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Enhancing Rose Bengal penetration in ex vivo human corneas using iontophoresis

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Received 02 May 2024, Accepted 20 Jun 2024, Published online: 18 Jul 2024

References

  • Cabrera-Aguas M, Khoo P, Watson SL. Infectious keratitis: a review. Clin Exp Ophthalmol. 2022;50(5):543–562. doi:10.1111/ceo.14113
  • Ung L, Bispo PJM, Shanbhag SS, et al. The persistent dilemma of microbial keratitis: global burden, diagnosis, and antimicrobial resistance. Surv Ophthalmol. 2019;64(3):255–271. doi:10.1016/j.survophthal.2018.12.003
  • Zhang Y, Xu X, Wei Z, et al. The global epidemiology and clinical diagnosis of Acanthamoeba keratitis. J Infect Public Health. 2023;16(6):841–852. doi:10.1016/j.jiph.2023.03.020
  • Bharathi JM, Srinivasan M, Ramakrishnan R, et al. A study of the spectrum of Acanthamoeba keratitis: a three-year study at a tertiary eye care referral center in South India. Indian J Ophthalmol. 2007;55(1):37–42. doi:10.4103/0301-4738.29493
  • Stehr-Green JK, Bailey TM, Visvesvara GS. The epidemiology of Acanthamoeba keratitis in the United States. Am J Ophthalmol. 1989;107(4):331–336. doi:10.1016/0002-9394(89)90654-5
  • Carnt N, Minassian DC, Dart JKG. Acanthamoeba keratitis risk factors for daily wear contact lens users: a case-control study. Ophthalmology. 2023;130(1):48–55. doi:10.1016/j.ophtha.2022.08.002
  • Alfawaz A. Radial keratoneuritis as a presenting sign in acanthamoeba keratitis. Middle East Afr J Ophthalmol. 2011;18(3):252–255. doi:10.4103/0974-9233.84062
  • Johns KJ, O'Day DM, Head WS, et al. Herpes simplex masquerade syndrome: acanthamoeba keratitis. Curr Eye Res. 1987;6(1):207–212. doi:10.3109/02713688709020092
  • Robaei D, Carnt N, Minassian DC, et al. The impact of topical corticosteroid use before diagnosis on the outcome of Acanthamoeba keratitis. Ophthalmology. 2014;121(7):1383–1388. doi:10.1016/j.ophtha.2014.01.031
  • Scruggs BA, Quist TS, Zimmerman MB, et al. Risk factors, management, and outcomes of Acanthamoeba keratitis: a retrospective analysis of 110 cases. Am J Ophthalmol Case Rep. 2022;25:101372. doi:10.1016/j.ajoc.2022.101372
  • Dart JKG, Papa V, Rama P, et al. The orphan drug for Acanthamoeba keratitis (ODAK) trial: PHMB 0.08% (Polihexanide) and placebo versus PHMB 0.02% and propamidine 0.1%. Ophthalmology. 2024;131(3):277–287. doi:10.1016/j.ophtha.2023.09.031
  • Fernández-Ferreiro A, Santiago-Varela M, Gil-Martínez M, et al. In vitro evaluation of the ophthalmic toxicity profile of chlorhexidine and propamidine isethionate eye drops. J Ocul Pharmacol Ther. 2017;33(3):202–209. doi:10.1089/jop.2016.0053
  • Spoerl E, Huhle M, Seiler T. Induction of cross-links in corneal tissue. Experimental Eye Res. 1998;66(1):97–103. doi:10.1006/exer.1997.0410
  • Raiskup F, Spoerl E. Corneal crosslinking with riboflavin and ultraviolet A. I. principles. Ocul Surface. 2013;11(2):65–74. doi:10.1016/j.jtos.2013.01.002
  • Wu D, Lim DK, Lim BXH, et al. Corneal cross-linking: the evolution of treatment for corneal diseases. Front Pharmacol. 2021;12:686630. doi:10.3389/fphar.2021.686630
  • Iseli HP, Thiel MA, Hafezi F, et al. Ultraviolet A/riboflavin corneal cross-linking for infectious keratitis associated with corneal melts. Cornea. 2008;27(5):590–594. doi:10.1097/ICO.0b013e318169d698
  • Schnitzler E, Spörl E, Seiler T. Irradiation of cornea with ultraviolet light and riboflavin administration as a new treatment for erosive corneal processes, preliminary results in four patients. Klin Monbl Augenheilkd. 2000;217(3):190–193. doi:10.1055/s-2000-10344
  • Kwiatkowski S, Knap B, Przystupski D, et al. Photodynamic therapy – mechanisms, photosensitizers and combinations. Biomed Pharmacother. 2018;106:1098–1107. doi:10.1016/j.biopha.2018.07.049
  • Youf R, Müller M, Balasini A, et al. Antimicrobial photodynamic therapy: latest developments with a focus on combinatory strategies. Pharmaceutics. 2021;13(12):1995. doi:10.3390/pharmaceutics13121995
