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Review

Review of Ebola virus disease in children – how far have we come?

ORCID Icon, , &
Pages 12-27 | Received 30 Mar 2020, Accepted 30 Jul 2020, Published online: 07 Sep 2020

References

  • World Health Organization. Outbreaks and emergencies bulletin; [cited Jun 30]. Available from: https://www.afro.who.int/health-topics/disease-outbreaks/outbreaks-and-other-emergencies-updates
  • Emanuel J, Marzi A, Feldmann H. Filoviruses: ecology, molecular biology, and evolution. Adv Virus Res. 2018;100:189–221.
  • Miranda ME, Miranda NL. Reston ebolavirus in humans and animals in the Philippines: a review. J Infect Dis. 2011;204(Suppl 3):S757–S760.
  • Goldstein T, Anthony SJ, Gbakima A, et al. The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses. Nat Microbiol. 2018;3:1084–1089.
  • Karan LS, Makenov MT, Korneev MG, et al. Bombali virus in Mops condylurus bats, Guinea. Emerg Infect Dis. 2019;25. DOI:10.3201/eid2509.190581.
  • Forbes KM, Webala PW, Jaaskelainen AJ, et al. Bombali virus in Mops condylurus bat, Kenya. Emerg Infect Dis. 2019;25:955–957.
  • Martell HJ, Masterson SG, McGreig JE, et al. Is the Bombali virus pathogenic in humans? Bioinformatics. 2019;35:3553–3558.
  • Murray MJ. Ebola virus disease: a review of its past and present. Anesth Analg. 2015;121:798–809.
  • Nsio J, Kapetshi J, Makiala S, et al. outbreak of Ebola virus disease in Northern Democratic Republic of Congo. J Infect Dis. 2017;2020(221):701–706.
  • Matson MJ, Chertow DS, Munster VJ. Delayed recognition of Ebola virus disease is associated with longer and larger outbreaks. Emerg Microbes Infect. 2020;9:291–301.
  • Ebola Outbreak Epidemiology Team. Outbreak of Ebola virus disease in the Democratic Republic of the Congo, April–May, 2018: an epidemiological study. Lancet. 2018;392:213–221.
  • Nicastri E, Kobinger G, Vairo F, et al. Ebola virus disease: epidemiology, clinical features, management, and prevention. Infect Dis Clin North Am. 2019;33:953–976.
  • Bower H, Johnson S, Bangura MS, et al. Exposure-specific and age-specific attack rates for Ebola virus disease in Ebola-affected households, Sierra Leone. Emerg Infect Dis. 2016;22:1403–1411.
  • Fitzgerald F, Awonuga W, Shah T, et al. Ebola response in Sierra Leone: the impact on children. J Infect. 2016;72(Suppl):S6–S12. .
  • Agua-Agum J, Ariyarajah A, Blake IM, et al. Ebola virus disease among children in West Africa. N Engl J Med. 2015;372:1274–1277.
  • Fitzgerald F, Naveed A, Wing K, et al. Ebola virus disease in children, Sierra Leone, 2014–2015. Emerg Infect Dis. 2016;22:1769–1777.
  • Okware SI, Omaswa FG, Zaramba S, et al. An outbreak of Ebola in Uganda. Trop Med Int Health. 2002;7:1068–1075.
  • Peacock G, Uyeki TM, Rasmussen SA. Ebola virus disease and children: what pediatric health care professionals need to know. JAMA Pediatr. 2014;168:1087–1088.
  • Kourtis AP, Appelgren K, Chevalier MS, et al. Ebola virus disease: focus on children. Pediatr Infect Dis J. 2015;34:893–897.
  • World Health Organization. Ebola situation report; [cited 2020 Mar 22]. Available from: https://apps.who.int/iris/bitstream/handle/10665/183035/ebolasitrep_19Aug2015_eng.pdf?sequence=1
  • Smit MA, Michelow IC, Glavis-Bloom J, et al. Characteristics and outcomes of pediatric patients with Ebola virus disease admitted to treatment units in Liberia and Sierra Leone: a retrospective cohort study. Clin Infect Dis. 2017;64:243–249.
