Metastatic glioblastoma to the lungs: a case report and literature review

References

• Ostrom QT, Price M, Neff C, et al. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2015–2019. Neuro Oncol. 2022;24(Suppl. 5):v1–v95. doi:10.1093/neuonc/noac202
   PubMedGoogle Scholar
• Liu J, Shen L, Tang G, et al. Multiple extracranial metastases from glioblastoma multiforme: a case report and literature review. J Int Med Res. 2020;48(6):300060520930459. doi:10.1177/0300060520930459
   PubMed Web of Science ®Google Scholar
• Carvalho J, Barbosa CCL, Feher O, et al. Systemic dissemination of glioblastoma: literature review. Rev Assoc Med Bras (1992). 2019;65(3):460–468. doi:10.1590/1806-9282.65.3.460
   PubMed Web of Science ®Google Scholar
• Robert M, Wastie M. Glioblastoma multiforme: a rare manifestation of extensive liver and bone metastases. Biomed Imaging Interv J. 2008;4(1):e3. doi:10.2349/biij.4.1.e3
   PubMedGoogle Scholar
• Beauchesne P. Extra-neural metastases of malignant gliomas: myth or reality? Cancers (Basel). 2011;3(1):461–477. doi:10.3390/cancers3010461
   PubMedGoogle Scholar
• Erlich SS, Davis RL. Spinal subarachnoid metastasis from primary intracranial glioblastoma multiforme. Cancer. 1978;42(6):2854–2864. doi:10.1002/1097-0142(197812)42:6
   PubMed Web of Science ®Google Scholar
• Anghileri E, Castiglione M, Nunziata R, et al. Extraneural metastases in glioblastoma patients: two cases with YKL-40-positive glioblastomas and a meta-analysis of the literature. Neurosurg Rev. 2016;39(1):37–45; discussion 45–36. doi:10.1007/s10143-015-0656-9
   PubMed Web of Science ®Google Scholar
• Pietschmann S, Von Bueren AO, Kerber MJ, Baumert BG, Kortmann RD, Muller K. An individual patient data meta-analysis on characteristics, treatments and outcomes of glioblastoma/gliosarcoma patients with metastases outside of the central nervous system. PLOS ONE. 2015;10(4):e0121592. doi:10.1371/journal.pone.0121592
   PubMed Web of Science ®Google Scholar
• Muller C, Holtschmidt J, Auer M, et al. Hematogenous dissemination of glioblastoma multiforme. Sci Transl Med. 2014;6(247):247ra101. doi:10.1126/scitranslmed.3009095
   PubMed Web of Science ®Google Scholar
• Sullivan JP, Nahed BV, Madden MW, et al. Brain tumor cells in circulation are enriched for mesenchymal gene expression. Cancer Discov. 2014;4(11):1299–1309. doi:10.1158/2159-8290.CD-14-0471
   PubMed Web of Science ®Google Scholar
• Chai M, Shi Q. Extracranial metastasis of glioblastoma with genomic analysis: a case report and review of the literature. Transl Cancer Res. 2022;11(8):2917–2925. doi:10.21037/tcr-22-955
   PubMed Web of Science ®Google Scholar
• Yasuhara T, Tamiya T, Meguro T, et al. Glioblastoma with metastasis to the spleen – case report. Neurol Med Chir (Tokyo). 2003;43(9):452–456. doi:10.2176/nmc.43.452
   PubMed Web of Science ®Google Scholar
• Fidler IJ. The pathogenesis of cancer metastasis: the “seed and soil” hypothesis revisited. Nat Rev Cancer. 2003;3(6):453–458. doi:10.1038/nrc1098
   PubMed Web of Science ®Google Scholar
• Nduom EK, Yang C, Merrill MJ, Zhuang Z, Lonser RR. Characterization of the blood–brain barrier of metastatic and primary malignant neoplasms. J Neurosurg. 2013;119(2):427–433. doi:10.3171/2013.3.JNS122226
