128
Views
3
CrossRef citations to date
0
Altmetric
Original Article

The detection of Trypanosoma cruzi by nested-PCR in elderly patients: relationship to the clinical and epidemiological profile

, , , , , , & show all

References

  • Moncayo A, Ortiz Yanine MI. An update on Chagas disease (human American trypanosomiasis). Ann Trop Med Parasitol. 2006;100:663–77.10.1179/136485906X112248
  • Rassi A, Rassi JA. Chagas disease. Lancet. 2010;375:1388–402.10.1016/S0140-6736(10)60061-X
  • Bern C. Chagas’ disease. N Engl J Med. 2015;373:456–66.
  • Prata A. Clinical and epidemiological aspects of Chagas disease. Lancet Infect Dis. 2001;1:92–100.10.1016/S1473-3099(01)00065-2
  • Clayton J. Chagas disease 101. Nat Outlook. 2010;465:S4–S5.10.1038/nature09220
  • Lima e Costa MF, Barreto SM, Guerra HL, Firmo JO, Uchoa E, Vidigal PG. Ageing with Trypanosoma cruzi infection in a community where the transmission has been interrupted: the Bambuí Health and Ageing Study (BHAS). Int J Epidemiol. 2001;30:887–93.10.1093/ije/30.4.887
  • Pilger C, Menon MH, Mathias TAF. Socio-demographic and health characteristics of elderly individuals: support for health services. Rev Lat Am Enfermagem. 2011;19:1230–8.10.1590/S0104-11692011000500022
  • Lima-Costa MF, Barreto SM, Giatti L. Health status, physical functioning, health services utilization, and expenditures on medicines among Brazilian elderly: a descriptive study using data from the national household survey. Cad Saude Publica. 2003;19:735–43.10.1590/S0102-311X2003000300006
  • Pereira LS, Freitas EC, Fidalgo ASO de BV, Andrade MC, Candido DS, Silva Filho JD, et al. Clinical and epidemiological profile of elderly patients with chagas disease followed between 2005–2013 by pharmaceutical care service in ceará state, Northeastern Brazil. Rev Inst Med Trop São Paulo. 2015;57:145–52.10.1590/S0036-46652015000200008
  • Martins-Melo FR, Alencar CH, Ramos AN, Heukelbach J. Epidemiology of mortality related to Chagas’ disease in Brazil, 1999–2007. PLoS Negl Trop Dis. 2012;6:e1508.10.1371/journal.pntd.0001508
  • Britto CC. Usefulness of PCR-based assays to assess drug efficacy in Chagas disease chemotherapy: value and limitations. Mem Inst Oswaldo Cruz. 2009;104:122–35.10.1590/S0074-02762009000900018
  • Castro A, Luquetti A, Rassi A, Rassi GG, Chiari E, Galvão LMC. Blood culture and polymerase chain reaction for the diagnosis of the chronic phase of human infection with Trypanosoma cruzi. Parasitol Res. 2002;88:894–900.
  • Portela-Lindoso AAB, Shikanai-Yasuda MA. Chronic Chagas’ disease: from xenodiagnosis and hemoculture to polymerase chain reaction. Rev Saude Publica. 2003;37:107–15.10.1590/S0034-89102003000100016
  • Marcon GEB, Andrade PD, de Albuquerque DM, Wanderley JS, de Almeida EA, Guariento ME, et al. Use of a nested polymerase chain reaction (N-PCR) to detect Trypanosoma cruzi in blood samples from chronic chagasic patients and patients with doubtful serologies. Diagn Microbiol Infect Dis. 2002;43:39–43.10.1016/S0732-8893(02)00366-8
  • Aguiar C, Batista AM, Pavan TBS, Almeida EA, Gurariento ME, Wanderley JS, et al. Serological profiles and evaluation of parasitaemia by PCR and blood culture in individuals chronically infected by Trypanosoma cruzi treated with benzonidazole. Trop Med Int Health. 2012;17:368–73.
  • Batista AM, Aguiar C, Almeida EA, Guariento ME, Wanderley JS, Costa SCB. Evidence of Chagas disease in seronegative Brazilian patients with megaesophagus. Int J Infect Dis. 2010;14:e974–7.10.1016/j.ijid.2010.05.017
  • Martins-Melo FR, Ramos AN, Alencar CH, Heukelbach J. Prevalence of Chagas disease in Brazil: a systematic review and meta-analysis. Acta Trop. 2014;130:167–74.10.1016/j.actatropica.2013.10.002
  • Alves RMA, Thomaz RP, Almeida EA, Wanderley JS, Guariento ME. Chagas’ disease and ageing: the coexistence of other chronic diseases with Chagas’ disease in elderly patients. Rev Soc Bras Med Trop. 2009;42:622–8.10.1590/S0037-86822009000600002
  • Almeida EA, Barbosa Neto RM, Guariento ME, Wanderley JS, Souza ML. Clinical presentation of chronic Chagas disease in elderly individuals. Rev Soc Bras Med Trop. 2007;40:311–5.10.1590/S0037-86822007000300012