  • Ilunga Kalenga O, Moeti M, Sparrow A, et al. The ongoing Ebola epidemic in the Democratic Republic of Congo, 2018–2019. N Engl J Med. 2019;381:373–383.
  • Mbala-Kingebeni P, Aziza A, Di Paola N, et al. Medical countermeasures during the 2018 Ebola virus disease outbreak in the North Kivu and Ituri Provinces of the Democratic Republic of the Congo: a rapid genomic assessment. Lancet Infect Dis. 2019;19:648–657.
  • Mbala-Kingebeni P, Pratt CB, Wiley MR, et al. Ebola virus disease outbreak in Equateur Province, Democratic Republic of the Congo: a retrospective genomic characterisation. Lancet Infect Dis. 2018;2019(19):641–647.
  • Mbala-Kingebeni P, Villabona-Arenas CJ, Vidal N, et al. Rapid confirmation of the Zaire Ebola virus in the outbreak of the Equateur Province in the Democratic Republic of Congo: implications for public health interventions. Clin Infect Dis. 2019;68:330–333.
  • Aruna A, Mbala P, Minikulu L, et al. Ebola virus disease outbreak – democratic Republic of the Congo, August 2018–November 2019. MMWR Morb Mortal Wkly Rep. 2019;68:1162–1165.
  • World Health Organization. Ebola in the Democratic Republic of the Congo. North Kivu, Ituri 2018–2020; [cited 2020 Jun 29]. Available from: https://www.who.int/emergencies/diseases/ebola/drc-2019
  • World Health Organization. Ebola virus disease; [cited 2020 Jun 30]. Available from: https://www.afro.who.int/health-topics/ebola-virus-disease
  • World Health Organization. Ebola virus disease – democratic Republic of the Congo. Disease outbreak news: update. 2019; [cited 2020 Mar 22]. Available from: https://www.who.int/csr/don/10-october-2019-ebola-drc/en/
  • Editorial. Children’s needs in an Ebola virus disease outbreak. Lancet Child Adolesc Health. 2019;3:55.
  • World Health Organization. Ebola virus disease Democratic Republic of Congo: external situation report 98/2020; [cited 2020 Jun 30]. Available from: https://www.who.int/publications/i/item/10665-332654
  • World Health Organization. Ebola virus disease - Democratic Republic of the Congo: disease Outbreak news; [cited 2020 Jun 29]. Available from: https://www.who.int/csr/don/03-June-2020-ebola-drc/en/
  • World Health Organization. AFRO Weekly Bulletin on Outbreaks and Other Emergencies Week 3 0; [cited 2020 July 26]. Available  : https://apps.who.int/iris/bitstream/handle/10665/333517/OEW30-2026072020.pdf
  • Funk DJ, Kumar A. Ebola virus disease: an update for anesthesiologists and intensivists. Can J Anaesth. 2015;62:80–91.
  • Lado M, Howlett P. Ebola virus disease in children: towards a better clinical picture and improved management. Lancet Glob Health. 2016;4:e436–437.
  • Emond RT, Evans B, Bowen ET, et al. A case of Ebola virus infection. BMJ. 1977;2:541–544.
  • Sonnenberg P, Field N. Sexual and mother-to-child transmission of Ebola virus in the postconvalescent period. Clin Infect Dis. 2015;60:974–975.
  • Rowe AK, Bertolli J, Khan AS, et al. Clinical, virologic, and immunologic follow-up of convalescent Ebola hemorrhagic fever patients and their household contacts, Kikwit, Democratic Republic of the Congo. Commission de Lutte contre les Epidemies a Kikwit [Commission for the response to epidemics in Kikwit]. J Infect Dis. 1999;179(Suppl 1):S28–S35. .