   PubMed Web of Science ®Google Scholar
• Kurdi M, Baeesa S, Okal F, et al. Extracranial metastasis of brain glioblastoma outside CNS: pathogenesis revisited. Cancer Rep (Hoboken). 2023;6(12):e1905. doi:10.1002/cnr2.1905
   PubMedGoogle Scholar
• Fonkem E, Lun M, Wong ET. Rare phenomenon of extracranial metastasis of glioblastoma. J Clin Oncol. 2011;29(34):4594–4595. doi:10.1200/JCO.2011.39.0187
   PubMed Web of Science ®Google Scholar
• Goodwin CR, Liang L, Abu-Bonsrah N, et al. Extraneural glioblastoma multiforme vertebral metastasis. World Neurosurg. 2016;89:578–582; e573. doi:10.1016/j.wneu.2015.11.061
   PubMed Web of Science ®Google Scholar
• Piccirilli M, Brunetto GM, Rocchi G, Giangaspero F, Salvati M. Extra central nervous system metastases from cerebral glioblastoma multiforme in elderly patients. Clinico-pathological remarks on our series of seven cases and critical review of the literature. Tumori. 2008;94(1):40–51. doi:10.1177/030089160809400109
   PubMed Web of Science ®Google Scholar
• Lun M, Lok E, Gautam S, Wu E, Wong ET. The natural history of extracranial metastasis from glioblastoma multiforme. J Neurooncol. 2011;105(2):261–273. doi:10.1007/s11060-011-0575-8
   PubMed Web of Science ®Google Scholar
• Mirzayan MJ, Samii M, Petrich T, Borner AR, Knapp WH, Samii A. Detection of multiple extracranial metastases from glioblastoma multiforme by means of whole-body [18F]FDG-PET. Eur J Nucl Med Mol Imaging. 2005;32(7):853. doi:10.1007/s00259-004-1749-9
   PubMed Web of Science ®Google Scholar
• Onda K, Tanaka R, Takahashi H, Takeda N, Ikuta F. Cerebral glioblastoma with cerebrospinal fluid dissemination: a clinicopathological study of 14 cases examined by complete autopsy. Neurosurgery. 1989;25(4):533–540. doi:10.1227/00006123-198910000-00005
   PubMed Web of Science ®Google Scholar
• Noch EK, Sait SF, Farooq S, Trippett TM, Miller AM. A case series of extraneural metastatic glioblastoma at Memorial Sloan Kettering Cancer Center. Neurooncol Pract. 2021;8(3):325–336. doi:10.1093/nop/npaa083
   PubMed Web of Science ®Google Scholar
• Hersh AM, Lubelski D, Theodore N. Management of glioblastoma metastatic to the vertebral spine. World Neurosurg. 2022;161:52–53. doi:10.1016/j.wneu.2022.01.074
   PubMed Web of Science ®Google Scholar
• Sickler R 3rd, Bhattacharjee M, Tandon N, Zhu J, Stark J. Metastatic glioblastoma multiforme to the vertebral column. JCO Oncol Pract. 2021;17(2):113–115. doi:10.1200/OP.20.00347
   PubMedGoogle Scholar
• Lawton CD, Nagasawa DT, Yang I, Fessler RG, Smith ZA. Leptomeningeal spinal metastases from glioblastoma multiforme: treatment and management of an uncommon manifestation of disease. J Neurosurg Spine. 2012;17(5):438–448. doi:10.3171/2012.7.SPINE12212
   PubMed Web of Science ®Google Scholar
• Potter CR, Kaufman R, Page RB, Chung C. Glioblastoma multiforme metastatic to the neck. Am J Otolaryngol. 1983;4(1):74–76. doi:10.1016/S0196-0709(83)80007-6
   PubMed Web of Science ®Google Scholar
• Wallace CJ, Forsyth PA, Edwards DR. Lymph node metastases from glioblastoma multiforme. AJNR Am J Neuroradiol. 1996;17(10):1929–1931.
