. Indust. Med., 13, 317–330, 1988.
  • Zahm, S.H., Blair, A., Holmes, F.F., Boysen, C.D., and Robel, R.J. A case-referent study of soft-tissue sarcoma and Hodgkin’s disease. Scand. J. Work Environ. Health, 14, 224–230, 1988.
  • Blair, A., Cantor, K.P., Hanrahan, L., and Ander- son, H.A. Cancer and other causes of death among Wisconsin farmers. Am. J. Indust. Med., 11, 119–129, 1987.
  • Pearce, N.E., Sheppard, R.A., Smith, A.H., and Teague, C.A. Non-hodgkin’s lymphoma and farm- ing: an expanded case-control study. Int. J. Cancer, 39, 155–161, 1987.
  • Pearce, N.E., Smith, A.H., and Fisher, D.O. Malig- nant lymphoma and multiple myeloma linked with agricultural occupations in a New Zealand cancer reg- istry-based study. Am. J. Epid., 121, 225–237, 1985.
  • Blair, A., Malker, H., Cantor, K.P., Burmeister, L., and Wiklund, K. Cancer among farmers. Scand. J. Work Environ. Health, 11, 397–407, 1985.
  • Delzell, E. and Grufferman, S. Mortality among white and nonwhite farmers in North Carolina, 1976– 1978. Am. J. Epid., 121, 391–402, 1985.
  • Schumacher, M.C. Farming occupations and mortal- ity from non-Hodgkin’s lymphoma in Utah. JOM, 27, 580–584, 1985.
  • Gallagher, R.P. et al. Cancer and aplastic anemia in British Columbia farmers. J. Natl. Cancer Inst., 72, 1311–1315, 1984.
  • Cantor, K.P. Farming and mortality from non- Hodgkin’s lymphoma: a case-control study. Int. J. Cancer, 29, 239–247, 1982.
  • Burmeister, L.F. Cancer mortality in Iowa farmers, 1971–78. J. Natl. Cancer Inst., 66, 461–464, 1981.
  • Blair, A. and Thomas, T.L. Leukemia among Ne- braska farmers: a death certificate study. J. Natl. Can- cer Inst., 61, 2–20, 1978.
  • Wiklund, K., Dich, J., and Holm, L.-E. Risk of malignant lymphoma in Swedish pesticide appliers. Br. J. Cancer, 56, 505–508, 1987.
  • Wiklund, K., Dich, J., and Holm, L.-E. Risk of soft tissue sarcoma, Hodgkin’s disease and non-Hodgkin’s lymphoma among Swedish licensed pesticide appli- cators. Chemosphere, 18, 395–400, 1989.
  • Burns, C.J., Beard, K.K., and Cartmill, J.B. Mor- tality in chemical workers potentially exposed to 2,4– dichlorophenoxyacetic acid (2.4–D) 1945–94: an up- date. Occup. Environ. Med., 58, 24–30, 2001.
  • Bond, G.G. et al. Cause specific mortality among employees engaged in the manufacture, formulation, or packaging of 2,4– dichlorophenoxyacetic acid and related salts. Br. J. Indust. Med., 45, 98–105, 1988.
  • Bloemen, L.J. et al. An update of mortality among chemical workers potentially exposed to the herbicide 2,4–dichlorophenoxyacetic acid and its derivatives. JOM, 35, 1208–1212, 1993.
  • Bond, G.G., Wetterstroem, N.H., Roush, G.J., McLaren, E.A., and Lipps, T.E. Cause specific mor- tality among employees engaged in the manufacture, formulation, or packaging of 2,4–dichlorophenoxy- acetic acid and related salts. Br. J. Indust. Med., 45, 98–105, 1988.
  • Cantor, K.P. and Booze, C.F. Mortality among aerial pesticide applicators and flight instructors: a reprint. Arch. Environ. Health, 46, 110–116, 1991.
  • Asp, S., Riihimaki, V., Hernberg, S., and Pukkala, E. Mortality and cancer morbidity of Finnish chlorophenoxy herbicide applicators: an 18-year pro- spective follow-up. Am. J. Indust. Med., 26, 243–253, 1994.
  • Riihimaki, V., Asp, S., and Hernberg, S. Mortality of 2,4–dichlorophenoxyacetic acid and 2,4,5– trichlorophenoxyacetic acid herbicide applicators in Finland. Scand. J. Work Environ. Health, 8, 37–42, 1982.
  • Saracci, R. et al. Cancer mortality in workers ex- posed to chlorophenoxy herbicides and chlorophenols. Lancet, 338, 1027–1032, 1991.
  • Kogevinas, M., Becher, H., Benn, T., Bertazzi, P.A., and Boffetta, P. Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols, and dioxins. Am. J. Epid., 145, 1061–1075, 1997.
  • Coggon, D., Pannett, B., and Winter, P. Mortality and incidence of cancer at four factories making phe- noxy herbicides. Br. J. Indust. Med., 48, 173–178, 1991.