  • Bausch DG, Towner JS, Dowell SF, et al. Assessment of the risk of Ebola virus transmission from bodily fluids and fomites. J Infect Dis. 2007;196(Suppl 2):S142–S147. .
  • Dunn AC, Walker TA, Redd J, et al. Nosocomial transmission of Ebola virus disease on pediatric and maternity wards: bombali and Tonkolili, Sierra Leone, 2014. Am J Infect Control. 2016;44:269–2672.
  • Kasereka MC, Hawkes MT. ‘The cat that kills people:’ community beliefs about Ebola origins and implications for disease control in Eastern Democratic Republic of the Congo. Pathog Glob Health. 2019;113:149–157.
  • Bakshi SS, McMahon S, George A, et al. The role of traditional treatment on health care seeking by caregivers for sick children in Sierra Leone: results of a baseline survey. Acta Trop. 2013;127:46–52.
  • Van Kerkhove MD, Bento AI, Mills HL, et al. A review of epidemiological parameters from Ebola outbreaks to inform early public health decision-making. Sci Data. 2015;2:150019.
  • Eichner M, Dowell SF, Firese N. Incubation period of ebola hemorrhagic virus subtype zaire. Osong Public Health Res Perspect. 2011;2:3–7.
  • Jacob ST, Crozier I, Fischer WA 2nd, et al. Ebola virus disease. Nat Rev Dis Primers. 2020;6:13.
  • Olupot-Olupot P. Ebola in children: epidemiology, clinical features, diagnosis and outcomes. Pediatr Infect Dis J. 2015;34:314–316.
  • Damkjaer M, Rudolf F, Mishra S, et al. Clinical features and outcome of Ebola virus disease in pediatric patients: a retrospective case series. J Pediatr. 2017;182:378–381.e1.
  • Shah T, Greig J, van der Plas LM, et al. Inpatient signs and symptoms and factors associated with death in children aged 5 years and younger admitted to two Ebola management centres in Sierra Leone, 2014: a retrospective cohort study. Lancet Glob Health. 2016;4:e495–e501.
  • Cherif MS, Koonrungsesomboon N, Kasse D, et al. Ebola virus disease in children during the 2014-2015 epidemic in Guinea: a nationwide cohort study. Eur J Pediatr. 2017;176:791–796.
  • Sow MS, Sow DC, Diallo ML, et al. Ebola virus disease in children in Conakry and Coyah Ebola treatment centers and risk factors associated with death. Med Mal Infect. 2019;19:S0399.
  • Billioux BJ. Neurological complications and sequelae of Ebola virus disease. Curr Infect Dis Rep. 2017;19:19.
  • Varkey JB, Shantha JG, Crozier I, et al. Persistence of Ebola virus in ocular fluid during convalescence. N Engl J Med. 2015;372:2423–2427.
  • Shantha JG, Hayek BR, Crozier I, et al. Development of a screening eye clinic for Ebola virus disease survivors: lessons learned and rapid implementation at ELWA Hospital in Monrovia, Liberia 2015. PLoS Negl Trop Dis. 2019;13:e0007209.
  • Jacobs M, Rodger A, Bell DJ, et al. Late Ebola virus relapse causing meningoencephalitis: a case report. Lancet. 2016;388:498–503.
  • Bwaka MA, Bonnet MJ, Calain P, et al. Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients. J Infect Dis. 1999;179(Suppl 1):S1–S7. .
  • Ndambi R, Akamituna P, Bonnet MJ, et al. Epidemiologic and clinical aspects of the Ebola virus epidemic in Mosango, Democratic Republic of the Congo, 1995. J Infect Dis. 1999;179(Suppl 1):S8–S10. .
  • Schieffelin JS, Shaffer JG, Goba A, et al. Clinical illness and outcomes in patients with Ebola in Sierra Leone. N Engl J Med. 2014;371:2092–2100.