   PubMed Web of Science ®Google Scholar
• Beauchesne P, Soler C, Mosnier JF. Diffuse vertebral body metastasis from a glioblastoma multiforme: a technetium-99m Sestamibi single-photon emission computerized tomography study. J Neurosurg. 2000;93(5):887–890. doi:10.3171/jns.2000.93.5.0887
   PubMed Web of Science ®Google Scholar
• Hubner F, Braun V, Richter HP. Case reports of symptomatic metastases in four patients with primary intracranial gliomas. Acta Neurochir (Wien). 2001;143(1):25–29. doi:10.1007/s007010170134
   PubMed Web of Science ®Google Scholar
• Allan RS. Scalp metastasis from glioblastoma. J Neurol Neurosurg Psychiatry. 2004;75(4):559.
   PubMed Web of Science ®Google Scholar
• Ogungbo BI, Perry RH, Bozzino J, Mahadeva D. Report of GBM metastasis to the parotid gland. J Neurooncol. 2005;74(3):337–338. doi:10.1007/s11060-005-1480-9
   PubMed Web of Science ®Google Scholar
• Taha M, Ahmad A, Wharton S, Jellinek D. Extra-cranial metastasis of glioblastoma multiforme presenting as acute parotitis. Br J Neurosurg. 2005;19(4):348–351. doi:10.1080/02688690500305506
   PubMed Web of Science ®Google Scholar
• Templeton A, Hofer S, Topfer M, et al. Extraneural spread of glioblastoma – report of two cases. Onkologie. 2008;31(4):192–194. doi:10.1159/000118627
   PubMedGoogle Scholar
• Zhen L, Yufeng C, Zhenyu S, Lei X. Multiple extracranial metastases from secondary glioblastoma multiforme: a case report and review of the literature. J Neurooncol. 2010;97(3):451–457. doi:10.1007/s11060-009-0044-9
   PubMed Web of Science ®Google Scholar
• Armstrong TS, Prabhu S, Aldape K, et al. A case of soft tissue metastasis from glioblastoma and review of the literature. J Neurooncol. 2011;103(1):167–172. doi:10.1007/s11060-010-0370-y
   PubMed Web of Science ®Google Scholar
• Kalokhe G, Grimm SA, Chandler JP, Helenowski I, Rademaker A, Raizer JJ. Metastatic glioblastoma: case presentations and a review of the literature. J Neurooncol. 2012;107(1):21–27. doi:10.1007/s11060-011-0731-1
   PubMed Web of Science ®Google Scholar
• Seo YJ, Cho WH, Kang DW, Cha SH. Extraneural metastasis of glioblastoma multiforme presenting as an unusual neck mass. J Korean Neurosurg Soc. 2012;51(3):147–150. doi:10.3340/jkns.2012.51.3.147
   PubMed Web of Science ®Google Scholar
• Blume C, Von Lehe M, Van Landeghem F, Greschus S, Bostrom J. Extracranial glioblastoma with synchronous metastases in the lung, pulmonary lymph nodes, vertebrae, cervical muscles and epidural space in a young patient – case report and review of literature. BMC Res Notes. 2013;6:290. doi:10.1186/1756-0500-6-290
   PubMedGoogle Scholar
• Dawar R, Fabiano AJ, Qiu J, Khushalani NI. Secondary gliosarcoma with extra-cranial metastases: a report and review of the literature. Clin Neurol Neurosurg. 2013;115(4):375–380. doi:10.1016/j.clineuro.2012.06.017
   PubMed Web of Science ®Google Scholar
• Lettau M, Jedrusik P, Laible M. Dural metastases of a glioblastoma. Clin Neuroradiol. 2013;23(4):323–325. doi:10.1007/s00062-012-0192-8
   PubMed Web of Science ®Google Scholar
• Romero-Rojas AE, Diaz-Perez JA, Amaro D, Lozano-Castillo A, Chinchilla-Olaya SI. Glioblastoma metastasis to parotid gland and neck lymph nodes: fine-needle aspiration cytology with histopathologic correlation. Head Neck Pathol. 2013;7(4):409–415. doi:10.1007/s12105-013-0448-x
   PubMedGoogle Scholar
• Undabeitia J, Castle M, Arrazola M, Pendleton C, Ruiz I, Urculo E. Multiple extraneural metastasis of glioblastoma multiforme. An Sist Sanit Navar. 2015;38(1):157–161. doi:10.4321/S1137-66272015000100022
   PubMed Web of Science ®Google Scholar
• Franceschi S, Lessi F, Aretini P, et al. Molecular portrait of a rare case of metastatic glioblastoma: somatic and germline mutations using whole-exome sequencing. Neuro Oncol. 2016;18(2):298–300. doi:10.1093/neuonc/nov314
   PubMed Web of Science ®Google Scholar