  • Altamirano D, Martinez J, Leviste KD, et al. Photodynamic therapy for infectious keratitis. Curr Ophthalmol Rep. 2020;8:245–251. doi:10.1007/s40135-020-00252-y
  • Piksa M, Lian C, Samuel IC, et al. The role of the light source in antimicrobial photodynamic therapy. Chemical Society Reviews. 2023;52(5):1697–1722. doi:10.1039/D0CS01051K
  • Tabibian D, Richoz O, Hafezi F. PACK-CXL: corneal cross-linking for treatment of infectious keratitis. J Ophthalmic Vis Res. 2015;10(1):77–80. doi:10.4103/2008-322X.156122
  • Pucelik B, Dąbrowski JM. Photodynamic inactivation (PDI) as a promising alternative to current pharmaceuticals for the treatment of resistant microorganisms. Adv Inorg Chem. 2022;79:65–103. doi:10.1016/bs.adioch.2021.12.003
  • Doughty MJ. Rose bengal staining as an assessment of ocular surface damage and recovery in dry eye disease-a review. Cont Lens Anterior Eye. 2013;36(6):272–280. doi:10.1016/j.clae.2013.07.008
  • Martinez JD, Arrieta E, Naranjo A, et al. Rose Bengal photodynamic antimicrobial therapy: a pilot safety study. Cornea. 2021;40(8):1036–1043. doi:10.1097/ICO.0000000000002717
  • Amescua G, Arboleda A, Nikpoor N, et al. Rose Bengal photodynamic antimicrobial therapy: a novel treatment for resistant fusarium keratitis. Cornea. 2017;36(9):1141–1144. doi:10.1097/ICO.0000000000001265
  • Batistela VR, Pellosi DS, de Souza FD, et al. pKa determinations of xanthene derivates in aqueous solutions by multivariate analysis applied to UV-Vis spectrophotometric data. Spectrochim Acta Part A. 2011;79(5):889–897. doi:10.1016/j.saa.2011.03.027
  • Chow SY, Yen-Chow YC, Woodbury DM. Studies on pH regulatory mechanisms in cultured astrocytes of DBA and C57 mice. Epilepsia. 1992;33(5):775–784. doi:10.1111/j.1528-1157.1992.tb02181.x
  • Reddi BA. Why is saline so acidic (and does it really matter?). Int J Med Sci. 2013;10(6):747–750. doi:10.7150/ijms.5868
  • Begum G, Leigh T, Courtie E, et al. Rapid assessment of ocular drug delivery in a novel ex vivo corneal model. Scient Report. 2020;10(1):11754. doi:10.1038/s41598-020-68254-1
  • Naranjo A, Arboleda A, Martinez JD, et al. Rose Bengal photodynamic antimicrobial therapy for patients with progressive infectious keratitis: a pilot clinical study. Am J Ophthalmol. 2019;208:387–396. doi:10.1016/j.ajo.2019.08.027
  • Santana CP, Matter BA, Patil MA, et al. Corneal permeability and uptake of twenty-five drugs: species comparison and quantitative structure-permeability relationships. Pharmaceutics. 2023;15(6):1646. doi:10.3390/pharmaceutics15061646
  • Sridhar MS. Anatomy of cornea and ocular surface. Indian J Ophthalmol. 2018;66(2):190–194. doi:10.4103/ijo.IJO_646_17
  • Rocchetti TT, Pinto LF, de São Leão CSO, et al. Action of Rose Bengal photoactivated by green light associated or not to Propamidine Isethionate and/or Polyhexamethyl Biguanide on Acanthamoeba trophozoites cells – in vitro study. Investig Ophthalmol Visual Sci. 2023;64(8):3294–3294.
  • Naranjo A, Arboleda A, Martinez JD, et al. Rose Bengal photodynamic antimicrobial therapy for patients with progressive infectious keratitis: a pilot clinical study. Am J Ophthalmol. 2019;208:387–396. doi:10.1016/j.ajo.2019.08.027
  • Alarcon E, Poblete H, Roh H, et al. Rose Bengal binding to collagen and tissue photobonding. ACS Omega. 2017;2:6646–6657. doi:10.1021/acsomega.7b00675
  • Results of the Endophthalmitis Vitrectomy Study. A randomized trial of immediate vitrectomy and of intravenous antibiotics for the treatment of postoperative bacterial endophthalmitis. Endophthalmitis Vitrectomy Study Group. Arch Ophthalmol. 1995;113(12):1479–1496. doi:10.1001/archopht.1995.01100120009001
  • Perez VL, Wirostko B, Korenfeld M, From S, Raizman M. Ophthalmic drug delivery using iontophoresis: recent clinical applications. J Ocul Pharmacol Therapeut. 2020;36(2):75–87. doi:10.1089/jop.2019.0034
  • Parkinson T, Ferguson E, Febbraro S, et al. Tolerance of ocular iontophoresis in healthy volunteers. Investigat Ophthalmol Visual Sci. 2002;43(13):1854–1854.