  • Lalle E, Biava M, Nicastri E, et al. Pulmonary involvement during the Ebola virus disease. Viruses. 2019;11:780.
  • Dallatomasina S, Crestani R, Sylvester Squire J, et al. Ebola outbreak in rural West Africa: epidemiology, clinical features and outcomes. Trop Med Int Health. 2015;20:448–454.
  • Pinsky BA, Sahoo MK, Sandlund J, et al. Analytical performance characteristics of the Cepheid GeneXpert Ebola Assay for the detection of Ebola virus. PLoS One. 2015;10:e0142216.
  • McMullan LK, Flint M, Chakrabarti A, et al. Characterisation of infectious Ebola virus from the ongoing outbreak to guide response activities in the Democratic Republic of the Congo: a phylogenetic and in vitro analysis. Lancet Infect Dis. 2019;19:1023–1032.
  • Uyeki TM, Mehta AK, Davey RT Jr., et al. Clinical management of Ebola virus disease in the United States and Europe. N Engl J Med. 2016;374:636–646.
  • Malvy D, McElroy AK, de Clerck H, et al. Ebola virus disease. Lancet. 2019;393:936–948.
  • World Health Organization. Optimized supportive care for Ebola virus disease clinical management standard operating procedures; [cited 2020 Mar 22]. Available from: https://www.who.int/csr/resources/publications/optimized-supportive-care/en/
  • Trehan I, De Silva SC. Management of Ebola virus disease in children. Infect Dis Clin North Am. 2018;32:201–214.
  • Trehan I, Kelly T, Marsh RH, et al. Moving Towards a More Aggressive and Comprehensive Model of Care for Children with Ebola. J Pediatr. 2016;170:28–33 e1–7.
  • Li J, Duan HJ, Chen HY, et al. Age and Ebola viral load correlate with mortality and survival time in 288 Ebola virus disease patients. Int J Infect Dis. 2016;42:34–39.
  • Mulangu S, Dodd LE, Davey RT Jr., et al. A randomized, controlled trial of Ebola virus disease therapeutics. N Engl J Med. 2019;381:2293–2303.
  • World Health Organization. Ebola virus disease – democratic Republic of the Congo; [cited 2020 Mar 22]. Available from: https://apps.who.int/iris/bitstream/handle/10665/330032/SITREP_EVD_DRC_20191203-eng.pdf
  • Lamontagne F, Fowler RA, Adhikari NK, et al. Evidence-based guidelines for supportive care of patients with Ebola virus disease. Lancet. 2018;391:700–708.
  • Steiner MJ, DeWalt DA, Byerley JS. Is this child dehydrated? JAMA. 2004;291:2746–2754.
  • Levine AC, Glavis-Bloom J, Modi P, et al. External validation of the DHAKA score and comparison with the current IMCI algorithm for the assessment of dehydration in children with diarrhoea: a prospective cohort study. Lancet Glob Health. 2016;4:e744–e751.
  • Maitland K, Kiguli S, Opoka RO, et al. Mortality after fluid bolus in African children with severe infection. N Engl J Med. 2011;364:2483–2495.
  • Levin M, Cunnington AJ, Wilson C, et al. Effects of saline or albumin fluid bolus in resuscitation: evidence from re-analysis of the FEAST trial. Lancet Respir Med. 2019;7:581–593.
  • Ververs M, Gabra M. Nutritional care for patients with Ebola virus disease. Emerg Infect Dis. 2020;26:20–25.
  • Aluisio AR, Perera SM, Yam D, et al. Vitamin A supplementation was associated with reduced mortality in patients with Ebola virus disease during the West African outbreak. J Nutr. 2019;149:1757–1765.
  • Sissoko D, Laouenan C, Folkesson E, et al. Experimental treatment with Favipiravir for Ebola virus disease (the JIKI Trial): a historically controlled, single-arm proof-of-concept trial in Guinea. PLOS Med. 2016;13:e1001967.