• Lewis GD, Rivera AL, Tremont-Lukats IW, Ballester-Fuentes LY, Zhang YJ, Teh BS. GBM skin metastasis: a case report and review of the literature. CNS Oncol. 2017;6(3):203–209. doi:10.2217/cns-2016-0042
   PubMedGoogle Scholar
• Simonetti G, Silvani A, Fariselli L, et al. Extra central nervous system metastases from glioblastoma: a new possible trigger event? Neurol Sci. 2017;38(10):1873–1875. doi:10.1007/s10072-017-3036-0
   PubMed Web of Science ®Google Scholar
• Hori YS, Fukuhara T, Aoi M, Oda K, Shinno Y. Extracranial glioblastoma diagnosed by examination of pleural effusion using the cell block technique: case report. Neurosurg Focus. 2018;44(6):E8. doi:10.3171/2017.8.FOCUS17403
   PubMed Web of Science ®Google Scholar
• Janik K, Och W, Popeda M, et al. Glioblastoma with BRAFV600E mutation and numerous metastatic foci: a case report. Folia Neuropathol. 2019;57(1):72–79. doi:10.5114/fn.2019.83833
   PubMed Web of Science ®Google Scholar
• Tamai S, Kinoshita M, Sabit H, et al. Case of metastatic glioblastoma with primitive neuronal component to the lung. Neuropathology. 2019;39(3):218–223. doi:10.1111/neup.12553
   PubMed Web of Science ®Google Scholar
• Houston SC, Crocker IR, Brat DJ, Olson JJ. Extraneural metastatic glioblastoma after interstitial brachytherapy. Int J Radiat Oncol Biol Phys. 2000;48(3):831–836. doi:10.1016/S0360-3016(00)00662-3
   PubMed Web of Science ®Google Scholar
• Hsu BH, Lee WH, Yang ST, Han CT, Tseng YY. Spinal metastasis of glioblastoma multiforme before gliosarcomatous transformation: a case report. BMC Neurol. 2020;20(1):178. doi:10.1186/s12883-020-01768-3
   PubMed Web of Science ®Google Scholar
• Rossi J, Giaccherini L, Cavallieri F, et al. Extracranial metastases in secondary glioblastoma multiforme: a case report. BMC Neurol. 2020;20(1):382. doi:10.1186/s12883-020-01959-y
   PubMed Web of Science ®Google Scholar
• Umphlett M, Shea S, Tome-Garcia J, et al. Widely metastatic glioblastoma with BRCA1 and ARID1A mutations: a case report. BMC Cancer. 2020;20(1):47. doi:10.1186/s12885-020-6540-1
   PubMed Web of Science ®Google Scholar
• Al-Sardi M, Alfayez A, Alwelaie Y, Al-Twairqi A, Hamadi F, Alokla K. A rare case of metastatic glioblastoma diagnosed by endobronchial ultrasound-transbronchial needle aspiration. Case Rep Pulmonol. 2022;2022:5453420. doi:10.1155/2022/5453420
   PubMedGoogle Scholar
• Kumaria A, Teale A, Kulkarni GV, Ingale HA, Macarthur DC, Robertson IJA. Glioblastoma multiforme metastatic to lung in the absence of intracranial recurrence: case report. Br J Neurosurg. 2022;36(2):290–292. doi:10.1080/02688697.2018.1529296
   PubMed Web of Science ®Google Scholar
• Nakib CE, Hajjar R, Zerdan MB, et al. Glioblastoma multiforme metastasizing to the skin, a case report and literature review. Radiol Case Rep. 2022;17(1):171–175. doi:10.1016/j.radcr.2021.10.029
   PubMedGoogle Scholar
• Cunha M, Maldaun MVC. Metastasis from glioblastoma multiforme: a meta-analysis. Rev Assoc Med Bras (1992). 2019;65(3):424–433. doi:10.1590/1806-9282.65.3.424
   PubMed Web of Science ®Google Scholar
• Hamilton JD, Rapp M, Schneiderhan T, et al. Glioblastoma multiforme metastasis outside the CNS: three case reports and possible mechanisms of escape. J Clin Oncol. 2014;32(22):e80–e84. doi:10.1200/JCO.2013.48.7546
   PubMed Web of Science ®Google Scholar
• Anzil AP. Glioblastoma multiforme with extracranial metastases in the absence of previous craniotomy. Case Rep J Neurosurg. 1970;33(1):88–94. doi:10.3171/jns.1970.33.1.0088
   PubMed Web of Science ®Google Scholar
• Hulbanni S, Goodman PA. Glioblastoma multiforme with extraneural metastases in the absence of previous surgery. Cancer. 1976;37(3):1577–1583. doi:10.1002/1097-0142(197603)37:3
   PubMed Web of Science ®Google Scholar
• Brew BJ, Garrick R. Gliomas presenting outside the central nervous system. Clin Exp Neurol. 1987;23:111–117.
