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Research Article

Investigating alginate and chitosan electrospun nanofibers as a potential wound dressing: an in vitro study

, , , , , , & ORCID Icon show all
Pages 254-267 | Received 07 Mar 2024, Accepted 27 May 2024, Published online: 06 Jun 2024

References

  • Afshari M, Kotek R, Chen P. High performance fibers. In: High performance polymers and engineering plastics. New York: John Wiley & Sons, Inc; 2011. p. 269–340. doi: 10.1002/J9781118171950.ch9.
  • Umar M, Ullah A, Nawaz H, et al. Wet-spun bi-component alginate based hydrogel fibers: development and in-vitro evaluation as a potential moist wound care dressing. Int J Biol Macromol. 2021;168:601–610. doi: 10.1016/j.ijbiomac.2020.12.088.
  • Grand View Research. 2023. Medical textiles market size, share and trend analysis.
  • Dhivya S, Padma VV, Santhini E. Wound dressings: a review. Biomedicine (Taipei). 2015;5(4):22. doi: 10.7603/s40681-015-0022-9.
  • Masood R, Hussain T, Miraftab M, et al. Development of tri-component antibacterial hybrid fibres for potential use in wound care. J Wound Care. 2018;27(6):394–402. doi: 10.12968/jowc.2018.27.6.394.
  • Dabiri G, Damstetter E, Phillips T. Choosing a wound dressing based on common wound characteristics. Adv Wound Care (New Rochelle). 2016;5(1):32–41. doi: 10.1089/wound.2014.0586.
  • Boateng JS, Matthews KH, Stevens HNE, et al. Wound healing dressings and drug delivery systems: a review. J Pharm Sci. 2008;97(8):2892–2923. doi: 10.1002/jps.21210.
  • Hussain T, Masood R, Umar M, et al. Development and characterization of alginate–chitosan–hyaluronic acid (ACH) composite fibers for medical applications. Fibers Polym. 2016;17(11):1749–1756. doi: 10.1007/s12221-016-6487-7.
  • Masood R, Hussain T, Miraftab M, et al. Novel alginate, chitosan, and psyllium composite fiber for wound-care applications. J Ind Text. 2017;47(1):20–37. doi: 10.1177/1528083716632805.
  • Ambekar RS, Kandasubramanian B. Advancements in nanofibers for wound dressing: a review. Eur Polym J. 2019;117(March):304–336. doi: 10.1016/j.eurpolymj.2019.05.020.
  • Liu L, Zhang J, Zou X, et al. A high-stable and sensitive colorimetric nanofiber sensor based on PCL incorporating anthocyanins for shrimp freshness. Food Chem. 2022;377(July 2021):131909. doi: 10.1016/j.foodchem.2021.131909.
  • Yang J, Xu L. Electrospun nanofiber membranes with various structures for wound dressing. Materials (Basel). 2023;16(17). doi: 10.3390/ma16176021.
  • Rogalski JJ, Bastiaansen CWM, Peijs T. Rotary jet spinning review: a potential high yield future for polymer nanofibers. Nanocomposites. 2017;3(4):97–121. doi: 10.1080/20550324.2017.1393919.
  • Ullah A, Sun L, Wang F, et al. Eco-friendly bioactive β-caryophyllene/halloysite nanotubes loaded nanofibrous sheets for active food packaging. Food Packag Shelf Life. 2023;35(March):101028. doi: 10.1016/j.fpsl.2023.101028.
  • Ullah A, Yang H, Takemae K, et al. Sustainable bioactive food packaging based on electrospun zein-polycaprolactone nanofibers integrated with aster Yomena extract loaded halloysite nanotubes. Int J Biol Macromol. 2024;267(Pt 2):131375. doi: 10.1016/j.ijbiomac.2024.131375.
  • Hakro RA, Mehdi M, Qureshi RF, et al. Efficient removal of reactive blue-19 dye by co-electrospun nanofibers. Mater Res Expr. 2021;8(5):055502. doi: 10.1088/2053-1591/abfc7d.
  • Hashmi M, Ullah S, Ullah A, et al. An optimistic approach “from hydrophobic to super hydrophilic nanofibers” for enhanced absorption properties. Polym Test. 2020;90(March):106683. doi: 10.1016/j.polymertesting.2020.106683.
  • Jamali AA, Mahar FK, Hussain N, et al. Fabrication of chitosan-β-cyclodextrin-Fe nanofibers for the adsorption of As-III from aqueous solution using a lab-scale filtration system. J Appl Polym Sci. 2023;140(36):10. doi: 10.1002/app.54367.