  • Dunning J, Kennedy SB, Antierens A, et al. Experimental treatment of Ebola virus disease with Brincidofovir. PLoS One. 2016;11:e0162199.
  • van Griensven J, De Weiggheleire A, Delamou A, et al. The use of Ebola convalescent plasma to treat Ebola virus disease in resource-constrained settings: a perspective from the field. Clin Infect Dis. 2016;62:69–74.
  • van Griensven J, Edwards T, de Lamballerie X, et al. Evaluation of convalescent plasma for Ebola virus disease in Guinea. N Engl J Med. 2016;374:33–42.
  • van Griensven J, Edwards T, Baize S, et al. Efficacy of convalescent plasma in relation to dose of Ebola virus antibodies. N Engl J Med. 2016;375:2307–2309.
  • World Health Organization. Consultation on monitored emergency use of unregistered and investigational interventions for Ebola virus disease (EVD); [cited 2020 Mar 22]. Available from: https://www.who.int/emergencies/ebola/MEURI-Ebola.pdf
  • World Health Organization. Ethical considerations for use of unregistered interventions for Ebola virus disease. Report of an advisory panel to WHO; [cited 2020 Feb 24]. Available from: https://www.who.int/csr/resources/publications/ebola/ethical-considerations/en/
  • Nakkazi E. Randomised controlled trial begins for Ebola therapeutics. Lancet. 2018;392:2338.
  • World Health Organization. Guidance for managing ethical issues in infectious disease outbreaks; [cited 2020 Mar 22]. Available from: https://apps.who.int/iris/bitstream/handle/10665/250580/9789241549837-eng.pdf?sequence=1
  • Hoenen T, Groseth A, Feldmann H. Therapeutic strategies to target the Ebola virus life cycle. Nat Rev Microbiol. 2019;17:593–606.
  • Davey RT Jr, Dodd L, Proschan MA et al.; PREVAIL II Writing Group, Multi-National PREVAIL II Study Team. A randomized, controlled trial of ZMapp for Ebola virus infection. N Engl J Med. 2016;375:1448–1456.
  • Qiu X, Wong G, Audet J, et al. Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp. Nature. 2014;514:47–53.
  • Tchesnokov EP, Feng JY, Porter DP, et al. Mechanism of inhibition of Ebola virus RNA-dependent RNA polymerase by remdesivir. Viruses. 2019;11:326.
  • Siegel D, Hui HC, Doerffler E, et al. Discovery and synthesis of a phosphoramidate prodrug of a Pyrrolo[2,1-f][triazin-4-amino] adenine C-nucleoside (GS-5734) for the treatment of Ebola and emerging viruses. J Med Chem. 2017;60:1648–1661.
  • Warren TK, Jordan R, Lo MK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016;531:381–385.
  • Dornemann J, Burzio C, Ronsse A, et al. First newborn baby to receive experimental therapies survives Ebola virus disease. J Infect Dis. 2017;215:171–174.
  • Sivapalasingam S, Kamal M, Slim R, et al. Safety, pharmacokinetics, and immunogenicity of a co-formulated cocktail of three human monoclonal antibodies targeting Ebola virus glycoprotein in healthy adults: a randomised, first-in-human phase 1 study. Lancet Infect Dis. 2018;18:884–893.
  • Lucey DR. New treatments for Ebola virus disease. BMJ. 2019;366:l5371.
  • Gaudinski MR, Coates EE, Novik L, et al. Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study. Lancet. 2019;393:889–898.
  • Shah T. Ebola in children: a personal perspective. J Virus Erad. 2015;1:206–207.
  • Cieslak TJ, Evans L, Kortepeter MG, et al. Perspectives on the management of children in a biocontainment unit: report of the NETEC pediatric workgroup. Health Secur. 2019;17:11–17.