  • Green, L.M. A cohort mortality study of forestry workers exposed to phenoxy acid herbicides. Br. J. Indust. Med., 48, 234–238, 1991.
  • Coggon, D., Pannett, B., Winter, P.D., Acheson, E.D., and Bonsall, J. Mortality of workers exposed to 2 methyl-4 chlorophenoxyacetic acid. Scand. J. Work Environ. Health, 12, 448–454, 1986.
  • Lynge, E. Cancer in phenoxy herbicide manufactur- ing workers in Denmark, 1947–87 — an update. Can- cer Causes and Control, 4, 261–272, 1993.
  • Lynge, E. Background and design of a Danish cohort study of workers in phenoxy herbicide manufacture. Am. J. Indust. Med., 11, 427–437, 1987.
  • Bas Bueno de Mesquita, H., Doornbos, G., van der Kuip, D.A.M., Kogevinas, M., and Winkelmann, R. Occupational exposure to phenoxy herbicides and chlorophenols and cancer mortality in the Nether- lands. Am. J. Indust. Med., 22, 289–300, 1993.
  • Zahm, S.H. Mortality study of pesticide applicators and other empoyees of a lawn care service company. JOEM, 39, 1055–1067, 1997.
  • Lynge, E. Cancer incidence in Danish phenoxy her- bicide workers, 1947–1993. Environ. Health Perspect., 106, 683–688, 1998.
  • Kogevinas, M. et al. Soft tissue sarcoma and non- Hodgkin’s lymphoma in workers exposed to phenoxy herbicides, chlorophenols, and dioxins: two nested case-control studies. Epidemiology, 6, 396–402, 1995.
  • Fleming, L.E., Bean, J.A., Rudolph, M., and Hamilton, K. Cancer incidence in a cohort of li- censed pesticide applicators in Florida. JOEM, 41, 279–288, 1999.
  • Fleming, L.E., Bean, J.A., Rudolph, M., and Hamilton, K. Mortality in a cohort of licensed pesti- cide applicators. Occupat. Environ. Med., 56, 14–21, 1999.
  • Blair, A., Grauman, D.J., Lubin, J.H., and Fraumeni, J.F., Jr. Lung cancer and other causes of death among licensed pesticide applicators. J. Natl. Cancer Inst., 71, 31–37, 1983.
  • Eriksson, M., Hardell, L., Berg, N.O., Moller, T., and Axelson, O. Soft-tissue sarcomas and exposure to chemical substances: a case-referent study. Br. J. Indust. Med., 38, 27–33, 1981.
  • Smith, A.H., Fisher, D.O., Giles, H.J., and Pearce, N. The New Zealand soft tissue sarcoma case-control study: interview findings concerning phenoxyacetic acid exposure. Chemosphere, 12, 565, 1983.
  • Smith, A.H. et al. Soft tissue sarcoma and exposure to phenoxyherbicides and chlorophenols in New Zealand. J. Natl. Cancer Inst., 73, 1111–1117, 1984.
  • Woods, J.S., Polissar, L., Severson, R.K., Heuser, L.S., and Kulander, B.G. Soft tissue sarcoma and non- Hodgkin’s lymphoma in relation to phenoxyherbicide and chlorinated phenol exposure in western Washington. J. Natl. Cancer Inst., 78: 5,899–910, 1987.
  • Smith, J.G. and Christophers, A.J. Phenoxy herbi- cides and chlorophenols: a case control study on soft tissue sarcoma and malignant lymphoma. Br. J. Can- cer, 65, 442–448, 1992.
  • Hoar, S.K., Blair, A., Holmes, F.F., and Boysen, C.D. Correction re: Agricultural herbicide use and risk of lymphoma and soft-tissue sarcoma. JAMA, 256, 3351, 1986.
  • Zahm, S.H. et al. A case-control study of non- Hodgkin’s lymphoma and the herbicide 2,4–dichlo- rophenoxyacetic acid (2,4–D) in eastern Nebraska. Epidemiology, 1, 349–356, 1990.
  • Cantor, K.P. et al. Pesticides and other agricultural risk factors for non-hodgkin’s lymphoma among men in Iowa and Minnesota. Cancer Res., 52, 2447–2455, 1992.
  • Cantor, K.P., Burmeister, L.F., and Everett, G. Correspondence Re: K.P. Cantor, et al. Pesticides and other agricultural risk factors for non-Hodgkin’s lym- phoma among men in Iowa and Minnesota. Cancer Res., 53, 2421, 1993.
  • Olsen, G.W. The effect of the type of respondent on risk estimates of pesticide exposure in a non-Hodgkin’s lymphoma case-control study. J. Agromed., 3, 37–50, 1996.
  • Johnson, R.A. et al. Data on prior pesticide use col- lected form self- and proxy respondents. Epidemiol- ogy, 4, 157–164, 1993.