  • Spoerl E, Huhle M, Seiler T. Induction of cross-links in corneal tissue. Exp Eye Res. 1998;66(1):97–103. doi:10.1006/exer.1997.0410
  • Vinciguerra P, Romano V, Rosetta P, et al. Iontophoresis-assisted corneal collagen cross-linking with epithelial debridement: preliminary results. BioMed Res Inter. 2016;2016:3720517. doi:10.1155/2016/3720517
  • Cherfan D, Verter EE, Melki S, et al. Collagen cross-linking using Rose Bengal and green light to increase corneal stiffness. Invest Ophthalmol Vis. Sci. 2013;54(5):3426–3433. doi:10.1167/iovs.12-11509
  • Martinez JD, Naranjo A, Amescua G, et al. Human corneal changes after Rose Bengal photodynamic antimicrobial therapy for treatment of fungal keratitis. Cornea. 2018;37(10):e46–e48. doi:10.1097/ICO.0000000000001701
  • Tefon Aribas AB, Sarikaya B, Bilgihan K. Iontophoresis-assisted Rose Bengal and green light corneal cross-linking. Cornea. 2020;39(12):1533–1540. doi:10.1097/ICO.0000000000002494
  • Jablonski-Stiemke MM, Edelhauser HF. Comparison of rabbit and human corneas stored in Optisol-GS: changes in stromal sodium. Curr Eye Res. 1998;17(11):1044–1048. doi:10.1076/ceyr.17.11.1044.5229
  • Pei W, Chen J, Wu W, et al. Comparison of the rabbit and human corneal endothelial proteomes regarding proliferative capacity. Experimental Eye Research. 2021;209:108629. doi:10.1016/j.exer.2021.108629
  • Robaei D, Chan UT, Khoo P, et al. Corneal biopsy for diagnosis of recalcitrant microbial keratitis. Graefes Arch Clin Exp Ophthalmol. 2018;256(8):1527–1533. doi:10.1007/s00417-018-3981-1
  • Whitehouse G, Reid K, Hudson B, et al. Corneal biopsy in microbial keratitis. Aust NZJ Ophthalmol. 1991;19(3):193–196. doi:10.1111/j.1442-9071.1991.tb00659.x
  • Hudson J, Al-Khersan H, Carletti P, et al. Role of corneal biopsy in the management of infectious keratitis. Curr Opin Ophthalmol. 2022;33(4):290–295. doi:10.1097/ICU.0000000000000852
  • Martinez JDM, Huang J, Navia JC. UPMC. Histopathologic Correlation Between Acanthamoeba Species Recovered from Patients Who Underwent Therapeutic and Optical Penetrating Keratoplasties After Rose Bengal Photodynamic Antimicrobial Therapy. In: Ocular Microbiology and Immunology Group editor. Ocular Microbiology and Immunology Group. Pittsburgh (PA): OMIG: University of Pittsburgh Medical Center; 2023.
  • Patane MA, Cohen A, From S, et al. Ocular iontophoresis of EGP-437 (dexamethasone phosphate) in dry eye patients: results of a randomized clinical trial. Clin Ophthalmol. 2011;5:633–643.
  • Napolitano P, Tranfa F, D'Andrea L, et al. Topographic outcomes in keratoconus surgery: epi-on versus epi-off iontophoresis corneal collagen cross-linking. J Clin Med. 2022;11(7):1785. doi:10.3390/jcm11071785
  • Sabet Sarvestani A, Sienko KH. Medical device landscape for communicable and noncommunicable diseases in low-income countries. Global Health. 2018;14(1):65. doi:10.1186/s12992-018-0355-8
  • Vasan A, Friend J. Medical devices for low- and middle-income countries: a review and directions for development. J Med Device. 2020;14(1):010803. doi:10.1115/1.4045910
  • Javaid M, Haleem A, Singh RP, et al. 3D printing applications for healthcare research and development. Global Health Journal. 2022;6(4):217–226. doi:10.1016/j.glohj.2022.11.001
  • Ibrahim AMS, Jose RR, Rabie AN, et al. Three-dimensional printing in developing countries. Plastic Reconstruct Surg. 2015;3(7):e443. doi:10.1097/GOX.0000000000000298
  • Lee RC, Berzins S, Alfieri N. Single-use device reuse risks. Can J Infect Control. 2007;22(3):142–146.
  • Naranjo A, Pelaez D, Arrieta E, et al. Cellular and molecular assessment of Rose Bengal photodynamic antimicrobial therapy on keratocytes, corneal endothelium and limbal stem cell niche. Exp Eye Res. 2019;188:107808. doi:10.1016/j.exer.2019.107808
  • Wang T, Zhu L, Zhu J, et al. Subacute effects of rose Bengal/Green light cross linking on rabbit thin corneal stability and safety. Lasers Surg Med. 2018;50(4):324–332. doi:10.1002/lsm.22762

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