  • Abramowitz SA, McLean KE, McKune SL, et al. Community-centered responses to Ebola in urban Liberia: the view from below. PLoS Negl Trop Dis. 2015;9:e0003706.
  • Centers for Disease Control. Years of Ebola virus disease outbreaks. 2019; [cited 2020 Mar 22]. Available from: https://www.cdc.gov/vhf/ebola/history/chronology.html
  • World Health Organization. Ebola virus disease; [cited 2020 Mar 22]. Available from: https://www.who.int/news-room/fact-sheets/detail/ebola-virus-disease
  • Forna A, Nouvellet P, Dorigatti I, et al. Case fatality ratio estimates for the 2013–2016 West African Ebola epidemic: application of boosted regression trees for imputation. Clin Infect Dis. 2019;70:2476–2483.
  • Kucharski AJ, Edmunds WJ. Case fatality rate for Ebola virus disease in west Africa. Lancet. 2014;384:1260.
  • Aylward B, Barboza P, Bawo L, et al. Ebola virus disease in West Africa – the first 9 months of the epidemic and forward projections. N Engl J Med. 2014;371:1481–1495.
  • Dowell SF. Ebola hemorrhagic fever: why were children spared? Pediatr Infect Dis J. 1996;15:189–191.
  • Glynn JR. Age-specific incidence of Ebola virus disease. Lancet. 2015;386:432.
  • Keita M, Diallo B, Mesfin S, et al. Subsequent mortality in survivors of Ebola virus disease in Guinea: a nationwide retrospective cohort study. Lancet Infect Dis. 2019;19:1202–1208.
  • Wilkinson AL, Kaiser R, Jalloh MF, et al. Reporting deaths among children aged <5 years after the ebola virus disease epidemic – bombali district, sierra leone, 2015–2016. MMWR Morb Mortal Wkly Rep. 2017;66:1116–1118.
  • Skrable K, Roshania R, Mallow M, et al. The natural history of acute Ebola virus disease among patients managed in five Ebola treatment units in West Africa: a retrospective cohort study. PLoS Negl Trop Dis. 2017;11:e0005700.
  • Langer M, Portella G, Finazzi S, et al. Intensive care support and clinical outcomes of patients with Ebola virus disease (EVD) in West Africa. Intensive Care Med. 2018;44:1266–1275.
  • Rosello A, Mossoko M, Flasche S, et al. Ebola virus disease in the Democratic Republic of the Congo, 1976-2014. Elife. 2015;4:e09015.
  • Report of an International Commission. Ebola haemorrhagic fever in Zaire, 1976. Bull WHO. 1978;56:271–293.
  • Nelson JM, Griese SE, Goodman AB, et al. Live neonates born to mothers with Ebola virus disease: a review of the literature. J Perinatol. 2016;36:411–414.
  • Baraka NK, Mumbere M, Ndombe E. One month follow up of a neonate born to a mother who survived Ebola virus disease during pregnancy: a case report in the Democratic Republic of Congo. BMC Pediatr. 2019;19:202.
  • Scott JT, Sesay FR, Massaquoi TA, et al. Post-Ebola syndrome, Sierra Leone. Emerg Infect Dis. 2016;22:641–646.
  • Sneller MC, Reilly C, Badio M, et al.; PREVAIL III Study Group. A longitudinal study of Ebola sequelae in Liberia. N Engl J Med. 2019;380:924–934.
  • Ververs M, Arya A. Ebola virus disease and breastfeeding: time for attention. Lancet. 2019;394:825.
  • Bower H, Johnson S, Bangura MS, et al. Effects of mother’s illness and breastfeeding on risk of Ebola virus disease in a cohort of very young children. PLos Neglect Trop Dis. 2016;10:e0004622.
  • Sissoko D, Keita M, Diallo B, et al. Ebola virus persistence in breast milk after no reported illness: a likely source of virus transmission from mother to child. Clin Infect Dis. 2017;64:513–516.