  • Kausar A, Ahmad I, Aldaghri O, et al. Cutting-edge green nanoclay nanocomposites: fundamentals and technological opportunities for packaging, dye removal, and biomedical sectors. Nanocomposites. 2024;10(1):172–196. doi: 10.1080/20550324.2024.2336356.
  • Wang F, Zhang Y, Shi J, et al. Bioinspired and biodegradable functionalized graphene oxide/deacetylated cellulose acetate composite Janus membranes for water evaporation-induced electricity generation. ACS Sustain Chem Eng. 2023;11(26):9792–9803. doi: 10.1021/acssuschemeng.3c01952.
  • Sun L, Cai Y, Kim D, et al. Enhanced properties of solid polymer electrolytes by a bilayer nonwoven pet/nanofiber PVDF substrate for use in all-solid-state lithium metal batteries. J Power Sources. 2023a;564(April):232851. doi: 10.1016/j.jpowsour.2023.232851.
  • Sun L, Miyagi D, Cai Y, et al. Rational construction of hierarchical nanocomposites by growing dense polyaniline nanoarrays on carbon black-functionalized carbon nanofiber backbone for freestanding supercapacitor electrodes. J Storage Mater. 2023b;61(vember 2022):106738. doi: 10.1016/j.est.2023.106738.
  • Audtarat S, Hongsachart P, Dasri T, et al. Green synthesis of silver nanoparticles loaded into bacterial cellulose for antimicrobial application. Nanocomposites. 2022;8(1):34–46. doi: 10.1080/20550324.2022.2055375.
  • Haider MK, Kharaghani D, Sun L, et al. Synthesized bioactive lignin nanoparticles/polycaprolactone nanofibers: a novel nanobiocomposite for bone tissue engineering. Biomater Adv. 2023;144(June 2022):213203. doi: 10.1016/j.bioadv.2022.213203.
  • Parın FN, El-Ghazali S, Yeşilyurt A, et al. PVA/inulin-based sustainable films reinforced with pickering emulsion of niaouli essential oil for potential wound healing applications. Polymers (Basel). 2023;15(4):1002. doi: 10.3390/polym15041002.
  • Ullah A, Haider K, Wang F, et al. Clay-corn-caprolactone” a novel bioactive clay polymer nanofibrous scaffold for bone tissue engineering. Appl Clay Sci. 2022a;220:106455. doi: 10.1016/j.clay.2022.106455.
  • Ullah A, Sarwar MN, Wang F, et al. In vitro biocompatibility, antibacterial activity, and release behavior of halloysite nanotubes loaded with diclofenac sodium salt incorporated in electrospun soy protein isolate/hydroxyethyl cellulose nanofibers. Curr Res Biotechnol. 2022b;4(May):445–458. doi: 10.1016/j.crbiot.2022.09.008.
  • Liu Y, Zhou S, Gao Y, et al. Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer. Asian J Pharm Sci. 2019;14(2):130–143. doi: 10.1016/J.AJPS.2018.04.004.
  • Abid S, Hussain T, Nazir A, et al. Development of nanofibers based neuropathic patch loaded with Lidocaine to deal with nerve pain in burn patients. IOP Conf Ser: Mater Sci Eng. 2018;414(1):012019. doi: 10.1088/1757-899X/414/1/012019.
  • Abid S, Hussain T, Nazir A, et al. Acetaminophen loaded nanofibers as a potential contact layer for pain management in burn wounds. Mater Res Expr. 2018;5(8):085017. doi: 10.1088/2053-1591/aad2eb.
  • Abid S, Hussain T, Nazir A, et al. Enhanced antibacterial activity of PEO-chitosan nanofibers with potential application in burn infection management. Int J Biol Macromol. 2019;135:1222–1236. doi: 10.1016/j.ijbiomac.2019.06.022.
  • Chen S, Boda SK, Batra SK, et al. Emerging roles of electrospun nanofibers in cancer research. Adv Healthc Mater. 2018;7(6):e1701024. doi: 10.1002/adhm.201701024.
  • Haider MK, Ullah A, Sarwar MN, et al. Lignin-mediated in-situ synthesis of CuO nanoparticles on cellulose nanofibers: a potential wound dressing material. Int J Biol Macromol. 2021;173:315–326. doi: 10.1016/j.ijbiomac.2021.01.050.