   PubMedGoogle Scholar
• Hegi ME, Diserens AC, Gorlia T, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 2005;352(10):997–1003. doi:10.1056/NEJMoa043331
   PubMed Web of Science ®Google Scholar
• Huang P, Allam A, Taghian A, Freeman J, Duffy M, Suit HD. Growth and metastatic behavior of five human glioblastomas compared with nine other histological types of human tumor xenografts in SCID mice. J Neurosurg. 1995;83(2):308–315. doi:10.3171/jns.1995.83.2.0308
   PubMed Web of Science ®Google Scholar
• Morantz RA, Feigin I, Ransohoff J 3rd. Clinical and pathological study of 24 cases of gliosarcoma. J Neurosurg. 1976;45(4):398–408. doi:10.3171/jns.1976.45.4.0398
   PubMed Web of Science ®Google Scholar
• Friker LL, Tzaridis T, Enkirch SJ, et al. Gliosarcoma with extensive extracranial metastatic spread and familial coincidence: a case report. Pathol Res Pract. 2023;244:154399. doi:10.1016/j.prp.2023.154399
   PubMed Web of Science ®Google Scholar
• Perry JR, Laperriere N, O'Callaghan CJ, et al. Short-course radiation plus temozolomide in elderly patients with glioblastoma. N Engl J Med. 2017;376(11):1027–1037. doi:10.1056/NEJMoa1611977
   PubMed Web of Science ®Google Scholar
• Wick W, Platten M, Meisner C, et al. Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, Phase III trial. Lancet Oncol. 2012;13(7):707–715. doi:10.1016/S1470-2045(12)70164-X
   PubMed Web of Science ®Google Scholar
• Reis RM, Konu-Lebleblicioglu D, Lopes JM, Kleihues P, Ohgaki H. Genetic profile of gliosarcomas. Am J Pathol. 2000;156(2):425–432. doi:10.1016/S0002-9440(10)64746-3
   PubMed Web of Science ®Google Scholar
• Marinari E, Dutoit V, Nikolaev S, et al. Clonal evolution of a high-grade pediatric glioma with distant metastatic spread. Neurol Genet. 2021;7(2):e561. doi:10.1212/NXG.0000000000000561
   PubMed Web of Science ®Google Scholar
• Georgescu MM, Olar A. Genetic and histologic spatiotemporal evolution of recurrent, multifocal, multicentric and metastatic glioblastoma. Acta Neuropathol Commun. 2020;8(1):10. doi:10.1186/s40478-020-0889-x
   PubMed Web of Science ®Google Scholar
• Schonsteiner SS, Bommer M, Haenle MM, et al. Rare phenomenon: liver metastases from glioblastoma multiforme. J Clin Oncol. 2011;29(23):e668–e671. doi:10.1200/JCO.2011.35.9232
   PubMed Web of Science ®Google Scholar
• Jimsheleishvili S, Alshareef AT, Papadimitriou K, et al. Extracranial glioblastoma in transplant recipients. J Cancer Res Clin Oncol. 2014;140(5):801–807. doi:10.1007/s00432-014-1625-3
   PubMed Web of Science ®Google Scholar
• Yang G, Fang Y, Zhou M, et al. Case report: the effective response to pembrolizumab in combination with bevacizumab in the treatment of a recurrent glioblastoma with multiple extracranial metastases. Front Oncol. 2022;12:948933. doi:10.3389/fonc.2022.948933
   PubMed Web of Science ®Google Scholar