  • Brandt A, Serrano Oria O, Kallon M, et al. Infant feeding policy and programming during the 2014–2015 Ebola virus disease outbreak in Sierra Leone. Glob Health Sci Pract. 2017;5:507–515.
  • World Health Organization. Guidelines for the management of pregnant and breastfeeding women in the context of Ebola virus disease, 2020; [cited 2020 April 10]. Available from: https://www.who.int/publications/i/item/guidelines-for-the-management-of-pregnant-and-breastfeeding-women-in-the-context-of-ebola-virus-disease
  • Thorson AE, Foeller M, Rayco-Solon P, et al. Ebola virus disease and breastfeeding. Lancet. 2020;395:491.
  • World Health Organization. Guidelines for the management of pregnant and breastfeeding women in the context of Ebola virus disease; [cited 2020 Mar 22]. Available from: https://apps.who.int/iris/bitstream/handle/10665/330851/9789240001381-eng.pdf
  • Davies HD, Byington CL; Committee on Infectious Diseases. Parental presence during treatment of Ebola or other highly consequential infection. Pediatrics. 2016;138:e20161891.
  • World Health Organization. Overview of candidate Ebola vaccines as of August 19, 2019; [cited 2020 Mar 22]. Available from: https://www.who.int/immunization/sage/meetings/2019/october/6_Ebola_Candidate_Vaccines_19-09-19.pdf
  • Mutua G, Anzala O, Luhn K, et al. Safety and immunogenicity of a 2-dose heterologous vaccine regimen with Ad26.ZEBOV and MVA-BN-Filo Ebola vaccines: 12-month data from a phase 1 randomized clinical trial in Nairobi, Kenya. J Infect Dis. 2019;220::57–67.
  • Kennedy SB, Bolay F, Kieh M, et al. Phase 2 placebo-controlled trial of two vaccines to prevent Ebola in Liberia. N Engl J Med. 2017;377:1438–1447.
  • Samai M, Seward JF, Goldstein ST, et al. The Sierra Leone Trial to introduce a vaccine against Ebola: an evaluation of rVSVG-ZEBOV-GP vaccine tolerability and safety during the West Africa Ebola outbreak. J Infect Dis. 2018;217:S6–S15.
  • Henao-Restrepo AM, Camacho A, Longini IM, et al. Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ca Suffit!). Lancet. 2017;389:505–518.
  • Kasereka MC, Ericson AD, Conroy AL, et al. Prior vaccination with recombinant Vesicular Stomatitis Virus - Zaire Ebolavirus vaccine is associated with improved survival among patients with Ebolavirus infection. Vaccine. 2020;38:3003–3007.
  • Anywaine Z, Whitworth H, Kaleebu P, et al. Safety and immunogenicity of a 2-dose heterologous vaccination regimen with Ad26.ZEBOV and MVA-BN-Filo Ebola vaccines: 12-month data from a Phase 1 randomized clinical trial in Uganda and Tanzania. J Infect Dis. 2019;220::46–56.
  • World Health Organization. Strategic advisory group of experts (SAGE) on immunization. Interim recommendations on vaccination against Ebola virus disease (EVD); [cited 2020 Mar 22]. Available from: https://www.who.int/immunization/policy/position_papers/interim_ebola_recommendations_may_2019.pdf?ua=1
  • Jacobs M, Aarons E, Bhagani S, et al. Post-exposure prophylaxis against Ebola virus disease with experimental antiviral agents: a case-series of health-care workers. Lancet Infect Dis. 2015;15:1300–1304.
  • Davis C, Tipton T, Sabir S, et al. Post-exposure prophylaxis with rVSV-ZEBOV following exposure to a patient with Ebola virus disease relapse in the UK: an operational, safety and immunogenicity report. Clin Infect Dis. 2019:ciz1165. DOI:10.1093/cid/ciz1165.
  • Aregawi M, Smith SJ, Sillah-Kanu M, et al. Impact of the mass drug administration for malaria in response to the Ebola outbreak in Sierra Leone. Malar J. 2016;15:480.