  • Rasouli R, Barhoum A, Bechelany M, et al. Nanofibers for biomedical and healthcare applications. Macromol Biosci. 2019;19(2):e1800256. doi: 10.1002/mabi.201800256.
  • Sridhar R, Venugopal JR, Sundarrajan S, et al. Electrospun nanofibers for pharmaceutical and medical applications. J Drug Deliv Sci Technol. 2011;21(6):451–468. doi: 10.1016/S1773-2247(11)50075-9.
  • Sen S, Kumbhar AP, Patil JR, et al. Nanofibers: an effective biomedical tool for burn management. J Drug Deliv Sci Technol. 2023;87(July):104882. doi: 10.1016/j.jddst.2023.104882.
  • Sari MHM, Cobre ADF, Pontarolo R, et al. Status and future scope of soft nanoparticles-based hydrogel in wound healing. Pharmaceutics. 2023;15(3):874. doi: 10.3390/pharmaceutics15030874.
  • Nozari M, Gholizadeh M, Zahiri Oghani F, et al. Studies on novel chitosan/alginate and chitosan/bentonite flexible films incorporated with ZnO nano particles for accelerating dermal burn healing: in vivo and in vitro evaluation. Int J Biol Macromol. 2021;184(June):235–249. doi: 10.1016/j.ijbiomac.2021.06.066.
  • Aboomeirah AA, Sarhan WA, Khalil EA, et al. Wet electrospun nanofibers-fortified gelatin/alginate-based nanocomposite as a single-dose biomimicking skin substitute. ACS Appl Bio Mater. 2022;5(8):3678–3694. doi: 10.1021/acsabm.2c00147.
  • Hu Y, Zhang Z, Li Y, et al. Dual-crosslinked amorphous polysaccharide hydrogels based on chitosan/alginate for wound healing applications. Macromol Rapid Commun. 2018;39(20):e1800069. doi: 10.1002/marc.201800069.
  • Sadeghi-Aghbash M, Rahimnejad M, Adeli H, et al. Fabrication and development of PVA/alginate nanofibrous mats containing Arnebia Euchroma extract as a burn wound dressing. React Funct Polym. 2022;181(June):105440. doi: 10.1016/j.reactfunctpolym.2022.105440.
  • Stoica AE, Chircov C, Grumezescu AM. Hydrogel dressings for the treatment of burn wounds: an up-to-date overview. Materials (Basel). 2020;13(12):2853. doi: 10.3390/ma13122853.
  • Dragostin OM, Samal SK, Dash M, et al. New antimicrobial chitosan derivatives for wound dressing applications. Carbohydr Polym. 2016;141:28–40. doi: 10.1016/j.carbpol.2015.12.078.
  • Sami DG, Abdellatif A, Azzazy HME. Turmeric/oregano formulations for treatment of diabetic ulcer wounds. Drug Dev Indus Pharm. 2020;46(10):1613–1621. doi: 10.1080/03639045.2020.1811305.
  • Safi S, Morshed M, Hosseini Ravandi SA, et al. Study of electrospinning of sodium alginate, blended solutions of sodium alginate/poly(vinyl alcohol) and sodium alginate/poly(ethylene oxide). J Appl Polym Sci. 2007;104(5):3245–3255. doi: 10.1002/app.25696.
  • Duval M, Sarazin D. Properties of PEO in dilute solution under stirring. Macromolecules. 2003;36(4):1318–1323. doi: 10.1021/ma0208638.
  • Rafiq M, Hussain T, Abid S, et al. Development of sodium alginate/PVA antibacterial nanofibers by the incorporation of essential oils. Mater Res Expr. 2018;5(3):035007. doi: 10.1088/2053-1591/aab0b4.
  • Haider A, Haider S, Kang I-K. A comprehensive review summarizing the effect of electrospinning parameters and potential applications of nanofibers in biomedical and biotechnology. Arab J Chem. 2015;11(8):1165–1188. doi: 10.1016/j.arabjc.2015.11.015.
  • Subbiah T, Bhat GS, Tock RW, et al. Electrospinning of nanofibers. J Appl Polym Sci. 2005;96(2):557–569. doi: 10.1002/app.21481.
  • Islan GA, Tornello PC, Abraham GA, et al. Smart lipid nanoparticles containing levofloxacin and DNase for lung delivery: design and characterization. Colloids Surf B Biointerfaces. 2016;143:168–176. doi: 10.1016/j.colsurfb.2016.03.040.