  • Fryzek, J.P., Lipworth, L., Garabrant, D.H., and McLaughlin, J.K. Comparison of surrogate with self- respondents for occupational factors. JOEM, 42, 425– 429, 2000.
  • Zahm, S.H., Weisenburger, D.D., Cantor, K.P., Holmes, F.F., and Blair, A. Role of the herbicide atrazine in the development of non-Hodgkin’s lym- phoma. Scand. J. Work Environ. Health, 19, 108–114, 1993.
  • Wilkins, I.J.R. and Comstock, G.W. Source of drink- ing water at home and site-specific cancer incidence in Washington County, Maryland. Am. J. Epid., 114, 178–190, 1981.
  • Pearce, N.E. et al. Non-Hodgkin’s lymphoma and exposure to phenoxyherbicides, chlorophenols, fenc- ing work, and meat works employment: a case- con- trol study. Br. J. Indust. Med., 43, 75–83, 1986.
  • Pearce, N.E., Sheppard, R.A., Smith, A.H., and Teague, C.A. Non-Hodgkin’s lymphoma and farm- ing: an expanded case-control study. Int. J. Cancer, 39, 155–161, 1987.
  • Pearce, N. Phenoxy herbicides and non-Hodgkin’s lymphoma in New Zealand: frequency and duration of herbicide use. Br. J. Indust. Med., 46, 143–144, 1989.
  • Hardell, L., Eriksson, M., and Degerman, A. Expo- sure to phenoxyacetic acids, chlorophenols, or or- ganic solvents in relation to histopathology, stage, and anatomical localization of non-Hodgkin’s lymphoma. Cancer Res. 54, 2386–2389, 1994.
  • Hardell, L. and Eriksson, M., A case control study of non-Hodgkin’s lymphoma and exposure to pesti- cides, American Cancer Society, 1999, 1353–1368.
  • Garabedian, M.J., Hoppin, J.A., Tolbert, P.E., Herrick, R.F., and Brann, E.A. Occupational chlo- rophenol exposure and non-Hodgkin’s lymphoma. JOEM, 41, 267–272, 1999.
  • Divine, B.J. and Hartman, C.M. Mortality update of butadiene production workers. Toxicology, 113, 169– 181, 1996.
  • Sternberg, S.S. Canine malignant lymphoma and 2,4– dichlorophenoxyacetic acid herbicides. J. Natl. Can- cer Inst., 84, 271–271, 1992.
  • Carlo, G.L. et al. Review of a study reporting an association between 2,4–dichlorophenoxyacetic acid and canine malignant lymphoma: report of an expert panel. Regul. Toxicol. Pharmacol., 16, 245–252, 1992.
  • Hayes, H.M., Tarone, R.E., and Cantor, K.P. On the association between canine malignant lymphoma and opportunity for exposure to 2,4–dichlorophenoxy- acetic acid. Environ. Res., 70, 119–125, 1995.
  • Hansen, W.H., Quaife, M.L., Habermann, R.T., and Fitzhugh, O.G. Chronic toxicity of 2,4–dichlo- rophenoxyacetic acid in rats and dogs. Toxicol. Appl. Pharmacol., 20, 122–129, 1971.
  • Blair, A., Kross, B., Stewart, P.A., Ogilivie, L., and Falk, R. Comparability of information on pesticide use obtained from farmers and their proxy respon- dents. J. Agricul. Safety Health, 1, 165–176, 1995.
  • Bond, G.G., Bodner, K.M., Sobel, W., Shellenberger, R.J., and Flores, G.H. Validation of work histories obtained from interviews. Amer. J. Epid., 128, 343–351, 1988.
  • Bourbonnais, R., Meyer, F., and Theriault, G.P. Validity of self reported work history. Br. J. Indust. Med., 45, 29–32, 1988.
  • Checkoway, H., Seixas, N.S., and Demers, P.A. The influence of occupational exposure assessment on epidemiological inferences. Occupat. Hygiene, 3, 7–21, 1996.
  • Henneberger, P.K. Collection of occupational epide- miologic data: the use of surrogate respondents to provide occupational histories. Occupational Medi- cine: State of the Art Reviews, 11, 393–401, 1996.
  • Lerchen, M.L. and Samet, J.M. An assessment of the validity of questionnaire responses provided by a surviving spouse. Am. J. Epid., 123, 481–489, 1986.
  • McLaughlin, J.K., Mandel, J.S., Mehl, E.S., and Blot, W.J. Comparison of next-of-kin with self-re- spondents regarding questions on cigarette, coffee, and alcohol consumption. Epidemiology, 1, 408–412, 1990.
  • Nelson, L.M., Longstreth, J.W.T., Koepsell, T.D., and VanBelle, G. Proxy respondents in epidemio- logic research. Epidemiol. Rev., 12, 71–86, 1990.
  • Pickle, L.W., Brown, L.M., and Blot, W.J. Informa- tion available from surrogate respondents in case- control interview studies. Am. J. Epid., 118, 99–108, 1983.

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