  • Nunes MCP, Dones W, Morillo CA, Encina JJ, Ribeiro AL. Chagas disease: an overview of clinical and epidemiological aspects. J Am Coll Cardiol. 2013;62:767–76.10.1016/j.jacc.2013.05.046
  • Guariento ME, Carrijo CM, Almeida EA, Magna LA. Clinic profile of chagasic elders followed in a reference service. Rev Soc Bras Clín Méd. 2011;9:20–4.
  • Rocha MOC, Correia PC, Barros MVL, Torres RM, Ribeiro ALP, Teixeira MM. Cardiovascular function in elderly patients with chronic chagasic cardiopathy. Rev Soc Bras Med Trop. 2003;36:545–50.10.1590/S0037-86822003000500001
  • Ribeiro ALP, Marcolino MS, Prineas RJ, Lima-Costa MF. Electrocardiographic abnormalities in elderly Chagas disease patients: 10-year follow-up of the bambui cohort study of aging. J Am Heart Assoc. 2014;3:e000632.10.1161/JAHA.113.000632
  • Valderas JM, Sibbald B, Salisbury C. Defining comorbidity: implications for understanding health and health services. Ann Fam Med. 2009;7:357–63.10.1370/afm.983
  • Gurgel CBFM, Almeida EA. Frequency of hypertension in patients with chronic Chagas’ disease and its consequences on the heart: a clinical and pathological study. Arq Bras Cardiol. 2007;89:191–200.
  • Vicco MH, Bontempi I, Ortiz S, Solari A, Botasso OA, Marcipar I. Chronic Chagas disease with cardiodigestive involvement and the TcVI infective form of Trypanosoma cruzi. A case report. Parasitol Int. 2012;61:735–7.10.1016/j.parint.2012.04.007
  • Bertanha L, Guariento ME, Magna LA, Almeida EA. Clinical and laboratory characterization of hypertensive Chagas’ disease patients without evident heart failure. Rev Soc Bras Med Trop. 2008;41:163–8.
  • Hajjar ER, Cafiero AC, Hanlon JT. Polypharmacy in elderly patients. Am J Geriatr Pharmacother. 2007;5:345–51.10.1016/j.amjopharm.2007.12.002
  • Santos APAL, da Silva DT, dos Santos Júnior GA, Silvestre CC, Nunes MAP, Lyra DP, et al. Evaluation of the heterogeneity of studies estimating the association between risk factors and the use of potentially inappropriate drug therapy for the elderly: a systematic review with meta-analysis. Eur J Clin Pharmacol. 2015;71:1037–50.10.1007/s00228-015-1891-2
  • Loyola Filho AI, Uchoa E, Firmo JOA, Lima-Costa MF. A population-based study on use of medications by elderly Brazilians: the Bambuí Health and Aging Study (BHAS). Cad Saude Publica. 2005;21:545–53.10.1590/S0102-311X2005000200021
  • World Health Organization. Active ageing: a policy framework. Geneva: WHO; 2005.
  • Gurwitz JH, Field TS, Harrold LR, Rothschild J, Debellis KS, Andrew C, et al. Incidence and preventability of adverse drug events among older persons in the ambulatory setting. JAMA. 2003;289:1107–16.10.1001/jama.289.9.1107
  • Pompilio MA, Dorval MEMC, Cunha RV, Britto C, Borges-Pereira J. Epidemiological, clinical and parasitological aspects of Chagas’ disease in Mato Grosso do Sul State. Rev Soc Bras Med Trop. 2005;38:473–8.10.1590/S0037-86822005000600005
  • Silva ÉM, Rocha MOC, Silva RC, Paixão GC, Buzzati H, Santos AN, et al. Clinic and epidemiological study on Chagas disease in the Serra Azul district of Mateus Leme, central-western region of the State of Minas Gerais, Brazil. Rev Soc Bras Med Trop. 2010;43:178–81.10.1590/S0037-86822010000200014
  • Brasil PEAA, De Castro L, Hasslocher-Moreno AM, Sangenis LHC, Braga JU. ELISA versus PCR for diagnosis of chronic Chagas disease: systematic review and meta-analysis. BMC Infect Dis. 2010;10:337–53.10.1186/1471-2334-10-337
  • SVS. Brazilian consensus on Chagas disease. Rev Soc Bras Med Trop. 2005;38:1–29.
  • Schijman AG, Bisio M, Orellana L, Sued M, Duffy T, Jaramillo AMM, et al. International study to evaluate PCR methods for detection of Trypanosoma cruzi DNA in blood samples from Chagas disease patients. PLoS Negl Trop Dis. 2011;5:e931.10.1371/journal.pntd.0000931
  • Piron M, Fisa R, Casamitjana N, López-Chejade P, Puig L, Vergés M, et al. Development of a real-time PCR assay for Trypanosoma cruzi detection in blood samples. Acta Trop. 2007;103:195–200.10.1016/j.actatropica.2007.05.019
  • Campos RF, Magalhães JB, Reis EAG, Mitermayer GR, Andrade SG. Sensitivity of polymerase chain reaction for detection of known aliquots of Trypanosoma cruzi in the blood of mice: an in vitro study. Rev Soc Bras Med Trop. 2002;35:487–90.10.1590/S0037-86822002000500011

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.