  • Singh YP, Dasgupta S, Nayar S, et al. Optimization of electrospinning process and parameters for producing defect-free chitosan/polyethylene oxide nanofibers for bone tissue engineering. J Biomater Sci Polym Ed. 2020;31(6):781–803. doi: 10.1080/09205063.2020.1718824.
  • Bonino CA, Krebs MD, Saquing CD, et al. Electrospinning alginate-based nanofibers: from blends to crosslinked low molecular weight alginate-only systems. Carbohydr Polym. 2011;85(1):111–119. doi: 10.1016/j.carbpol.2011.02.002.
  • Kane SN, Mishra A, Dutta AK. Preface: international conference on recent trends in physics (ICRTP 2016). J Phys Conf Ser. 2016;755(1). doi: 10.1088/1742-6596/755/1/011001.
  • Nista SVG, Bettini J, Mei LHI. Coaxial nanofibers of chitosan–alginate–PEO polycomplex obtained by electrospinning. Carbohydr Polym. 2015;127:222–228. doi: 10.1016/j.carbpol.2015.03.063.
  • Qassim AW. Determination of levofloxacin in pharmaceutical formulationtavanic by visible spectrophotometry of its chelating complex with aluminum ion (III). Researchgate.Net, June. 2015. https://www.researchgate.net/publication/285494150.
  • Çaykara T, Demirci S, Eroğlu MS, et al. Poly(ethylene oxide) and its blends with sodium alginate. Polymer. 2005;46(24):10750–10757. doi: 10.1016/j.polymer.2005.09.041.
  • Qin Y. Absorption characteristics of alginate wound dressings. J Appl Polym Sci. 2004;91(3):1641–1645. doi: 10.1002/app.13291.
  • Yong K, Mooney DJ. Alginate: properties and biomedical applications. Prog Polym Sci. 2012;37(1):106–126. doi: 10.1016/j.progpolymsci.2011.06.003.
  • Aadil KR, Nathani A, Sharma CS, et al. Fabrication of biocompatible alginate-poly(vinyl alcohol) nanofibers scaffolds for tissue engineering applications. Mater Technol. 2018;33(8):507–512. doi: 10.1080/10667857.2018.1473234.
  • Qasim SB, Najeeb S, Delaine-Smith RM, et al. Potential of electrospun chitosan fibers as a surface layer in functionally graded GTR membrane for periodontal regeneration. Dent Mater. 2017;33(1):71–83. doi: 10.1016/J.DENTAL.2016.10.003.
  • Pervez M, Stylios G. Investigating the synthesis and characterization of a novel “green” H2O2-assisted, water-soluble chitosan/polyvinyl alcohol nanofiber for environmental end uses. Nanomaterials. 2018;8(6):395. doi: 10.3390/nano8060395.
  • Li X, Kanjwal MA, Lin L, et al. Electrospun polyvinyl-alcohol nanofibers as oral fast-dissolving delivery system of caffeine and riboflavin. Colloids Surf B Biointerfaces. 2013;103:182–188. doi: 10.1016/j.colsurfb.2012.10.016.
  • Kaassis AYA, Young N, Sano N, et al. Pulsatile drug release from electrospun poly(ethylene oxide)–sodium alginate blend nanofibres. J Mater Chem B. 2014;2(10):1400–1407. doi: 10.1039/C3TB21605E.
  • Cheng F, Gao J, Wang L, et al. Composite chitosan/poly(ethylene oxide) electrospun nanofibrous mats as novel wound dressing matrixes for the controlled release of drugs. J Appl Polym Sci. 2015;132(24):1–8. doi: 10.1002/app.42060.
  • Ullah A, Saito Y, Ullah S, et al. Bioactive Sambong oil-loaded electrospun cellulose acetate nanofibers: preparation, characterization, and in-vitro biocompatibility. Int J Biol Macromol. 2021;166:1009–1021. doi: 10.1016/j.ijbiomac.2020.10.257.
  • Sarker B, Singh R, Silva R, et al. Evaluation of fibroblasts adhesion and proliferation on alginate–gelatin crosslinked hydrogel. PLoS One. 2014;9(9):e107952. doi: 10.1371/journal.pone.0107952.
  • Denda M, Nakanishi S. Do epidermal keratinocytes have sensory and information processing systems? Exp Dermatol. 2022;31(4):459–474. doi: 10.1111/exd.14494.
  • Davis R, Bryson HM. Levofloxacin a review of its antibacterial activity, pharmacokinetics and therapeutic efficacy. Drug Eval. 2012;47:677–700. doi: 10.2165/00003495-199447040-00008.