• Pietschmann S, Von Bueren AO, Henke G, Kerber MJ, Kortmann RD, Muller K. An individual patient data meta-analysis on characteristics, treatments and outcomes of the glioblastoma/gliosarcoma patients with central nervous system metastases reported in literature until 2013. J Neurooncol. 2014;120(3):451–457. doi:10.1007/s11060-014-1596-x
   PubMed Web of Science ®Google Scholar
• Liu H, Chen C, Li F, et al. Glioblastoma multiforme with vertebral metastases: a case report. CNS Neurosci Ther. 2022;28(2):310–313. doi:10.1111/cns.13785
   PubMed Web of Science ®Google Scholar
• Engelhard HH, Willis AJ, Hussain SI, et al. Etoposide-bound magnetic nanoparticles designed for remote targeting of cancer cells disseminated within cerebrospinal fluid pathways. Front Neurol. 2020;11:596632. doi:10.3389/fneur.2020.596632
   PubMed Web of Science ®Google Scholar
• Perez-Fidalgo JA, Martinelli E. Lenvatinib plus pembrolizumab a new effective combination of targeted agents. ESMO Open. 2023;8(2):101157. doi:10.1016/j.esmoop.2023.101157
   PubMed Web of Science ®Google Scholar
• Szklener K, Mazurek M, Wieteska M, Waclawska M, Bilski M, Mandziuk S. New directions in the therapy of glioblastoma. Cancers (Basel). 2022;14(21):5377. doi:10.3390/cancers14215377
   PubMed Web of Science ®Google Scholar
• Li J, Zou CL, Zhang ZM, Lv LJ, Qiao HB, Chen XJ. A multi-targeted tyrosine kinase inhibitor lenvatinib for the treatment of mice with advanced glioblastoma. Mol Med Rep. 2017;16(5):7105–7111. doi:10.3892/mmr.2017.7456
   PubMed Web of Science ®Google Scholar
• Arai N, Sasaki H, Tamura R, Ohara K, Yoshida K. Unusual magnetic resonance imaging findings of a glioblastoma arising during treatment with lenvatinib for thyroid cancer. World Neurosurg. 2017;107:1047.e1049–1047.e1015. doi:10.1016/j.wneu.2017.08.017
   Web of Science ®Google Scholar
• Wen PY, Cloughesy TF, Ellingson BM, et al. Report of the jumpstarting brain tumor drug development coalition and FDA clinical trials neuroimaging endpoint workshop (January 30, 2014, Bethesda MD). Neuro Oncol. 2014;16(Suppl. 7):vii36–vii47. doi:10.1093/neuonc/nou226
   PubMed Web of Science ®Google Scholar
• Chinot OL, De La Motte Rouge T, Moore N, et al. AVAglio: Phase III trial of bevacizumab plus temozolomide and radiotherapy in newly diagnosed glioblastoma multiforme. Adv Ther. 2011;28(4):334–340. doi:10.1007/s12325-011-0007-3
   PubMed Web of Science ®Google Scholar
• Motzer RJ, Taylor MH, Evans TRJ, et al. Lenvatinib dose, efficacy, and safety in the treatment of multiple malignancies. Expert Rev Anticancer Ther. 2022;22(4):383–400. doi:10.1080/14737140.2022.2039123
   PubMed Web of Science ®Google Scholar
• Casadei-Gardini A, Rimini M, Tada T, et al. Atezolizumab plus bevacizumab versus lenvatinib for unresectable hepatocellular carcinoma: a large real-life worldwide population. Eur J Cancer. 2023;180:9–20. doi:10.1016/j.ejca.2022.11.017
   PubMed Web of Science ®Google Scholar