  • Garbern SC, Yam D, Aluisio AR, et al. Effect of mass artesunate-amodiaquine distribution on mortality of patients with Ebola virus disease during West African outbreak. Open Forum Infect Dis. 2019;6:ofz250.
  • Kuehne A, Tiffany A, Lasry E, et al. Impact and lessons learned from mass drug administrations of malaria chemoprevention during the Ebola outbreak in Monrovia, Liberia, 2014. PLoS One. 2016;11:e0161311.
  • Plucinski MM, Guilavogui T, Sidikiba S, et al. Effect of the Ebola-virus-disease epidemic on malaria case management in Guinea, 2014: a cross-sectional survey of health facilities. Lancet Infect Dis. 2015;15:1017–1023.
  • Dodd LE, Follmann D, Proschan M, et al. A meta-analysis of clinical studies conducted during the West Africa Ebola virus disease outbreak confirms the need for randomized control groups. Sci Transl Med. 2019;11:eaaw1049.
  • Masumbuko Claude K, Underschultz J, Hawkes MT. Social resistance drives persistent transmission of Ebola virus disease in Eastern Democratic Republic of Congo: a mixed-methods study. PLoS One. 2019;14:e0223104.
  • Claude KM, Underschultz J, Hawkes MT. Ebola virus epidemic in war-torn eastern DR Congo. Lancet. 2018;392:1399–1401.
  • Kasereka MC, Sawatzky J, Hawkes MT. Ebola epidemic in war-torn Democratic Republic of Congo, 2018: acceptability and patient satisfaction of the recombinant vesicular stomatitis virus – zaire Ebolavirus vaccine. Vaccine. 2019;37:2174–2178.
  • Schwartz DA. Being pregnant during the Kivu Ebola virus outbreak in DR Congo: the rVSV-ZEBOV vaccine and its accessibility by mothers and infants during humanitarian crises and in conflict areas. Vaccines (Basel). 2020;8:38.
  • Schwartz DA. Maternal and infant death and the rVSV-ZEBOV vaccine through three recent Ebola virus epidemics – west Africa, DRC Équateur and DRC Kivu: 4 years of excluding pregnant and lactating women and their infants from immunization. Curr Trop Med Rep. 2019;6:213–222.
  • Leach M, Scoones I, Stirling A. Governing epidemics in an age of complexity: narratives, politics and pathways to sustainability. Global Environ Chang. 2010;20:369–377.
  • Hewlett BS, Amola RP. Cultural contexts of Ebola in northern Uganda. Emerg Infect Dis. 2003;9:1242–1248.
  • Kinsman J. “A time of fear”: local, national, and international responses to a large Ebola outbreak in Uganda. Globalization Health. 2012;8:15.
  • Hartog K, Hubbard CD, Krouwer AF, et al. Stigma reduction interventions for children and adolescents in low- and middle-income countries: systematic review of intervention strategies. Soc Sci Med. 2020;246:112749.
  • UNICEF Press Centre. Thousands of children still need care and support in wake of Ebola epidemic; [cited 2020 April 10]. Available from: https://www.unicef.org/media/media_89810.html
  • Evans DK, Popova A. West African Ebola crisis and orphans. Lancet. 2015;385:945–946.
  • Ainsworth M, Filmer D. Inequalities in children’s schooling: AIDS, orphanhood, poverty, and gender. World Dev. 2006;34:1099–1128.
  • Nuriddin A, Jalloh MF, Meyer E, et al. Trust, fear, stigma and disruptions: community perceptions and experiences during periods of low but ongoing transmission of Ebola virus disease in Sierra Leone, 2015. BMJ Glob Health. 2018;3:e000410.
  • Menendez C, Lucas A, Munguambe K, et al. Ebola crisis: the unequal impact on women and children’s health. Lancet Glob Health. 2015;3:e130.

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